Vorinostat (SAHA, MK0683)

製品コードS1047 別名:SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW):264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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JPY 31706.00
JPY 24402.00
JPY 36520.00

文献中Selleckの製品使用例(103)

カスタマーフィードバック(20)

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MVrLbY5ie2ViQYPzZZk> NEHuPFkyKGh? NWnPWpNNTE2VTx?= M3L5OoFvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= NG\V[WcyOTl4MES4PS=>
Friend leukemic cell NGPldmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqx[ZI2OCEQvF2= MoSxO|IhcA>? MXHEUXNQ MWPJR|UxRTBwOUmg{txO NX6zUXJNOTJzMEm5NVM>
K562 NXXxWWpmU2mwYYPlJGF{e2G7 NVPDcVM5PiCq NVrsVlZiTE2VTx?= NYK4dJlkUW6qaXLpeIlwdiCxZjDoeY1idiCqaYP0c45mKGSnYXPleJlt[XOnIDjtbZh1fXKnIH;mJGhFSUNzIHHu[EBJTEGFMjmge4l1cCCLQ{WwJI9nKDBwMEGg{txO M3vzU|EzPDF7M{iw
HT1080 M{nMU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LPVVczKGh? M1XRe2ROW09? NVPLWJM5UUN3ME2yMlQh|ryP Mn7RNVIzPzBzN{W=
H1299 NXvIWod[U2mwYYPlJGF{e2G7 MWeyNEBucW5? NY\0UY9iTE2VTx?= M2TjWWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN NUf5V3VNOTR3MkG0NlI>
H1299 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[xfYY4OiCq NIHJOY1FVVOR MWfJR|UxRTdwMkSg{txO MUmxOFUzOTR{Mh?=
HeLa M170N2tqdmG|ZTDBd5NigQ>? Ml;WN|AhdWmw NXznVY9HUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? NWe4NHBiOTV4MEO5OFk>
LOX-IMVI MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TscFQ5KGh? NFvxSm9KSzVyPUGuN{DPxE1? NE\KUpcyPTdzNUS3NC=>
NCI-H226 NWfCUI5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;j[VQ5KGh? MXXJR|UxRTJwNjFOwG0> MlmyNVU4OTV2N{C=
RXF-631L NHu5Xm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfBWXBJPDhiaB?= MVLJR|UxRTJizszN NXXUVXllOTV5MUW0O|A>
SNB-78 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHGV2lzPDhiaB?= Mn\BTWM2OD1zNjFOwG0> NXzGOZJJOTV5MUW0O|A>
St-4 NYO2Zo5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr0flNOPDhiaB?= MnPZTWM2OD13LkKg{txO NW\xV3pSOTV5MUW0O|A>
ARP1 M{LXOWZ2dmO2aX;uJGF{e2G7 MkfINkDPxE1? MVS2JIg> NWHF[HJbUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NV3YTnhPOTR5M{S4NFY>
CEM Mlm5T4lv[XOnIFHzd4F6 Mn;ZNUBp MWfEUXNQ NVH2RmtWUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= MXqxOlQzODB4NB?=
HCT15 M1jXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXTOFghcA>? MVnHTVUxRTBwOEKg{txO NFvVS2oyPjd{M{KyOy=>
NCI-H23 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfjeVR1PDhiaB?= NECwVGJIUTVyPUCuPVIh|ryP MnPPNVY4OjN{Mke=
GM15850 MYPLbY5ie2ViQYPzZZk> NF\YOVAzNjVizszN Mnr4PVYhcA>? M2m2R2ROW09? NV\4S2l2UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MW[xOlkzOTN4Nx?=
GM15850 NIjjWGRMcW6jc3WgRZN{[Xl? MoPlNk42KM7:TR?= Mn21PVYhcA>? NGr3elRFVVOR NVf5NHlLUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MYWxOlkzOTN4Nx?=
GM15850 MX7LbY5ie2ViQYPzZZk> NFyzXWozNjVizszN MUC5OkBp MUfEUXNQ NHHv[4dKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NVfzTnY5OTZ7MkGzOlc>
GM15850 MkL0T4lv[XOnIFHzd4F6 M3[1O|IvPSEQvF2= NU\kdI1kQTZiaB?= NYjlb4oxTE2VTx?= MUHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MlnLNVY6OjF|Nke=
GM15850 MnLOT4lv[XOnIFHzd4F6 M{P4ZVIvPSEQvF2= MX[5OkBp MX;EUXNQ M2Dmd2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n Ml7TNVY6OjF|Nke=
GM15850 NHXWUZhMcW6jc3WgRZN{[Xl? M1njNlIvPSEQvF2= MmnmPVYhcA>? MVzEUXNQ M2ruXGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MnfQNVY6OjF|Nke=
U937 MUTGeY5kfGmxbjDBd5NigQ>? NGPUbJY2KM7:TR?= NGrxbmEzPCCq Mlr5SG1UVw>? MoDzR4VtdCCleXPs[UBienKnc4SgZpkh[WOldX31cIF1cW:wIHH0JHMwTzJxTTDwbIF{\Q>? MlLuNVcxODR5MUi=
H661 NIPvTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3qwR|Q5KGh? NXHlWG1PUUN3ME2xJO69VQ>? NFXRPZMyPzF3N{CwPS=>
U937 M2D3e2Z2dmO2aX;uJGF{e2G7 MUG1JO69VQ>? MWmyOEBp Mn;USG1UVw>? NUH2T4dmUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> M1SxeVE4PDR5N{Ww
U937 MYXGeY5kfGmxbjDBd5NigQ>? NUTDbZZWOSEQvF2= M2D4elI1KGh? NX3ISppqTE2VTx?= MYXF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= NIPHSnAyPzR2N{e1NC=>
RAW264.7 MWPGeY5kfGmxbjDBd5NigQ>? NXPnZ3dTOTBizszN NWDsT5g2OjSq MV;3ZZRmeg>? M2HLeWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE44PiEQvF2= MkfsNVc1Pzd3MUi=
RAW264.7 NInMe|BHfW6ldHnvckBCe3OjeR?= MlrSNVAh|ryP NIHMeo0zPGh? NYPlOpdrf2G2ZYK= Mn\HTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> M{fMPFE4PDd5NUG4
SC9 NEHkWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M12yelQ5KGh? MU\JR|UxRTBwNkC2JO69VQ>? NG[yTZYyPzVyN{KxPS=>
ST14A Ml;rSpVv[3Srb36gRZN{[Xl? NXziZW46PSCwTR?= M3S4fFczKGh? NF;JNnBKdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v MojSNVc2PjV7OUO=
ST14A MlnCSpVv[3Srb36gRZN{[Xl? MlHLOUBvVQ>? NGPEZ2Y4OiCq MnvtTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? MnnvNVc2PjV7OUO=
PANC1 NIn6WmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX2xJO69VQ>? M3K4UmlEPTB;MD60OUDPxE1? MXSxO|U5QDd2NB?=
PANC1 MnHmSpVv[3Srb36gRZN{[Xl? MXixJO69VQ>? MoDXNlQhcA>? MXfJcoNz\WG|ZTDpckBxOjGZQV[xM2NKWDFiZ3Xu[UBmgHC{ZYPzbY9v MnLJNVc2QDh5NES=
PANC1 NVixTGpqTnWwY4Tpc44hSXO|YYm= MV:xJO69VQ>? MlW0NlQhcA>? Mm\5TY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= NFzmc2gyPzV6OEe0OC=>
PT45 NI\iRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ScYRKSzVyPUSg{txO M4jMdVE4PTh6N{S0
ACHN Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[yNUBp M4XOR2dKPTB;MD62OUDPxE1? MYixO|Y3OjZyNh?=
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NCI-H358 M1jh[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfaO|IhcA>? M1\ycWlEPTB;Mj61JO69VQ>? MoW5NlAyPDN5N{i=
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SCC25 NV\Ud21ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle2O|IhcA>? MYTJR|UxRTFwOUOg{txO M3P0O|IxOTR|N{e4
SKHEP1 M1vHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\HfZB5PzJiaB?= M2DSZ2lEPTB;Mz60OkDPxE1? MoPkNlAyPDN5N{i=
BJ M4PWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvnOJZPOTByIN88US=> NEnXTmI1QCCq NFrybHZFVVOR NFnhcphIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> MofYNlAyPDN6NEC=
MUF NU\HTpMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LaUVExOCEQvF2= MWW0PEBp MXPEUXNQ NV:zcYQ1T3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> MoPKNlAyPDN6NEC=
Caco-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ewVVExOCEQvF2= MWW0PIg> NFTpPFVFVVOR MkfhTWM2OD16LkGg{txO Mlz1NlAyPDN6NEC=
Caco-2 NFzFOGhMcW6jc3WgRZN{[Xl? M4DmbFUh|ryP MnHVOEBp MUXEUXNQ MVPJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN M3z6d|IxOTR|OESw
Caco-2 NF\te5JMcW6jc3WgRZN{[Xl? MlvZNE4{OTZibl2geI8hOzFwNjFOwG0> MVe0JIg> M1u4fWROW09? NWTEW2VFTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxJJdqfGhiSVO1NEBw\iByLkGxPUDPxE1? MlHYNlAyPDN6NEC=
Caco-2 MWPLbY5ie2ViQYPzZZk> NECwS|cxNjNzNjDuUUB1dyB|MT62JO69VQ>? MmqwOEBp NGnJVZJFVVOR MUPFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzNid3n0bEBKSzVyIH;mJFAvOTR5IN88US=> MX2yNFE1Ozh2MB?=
Caco-2 NH73S2tMcW6jc3WgRZN{[Xl? MmP3Ok4{OiCwTTD0c{A3OzJizszN MX[0JIg> MYjEUXNQ M1r5fWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNTD3bZRpKEmFNUCgc4YhOTJwNjFOwG0> NXfXZmhHOjBzNEO4OFA>
Caco-2 M4jlfmtqdmG|ZTDBd5NigQ>? NUn2bJBwPi5|MjDuUUB1dyB4M{Kg{txO M{HMblQhcA>? M3mx[WROW09? MnX0SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= MV[yNFE1Ozh2MB?=
Caco-2 MYXLbY5ie2ViQYPzZZk> MnjRNE4{OTZibl2geI8hOzFwNjFOwG0> NXH5W3BJPCCq M2LIcGROW09? NHnBRYlGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[= MV2yNFE1Ozh2MB?=
HepG2 NW\peYU{U2mwYYPlJGF{e2G7 MVi1JO69VQ>? M{nXTVZp MYPEUXNQ MUHJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u MX:yNFE1Ozh2MB?=
HepG2 NWPWN2I2U2mwYYPlJGF{e2G7 MleyOUDPxE1? NHPOdnA3cA>? NVrjdZlnTE2VTx?= MXfJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? NYHqRmR7OjBzNEO4OFA>
HepG2 M4XKWWtqdmG|ZTDBd5NigQ>? NFSzVJA2KM7:TR?= MnzlOog> MUfEUXNQ MXnJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w M4rwRVIxOTR|OESw
HepG2 M37yUGtqdmG|ZTDBd5NigQ>? MYm1JO69VQ>? MnT3Oog> M3LC[GROW09? NGHKc2tKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u Mn;XNlAyPDN6NEC=
COLO205 NFjTNm9McW6jc3WgRZN{[Xl? M{nOXVExKM7:TR?= MVyyOEBp M2XyfmROW09? MnHUTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NXfsXmt7OjB2NUGzO|g>
SCC4 M1XvUGtqdmG|ZTDBd5NigQ>? NWHJXpVkOSEQvF2= NEDte4gzPGh? MkP5TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= Mn;nNlA1PTJ{MkW=
SCC4 M3n1Z2tqdmG|ZTDBd5NigQ>? NYPUVYwxOSEQvF2= M4fvd|I1cA>? M2m1OGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u MUiyNFQ2OjJ{NR?=
SCC4 NXO3WGo4TnWwY4Tpc44hSXO|YYm= NEDvbFkyKM7:TR?= Mn;zOUBucW5? M2LKfGFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36= NXTPeXpoOjB2NUKyNlU>
NB4 MoXoSpVv[3Srb36gRZN{[Xl? M4jyVFUh|ryP MXqyOEBp M1;Oe2ROW09? NH\W[YRE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl M1LuWFIxPDlzNESw
NB4 Mlr3T4lv[XOnIFHzd4F6 Mm\uOUDPxE1? NWXUcXBrOjRiaB?= NHPhOpJFVVOR Mn3yTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHj[ZR6dGG2ZTD0eYJ2dGmwIHzleoVt NH62VnkzODR7MUS0NC=>
NB4 NUP2OYFwTnWwY4Tpc44hSXO|YYm= M{GyUVUh|ryP MVyyOEBp NY\4XJVETE2VTx?= NVS4bYZ6UW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v MVWyNFQ6OTR2MB?=
NB4 Mo\2T4lv[XOnIFHzd4F6 MUC1JO69VQ>? NYf4VXI6OjRiaB?= MXTEUXNQ Mke1TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgZYNmfHmuYYTpc44> MoH5NlA1QTF2NEC=
NUGC3 M3uxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D1UWdKPTB;Mj65OEDPxE1? NW[2XFAxOjB6NUC5O|E>
A549 M2\0WmZ2dmO2aX;uJGF{e2G7 M4rKblUh|ryP M4W5T|MhcA>? M3zvbWROW09? NHS3bplKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> NFPRRnozODh3NUKwPC=>
HUT78 NHPHO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX63NkBp MknYSG1UVw>? M2e1d2dKPTB;MD6zJO69VQ>? M2XUNlIxQDh2MkC4
U937 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjXO|IhcA>? MluzSG1UVw>? NGLKRWJIUTVyPUCuN|kh|ryP NUnDW5BmOjB6OESyNFg>
A431 NYLTd3F6S3m2b4TvfIlkKEG|c3H5 MkTOO|IhcA>? MoqzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP M3;kPVIyODhyNkK5
A549 MmL1R5l1d3SxeHnjJGF{e2G7 NEf3WHk4OiCq MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuPEDPxE1? NVXQV2dKOjFyOEC2Nlk>
CAL27 MmHSR5l1d3SxeHnjJGF{e2G7 MoLhO|IhcA>? NF7RcY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN MlfLNlExQDB4Mkm=
HeLa MVvDfZRwfG:6aXOgRZN{[Xl? NYLjW|hyPzJiaB?= MnzTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlUh|ryP NYTF[lBPOjFyOEC2Nlk>
Sf21 NH\vSFFMcW6jc3WgRZN{[Xl? MmP5N{Bp NUi5UXk1UW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> NYOwXJJNOjFyOEC2Nlk>
SKBR3 MXnDfZRwfG:6aXOgRZN{[Xl? NXfuNmRPPzJiaB?= Mn3rR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= MVWyNVA5ODZ{OR?=
SKOV3 M2P4c2N6fG:2b4jpZ{BCe3OjeR?= M13xblczKGh? NUHzO5NWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NIL0fZYzOTB6ME[yPS=>
COR-L23 NUfWUJRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[0blExKM7:TR?= NH3tW4s4OiCq NVfyOZd6TE2VTx?= NUK3NVVMT0l3ME2xMlEh|ryP NYmyfYdpOjFyOEC2OFc>
DU145 M1PITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hq[lExKM7:TR?= NYfi[HVZPzJiaB?= MYrEUXNQ NF;qUIhIUTVyPUGuNFUh|ryP MnHYNlExQDB4NEe=
LoVo NEjYRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7KNVAh|ryP NFLMWmI4OiCq NXzPXVQ1TE2VTx?= M3rObmdKPTB;MT63JO69VQ>? M2nRWFIyODhyNkS3
MCR5-SV2 NGHiV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:xNEDPxE1? M1LlS|czKGh? NFzRfVFFVVOR M4XBPWdKPTB;Mj6xJO69VQ>? M4rrdlIyODhyNkS3
HCT116 NX3LS3RSU2mwYYPlJGF{e2G7 Mmr1N|Ah|ryP Ml3RN|AhcA>? MmXxSG1UVw>? NHjNemFKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NGmzWJAzOTB6ME[0Oy=>
HCT116 M2P0TGtqdmG|ZTDBd5NigQ>? MV[zNEDPxE1? NGrSPJU{OCCq NXX6S2I5TE2VTx?= MoTCTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN2s6KGGlZYT5cIF1cW:w NF7Kb3YzOTB6ME[0Oy=>
U937 MVvLbY5ie2ViQYPzZZk> MV:1JO69VQ>? Mn:zNlQhcA>? M3ftXGROW09? Mm\PTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? NHnRcHEzOTJ7MkS5Ni=>
U937 MYjLbY5ie2ViQYPzZZk> NV7obVJuPSEQvF2= M16wXlI1KGh? NUjCZVA{TE2VTx?= NWroc5ZQUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NIDxPGkzOTJ7MkS5Ni=>
U937 NFmxXJlMcW6jc3WgRZN{[Xl? MlrVOUDPxE1? NEf5NnozPCCq M1zBTGROW09? Mlf4TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? NXrXWow{OjF{OUK0PVI>
U937 M2TxTGtqdmG|ZTDBd5NigQ>? MUC1JO69VQ>? M3vW[|E2KG2rbh?= MorTSG1UVw>? NXfQfpNGUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? MmTKNlEzQTJ2OUK=
A2780 NYX6UJJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUe5OkBp NEDpU|VFVVOR NHnZeIdKSzVyPUGuOlIh|ryP Ml7qNlE3OzR2M{C=
COLO205 M1zT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m4Zlk3KGh? M{PEeWROW09? NUjlTW86UUN3ME2yMlEzKM7:TR?= NXP1XW9mOjF4M{S0N|A>
Hep3B MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH64PY01QCCq MmHNSG1UVw>? MXnHTVUxRTFwMkGg{txO M1;hXlIyPzF{MUS2
GM11272 NI[wOVdHfW6ldHnvckBCe3OjeR?= MWWxNFAhdk1? MlX2O|IhcA>? NWnJXIRyTE2VTx?= NE[zd|VT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O MmrWNlE5PDB5MU[=
CFBE41o NIj4VllMcW6jc3WgRZN{[Xl? M33DZVUh|ryP Ml;iSG1UVw>? M{\MW2Rwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? MUeyNVk5PDl3OB?=
CFBE41o MYPGeY5kfGmxbjDBd5NigQ>? NXLPRYpTOSEQvF2= M4PwVlI1KGh? NXvQZZRbTE2VTx?= MmnTVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| MX2yNVk5PDl3OB?=
DU145 M1z2N2tqdmG|ZTDBd5NigQ>? NVy2WnMzOi53IN88US=> NFPhVpQzPCCq M2S0c2ROW09? NE\n[ZNKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKHB{MYfh[lEheHKxdHXpckBmgHC{ZYPzbY9v M4e1dVIzOjZyMU[2
DU145 MXjLbY5ie2ViQYPzZZk> NG\qdFU2KM7:TR?= MlmwNlQhcA>? NEXXO2NFVVOR NYHwbFNZUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> M{TQelIzOjZyMU[2
DU145 NV\lR|d[U2mwYYPlJGF{e2G7 M1P4b|Uh|ryP Mn;pNlQhcA>? NXLKXYx6TE2VTx?= MVfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v MnjSNlIzPjBzNk[=
786-0 MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe2MlIh|ryP M{nOXFczKGh? NGDmO2NFVVOR MoTHS2k2OD1|LkKg{txO MUGyNlQ{PTZ4OR?=
A498 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLwWZg6Pi5{IN88US=> MUS3NkBp MVvEUXNQ NWTSZo43T0l3ME2xMlYh|ryP MVOyNlQ{PTZ4OR?=
A549/ATCC Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjLOk4zKM7:TR?= NXzkZXVMPzJiaB?= NH3nUYZFVVOR NH7CTndIUTVyPUGuOkDPxE1? MknqNlI1OzV4Nkm=
ACHN MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL6V45xPi5{IN88US=> Mm\XO|IhcA>? MnH2SG1UVw>? M33hR2dKPTB;MT6zJO69VQ>? MWeyNlQ{PTZ4OR?=
BT549 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorEOk4zKM7:TR?= NXPYRnR1PzJiaB?= M3KybGROW09? NX\l[XV[T0l3ME2xMlMh|ryP MlXENlI1OzV4Nkm=
EKVX MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm4ZXpPPi5{IN88US=> M3O3VVczKGh? MkHmSG1UVw>? MXfHTVUxRTFwMzFOwG0> MnnzNlI1OzV4Nkm=
HCT15 NH\u[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;NdVk3NjJizszN MnzOO|IhcA>? NEixbXdFVVOR NWjEWVdYT0l3ME2yMlUh|ryP MnfPNlI1OzV4Nkm=
HOP92 M17Obmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXm2MlIh|ryP M{L0ZVczKGh? M4PFSWROW09? NILKOGRIUTVyPUSg{txO MkXKNlI1OzV4Nkm=
IGROV1 MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jRZVYvOiEQvF2= NGLke3g4OiCq NX3HOVhUTE2VTx?= MXfHTVUxRTFwMzFOwG0> NEDIZYIzOjR|NU[2PS=>
LOXIMVI MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HzTlYvOiEQvF2= NEfETWQ4OiCq NI\4U3dFVVOR NGDJOndIUTVyPUGg{txO NHXTPIQzOjR|NU[2PS=>
M14 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVu2MlIh|ryP M2DRZVczKGh? M2fnV2ROW09? MV3HTVUxRTFwMzFOwG0> NIXhRWEzOjR|NU[2PS=>
MALME-3M MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\CPFE3NjJizszN NF\qbog4OiCq M3;xS2ROW09? NWf4WVFyT0l3ME2wMlMzKM7:TR?= Mof6NlI1OzV4Nkm=
MCF10A MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jW[VYvOiEQvF2= MUm0PEBp M3W0SmROW09? M2jjU2dKPTB;OT62JO69VQ>? M{\ublIzPDN3Nk[5
MDA-MB-435 NEXQRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGiyc3I3NjJizszN M4\vb|czKGh? NI\ybm5FVVOR NEn1emxIUTVyPUCuOUDPxE1? MoXZNlI1OzV4Nkm=
MDA-MB-468 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXW2MlIh|ryP NX;wSm53PzJiaB?= M{fYbWROW09? NEXiRY1IUTVyPUCuOlMh|ryP MXSyNlQ{PTZ4OR?=
MOLT4 NEL3XmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXZT2g3NjJizszN MkTNO|IhcA>? NXnGVXhmTE2VTx?= MnnPS2k2OD1yLkSg{txO NF;nUXkzOjR|NU[2PS=>
NCI-ADR-RES NGTSXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYC2MlIh|ryP MVK3NkBp NHjrc|RFVVOR M4LXWmdKPTB;MD6xOkDPxE1? Mk[0NlI1OzV4Nkm=
NCI-H23 M4DMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX6Ok4zKM7:TR?= NFPsWnc4OiCq NXzpVGhETE2VTx?= MWnHTVUxRTFizszN NFHNdm8zOjR|NU[2PS=>
NCI-H322M MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf0WpU3NjJizszN MnfRO|IhcA>? MlPqSG1UVw>? NVrYemRZT0l3ME2wMlc6KM7:TR?= MXqyNlQ{PTZ4OR?=
NCI-H460 NG\3RWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17kblYvOiEQvF2= NHe4PZM4OiCq NWHFRXg3TE2VTx?= MnjSS2k2OD1yLke5JO69VQ>? MmjpNlI1OzV4Nkm=
NCI-H522 NXK5ZoJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXu[YpNPi5{IN88US=> NWnBWoo{PzJiaB?= NXPNb49lTE2VTx?= NIf2S3JIUTVyPUCuOUDPxE1? NHvUNoMzOjR|NU[2PS=>
OVCAR3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTwR|JOPi5{IN88US=> NGHFT2k4OiCq NVi4RldRTE2VTx?= Mn7OS2k2OD1zLkOg{txO MoTUNlI1OzV4Nkm=
OVCAR4 NXjTUYpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\MOk4zKM7:TR?= M3rBSlczKGh? MXnEUXNQ M3m4d2dKPTB;NDFOwG0> NXf0UoxsOjJ2M{W2Olk>
OVCAR5 NUD1VWZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWm2MlIh|ryP MVK3NkBp NXzLb5hkTE2VTx?= MmKyS2k2OD1yLke5JO69VQ>? NV;yOYxvOjJ2M{W2Olk>
OVCAR8 NFG4dGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYe2MlIh|ryP M4\DPVczKGh? NYKwWVZMTE2VTx?= NITlcoRIUTVyPUCuOUDPxE1? Ml\3NlI1OzV4Nkm=
RXF393 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDCOk4zKM7:TR?= NWDCSWJNPzJiaB?= Mmi5SG1UVw>? NVi0eIpuT0l3ME2xMlMh|ryP NUTMPXU{OjJ2M{W2Olk>
SF268 M4n0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLQOk4zKM7:TR?= M{CwNVczKGh? M2qycWROW09? MWfHTVUxRTFwNjFOwG0> MU[yNlQ{PTZ4OR?=
SF295 NWPqXmVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC2MlIh|ryP MlS4O|IhcA>? M{LaO2ROW09? MnnXS2k2OD1zLk[g{txO NVvHVZgyOjJ2M{W2Olk>
SF539 NIrzWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX62MlIh|ryP MoXKO|IhcA>? M4DvUWROW09? NEfH[4dIUTVyPUKg{txO NV23R29FOjJ2M{W2Olk>
SK-MEL-2 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXEOk4zKM7:TR?= NGf3UXc4OiCq NGj3No9FVVOR M2rqRmdKPTB;MT6zJO69VQ>? MmTTNlI1OzV4Nkm=
SK-MEL-28 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HLXFYvOiEQvF2= NVu1ZZdtPzJiaB?= NX7LO5VCTE2VTx?= MUjHTVUxRTFizszN M13NOlIzPDN3Nk[5
SK-MEL-5 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUO2MlIh|ryP MlT3O|IhcA>? MnjNSG1UVw>? NGrDfVhIUTVyPUCuOlMh|ryP NHPo[YQzOjR|NU[2PS=>
SKOV3 NXyycXZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnnZ25jPi5{IN88US=> NWTWboRzPzJiaB?= NXPY[4M1TE2VTx?= NWrNbHhzT0l3ME2xJO69VQ>? M2DsXFIzPDN3Nk[5
SN12C MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:5[3o3NjJizszN NH\Ze4c4OiCq NVz6foZRTE2VTx?= M13z[GdKPTB;MjFOwG0> NEfSW2szOjR|NU[2PS=>
SNB19 NHvKbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXCOk4zKM7:TR?= M{P4eFczKGh? M4\qbWROW09? NELpeY5IUTVyPUCuOlMh|ryP MVmyNlQ{PTZ4OR?=
SNB75 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIGwU4w3NjJizszN NVn0W2hpPzJiaB?= M1\IUGROW09? M3j1WmdKPTB;MD63PUDPxE1? NYXLRlF7OjJ2M{W2Olk>
SR M17CZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvjOk4zKM7:TR?= MXK3NkBp MX7EUXNQ M{fU[GdKPTB;MD60JO69VQ>? M2rTSFIzPDN3Nk[5
T47D NV3v[YhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTpOok3NjJizszN MUe3NkBp M2e2dWROW09? MmrpS2k2OD1yLkWg{txO Mly1NlI1OzV4Nkm=
TK10 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;vOnljPi5{IN88US=> NHXnVm44OiCq NIqwU2dFVVOR MnHyS2k2OD1yLk[zJO69VQ>? NEn2XnczOjR|NU[2PS=>
UACC257 NFjRUmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnaOk4zKM7:TR?= NV:1W3FyPzJiaB?= M3T3XmROW09? M{nvOWdKPTB;MD61JO69VQ>? MlvQNlI1OzV4Nkm=
UACC62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqydZM3NjJizszN NV:zT285PzJiaB?= M13jbWROW09? M1uzfGdKPTB;MD60JO69VQ>? MkHVNlI1OzV4Nkm=
UO31 M3;CT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX5Ok4zKM7:TR?= NGTHZ3I4OiCq MWrEUXNQ M3vwWGdKPTB;MD61JO69VQ>? Ml\nNlI1OzV4Nkm=
Hep3B MmXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon4OFghcA>? M332eGROW09? NWnJdnlsT0l3ME2wMlY6KM7:TR?= MXmyNlQ{QTh4Mx?=
BE(2)-C NFG0ZpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjle5RuPzJiaB?= MU\EUXNQ Mm\PTWM4OD1{IN88US=> NG\x[W8zOjl|MkOxOi=>
Bel7402 NH\FbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;rPVVvPzJiaB?= MUPEUXNQ NXThTm1nT0l7ME2xO{DPxE1? NUXMVVF1OjNyNkGzO|Y>
Bel7404 M1vp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnkO|IhcA>? MoDISG1UVw>? MnT0S2k6OD1zODFOwG0> MX[yN|A3OTN5Nh?=
BGC823 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17JT|czKGh? M4PxR2ROW09? NVHZW2hbT0l7ME23MlUh|ryP NXzm[2FIOjNyNkGzO|Y>
MGC803 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfiO|IhcA>? NVPUb3k1TE2VTx?= MnPKS2k6OD1zMD64JO69VQ>? MWGyN|A3OTN5Nh?=
SGC7901 M37zc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjQO|IhcA>? NImyNJpFVVOR NX\TSnhkT0l7ME25MlQh|ryP NFr6T3gzOzB4MUO3Oi=>
SKHEP1 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLnO3A4OiCq NHLtW2hFVVOR M2rLcmdKQTB;MUeg{txO NELEVIgzOzB4MUO3Oi=>
SMMC7721 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVW3NkBp MlixSG1UVw>? M3fCdGdKQTB;MkCg{txO MkLiNlMxPjF|N{[=
NUGC3 M1TSNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnRbJkyOCEQvF2= NH7MdJpIUT1{Lkm0JO69VQ>? NGfYVJAzOzF4M{OzNi=>
A2780 CisR NVHCW5kzU2mwYYPlJGF{e2G7 NI\MPJUyQCCq MmHhTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? M4L2dlI{OjV{NkCz
CAL27 sens MV;LbY5ie2ViQYPzZZk> MVyxPEBp MnH2TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? MXiyN|I2OjZyMx?=
CAL27 CisR NYrqWmlQU2mwYYPlJGF{e2G7 MUKxPEBp M{jpSWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M3P1blI{OjV{NkCz
KYSE-510 CisR MWrLbY5ie2ViQYPzZZk> M2DZdlE5KGh? MoH6TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkW5JO69VQ>? MmrENlMzPTJ4MEO=
KYSE-510 sens M4GyV2tqdmG|ZTDBd5NigQ>? NYnIfYlVOThiaB?= M1rRVmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? MWWyN|I2OjZyMx?=
MDA-MB-231 sens NVLUXFRnU2mwYYPlJGF{e2G7 M4DKUVE5KGh? NVj2Z4FpUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= NGL6TpkzOzJ3Mk[wNy=>
MDA-MB-231 CisR NEnsV3NMcW6jc3WgRZN{[Xl? MVWxPEBp MYPJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NVixVIV2OjN{NUK2NFM>
ES2 NIW4PZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi0PEBp MnW3SG1UVw>? M{X0TmlEPTB;MUKuO{DPxE1? NFHCUZEzOzR7M{S0PS=>
MDA-MB-231 MVTLbY5ie2ViQYPzZZk> NH;oNIgyOCEQvF2= NGG2fZY{OCCvaX6= MVvEUXNQ M2PjO2lvcGmkaYTpc44hd2ZiSFTBR|Ji MV6yN|Q6OzR2OR?=
MDA-MB-231 NEX4cmlMcW6jc3WgRZN{[Xl? NFSzPW8yKM7:TR?= Mm\2NlQhcA>? NXPiVVFXTE2VTx?= M2nkbGlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NVfjd5NiOjN2OUO0OFk>
HS68 M33hdWN6fG:2b4jpZ{BCe3OjeR?= NYrmV2ZFOTBizszN NFXxdYo4OiCq NH3CfXNFVVOR MknqTWM2OD12Lk[g{txO NYjxZY5sOjN3N{C1OFI>
MEF NYn0enR3S3m2b4TvfIlkKEG|c3H5 MnfLNVAh|ryP M1zwWlczKGh? NFzy[5pFVVOR NHLVSXRKSzVyPUSuOEDPxE1? NH[0XGgzOzV5MEW0Ni=>
BGC823 NW\5eIx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jRV2ROW09? M{XiXmdKPTB;Mz6wPUDPxE1? MVKyN|YxOTdyNh?=
High5 MWLLbY5ie2ViQYPzZZk> NViwTIRSOjRiaB?= NXLiTHViUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= M2KzR|I{PjB{NUKz
High5 MWTLbY5ie2ViQYPzZZk> MnHiNlQhcA>? MlnuTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? NEXTRpUzOzZyMkWyNy=>
High5 MVvLbY5ie2ViQYPzZZk> NHf6NlMzPCCq MmnrTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? MYeyN|YxOjV{Mx?=
A549 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPEUXNQ M1O3dGlEPTB;MT6wO|kh|ryP NWS4WG9pOjN4NESyNVA>
HCT116 NIWwbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPBSG1UVw>? NHzx[phKSzVyPUCuO|U4KM7:TR?= NUK0PXlxOjN4NESyNVA>
K562 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\qR3lFVVOR NGnQVG5KSzVyPUCuOlQ2KM7:TR?= NXXuU|ZUOjN4NESyNVA>
GBC-SD NG\ETZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC1dIg2KM7:TR?= MX23NkBp NH;vTFNFVVOR MV3JR|UxRTF2Lkig{txO MUGyN|cxPzJ4MB?=
HGC27 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O2dlUh|ryP M1f4XVczKGh? NHfTNmZFVVOR NF;a[4JKSzVyPUWuOEDPxE1? MVuyN|cxPzJ4MB?=
HL60 NGTDZ|VMcW6jc3WgRZN{[Xl? MmjpOUDPxE1? NULMXWh[OjRiaB?= MVzEUXNQ MYTJcohq[mm2aX;uJI9nKEiGQVO= NEnOTGMzOzdyN{K2NC=>
Vero M2iye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3mO|IhcA>? NI\SVnhFVVOR NWK0S45KUUN3ME2wMlkh|ryP NEjTPFQzOzd6NkS1Ni=>
NCI60 M{HoPGN6fG:2b4jpZ{BCe3OjeR?= MmPUOFghcA>? NVLodXJuTE2VTx?= M1nDfGdKRTBwNUOg{txO M4n4bFI1ODF3M{K3
SW620 MVXDfZRwfG:6aXOgRZN{[Xl? MYG0PEBp NH7JSVFFVVOR M1XVUWdKRTBwNUSg{txO MmDkNlQxOTV|Mke=
U251 MYHDfZRwfG:6aXOgRZN{[Xl? MlfQOFghcA>? MnfiSG1UVw>? MXzHTV0yNjV|IN88US=> MVOyOFAyPTN{Nx?=
KM12 MljIR5l1d3SxeHnjJGF{e2G7 M1zHRVQ5KGh? MojzSG1UVw>? NInzN29IUT1zLki4JO69VQ>? MVOyOFAyPTN{Nx?=
Hs578T NEPGUHhEgXSxdH;4bYMhSXO|YYm= M4iwdlQ5KGh? NID0b3lFVVOR NGrPUWlIUT12LkizJO69VQ>? NHOyTlAzPDBzNUOyOy=>
MDA-MB-231 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[5OFghcA>? MkDXTWM2OD1yLkG2JO69VQ>? NIjueoIzPDB7NUCxOi=>
MCF7 Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjyfG9wPDhiaB?= NXvoe5RrT0l;MD60OUDPxE1? M4\yNVI1OTF7NUW1
MDA-MB-435 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[0PEBp M4HKSWdKRTBwOEig{txO NWLPZXpPOjRzMUm1OVU>
AsPC1 NFLqcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInGRo0{OCEQvF2= M2PRN|Q5KGh? NEGyPVhFVVOR NIWzUo9KSzVyPUOuOlYh|ryP NIi2bZEzPDF6NUO3PC=>
Jurkat E6.1 NVvLc|VCU2mwYYPlJGF{e2G7 NWX3W4VYOiCq MYfEUXNQ NEXZO4VKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= NUKxcGs5OjR{NkG4OlI>
KG1 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHGUWJVPDhiaB?= NXL1ZZdVUUN3ME2xMlE2KM7:TR?= NYDIOml[OjR3MkWwNFM>
HEL NWrSRmR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzwOFghcA>? M1;1fGROW09? NHLOUm9KSzVyPUCuOFkh|ryP NXnKWpp7OjR4OUSwOVU>
HSC3 M{C5fmN6fG:2b4jpZ{BCe3OjeR?= NYL1eXdXOTJiaB?= Ml\uSG1UVw>? NVznWGFQUUN3ME2wMlcyKM7:TR?= MUGyOFc3PjV4MB?=
HT-29 NG\UZ|BEgXSxdH;4bYMhSXO|YYm= NXPSOo1KOTJiaB?= M32wTWROW09? M2r0TWlEPTB;MD63NkDPxE1? M2foeFI1PzZ4NU[w
KB MXHDfZRwfG:6aXOgRZN{[Xl? MYGxNkBp NGryPVBFVVOR NFi2VXpKSzVyPUCuO|Uh|ryP M2HRflI1PzZ4NU[w
H460 NH6wW29EgXSxdH;4bYMhSXO|YYm= MXmxNkBp MnrNSG1UVw>? NInSPWpKSzVyPUCuPFIh|ryP NXnEV5pVOjR5Nk[1OlA>
MONE1 NU\CTGYyS3m2b4TvfIlkKEG|c3H5 MmPaNVIhcA>? M1XhWGROW09? MYXJR|UxRTFwMUig{txO MWWyOFc3PjV4MB?=
MKN45 MnO0R5l1d3SxeHnjJGF{e2G7 MV2xNkBp M1PrfGROW09? MkjTTWM2OD1zLkK1JO69VQ>? MUWyOFc3PjV4MB?=
TSGH M4TKXWN6fG:2b4jpZ{BCe3OjeR?= NHnnSXgyOiCq MlPuSG1UVw>? MWLJR|UxRTJwMEmg{txO NXy1O2JEOjR5Nk[1OlA>
HL60 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[zb|czKGh? NFnYe21FVVOR MnrXS2k2OD1yLkmzJO69VQ>? MV[yOFkxODVyMB?=
HEK293 NGjHdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojoO|IhcA>? MVrEUXNQ M3HVcWdKPTB;MUOg{txO M2noXFI1QTByNUCw
Jurkat NFrUT4NEgXSxdH;4bYMhSXO|YYm= NXy3[XlnOTByIN88US=> NXLabnVYPzJiaB?= NF;LXnNIUTVyPUCuPUDPxE1? NVrMWYJDOjR7MEC3OFM>
GM15850 M{KzZ2tqdmG|ZTDBd5NigQ>? MWKyMlUh|ryP NUf5NnpJQTZiaB?= M3n2[GROW09? MmnZ[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MXSxOlkzOTN4Nx?=
GM15850 MUPLbY5ie2ViQYPzZZk> NH7vUIwzNjVizszN MnHoPVYhcA>? MnvoSG1UVw>? M{jMfoRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MnXhNVY6OjF|Nke=
GM15850 NV75WnFOU2mwYYPlJGF{e2G7 NELORpgzNjVizszN MUi5OkBp NUj0S5pxTE2VTx?= MVLkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NHjmUoQyPjl{MUO2Oy=>
GM15850 MXHLbY5ie2ViQYPzZZk> NXvkUVZEOi53IN88US=> M1;tSlk3KGh? MmTtSG1UVw>? M2DlR4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NEHvSYQyPjl{MUO2Oy=>
GM15850 NHHndnNMcW6jc3WgRZN{[Xl? MkexNk42KM7:TR?= NFnhVlk6PiCq MmniSG1UVw>? MmXa[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWH2UIg1OTZ7MkGzOlc>
GM15850 MlXzT4lv[XOnIFHzd4F6 NIDrc40zNjVizszN MYq5OkBp NUXtRZZ1TE2VTx?= Mnn6[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXjNcJNiOTZ7MkGzOlc>
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PA-1 Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ6Nj6yOkBvVQ>? MXXTRW5ITVJ?
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CHP-212 M2HYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDMc45KSzVyPUS1O{42OyCwTR?= M4fOR3NCVkeHUh?=
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697 NYHjNFZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjp[lBKSzVyPUS3N{41OSCwTR?= MWPTRW5ITVJ?
BCPAP NF\1dldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli5TWM2OD13MEGuOFIhdk1? M{\3bXNCVkeHUh?=
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BE-13 NF;IbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjLTWM2OD13Mk[uPVYhdk1? M3zmOHNCVkeHUh?=
CTB-1 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTV|Nz65NkBvVQ>? NFrsZ2hUSU6JRWK=
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NKM-1 MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTV2ND6yO{BvVQ>? MWXTRW5ITVJ?
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DB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3uTWM2OD13OUiuOVchdk1? NWrGNmFPW0GQR1XS
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MV-4-11 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLqTWM2OD14NUmuNUBvVQ>? NIH5VoRUSU6JRWK=
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NB14 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjyWmtKSzVyPU[5Ok46PSCwTR?= NVjwR2tTW0GQR1XS
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D-423MG M364Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3STWM2OD15ME[uPFkhdk1? MnrNV2FPT0WU
D-283MED Ml\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXsUHVKSzVyPUexOE4yPCCwTR?= NYG5dog3W0GQR1XS
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LU-139 M1Pid2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTh{Mj64OkBvVQ>? M2fScXNCVkeHUh?=
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RCM-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r5fWlEPTB;MT6xNlExOiEQvF2= MnfqV2FPT0WU
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NCI-H1092 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjDTWM2OD1zLkG1OFA3KM7:TR?= MV3TRW5ITVJ?
EW-3 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDJTWM2OD1zLkG3NlEzKM7:TR?= M3;wPHNCVkeHUh?=
HCT-116 Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTFwMUe3OUDPxE1? NH72PWZUSU6JRWK=
MC-IXC M2HyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP5d3VTUUN3ME2xMlE4QDhzIN88US=> NX\Edo17W0GQR1XS
LB1047-RCC NHrMSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHub4F{UUN3ME2xMlE5OzF{IN88US=> NXPofo5LW0GQR1XS
VM-CUB-1 M3rIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnZ[VFKSzVyPUGuNVkyODhizszN MUPTRW5ITVJ?
NB5 NVG0Opk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwMUm4OVYh|ryP M1jkUHNCVkeHUh?=
SKG-IIIa NX;ET4kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrVPIpKSzVyPUGuNlM1PjRizszN NV63[5prW0GQR1XS
HO-1-N-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvS[W5SUUN3ME2xMlI{QDN3IN88US=> NHLuVYNUSU6JRWK=
EFO-27 NUHqZY9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMkWwOFMh|ryP NH;mPGVUSU6JRWK=
MHH-NB-11 MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O0e2lEPTB;MT6yPFMzQSEQvF2= NW[5eW16W0GQR1XS
SW620 NUTHNZNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTUTnhJUUN3ME2xMlI6ODF6IN88US=> MV3TRW5ITVJ?
MOLT-16 M3HsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[4WWlEPTB;MT6yPVc6PyEQvF2= M{nOVnNCVkeHUh?=
NTERA-S-cl-D1 NGPWfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13mS2lEPTB;MT6zNVc3OSEQvF2= NVzmXYZUW0GQR1XS
VA-ES-BJ MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFwM{K0O|ch|ryP NUTQcWdMW0GQR1XS
HCC1419 NUTGOVZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L5fWlEPTB;MT6zOFAzPyEQvF2= NFLKTYxUSU6JRWK=
NCI-H69 NUnMVpdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnYWpVKSzVyPUGuN|QyOTJizszN MoXHV2FPT0WU
DEL MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:2bXhKSzVyPUGuN|UyPjJizszN NUTxWmpnW0GQR1XS
LXF-289 M{DwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXiTWM2OD1zLkO1NlQh|ryP NH7Xd5ZUSU6JRWK=
EW-11 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XXOWlEPTB;MT6zOlAzPiEQvF2= NXvoWIFyW0GQR1XS
KP-4 Mo\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[zS2lEPTB;MT6zO|A5PSEQvF2= M2DXNnNCVkeHUh?=
NOS-1 NUTwOnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmwUmVKSzVyPUGuOFEyQTRizszN NUnmUGptW0GQR1XS
SK-NEP-1 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrydmZKSzVyPUGuOFE3QTNizszN MonyV2FPT0WU
LAMA-84 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\iTmlEPTB;MT60N|k1PSEQvF2= NF3tfmRUSU6JRWK=
ES5 NHfHSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHPTWM2OD1zLkS0N{DPxE1? MonMV2FPT0WU
HuO9 NHnxeZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3FO3p2UUN3ME2xMlQ2OzZ{IN88US=> MUfTRW5ITVJ?
COLO-684 NYP2W4pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uy[mlEPTB;MT60OlEyQCEQvF2= M33WcnNCVkeHUh?=
EW-24 NF\BVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;pTWM2OD1zLkS2OVMyKM7:TR?= NF31fHJUSU6JRWK=
BV-173 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqx[4dOUUN3ME2xMlQ4OjlzIN88US=> M2fXdnNCVkeHUh?=
NCI-H1770 NH;ycGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fzPWlEPTB;MT60PFU{PiEQvF2= NHz4ZodUSU6JRWK=
HuP-T4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHJWoR{UUN3ME2xMlQ6OyEQvF2= MWrTRW5ITVJ?
TYK-nu MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojFTWM2OD1zLkS5PFUyKM7:TR?= MYjTRW5ITVJ?
YH-13 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i1cmlEPTB;MT60PVg6PCEQvF2= MmLjV2FPT0WU
H4 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLZdIRKSzVyPUGuOVA6OTJizszN M3vYTHNCVkeHUh?=
OVCAR-8 NFvVcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[wVGlEPTB;MT61OFQ4PyEQvF2= MYPTRW5ITVJ?
NCI-H23 M4DKNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;0eJNKSzVyPUGuOVQ3PDVizszN M4HY[XNCVkeHUh?=
ES7 NXzIRXBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jQSGlEPTB;MT61OFc4OyEQvF2= MkTJV2FPT0WU
COR-L88 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm2TWM2OD1zLkW2OFI1KM7:TR?= NVfj[mRwW0GQR1XS
TI-73 NHXtUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwNUmwOkDPxE1? M13nWnNCVkeHUh?=
RT-112 M4PqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluyTWM2OD1zLkW5Nlg1KM7:TR?= MW\TRW5ITVJ?
HuO-3N1 M1;hTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3iz[2lEPTB;MT61PVM5PSEQvF2= MknKV2FPT0WU
HC-1 NVX6[pVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwNUm4OlYh|ryP MUfTRW5ITVJ?
HT55 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwNkWxN|Eh|ryP M2jXdHNCVkeHUh?=
IA-LM M3HnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\Y[GlEPTB;MT62PVI4QCEQvF2= NVnTbW1ZW0GQR1XS
EM-2 NHzyfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP1RYZyUUN3ME2xMlcxODF2IN88US=> MWjTRW5ITVJ?
MHH-ES-1 NH7v[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHvTWM2OD1zLkewOFM2KM7:TR?= NHn0U21USU6JRWK=
CAL-27 NGq0SW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\DUmlEPTB;MT63NFYzOSEQvF2= NHLVZVhUSU6JRWK=
COLO-800 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFwN{GxO|kh|ryP MYrTRW5ITVJ?
HCE-T NX\XVXZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILFfoRKSzVyPUGuO|E2KM7:TR?= M2PCS3NCVkeHUh?=
CAMA-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjPWpp7UUN3ME2xMlcyQTdzIN88US=> NXG3NFBtW0GQR1XS
LOXIMVI NV33WWdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTQXmJKSzVyPUGuO|IyOSEQvF2= MXrTRW5ITVJ?
NH-12 NVjCSJBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\FbZhiUUN3ME2xMlczPjlzIN88US=> NXjTVVdRW0GQR1XS
TCCSUP MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwN{K4Nlkh|ryP M4[5O3NCVkeHUh?=
MDA-MB-361 M37HOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jKWWlEPTB;MT63N|E2PyEQvF2= NGSyc5dUSU6JRWK=
EW-16 M3;Tdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT0PYRGUUN3ME2xMlc1OTB5IN88US=> MoCzV2FPT0WU
SNU-423 NWTCfmpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLvUY46UUN3ME2xMlc2QDJ5IN88US=> MVnTRW5ITVJ?
Daoy MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHYTWM2OD1zLke2N|E6KM7:TR?= MX7TRW5ITVJ?
ES4 NV3mcGk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwN{i3OFEh|ryP MUHTRW5ITVJ?
PFSK-1 NYXGO25MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnr[YxvUUN3ME2xMlgxOzdizszN M{m0d3NCVkeHUh?=
ES3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnziTWM2OD1zLkiyOlgyKM7:TR?= MVnTRW5ITVJ?
ONS-76 NUHueFNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu2TGdGUUN3ME2xMlgzQDl5IN88US=> MXTTRW5ITVJ?
JVM-3 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSwTWM2OD1zLki1OFUyKM7:TR?= M2fuRnNCVkeHUh?=
OS-RC-2 NFXKZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H0SmlEPTB;MT64O|E2OSEQvF2= M3TVV3NCVkeHUh?=
COLO-320-HSR Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7KbG53UUN3ME2xMlg5OTl5IN88US=> MX7TRW5ITVJ?
HN MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonFTWM2OD1zLki4O|I2KM7:TR?= MVHTRW5ITVJ?
HT NH\td|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\GSWFKSzVyPUGuPFg6PDdizszN MkPFV2FPT0WU
LoVo NV\I[pVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHCW2pKSzVyPUGuPFk5OSEQvF2= MXvTRW5ITVJ?
CGTH-W-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFwOEm5OFYh|ryP NG\uPJpUSU6JRWK=
NB6 NVLSUYh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFwOUGyPVgh|ryP NVTqNYxZW0GQR1XS
EW-22 M3fRS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHxWGdKSzVyPUGuPVI5QDdizszN M{PrUXNCVkeHUh?=
ES6 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PIcWlEPTB;MT65N|Y{OSEQvF2= MnjhV2FPT0WU
SCC-15 NFXq[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PhWWlEPTB;MT65N|gyQSEQvF2= NVTYNJY4W0GQR1XS
HL-60 NFS2cnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTDTWM2OD1zLkmzPVAzKM7:TR?= NFHsOmZUSU6JRWK=
human HOP-92 NULWXo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;pRWlEPTB;MT65OFA3PSEQvF2= NV75bmNmW0GQR1XS
SW626 NWPIVJdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTFwOUS4PVkh|ryP NEP1bYFUSU6JRWK=
HEC-1 NHPGS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTZVFZ[UUN3ME2xMlk2OzZizszN MlPZV2FPT0WU
LB2241-RCC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nMc2lEPTB;MT65PFI{OSEQvF2= NXjsTpRXW0GQR1XS
Ramos-2G6-4C10 M4mzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnBTWM2OD1zLkm5OFk{KM7:TR?= NGTLN|BUSU6JRWK=
A101D NGH3eVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OyfWlEPTB;Mj6yNFMxOyEQvF2= M1zaenNCVkeHUh?=
NCI-H446 M3;jVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnxTWM2OD1{LkC0OVk6KM7:TR?= M{LFZnNCVkeHUh?=
SBC-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HDOGlEPTB;Mj6wOlE1PyEQvF2= MXHTRW5ITVJ?
HOS NEXseodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwMEe2OVMh|ryP NVvzb4k3W0GQR1XS
K5 M2\rVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;YZXRKSzVyPUKuNFc5OTFizszN NFnUbGxUSU6JRWK=
HLE NGDWNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJwMEi1Nlkh|ryP MWnTRW5ITVJ?
HSC-2 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnYTWM2OD1{LkGyPFk5KM7:TR?= MUTTRW5ITVJ?
LCLC-97TM1 NVS4eWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2qxZmlEPTB;Mj6xOFU5OyEQvF2= Mo\vV2FPT0WU
DMS-273 M{HJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TlU2lEPTB;Mj6xOFg{PyEQvF2= M4W2b3NCVkeHUh?=
TE-8 NGLmPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwMUW3OlUh|ryP MkOyV2FPT0WU
DSH1 NF\qWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD6do84UUN3ME2yMlE3Ozl6IN88US=> Mn\oV2FPT0WU
CAL-51 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7ufZM1UUN3ME2yMlE3Pjl7IN88US=> MYjTRW5ITVJ?
IST-SL1 NVTxRXR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIL2RYNKSzVyPUKuNVY5PDRizszN M2[xfXNCVkeHUh?=
GCT MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TRVGlEPTB;Mj6xO|c4KM7:TR?= Ml7WV2FPT0WU
SW948 M{S1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwMUi0OVYh|ryP M{LEZXNCVkeHUh?=
NOMO-1 M1XzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfWUYhKSzVyPUKuNVk{OTdizszN NHGwUGJUSU6JRWK=
C8166 M4fE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVixTXpkUUN3ME2yMlIyOzN2IN88US=> MV;TRW5ITVJ?
OC-314 MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTJTWM2OD1{LkKzNlU6KM7:TR?= NGjXXYVUSU6JRWK=
CAL-39 NHexSmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTiUFlQUUN3ME2yMlI{PjJ4IN88US=> MY\TRW5ITVJ?
MDA-MB-453 Mmj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\OTWM2OD1{LkK0Nlc2KM7:TR?= M3T2OXNCVkeHUh?=
A673 NV3Xdno{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJwMkW4OlIh|ryP MXTTRW5ITVJ?
HTC-C3 NU\aU4VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7DTWM2OD1{LkK2PFUh|ryP NG[ydlZUSU6JRWK=
NCI-H1666 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rnZ2lEPTB;Mj6yPFEyOSEQvF2= NXTsU4Y{W0GQR1XS
PSN1 Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rrcmlEPTB;Mj6yPFkyOyEQvF2= NYP6PHpSW0GQR1XS
GI-1 NYLsXJJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\lZYZnUUN3ME2yMlMxPTR|IN88US=> MnrFV2FPT0WU
HuH-7 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIGzVXlKSzVyPUKuN|A3OzdizszN MWrTRW5ITVJ?
JAR M371U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LzdmlEPTB;Mj6zNVk5PyEQvF2= MWnTRW5ITVJ?
5637 NXTDbWVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwM{KxNlkh|ryP NIXOe4tUSU6JRWK=
GB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwM{KzN|Uh|ryP NGDwXoNUSU6JRWK=
KP-N-YS NXjQWZFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjJTWM2OD1{LkOyOlE2KM7:TR?= NH7z[olUSU6JRWK=
OAW-42 NG[xXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r2[2lEPTB;Mj6zN|QyPiEQvF2= NGjHcXRUSU6JRWK=
8-MG-BA MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle4TWM2OD1{LkOzPVA3KM7:TR?= M3\WT3NCVkeHUh?=
RH-18 M3TrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnT[pFHUUN3ME2yMlM2ODJ{IN88US=> MkLCV2FPT0WU
NCI-H1155 NIXYcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\QcI5KSzVyPUKuN|Y4OjVizszN NGDK[ndUSU6JRWK=
NB17 M{XOV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOxdHVKSzVyPUKuN|gzPDNizszN NEHIPW5USU6JRWK=
NCI-H1437 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X1T2lEPTB;Mj60NVg4OyEQvF2= MnziV2FPT0WU
SN12C NIXob3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJwNEOyNVQh|ryP MmrhV2FPT0WU
HSC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPibWZKSzVyPUKuOFQ2ODlizszN NWTufmhGW0GQR1XS
GAMG MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLVU|VvUUN3ME2yMlQ1PTZzIN88US=> MWLTRW5ITVJ?
HT-1080 NI\6TmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jSN2lEPTB;Mj60OFg3PCEQvF2= NVvtTYhPW0GQR1XS
A549 NEXvbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M330[GlEPTB;Mj60OFg6OyEQvF2= MVvTRW5ITVJ?
KNS-62 M3vIXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJwNEWwOlEh|ryP NVn5UXhTW0GQR1XS
YKG-1 NG\GPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjZOFB3UUN3ME2yMlQ2PDN5IN88US=> MnXEV2FPT0WU
LU-134-A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\NWWlEPTB;Mj60O|AxQCEQvF2= NITiV45USU6JRWK=
FADU M2Pjd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjCdZdvUUN3ME2yMlQ4OTZ{IN88US=> NUHNWWlVW0GQR1XS
TGBC11TKB NUXXdY9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLYfmFiUUN3ME2yMlQ4OTd5IN88US=> M2q0UnNCVkeHUh?=
HT-3 NV2yPI8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjHTWM2OD1{LkS5OVM2KM7:TR?= NHm2dotUSU6JRWK=
NCI-H2170 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P4TGlEPTB;Mj61NFU1QSEQvF2= NIroTGVUSU6JRWK=
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SK-MEL-28 NFrmW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzTSXJKSzVyPUGwMlAyQTNizszN NF;jN4VUSU6JRWK=
NCI-H2452 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfNOHRtUUN3ME2xNE4yPiEQvF2= MmS0V2FPT0WU
NCI-H1395 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jkVWlEPTB;MUCuNVc5KM7:TR?= MU\TRW5ITVJ?
NCI-H2052 NX7SVJZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvJZoVKSzVyPUGwMlE5QDJizszN MVzTRW5ITVJ?
A375 NFLPWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmyd2Y1UUN3ME2xNE4zPDV{IN88US=> MWXTRW5ITVJ?
HCC38 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHudpZKSzVyPUGwMlMzOiEQvF2= MnrtV2FPT0WU
LK-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXaTWM2OD1zMD60NlA5KM7:TR?= MkeyV2FPT0WU
SF126 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Py[mlEPTB;MUCuOFczPyEQvF2= NW\DSVkxW0GQR1XS
SK-MEL-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlu4TWM2OD1zMD63PFM5KM7:TR?= NGPKeI1USU6JRWK=
ACN M4fae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLtc|hKSzVyPUGwMlg3PzlizszN NVnBT3V1W0GQR1XS
BB30-HNC Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm5TGw5UUN3ME2xNE45PzFzIN88US=> MVTTRW5ITVJ?
NCI-H747 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzVTWM2OD1zMD64O|Q3KM7:TR?= NWjLTJBrW0GQR1XS
KYSE-150 MnnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\jTVNKSzVyPUGxMlA{QDdizszN MX\TRW5ITVJ?
D-247MG MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFzLkGwNFkh|ryP NETMd29USU6JRWK=
BxPC-3 NE\JZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v2cWlEPTB;MUGuN|c1PyEQvF2= NF\BToFUSU6JRWK=
SK-MEL-30 NH;WN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D3UmlEPTB;MUGuOFA4QSEQvF2= NFHRXWpUSU6JRWK=
CAS-1 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnqO|VYUUN3ME2xNU41OTB7IN88US=> MXjTRW5ITVJ?
no-10 M3\FWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPxd|c3UUN3ME2xNk4yOjF5IN88US=> MUjTRW5ITVJ?
NCI-H2405 MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlztTWM2OD1zMj6yNFM3KM7:TR?= NUTsbWdIW0GQR1XS
KGN MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF{LkK5NFEh|ryP M{XCV3NCVkeHUh?=
BB49-HNC M33GUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;0cplKSzVyPUGyMlM6PTZizszN NWn2ToxUW0GQR1XS
NCI-H1693 M2TIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfUWIlKSzVyPUGyMlU5OTZizszN M3;BenNCVkeHUh?=
RO82-W-1 NWHVPY5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n3cWlEPTB;MUOuNFY1QSEQvF2= MmXBV2FPT0WU
CAL-85-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XsNWlEPTB;MUOuOFM6QSEQvF2= NIGxSFJUSU6JRWK=
H-EMC-SS NWTyXJJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe4fGRKSzVyPUGzMlkyODRizszN NXrWc|I6W0GQR1XS
SW1783 NHq4TmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTF2LkKzPVEh|ryP Mm\ZV2FPT0WU
LB771-HNC NFHLNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF2LkSxPUDPxE1? MX3TRW5ITVJ?
HCC70 M3T3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF2LkSyN|Mh|ryP MVPTRW5ITVJ?
KNS-81-FD Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ITWM2OD1zND63NFQ2KM7:TR?= Moj5V2FPT0WU
KYSE-520 MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3TWM2OD1zND65Nlch|ryP M2rYeXNCVkeHUh?=
TGBC24TKB NXX1fHhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn4TWM2OD1zND65OVM6KM7:TR?= NUTBbnZ{W0GQR1XS
SNB75 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPuTWM2OD1zNT6wO|I6KM7:TR?= M4jhXHNCVkeHUh?=
SW872 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF3LkKyNVgh|ryP MYjTRW5ITVJ?
U031 M4XIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTxTWM2OD1zNT64NFI5KM7:TR?= MV7TRW5ITVJ?
ChaGo-K-1 NYrYPYp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTF3LkizOVkh|ryP MmjHV2FPT0WU
NCI-H441 M1vsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHpPXhKSzVyPUG2MlAxOzlizszN MnL6V2FPT0WU
TE-12 NF3DfZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF4LkG4O|Mh|ryP M2rPVHNCVkeHUh?=
NCI-H1755 NHXCVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC4TWM2OD1zNj61O|Mh|ryP NYruRXhmW0GQR1XS
KNS-42 M3i2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF4Lk[1PFkh|ryP M2j4V3NCVkeHUh?=
SK-PN-DW NYLoSJJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF5LkSyNFEh|ryP NXvPbZJPW0GQR1XS
NCI-H226 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTHTWM2OD1zNz65N|Q2KM7:TR?= NUm4PXZHW0GQR1XS
K-562 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzLWXpXUUN3ME2xPE43OzF5IN88US=> NYLkdXg5W0GQR1XS
A388 NFvUcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTrdFdKSzVyPUG5MlA{ODNizszN MYnTRW5ITVJ?
ZR-75-30 NXXlfm1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz1TWM2OD1zOT6wPVY5KM7:TR?= MWrTRW5ITVJ?
LU-135 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjWe2hmUUN3ME2xPU4zPjN4IN88US=> MYfTRW5ITVJ?
NCI-H2029 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrQR2dKSzVyPUG5MlYxOjFizszN Mk\CV2FPT0WU
HT-1197 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF7LkmyNlch|ryP M3XW[HNCVkeHUh?=
IGR-1 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HKTWlEPTB;MkCuN|EyPyEQvF2= NUTaS4tEW0GQR1XS
U-87-MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TNUGlEPTB;MkCuOlQyOyEQvF2= NIPlOFNUSU6JRWK=
NCI-H1304 NU\mOldKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjsXotKSzVyPUKwMlc2ODFizszN NIi3VG5USU6JRWK=
RCC10RGB MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XlW2lEPTB;MkGuNlgzQSEQvF2= NH[3d3VUSU6JRWK=
NCI-H520 NXTSfoxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M122c2lEPTB;MkKuO|YyOSEQvF2= MnHTV2FPT0WU
SK-LU-1 M{DiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPET4RIUUN3ME2yN{4xPzF6IN88US=> NW\rcmM{W0GQR1XS
UACC-893 NHTycHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ|LkGwN|gh|ryP M2nSWXNCVkeHUh?=
NCI-H2347 M{LWRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NECxWXJKSzVyPUKzMlI3PzRizszN Mln2V2FPT0WU
U-118-MG M{T4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vJTGlEPTB;MkOuO|IyPyEQvF2= MnPiV2FPT0WU
NCI-H596 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXVTWM2OD1{Mz65NFU2KM7:TR?= MWDTRW5ITVJ?
MZ1-PC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX21OXZKUUN3ME2yOE43PzV7IN88US=> NF3T[VFUSU6JRWK=
SW1417 MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nRTWlEPTB;MkWuNlQ6QCEQvF2= NHTrVHNUSU6JRWK=
NCI-H82 NWHONmlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXLVFJ4UUN3ME2yOk41Ojh6IN88US=> NUn1SoxCW0GQR1XS
COLO-678 M1Hmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LzTmlEPTB;MkeuOFkyQSEQvF2= MYnTRW5ITVJ?
KURAMOCHI NVXWVIhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonTTWM2OD1{OD6xNlYh|ryP MnH4V2FPT0WU
NCI-H1650 NFf1[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrnTWM2OD1|MD6xPVI1KM7:TR?= NFHNbZZUSU6JRWK=
HCC1954 MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnDTWM2OD1|MT6zOlY3KM7:TR?= MXzTRW5ITVJ?
GAK MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjQTWM2OD1|Mj6yOlE3KM7:TR?= M2rsPXNCVkeHUh?=
YAPC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL6TWM2OD1|Mz63OlQ5KM7:TR?= NUPFS3lbW0GQR1XS
NCI-H2228 NFnPSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjqSWdKSzVyPUO0MlM3ODVizszN MX3TRW5ITVJ?
VMRC-RCZ NG[wWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\qeHJKSzVyPUO2MlMxOjJizszN MkfvV2FPT0WU
NMC-G1 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jJeWlEPTB;M{euNFUzQSEQvF2= MUjTRW5ITVJ?
D-336MG NVq0ZWRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfLUpdCUUN3ME20NU45PDR{IN88US=> M3XZTnNCVkeHUh?=
UACC-62 M{LhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jreWlEPTB;NEKuOVUxPSEQvF2= NWLJOHdvW0GQR1XS
C-33-A M{TNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjqTHNEUUN3ME20OU4{OjV4IN88US=> NED0[IVUSU6JRWK=
HCC1937 MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH63Zo5KSzVyPUS3MlE6PThizszN MWnTRW5ITVJ?
HDLM-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LUNWlEPTB;NEeuNlI5PyEQvF2= NV3kTXNXW0GQR1XS
NCI-H727 M2K2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnVTWM2OD12Nz6yOFUyKM7:TR?= M2TTe3NCVkeHUh?=
NY NVLkeo1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLYWJdtUUN3ME20PU4{QTB6IN88US=> NGi5cWZUSU6JRWK=
NCI-H2291 NVXtd5BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTR7LkizNFEh|ryP NHrQdFdUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験:

[2]

+ 展開
  • 細胞株: LNCaP, PC-3, and TSU-Pr1
  • 濃度: Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間: 1, 2, 3 and 4 days
  • 実験の流れ:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤: Dissolved in DMSO
  • 投薬量: ~100 mg/kg/day
  • 投与方法: Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。
5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3

CAS No. 149647-78-9
保管
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System March 1 2019 Phase 1
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center December 2018 Early Phase 1
NCT03263533 Recruiting Schizophrenia Virginia Commonwealth University December 1 2018 Early Phase 1
NCT03259503 Not yet recruiting Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic|Lymphoma M.D. Anderson Cancer Center|AstraZeneca November 2018 Phase 1|Phase 2
NCT03713320 Recruiting Cutaneous T-Cell Lymphoma/Mycosis Fungoides miRagen Therapeutics Inc. October 2018 Phase 2
NCT03382834 Active not recruiting HIV Infections National Institute of Allergy and Infectious Diseases (NIAID) April 26 2018 Early Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDACシグナル伝達経路

HDAC Inhibitors with Unique Features

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID