Vorinostat (SAHA)

For research use only. Not for use in humans.

製品コードS1047 別名:MK0683, Suberoylanilide hydroxamic acid, Zolinza

Vorinostat (SAHA)化学構造

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 33700
JPY 26400
JPY 38500
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バルク問合せ

文献中Selleckの製品使用例(473)

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 Mn;UT4lv[XOnIFHzd4F6 NXzkTpFkOjBibXnu NFTDdoRFVVOR NUTDWmh2UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV{MUSyNkc,OTR3MkG0NlI9N2F-
HT1080 M{\kZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXy3NkBp MmHtSG1UVw>? MXLJR|UxRTJwNDFOwG0> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjJ5MEG3OUc,OTJ{N{CxO|U9N2F-
K562 MoTZT4lv[XOnIFHzd4F6 NHi1SFk3KGh? MnfVSG1UVw>? NFrtfmtKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjRzOUO4NEc,OTJ2MUmzPFA9N2F-
A20 Ml3IT4lv[XOnIFHzd4F6 MknKNUBp NX\y[28zTE2VTx?= NGDZTYZidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= NXjQUVMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG5OlA1QDlpPkGxPVYxPDh7PD;hQi=>
Friend leukemic cell M1XHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXm1NEDPxE1? NF7tdIY4OiCq NE[zZVVFVVOR NEPVOXJKSzVyPUCuPVkh|ryP MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjFyOUmxN{c,OTJzMEm5NVM9N2F-
H1299 NVLBPWFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi3NkBp M1Xs[mROW09? M1fYW2lEPTB;Nz6yOEDPxE1? NHmzblY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEWyNVQzOid-MUS1NlE1OjJ:L3G+
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CEM MojnT4lv[XOnIFHzd4F6 M1f1RlEhcA>? NYi0XYNxTE2VTx?= NEnYW5RKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NWjrdVBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NlAxPjRpPkG2OFIxODZ2PD;hQi=>
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GM15850 NV3HNopwU2mwYYPlJGF{e2G7 M4PMS|IvPSEQvF2= M4rSXFk3KGh? NIXWPJZFVVOR NYfpe|BFUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MnHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN|Y4RC:jPh?=
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CAL27 NH3J[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDxO|IhcA>? NXi5RXBQUUN3ME2zMlczKM7:TR?= MlLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
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LNCAP M4H2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWroXVdCPzJiaB?= NVzZTHU1UUN3ME2wMlU5KM7:TR?= NF;6TIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
NCI-H2122 NXHSdXNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW2fm1EPzJiaB?= NWP3TYtmUUN3ME23MlUh|ryP NXjiRpN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
NCI-H358 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvvO|IhcA>? MYDJR|UxRTJwNTFOwG0> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O|g9N2F-
SCC15 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{npelczKGh? NU\VeY94UUN3ME2yMlQ6KM7:TR?= Ml[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
SCC25 NWHURoxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;abVA{PzJiaB?= Mme5TWM2OD1zLkmzJO69VQ>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O|g9N2F-
SKHEP1 NX;DOGl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVG3NkBp NYLLR4pjUUN3ME2zMlQ3KM7:TR?= M4L4eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzO|c5Lz5{MEG0N|c4QDxxYU6=
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Caco-2 NGLte5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUKxNFAh|ryP MVq0PIg> MoeySG1UVw>? MoHHTWM2OD16LkGg{txO NY\3XHhvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
Caco-2 MmnHT4lv[XOnIFHzd4F6 M4n2VlUh|ryP MmW0OEBp NFPvNG1FVVOR MV3JcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN NH6zTHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|g1OCd-MkCxOFM5PDB:L3G+
Caco-2 NED3d3FMcW6jc3WgRZN{[Xl? NHznXVUxNjNzNjDuUUB1dyB|MT62JO69VQ>? NFHFcWI1KGh? NWPufHdnTE2VTx?= M37YU2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txO NHT0UYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|g1OCd-MkCxOFM5PDB:L3G+
Caco-2 NHjtSWhMcW6jc3WgRZN{[Xl? NGXTUZExNjNzNjDuUUB1dyB|MT62JO69VQ>? M{PaZVQhcA>? MXrEUXNQ M2PnRWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO NYTlWW5iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
Caco-2 MXHLbY5ie2ViQYPzZZk> MUK2MlMzKG6PIITvJFY{OiEQvF2= MXO0JIg> NFfEZWlFVVOR NHHVNFdGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Wge4l1cCCLQ{WwJI9nKDF{Lk[g{txO MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
Caco-2 NF3NXXpMcW6jc3WgRZN{[Xl? NHnKUHE3NjN{IH7NJJRwKDZ|MjFOwG0> NYf5dHUzPCCq NITvfW5FVVOR Mn7aSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= NX;SNG1XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
Caco-2 NHjiXnVMcW6jc3WgRZN{[Xl? MUGwMlMyPiCwTTD0c{A{OS54IN88US=> MY[0JIg> NU\z[WV5TE2VTx?= MVnFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzZ? NXTpZVJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
HepG2 MUTLbY5ie2ViQYPzZZk> NGrQW2E2KM7:TR?= MVO2bC=> NFnLeHVFVVOR NWTx[JpRUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdg>? MlnsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO4OFAoRjJyMUSzPFQxRC:jPh?=
HepG2 NXfhTGhqU2mwYYPlJGF{e2G7 NFHPN4k2KM7:TR?= MYi2bC=> NW\UNGJUTE2VTx?= NITRTIpKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIh6eGW{YXPleJlt[XSrb36= NVvTRphJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
HepG2 NUHSV|hpU2mwYYPlJGF{e2G7 M3LhZlUh|ryP NIjCdXo3cA>? M1TGbmROW09? NULSdJJlUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
HepG2 MWXLbY5ie2ViQYPzZZk> MXi1JO69VQ>? NVe5d3djPmh? M{HCRWROW09? Mn:yTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgTFMwUDRiaHnzeI9v\SCjY3X0fYxifGmxbh?= MlnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO4OFAoRjJyMUSzPFQxRC:jPh?=
COLO205 NUfrbGpuU2mwYYPlJGF{e2G7 NWi0SYRXOTBizszN NIDMTHEzPCCq MmrySG1UVw>? NY\yVYVxUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NEH3fIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES1NVM4QCd-MkC0OVE{Pzh:L3G+
SCC4 NYK3bYt1U2mwYYPlJGF{e2G7 MUixJO69VQ>? NYLuZ|k2OjSq NWnjcpFZUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NWG3e2g5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0OVIzOjVpPkKwOFUzOjJ3PD;hQi=>
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NB4 M1jMXmZ2dmO2aX;uJGF{e2G7 MXW1JO69VQ>? NGTHbJIzPCCq NYHuS|J2TE2VTx?= NHjzTZhE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR7MUS0NEc,OjB2OUG0OFA9N2F-
NB4 NGPYSYhMcW6jc3WgRZN{[Xl? NUfWVG95PSEQvF2= M{jteFI1KGh? M37hN2ROW09? NIPVfG5KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? MkDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2OUG0OFAoRjJyNEmxOFQxRC:jPh?=
NB4 MkLkSpVv[3Srb36gRZN{[Xl? NEHMTFc2KM7:TR?= MnOxNlQhcA>? NIXBNXhFVVOR NFuxZYtKdmS3Y4Tpc44hd2ZicEKxW2FHOS:FSWCxJIV5eHKnc4Ppc44> M{PlZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEmxOFQxLz5{MES5NVQ1ODxxYU6=
NB4 M3S3dmtqdmG|ZTDBd5NigQ>? Mm[wOUDPxE1? MkDuNlQhcA>? NIrV[HpFVVOR M1HJRWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v MkXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2OUG0OFAoRjJyNEmxOFQxRC:jPh?=
NUGC3 NV\VVW51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrL[GpXT0l3ME2yMlk1KM7:TR?= M2HDc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEWwPVcyLz5{MEi1NFk4OTxxYU6=
A549 NUDWSXZ6TnWwY4Tpc44hSXO|YYm= NVHaW5FxPSEQvF2= MorVN{Bp MYjEUXNQ MXLJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|SVm= M{CydFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEW1NlA5Lz5{MEi1OVIxQDxxYU6=
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U937 M2\YRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjFfos4OiCq NILSPI1FVVOR NFzEb2xIUTVyPUCuN|kh|ryP MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh6NEKwPEc,OjB6OESyNFg9N2F-
A431 Mm\lR5l1d3SxeHnjJGF{e2G7 NFfJ[mo4OiCq NUPkWGFFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA1NjJizszN NVfqcnpVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
A549 NHPE[IdEgXSxdH;4bYMhSXO|YYm= MXy3NkBp MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuPEDPxE1? NHy5NJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
CAL27 MYXDfZRwfG:6aXOgRZN{[Xl? M33SeVczKGh? NWKyPYI5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
HeLa NV7nSVBsS3m2b4TvfIlkKEG|c3H5 MoH4O|IhcA>? NF\HS|NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= M{e2[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
Sf21 MmnPT4lv[XOnIFHzd4F6 NXHpfYNNOyCq Mn[2TY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= Ml\UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
SKBR3 Mn\uR5l1d3SxeHnjJGF{e2G7 NYWyU|J[PzJiaB?= NXiwdXplS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
SKOV3 M2HGWGN6fG:2b4jpZ{BCe3OjeR?= MlSzO|IhcA>? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP NX3CPHBpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
COR-L23 NYrSPFBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XsXlExKM7:TR?= M2LER|czKGh? M2OwNGROW09? NVn3c4JNT0l3ME2xMlEh|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
DU145 M1TkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HL[lExKM7:TR?= M1ixRlczKGh? NXnjNpR2TE2VTx?= MWLHTVUxRTFwMEWg{txO MofEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2OFcoRjJzMEiwOlQ4RC:jPh?=
LoVo NYXvUYxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYixNEDPxE1? NVHLV2tkPzJiaB?= NYHiXFdKTE2VTx?= NFXLR2VIUTVyPUGuO{DPxE1? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
MCR5-SV2 Mm\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxNEDPxE1? NUnpdYNNPzJiaB?= MnHnSG1UVw>? M{jH[WdKPTB;Mj6xJO69VQ>? NVTJN5AzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
HCT116 MofkT4lv[XOnIFHzd4F6 NXnvTHVmOzBizszN MWSzNEBp NECyOZhFVVOR MnnzTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NWDkdm5vRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
HCT116 MXHLbY5ie2ViQYPzZZk> NW\seVR3OzBizszN MV2zNEBp M4jLb2ROW09? MVHJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? MmH6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2OFcoRjJzMEiwOlQ4RC:jPh?=
U937 NXnVenNoU2mwYYPlJGF{e2G7 MV61JO69VQ>? M37VbVI1KGh? MnT6SG1UVw>? MnHXTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? MkO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OUK0PVIoRjJzMkmyOFkzRC:jPh?=
U937 NEjqXZpMcW6jc3WgRZN{[Xl? NVPPU4R1PSEQvF2= M2XGelI1KGh? NXTuZ3UzTE2VTx?= M4XlbGlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= M{K3WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmyOFkzLz5{MUK5NlQ6OjxxYU6=
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U937 MlHXT4lv[XOnIFHzd4F6 MlL0OUDPxE1? NVS5[Y95OTVibXnu Mm\VSG1UVw>? M1fsXmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIHzleoVt M1[4b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmyOFkzLz5{MUK5NlQ6OjxxYU6=
A2780 NWTBOHo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDwUGtDQTZiaB?= MmTaSG1UVw>? Ml7oTWM2OD1zLk[yJO69VQ>? NXux[IFoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2N|Q1OzBpPkKxOlM1PDNyPD;hQi=>
COLO205 M3ywTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDhUG06PiCq M1W1W2ROW09? NITacZRKSzVyPUKuNVIh|ryP M1n3TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkO0OFMxLz5{MU[zOFQ{ODxxYU6=
Hep3B NFzVe|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHQVo5OPDhiaB?= M37w[GROW09? MYXHTVUxRTFwMkGg{txO MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzMkG0Okc,OjF5MUKxOFY9N2F-
GM11272 MV7GeY5kfGmxbjDBd5NigQ>? MXixNFAhdk1? MnThO|IhcA>? MWjEUXNQ MnPiVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> NIf2dZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi0NFcyPid-MkG4OFA4OTZ:L3G+
CFBE41o MoHsT4lv[XOnIFHzd4F6 M3:xcFUh|ryP NVzvOoNQTE2VTx?= MX7Ec5dvKHKnZ4XsZZRqd25ib3[gTGRCSzdiYYSgNE4zKHSxIEWgeW0> MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7OES5OVgoRjJzOUi0PVU5RC:jPh?=
CFBE41o M3XBbWZ2dmO2aX;uJGF{e2G7 NHLvVYkyKM7:TR?= NFfybY8zPCCq MnHVSG1UVw>? MUTS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? M{\MUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUi0PVU5Lz5{MUm4OFk2QDxxYU6=
DU145 MkHmT4lv[XOnIFHzd4F6 MkLINk42KM7:TR?= NGnTbJIzPCCq MlPsSG1UVw>? NYTifmRPUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? MoHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkCxOlYoRjJ{Mk[wNVY3RC:jPh?=
DU145 NFSwR2tMcW6jc3WgRZN{[Xl? NUm3SnZOPSEQvF2= Ml20NlQhcA>? NFf6TIlFVVOR NFvFbYZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKNDDhZ4V1gWyjdHnvci=> M33mUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mk[wNVY3Lz5{MkK2NFE3PjxxYU6=
DU145 NGO2[mlMcW6jc3WgRZN{[Xl? Mn7xOUDPxE1? MYmyOEBp Ml;3SG1UVw>? MXLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v NEm3eXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK2NFE3Pid-MkKyOlAyPjZ:L3G+
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A498 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr1ToVKPi5{IN88US=> NEPXXXE4OiCq MXzEUXNQ M1HWeWdKPTB;MT62JO69VQ>? MmfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
A549/ATCC NXOwRmQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVO2MlIh|ryP M13zVVczKGh? M164V2ROW09? NVfxTGw4T0l3ME2xMlYh|ryP M2D4eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
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IGROV1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\2fFYvOiEQvF2= NV:3N4R6PzJiaB?= Mn;ySG1UVw>? MoGxS2k2OD1zLkOg{txO Moj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
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MDA-MB-468 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnMc5VGPi5{IN88US=> MUe3NkBp Mn3ySG1UVw>? M3WxcGdKPTB;MD62N{DPxE1? MoHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
MOLT4 NETNZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\hU5RGPi5{IN88US=> Mn3mO|IhcA>? NYHNUXN6TE2VTx?= Mnu0S2k2OD1yLkSg{txO NUK0Z4lMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
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NCI-H460 M1rjXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHSzSoY3NjJizszN NFnWeVc4OiCq M4XldWROW09? MVjHTVUxRTBwN{mg{txO NIrZPIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
NCI-H522 MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfOb4NDPi5{IN88US=> NVi0NmhFPzJiaB?= NVT4O5pMTE2VTx?= M4r3PGdKPTB;MD61JO69VQ>? M{\SNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
OVCAR3 Mkm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\6Ok4zKM7:TR?= MYW3NkBp NVuyTVRoTE2VTx?= MojRS2k2OD1zLkOg{txO NInqeJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
OVCAR4 MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnziOk4zKM7:TR?= M{\BeFczKGh? MWjEUXNQ M4TrdWdKPTB;NDFOwG0> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
OVCAR5 NIL3S49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTMd3hjPi5{IN88US=> NYX0WHFXPzJiaB?= NEnXeFZFVVOR NUW2c2loT0l3ME2wMlc6KM7:TR?= NGOyTmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
OVCAR8 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXi2MlIh|ryP M3XDR|czKGh? MkLCSG1UVw>? MlTpS2k2OD1yLkWg{txO NEHFeGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
RXF393 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:1dFYxPi5{IN88US=> NF;RdWQ4OiCq MUHEUXNQ NYTUTmFrT0l3ME2xMlMh|ryP MorlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
SF268 NYDFdGszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmewOk4zKM7:TR?= NEXvNYc4OiCq NIPFfG9FVVOR NFrXXpRIUTVyPUGuOkDPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
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UACC257 MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;4RlYvOiEQvF2= NXK1VlZ1PzJiaB?= MWHEUXNQ MmWwS2k2OD1yLkWg{txO M3;XXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
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MGC803 NXPQT5NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml31O|IhcA>? NV3qUWVRTE2VTx?= NFz5flFIUTlyPUGwMlgh|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
SGC7901 M4r5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX63NkBp MYTEUXNQ NHe4TXFIUTlyPUmuOEDPxE1? NGHwbXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVM4Pid-MkOwOlE{PzZ:L3G+
SKHEP1 NH3BPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDtO|IhcA>? M1:yTmROW09? MXjHTVkxRTF5IN88US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4MUO3Okc,OjNyNkGzO|Y9N2F-
SMMC7721 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLYO|IhcA>? NXL1S4luTE2VTx?= NVjEbmVNT0l7ME2yNEDPxE1? M2W0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
NUGC3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPtNVAh|ryP NG\yb|VIUT1{Lkm0JO69VQ>? MnXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNkOzN|IoRjJ|MU[zN|MzRC:jPh?=
A2780 CisR M1rKdWtqdmG|ZTDBd5NigQ>? MUSxPEBp MlHmTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? M{\nPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
CAL27 sens NGTFcGdMcW6jc3WgRZN{[Xl? NYC3[FZNOThiaB?= M3zMU2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NEL2V5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
CAL27 CisR NXW1N2xWU2mwYYPlJGF{e2G7 NX6wN2ZpOThiaB?= NGLoPFlKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MnewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ|MkWyOlA{RC:jPh?=
KYSE-510 CisR NUnQdVNQU2mwYYPlJGF{e2G7 M3TKNFE5KGh? NGfqcldKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP NIXqUlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
KYSE-510 sens MmPHT4lv[XOnIFHzd4F6 NGnSb5MyQCCq MYPJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
MDA-MB-231 sens M3TodmtqdmG|ZTDBd5NigQ>? NWrOOopmOThiaB?= MYfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NUHSbmRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
MDA-MB-231 CisR M{\WTGtqdmG|ZTDBd5NigQ>? MWmxPEBp NUHzTpNNUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= M37M[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
ES2 NGHYNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[2elQ5KGh? MXLEUXNQ NUH3NFdTUUN3ME2xNk44KM7:TR?= NUjXeGxDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVM1PDlpPkKzOFk{PDR7PD;hQi=>
MDA-MB-231 NHXiO2dMcW6jc3WgRZN{[Xl? Mny3NVAh|ryP M1jaclMxKG2rbh?= NGfnOmRFVVOR MknNTY5pcWKrdHnvckBw\iCKRFHDNoE> M1X3Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEmzOFQ6Lz5{M{S5N|Q1QTxxYU6=
MDA-MB-231 MmnaT4lv[XOnIFHzd4F6 MonUNUDPxE1? NIniZW4zPCCq M1TXfGROW09? NEXCZYZKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu MlvYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUO0OFkoRjJ|NEmzOFQ6RC:jPh?=
HS68 MnTQR5l1d3SxeHnjJGF{e2G7 MnvWNVAh|ryP MW[3NkBp M4n6RWROW09? Mmn3TWM2OD12Lk[g{txO MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV5MEW0Nkc,OjN3N{C1OFI9N2F-
MEF NIjHfo5EgXSxdH;4bYMhSXO|YYm= MYKxNEDPxE1? MYm3NkBp Ml;lSG1UVw>? Mm\vTWM2OD12LkSg{txO MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV5MEW0Nkc,OjN3N{C1OFI9N2F-
BGC823 NELIN2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\wOmNFVVOR NH\nb2NIUTVyPUOuNFkh|ryP MkDWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEG3NFYoRjJ|NkCxO|A3RC:jPh?=
High5 NIizNnhMcW6jc3WgRZN{[Xl? NVG2UnJROjRiaB?= NHnJUplKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MlvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK1NlMoRjJ|NkCyOVI{RC:jPh?=
High5 MnPRT4lv[XOnIFHzd4F6 NWe4O21zOjRiaB?= MmTnTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? NFnvO3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNlUzOyd-MkO2NFI2OjN:L3G+
High5 NUPy[XUyU2mwYYPlJGF{e2G7 MXKyOEBp Ml3nTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkWyN{c,OjN4MEK1NlM9N2F-
A549 M4O2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfoW|JFVVOR NGXUO3BKSzVyPUGuNFc6KM7:TR?= M{DHVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkS0NlExLz5{M{[0OFIyODxxYU6=
HCT116 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\5SG1UVw>? M131XWlEPTB;MD63OVch|ryP NXnXRm4yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTBpPkKzOlQ1OjFyPD;hQi=>
K562 NFjvPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH0THFFVVOR MnK2TWM2OD1yLk[0OUDPxE1? NFTWfFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFIyOCd-MkO2OFQzOTB:L3G+
GBC-SD M2exWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7ZOUDPxE1? MUm3NkBp NFHIZpVFVVOR Mmf4TWM2OD1zND64JO69VQ>? MoXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5MEeyOlAoRjJ|N{C3NlYxRC:jPh?=
HGC27 NXTyXJpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NECySYg2KM7:TR?= NXrwVZBPPzJiaB?= Mn\TSG1UVw>? MojFTWM2OD13LkSg{txO M1zJZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{C3NlYxLz5{M{ewO|I3ODxxYU6=
HL60 NITiUFVMcW6jc3WgRZN{[Xl? MVi1JO69VQ>? NEOzdHUzPCCq M3vkN2ROW09? M4P1dWlvcGmkaYTpc44hd2ZiSFTBRy=> M3HkTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{C3NlYxLz5{M{ewO|I3ODxxYU6=
Vero NYW0WHlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonkO|IhcA>? M2HhVWROW09? MmX2TWM2OD1yLkmg{txO NUHFfJB2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PFY1PTJpPkKzO|g3PDV{PD;hQi=>
NCI60 MoXyR5l1d3SxeHnjJGF{e2G7 Mn7zOFghcA>? MVTEUXNQ NFHzZZNIUT1yLkWzJO69VQ>? MmrrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUWzNlcoRjJ2MEG1N|I4RC:jPh?=
SW620 MYLDfZRwfG:6aXOgRZN{[Xl? M2DTblQ5KGh? MX\EUXNQ MXjHTV0xNjV2IN88US=> M2rOclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG1N|I4Lz5{NECxOVMzPzxxYU6=
U251 NUnaW4lFS3m2b4TvfIlkKEG|c3H5 M{GyTlQ5KGh? NIfJclNFVVOR NYHVOZVIT0l;MT61N{DPxE1? NFvkS2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
KM12 MVjDfZRwfG:6aXOgRZN{[Xl? MmHZOFghcA>? M{\aemROW09? NUj4dFVTT0l;MT64PEDPxE1? M{PWTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG1N|I4Lz5{NECxOVMzPzxxYU6=
Hs578T MmfrR5l1d3SxeHnjJGF{e2G7 NVLmc4lKPDhiaB?= NWXIdGNtTE2VTx?= MmO0S2k:PC56MzFOwG0> NIfTcVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
MDA-MB-231 NFj4OIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLvUmNDPDhiaB?= M2ntXGlEPTB;MD6xOkDPxE1? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUCxOkc,OjRyOUWwNVY9N2F-
MCF7 NH[xVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrYUlI1QCCq NVj0UWI6T0l;MD60OUDPxE1? M4nSV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5OVU2Lz5{NEGxPVU2PTxxYU6=
MDA-MB-435 M1[wVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17GUlQ5KGh? M{S5OmdKRTBwOEig{txO MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzOUW1OUc,OjRzMUm1OVU9N2F-
AsPC1 M4\ubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC3ZY4xOzBizszN NUD5[ph{PDhiaB?= NV;lXoJ1TE2VTx?= NEmwS5JKSzVyPUOuOlYh|ryP MnHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzOEWzO|goRjJ2MUi1N|c5RC:jPh?=
Jurkat E6.1 NIC3T|lMcW6jc3WgRZN{[Xl? NVXLenM1OiCq Mli5SG1UVw>? M3vK[GlvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP M33iZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mk[xPFYzLz5{NEK2NVg3OjxxYU6=
KG1 NF7mN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXaVnJrPDhiaB?= MkXyTWM2OD1zLkG1JO69VQ>? M2DkVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUK1NFA{Lz5{NEWyOVAxOzxxYU6=
HEL M3L0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPzSG81QCCq MoDaSG1UVw>? NFHhT25KSzVyPUCuOFkh|ryP NUntUpRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PVQxPTVpPkK0Olk1ODV3PD;hQi=>
HSC3 NH\BT2JEgXSxdH;4bYMhSXO|YYm= NYG1XFRFOTJiaB?= NH7pWoZFVVOR NEfPcJJKSzVyPUCuO|Eh|ryP M{D4clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{[2OVYxLz5{NEe2OlU3ODxxYU6=
HT-29 MoP5R5l1d3SxeHnjJGF{e2G7 NHqzT3cyOiCq NWjuTItRTE2VTx?= M3nSN2lEPTB;MD63NkDPxE1? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
KB M4K1R2N6fG:2b4jpZ{BCe3OjeR?= M1vHVVEzKGh? MW\EUXNQ NWr6UVBVUUN3ME2wMlc2KM7:TR?= M{H2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{[2OVYxLz5{NEe2OlU3ODxxYU6=
H460 MlnTR5l1d3SxeHnjJGF{e2G7 MXqxNkBp NVi1U29jTE2VTx?= MXHJR|UxRTBwOEKg{txO MoHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
MONE1 MUTDfZRwfG:6aXOgRZN{[Xl? NVTzR2V5OTJiaB?= M4q0N2ROW09? NGPkSpRKSzVyPUGuNVgh|ryP MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
MKN45 M{PLUGN6fG:2b4jpZ{BCe3OjeR?= MVyxNkBp NE\jS|NFVVOR M4LIbGlEPTB;MT6yOUDPxE1? NGXY[GI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
TSGH MmnRR5l1d3SxeHnjJGF{e2G7 MV6xNkBp NFvC[ldFVVOR MYnJR|UxRTJwMEmg{txO NYLCU4FURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
HL60 NEDRZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HSXVczKGh? MYrEUXNQ MkXZS2k2OD1yLkmzJO69VQ>? NIX3T4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFUxOCd-MkS5NFA2ODB:L3G+
HEK293 M1fh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP0clc4OiCq M1nQUWROW09? MmLFS2k2OD1zMzFOwG0> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEWwNEc,OjR7MEC1NFA9N2F-
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