Vorinostat (SAHA, MK0683)

製品コードS1047 別名：SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW)：264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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文献中Selleckの製品使用例(100)

カスタマーフィードバック(20)

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]
細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NEHTPItMcW6jc3WgRZN{[Xl? NFHPPFMyKGh? NXjBbVk2TE2VTx?= M{\BdYFvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= Ml\qNVE6PjB2OEm=
Friend leukemic cell M3OzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfnOJg{PTBizszN NETSV204OiCq MnzrSG1UVw>? NX3je|ZxUUN3ME2wMlk6KM7:TR?= MWKxNlExQTlzMx?=
K562 Mn65T4lv[XOnIFHzd4F6 MVW2JIg> NVTERYFZTE2VTx?= M{PMdWlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NGDjOIIyOjRzOUO4NC=>
HT1080 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[3NkBp MlXSSG1UVw>? NXTETFdDUUN3ME2yMlQh|ryP Mn7uNVIzPzBzN{W=
H1299 NXvqeYpwU2mwYYPlJGF{e2G7 M1\rRVIxKG2rbh?= MW\EUXNQ M1i2bmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN MoX3NVQ2OjF2MkK=
H1299 NGrPWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2yO|IhcA>? Mn3USG1UVw>? M4rCTGlEPTB;Nz6yOEDPxE1? M1nYfFE1PTJzNEKy
HeLa M3PISmtqdmG|ZTDBd5NigQ>? MWWzNEBucW5? MX\Jcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> NEPLb5UyPTZyM{m0PS=>
LOX-IMVI M4rvbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDM[3MxPDhiaB?= M3TSN2lEPTB;MT6zJO69VQ>? MXyxOVcyPTR5MB?=
NCI-H226 NHLxO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYW0PEBp M4HLcWlEPTB;Mj62JO69VQ>? MVKxOVcyPTR5MB?=
RXF-631L M4fIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TOclQ5KGh? NEXpXZFKSzVyPUKg{txO M{Ta[VE2PzF3NEew
SNB-78 M1e0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S4WFQ5KGh? NHq1cmpKSzVyPUG2JO69VQ>? MkftNVU4OTV2N{C=
St-4 NUfNfldjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXO0PEBp NXLyZWNIUUN3ME21MlIh|ryP NGfXTZIyPTdzNUS3NC=>
ARP1 M1;rbWZ2dmO2aX;uJGF{e2G7 NFTuc|czKM7:TR?= M{X1[|YhcA>? MVLJcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= M1f6OVE1PzN2OEC2
CEM M{PVZ2tqdmG|ZTDBd5NigQ>? MmfKNUBp MVrEUXNQ M4TveWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NVvEWW54OTZ2MkCwOlQ>
HCT15 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvU[YtUPDhiaB?= MXPHTVUxRTBwOEKg{txO MmSzNVY4OjN{Mke=
NCI-H23 M{HINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XtfFQ5KGh? M1vmOmdKPTB;MD65NkDPxE1? M1PDNVE3PzJ|MkK3
GM15850 M3\GTmtqdmG|ZTDBd5NigQ>? M1zIZlIvPSEQvF2= M4XVbVk3KGh? MV7EUXNQ MVTJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? Mo\RNVY6OjF|Nke=
GM15850 MmjBT4lv[XOnIFHzd4F6 NEnGc4QzNjVizszN NVrTcm9HQTZiaB?= MUjEUXNQ NFX5[2hKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NXPWS4Y4OTZ7MkGzOlc>
GM15850 M1ftOGtqdmG|ZTDBd5NigQ>? NXvSVGFuOi53IN88US=> MYO5OkBp NELmeGZFVVOR Mlu2TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M3e2bVE3QTJzM{[3
GM15850 MnywT4lv[XOnIFHzd4F6 NX7WUWs5Oi53IN88US=> Mn;ZPVYhcA>? NWP2S4NtTE2VTx?= NYDTXnd1UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NYj4OHQ2OTZ7MkGzOlc>
GM15850 MXrLbY5ie2ViQYPzZZk> NV\tPWZCOi53IN88US=> MY[5OkBp NF34XFJFVVOR MmHQTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NXLJUGhWOTZ7MkGzOlc>
GM15850 NXzaPJRqU2mwYYPlJGF{e2G7 NYf3boZzOi53IN88US=> NU\Mc2RrQTZiaB?= NXvJVplqTE2VTx?= M3fyRWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MX:xOlkzOTN4Nx?=
U937 M1u3[mZ2dmO2aX;uJGF{e2G7 Mn36OUDPxE1? M4fXXFI1KGh? NG\LcnpFVVOR NES1TpFE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MWexO|AxPDdzOB?=
H661 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXK0PEBp M1POZWlEPTB;MTFOwG0> MUWxO|E2PzByOR?=
U937 NXTqXYhLTnWwY4Tpc44hSXO|YYm= MluzOUDPxE1? NWLFfGdkOjRiaB?= MV;EUXNQ M1vsV2lv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NF:zUVUyPzR2N{e1NC=>
U937 NYjkPY9KTnWwY4Tpc44hSXO|YYm= NVzR[lRxOSEQvF2= NU\pdopFOjRiaB?= MWPEUXNQ NEfFfpdG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> NEPDSoIyPzR2N{e1NC=>
RAW264.7 MXjGeY5kfGmxbjDBd5NigQ>? NW[5[olPOTBizszN MnPqNlRp MU\3ZZRmeg>? NUDUcm5QUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> NW\Kb3VqOTd2N{e1NVg>
RAW264.7 MUPGeY5kfGmxbjDBd5NigQ>? MkLhNVAh|ryP NUnZRlY4OjSq Mnv2e4F1\XJ? NWG3UJpvUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? M1ribVE4PDd5NUG4
SC9 M1TWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXPOFghcA>? M3\lU2lEPTB;MD62NFYh|ryP NFzpNIMyPzVyN{KxPS=>
ST14A MorwSpVv[3Srb36gRZN{[Xl? NYXiU5h3PSCwTR?= NG\BdY04OiCq M2PNVGlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> MoDpNVc2PjV7OUO=
ST14A M37LRmZ2dmO2aX;uJGF{e2G7 NWftcHJTPSCwTR?= NEfUcGo4OiCq M2\teWlv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:w NHv3XYEyPzV4NUm5Ny=>
PANC1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\UUFEh|ryP M{HPOGlEPTB;MD60OUDPxE1? MnvvNVc2QDh5NES=
PANC1 NY\PfoZJTnWwY4Tpc44hSXO|YYm= M3;LV|Eh|ryP NX:zSYZ4OjRiaB?= NHTrT2hKdmO{ZXHz[UBqdiCyMkHXRWYyN0OLUEGg[4Vv\SCneIDy[ZN{cW:w M4\YXVE4PTh6N{S0
PANC1 NH;rW5FHfW6ldHnvckBCe3OjeR?= NHfiOXoyKM7:TR?= M3jEZ|I1KGh? NYPSTIY4UW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> MVqxO|U5QDd2NB?=
PT45 MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTRizszN M2fDS|E4PTh6N{S0
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CFBE41o- NFXkO4pMcW6jc3WgRZN{[Xl? Mkm5OUDPxE1? MnTGNlQhcA>? MYXEUXNQ MlHETY5pcWKrdHnvckBw\iCKRFHDO{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDyZZRmKG:oIH3heJVz[XSrb36gc4YhS0[WUjDwdo91\WmwIITvJIl1eyCpbInjc4Zwem1? NG\rZZMyQTl4Nke4PS=>
CFBE41o- MWHLbY5ie2ViQYPzZZk> M1XBOlUh|ryP MUGyOEBp MYrEUXNQ MXHJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIP0ZYJqdGm2eTDv[kBH\GWudHG1NFghS0[WUjDwdo91\Wmw M3vQVVE6QTZ4N{i5
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Primary bronchial epithelial cell NGPqdZNMcW6jc3WgRZN{[Xl? MnvkNUDPxE1? M2nTc|k3KGh? NVXafotpTE2VTx?= M1O5TWlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gd4hwenRiY3nyZ5VqfCCldYLy[Y51ew>? MVuxPVk3Pjd6OR?=
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CAL27 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzpfXpiPzJiaB?= NVmxTpBmUUN3ME2zMlczKM7:TR?= M3z2UFIxOTR|N{e4
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NCI-H2122 NHPmTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv6O|IhcA>? M4HuUGlEPTB;Nz61JO69VQ>? NFz5NIEzODF2M{e3PC=>
NCI-H358 NX7LeIRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rhXVczKGh? M3\yT2lEPTB;Mj61JO69VQ>? NFn3doczODF2M{e3PC=>
SCC15 M1nEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\pPVczKGh? NEXOcolKSzVyPUKuOFkh|ryP M{LsWVIxOTR|N{e4
SCC25 MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXy3NkBp M1;FRmlEPTB;MT65N{DPxE1? NXnEZoNIOjBzNEO3O|g>
SKHEP1 NHrkWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\3O|IhcA>? MXzJR|UxRTNwNE[g{txO NX32eJZrOjBzNEO3O|g>
BJ M{TD[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTuO4wyODBizszN M37YR|Q5KGh? MnjnSG1UVw>? NWf3RnZXT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> NYnaWFRDOjBzNEO4OFA>
MUF Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnVeo8yODBizszN NIrL[Ig1QCCq MnX6SG1UVw>? NIrTWYRIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> MlXvNlAyPDN6NEC=
Caco-2 MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ezTVExOCEQvF2= Moj4OFhp M2LD[GROW09? M1KxbmlEPTB;OD6xJO69VQ>? MX6yNFE1Ozh2MB?=
Caco-2 M{e3bmtqdmG|ZTDBd5NigQ>? MorqOUDPxE1? MY[0JIg> M1T4NWROW09? M37admlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44hUUN3MDDv[kAxNjB|NzFOwG0> MVyyNFE1Ozh2MB?=
Caco-2 NGrrZm5McW6jc3WgRZN{[Xl? M1WyPFAvOzF4IH7NJJRwKDNzLk[g{txO MnXLOEBp MnLYSG1UVw>? NHf2cpFGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? NIHRWm8zODF2M{i0NC=>
Caco-2 NGGyZXZMcW6jc3WgRZN{[Xl? MmW0NE4{OTZibl2geI8hOzFwNjFOwG0> MmDrOEBp NXzLb|hqTE2VTx?= MVjFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzNid3n0bEBKSzVyIH;mJFAvOTR5IN88US=> Ml;QNlAyPDN6NEC=
Caco-2 M3fUSGtqdmG|ZTDBd5NigQ>? M{Tpd|YvOzJibl2geI8hPjN{IN88US=> NEDnZ241KGh? NWi5NGRsTE2VTx?= MVjFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzVid3n0bEBKSzVyIH;mJFEzNjZizszN M17V[lIxOTR|OESw
Caco-2 NE\LSZdMcW6jc3WgRZN{[Xl? MVK2MlMzKG6PIITvJFY{OiEQvF2= NGG5XYw1KGh? MkHRSG1UVw>? NYS0flJMTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO3JJdqfGhiSVO1NEBw\iB2MTFOwG0> NEnoXZQzODF2M{i0NC=>
Caco-2 MWnLbY5ie2ViQYPzZZk> NEf4UIUxNjNzNjDuUUB1dyB|MT62JO69VQ>? MoLkOEBp NYj4XZFFTE2VTx?= NI\GbFNGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[= NGnjc3YzODF2M{i0NC=>
HepG2 NEnnOlRMcW6jc3WgRZN{[Xl? NWnicnlqPSEQvF2= NE\YXWE3cA>? Ml;PSG1UVw>? MXTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u MXeyNFE1Ozh2MB?=
HepG2 MlPlT4lv[XOnIFHzd4F6 MkjuOUDPxE1? MWO2bC=> M2jnVWROW09? NW\qV4EzUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u NEL4cGIzODF2M{i0NC=>
HepG2 M4\HWmtqdmG|ZTDBd5NigQ>? M3\VNFUh|ryP NILkOZM3cA>? MUfEUXNQ MYTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w NVmwXnF1OjBzNEO4OFA>
HepG2 M2jnSmtqdmG|ZTDBd5NigQ>? MnfTOUDPxE1? NYHSS21EPmh? M3HDU2ROW09? NHS1OYtKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u NEKyXVAzODF2M{i0NC=>
COLO205 NFLHZVlMcW6jc3WgRZN{[Xl? MojvNVAh|ryP MYiyOEBp M{eyUWROW09? M1K0eGlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= NGC4fnMzODR3MUO3PC=>
SCC4 MkPPT4lv[XOnIFHzd4F6 NGHHUGkyKM7:TR?= NYraO3J7OjSq Ml;ETY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= MlLINlA1PTJ{MkW=
SCC4 M13acGtqdmG|ZTDBd5NigQ>? MVGxJO69VQ>? NYHOOHRFOjSq M2HPd2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u MUWyNFQ2OjJ{NR?=
SCC4 M1HGc2Z2dmO2aX;uJGF{e2G7 MlTwNUDPxE1? Ml7XOUBucW5? M1jrVGFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36= Mn\CNlA1PTJ{MkW=
NB4 MnfRSpVv[3Srb36gRZN{[Xl? NVPxeoxtPSEQvF2= NWLqPJYxOjRiaB?= M1\yS2ROW09? MYXD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn NETXeo8zODR7MUS0NC=>
NB4 M{D2SmtqdmG|ZTDBd5NigQ>? NYC0c5pyPSEQvF2= NGDHUWUzPCCq MoXqSG1UVw>? NGHkfFlKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? NHHZcW8zODR7MUS0NC=>
NB4 M3XTfGZ2dmO2aX;uJGF{e2G7 MlHTOUDPxE1? MnrqNlQhcA>? MXnEUXNQ Mnr3TY5lfWO2aX;uJI9nKHB{MWfBSlEwS0mSMTDlfJBz\XO|aX;u MoezNlA1QTF2NEC=
NB4 M4jGdWtqdmG|ZTDBd5NigQ>? NWnHXGR2PSEQvF2= MkWyNlQhcA>? NYTadWo3TE2VTx?= MVvJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> MorGNlA1QTF2NEC=
NUGC3 NUTvc2NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnZNYdIUTVyPUKuPVQh|ryP M2nMNVIxQDVyOUex
A549 NYSwO|Z1TnWwY4Tpc44hSXO|YYm= NHnvTHQ2KM7:TR?= MVSzJIg> NVzkWplbTE2VTx?= NWjORZF6UW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK NGLnNIQzODh3NUKwPC=>
HUT78 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTlfIx5PzJiaB?= M2HTSmROW09? MWfHTVUxRTBwMzFOwG0> NWn5dGNrOjB6OESyNFg>
U937 M1zIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUe3NkBp MWjEUXNQ NVPOUmg5T0l3ME2wMlM6KM7:TR?= MXOyNFg5PDJyOB?=
A431 NWDHdIRMS3m2b4TvfIlkKEG|c3H5 NYPGNWVZPzJiaB?= Mkf6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjC0MlIh|ryP MmXaNlExQDB4Mkm=
A549 M1ryeWN6fG:2b4jpZ{BCe3OjeR?= NXPYTlNjPzJiaB?= NUPJepE1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN NEPINoozOTB6ME[yPS=>
CAL27 Mom4R5l1d3SxeHnjJGF{e2G7 MV:3NkBp MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP MWCyNVA5ODZ{OR?=
HeLa NWntPFMyS3m2b4TvfIlkKEG|c3H5 Mn\iO|IhcA>? MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuOUDPxE1? MVGyNVA5ODZ{OR?=
Sf21 MWXLbY5ie2ViQYPzZZk> MkX1N{Bp MYrJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= MXmyNVA5ODZ{OR?=
SKBR3 MVHDfZRwfG:6aXOgRZN{[Xl? MWK3NkBp M2fjTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= NHLEWHYzOTB6ME[yPS=>
SKOV3 NYf6R5lES3m2b4TvfIlkKEG|c3H5 MYi3NkBp MlX6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NXvO[YtFOjFyOEC2Nlk>
COR-L23 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELJWWIyOCEQvF2= NUjGTlRNPzJiaB?= MXjEUXNQ MlPmS2k2OD1zLkGg{txO NG\LWnkzOTB6ME[0Oy=>
DU145 MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nnV|ExKM7:TR?= MUO3NkBp NHu4dohFVVOR NVnm[3ZvT0l3ME2xMlA2KM7:TR?= NUL0dpdCOjFyOEC2OFc>
LoVo MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y1c|ExKM7:TR?= M2K0clczKGh? M4myd2ROW09? NIHYZYFIUTVyPUGuO{DPxE1? M2Czc|IyODhyNkS3
MCR5-SV2 NGfnZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYixNEDPxE1? MXG3NkBp NYDPeWgzTE2VTx?= MlnhS2k2OD1{LkGg{txO NH\sUmszOTB6ME[0Oy=>
HCT116 M2\lPWtqdmG|ZTDBd5NigQ>? Mlz2N|Ah|ryP MnfyN|AhcA>? M{HVbmROW09? NFrxOolKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NY\iOmNiOjFyOEC2OFc>
HCT116 MnzsT4lv[XOnIFHzd4F6 NGnwS2o{OCEQvF2= M4fMZlMxKGh? MYDEUXNQ MkHtTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN2s6KGGlZYT5cIF1cW:w M321dVIyODhyNkS3
U937 NUD5UJFMU2mwYYPlJGF{e2G7 M2jKTFUh|ryP NXnGOI06OjRiaB?= NYrteGpuTE2VTx?= MWfJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMQQ>? NUXmeYNCOjF{OUK0PVI>
U937 MnniT4lv[XOnIFHzd4F6 MXS1JO69VQ>? MXWyOEBp NHTkcXhFVVOR NXyzO3l3UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NXP2Vo9IOjF{OUK0PVI>
U937 MmXRT4lv[XOnIFHzd4F6 MVO1JO69VQ>? NYP6dZNbOjRiaB?= NELQZ2dFVVOR MV7Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? NWrnXFlDOjF{OUK0PVI>
U937 NVzyZVBNU2mwYYPlJGF{e2G7 M3XNSFUh|ryP M1P2VlE2KG2rbh?= NIPZd29FVVOR NFjMc|dKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? Mn\tNlEzQTJ2OUK=
A2780 NXfWZ5JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfkPVYhcA>? MX7EUXNQ Mo[0TWM2OD1zLk[yJO69VQ>? MVSyNVY{PDR|MB?=
COLO205 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzlVWg6PiCq NIn5ZmpFVVOR NYTTO3ZKUUN3ME2yMlEzKM7:TR?= NUG2RYZ2OjF4M{S0N|A>
Hep3B NVHWfpB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[wSlQ5KGh? NV3lNnNFTE2VTx?= NIPDU49IUTVyPUGuNlEh|ryP NF7DU3AzOTdzMkG0Oi=>
GM11272 M2GyfWZ2dmO2aX;uJGF{e2G7 NGX6cYMyODBibl2= MX63NkBp MUTEUXNQ NHLHXHlT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O M{HNeVIyQDRyN{G2
CFBE41o MVvLbY5ie2ViQYPzZZk> MlTkOUDPxE1? MknYSG1UVw>? NWDQfXBSTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP MnXiNlE6QDR7NUi=
CFBE41o M2HndmZ2dmO2aX;uJGF{e2G7 M3TDc|Eh|ryP NXjZUWd7OjRiaB?= MmPzSG1UVw>? MVvS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? MoTVNlE6QDR7NUi=
DU145 MXTLbY5ie2ViQYPzZZk> M4DkOVIvPSEQvF2= MofWNlQhcA>? MWLEUXNQ NVvHRmJ1UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? Mn\zNlIzPjBzNk[=
DU145 NYToeJpoU2mwYYPlJGF{e2G7 NXT3VFUyPSEQvF2= NEDVboEzPCCq MlH2SG1UVw>? M4nQVWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u MkXsNlIzPjBzNk[=
DU145 NHXjWHRMcW6jc3WgRZN{[Xl? M4PZOVUh|ryP NG\nSJQzPCCq MVnEUXNQ M33lNWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? M3;rV|IzOjZyMU[2
786-0 NXrIdJJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWq2MlIh|ryP M4j0blczKGh? MnrZSG1UVw>? M3TLVGdKPTB;Mz6yJO69VQ>? MX[yNlQ{PTZ4OR?=
A498 NHfW[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzWOk4zKM7:TR?= MoP3O|IhcA>? NFnY[YxFVVOR M37sPGdKPTB;MT62JO69VQ>? NYG2VY5GOjJ2M{W2Olk>
A549/ATCC NHz2WGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILNUoY3NjJizszN MmjqO|IhcA>? NGPldI9FVVOR Mm\nS2k2OD1zLk[g{txO MojPNlI1OzV4Nkm=
ACHN NF3ZXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml25Ok4zKM7:TR?= NUT4XoJDPzJiaB?= NWL4XmpnTE2VTx?= NUG2Rm5ZT0l3ME2xMlMh|ryP NEnzTIgzOjR|NU[2PS=>
BT549 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XTRVYvOiEQvF2= NFTmXGI4OiCq M1KwNWROW09? MVfHTVUxRTFwMzFOwG0> MYWyNlQ{PTZ4OR?=
EKVX NH7EW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nWc|YvOiEQvF2= MVS3NkBp MYXEUXNQ MWXHTVUxRTFwMzFOwG0> MUCyNlQ{PTZ4OR?=
HCT15 M1z6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjxOk4zKM7:TR?= NFnwbIs4OiCq MlrqSG1UVw>? MWXHTVUxRTJwNTFOwG0> NYnVd5J[OjJ2M{W2Olk>
HOP92 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr2Ok4zKM7:TR?= M{faOlczKGh? NX[0XIFJTE2VTx?= NH\DNVlIUTVyPUSg{txO M37CXlIzPDN3Nk[5
IGROV1 NV\C[pRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfKOk4zKM7:TR?= NUXGZlFuPzJiaB?= MljsSG1UVw>? MXHHTVUxRTFwMzFOwG0> NVXUOGFiOjJ2M{W2Olk>
LOXIMVI NGDR[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz0Ok4zKM7:TR?= MUO3NkBp MVzEUXNQ NEG0cI5IUTVyPUGg{txO NXmyc|FFOjJ2M{W2Olk>
M14 M4f4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrOOk4zKM7:TR?= NWnkUZc6PzJiaB?= MX3EUXNQ MmfRS2k2OD1zLkOg{txO NF\ubogzOjR|NU[2PS=>
MALME-3M NVHUN2NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\GOk4zKM7:TR?= MWS3NkBp NGrESHdFVVOR NXzadFVuT0l3ME2wMlMzKM7:TR?= NWrFNpA3OjJ2M{W2Olk>
MCF10A MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jLR|YvOiEQvF2= MWq0PEBp MlHZSG1UVw>? MYTHTVUxRTlwNjFOwG0> NVexUm1qOjJ2M{W2Olk>
MDA-MB-435 NXfkOo9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTFOk4zKM7:TR?= MkLIO|IhcA>? M4TvVWROW09? M4O5cWdKPTB;MD61JO69VQ>? NVv0Z4F6OjJ2M{W2Olk>
MDA-MB-468 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX22MlIh|ryP Ml7JO|IhcA>? M4i1XmROW09? M{m1RWdKPTB;MD62N{DPxE1? MkTPNlI1OzV4Nkm=
MOLT4 Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXCXFA3NjJizszN NYHWZo5kPzJiaB?= MWLEUXNQ NF3VWGVIUTVyPUCuOEDPxE1? NFzNXGszOjR|NU[2PS=>
NCI-ADR-RES MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXO2MlIh|ryP MVi3NkBp NWLEOlFwTE2VTx?= MkDLS2k2OD1yLkG2JO69VQ>? MY[yNlQ{PTZ4OR?=
NCI-H23 NVzwd3puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV62MlIh|ryP MX[3NkBp NIPSOnBFVVOR M4fie2dKPTB;MTFOwG0> NYD5bmF2OjJ2M{W2Olk>
NCI-H322M NWD0VVdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWS2MlIh|ryP Mlr5O|IhcA>? MknxSG1UVw>? NF\jRplIUTVyPUCuO|kh|ryP NHzUcpMzOjR|NU[2PS=>
NCI-H460 NW\YTIR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTXTm43NjJizszN MV23NkBp M3rXOWROW09? MX;HTVUxRTBwN{mg{txO MnzwNlI1OzV4Nkm=
NCI-H522 NEXRT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPHOk4zKM7:TR?= MlvyO|IhcA>? Mn7kSG1UVw>? MXTHTVUxRTBwNTFOwG0> M131WFIzPDN3Nk[5
OVCAR3 NWPt[4F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHub4JpPi5{IN88US=> MVG3NkBp NXPx[nJSTE2VTx?= NXm3d5FST0l3ME2xMlMh|ryP Mnm5NlI1OzV4Nkm=
OVCAR4 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYO2MlIh|ryP NWDSR217PzJiaB?= MlXwSG1UVw>? NXHDdW9YT0l3ME20JO69VQ>? NYLucnlXOjJ2M{W2Olk>
OVCAR5 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUK2MlIh|ryP MWW3NkBp MXjEUXNQ MVvHTVUxRTBwN{mg{txO MnrONlI1OzV4Nkm=
OVCAR8 NHG1UllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW2MlIh|ryP NEPSNJc4OiCq NEHub2lFVVOR NX21NXNOT0l3ME2wMlUh|ryP M4TOUlIzPDN3Nk[5
RXF393 M2nrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHUOk4zKM7:TR?= MWC3NkBp NWOzU5VZTE2VTx?= MXXHTVUxRTFwMzFOwG0> MY[yNlQ{PTZ4OR?=
SF268 M3\pd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TEdFYvOiEQvF2= NXjZR29tPzJiaB?= NE\4TYtFVVOR MV;HTVUxRTFwNjFOwG0> MYGyNlQ{PTZ4OR?=
SF295 NEXHS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXG2MlIh|ryP MXO3NkBp MWLEUXNQ MkOzS2k2OD1zLk[g{txO NH25OZgzOjR|NU[2PS=>
SF539 M1W4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTVOGMzPi5{IN88US=> NVHnNm1SPzJiaB?= M{\nbmROW09? NUfWS286T0l3ME2yJO69VQ>? NHu1NZUzOjR|NU[2PS=>
SK-MEL-2 MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWS2MlIh|ryP NUTKNFBIPzJiaB?= M4rLVGROW09? MYjHTVUxRTFwMzFOwG0> MViyNlQ{PTZ4OR?=
SK-MEL-28 M1;sWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\Z[VYvOiEQvF2= NHPVTXc4OiCq NV3CdWxzTE2VTx?= NF3xPY9IUTVyPUGg{txO NVzsTY9sOjJ2M{W2Olk>
SK-MEL-5 NWHnXpo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYO2MlIh|ryP MXu3NkBp NIXvTVRFVVOR NHmzPI1IUTVyPUCuOlMh|ryP M2\vXlIzPDN3Nk[5
SKOV3 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW0Ok4zKM7:TR?= NUPoZnkzPzJiaB?= NYPr[|RsTE2VTx?= M1jZPWdKPTB;MTFOwG0> MVSyNlQ{PTZ4OR?=
SN12C MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;kOk4zKM7:TR?= NUTBTWRIPzJiaB?= NX[5VZZHTE2VTx?= NFu4bWNIUTVyPUKg{txO MVWyNlQ{PTZ4OR?=
SNB19 NEnhZXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP4NYU3NjJizszN NVL3VpZ1PzJiaB?= MVPEUXNQ Mo\RS2k2OD1yLk[zJO69VQ>? NGDwPYIzOjR|NU[2PS=>
SNB75 NHzx[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[2MlIh|ryP NHHxSYY4OiCq Mlf2SG1UVw>? NHzS[lFIUTVyPUCuO|kh|ryP M{XWPFIzPDN3Nk[5
SR NWT2Tpp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPSWpp7Pi5{IN88US=> MYm3NkBp NGKyOYZFVVOR NEOzfJpIUTVyPUCuOEDPxE1? MnfRNlI1OzV4Nkm=
T47D MmTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS1Ok4zKM7:TR?= MXi3NkBp NHjwfoxFVVOR MmDqS2k2OD1yLkWg{txO MXKyNlQ{PTZ4OR?=
TK10 NVXuPYNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLXe|Q3NjJizszN NHPDSY44OiCq NW\qSXpJTE2VTx?= M2PIc2dKPTB;MD62N{DPxE1? MVKyNlQ{PTZ4OR?=
UACC257 NV7ZTo0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPn[HA3NjJizszN Mn[zO|IhcA>? MYnEUXNQ M{T5NGdKPTB;MD61JO69VQ>? M3jISFIzPDN3Nk[5
UACC62 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne1Ok4zKM7:TR?= MWO3NkBp Mon2SG1UVw>? MkjwS2k2OD1yLkSg{txO MXOyNlQ{PTZ4OR?=
UO31 MmexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ewTlYvOiEQvF2= M1nIflczKGh? MnPuSG1UVw>? MnrRS2k2OD1yLkWg{txO MYSyNlQ{PTZ4OR?=
Hep3B NEDzVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHyOFghcA>? M3\MNWROW09? M3i5cmdKPTB;MD62PUDPxE1? M1rjbFIzPDN7OE[z
BE(2)-C MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUe3NkBp NXTaPXJCTE2VTx?= NETV[XhKSzdyPUKg{txO NIH6N3czOjl|MkOxOi=>
Bel7402 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzO|IhcA>? MVjEUXNQ MlnhS2k6OD1zNzFOwG0> NYDiSFM{OjNyNkGzO|Y>
Bel7404 NY\icJJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXGcYY4OiCq NHvSXHpFVVOR NX3uVJVtT0l7ME2xPEDPxE1? NVnwcJd7OjNyNkGzO|Y>
BGC823 M2XJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\FbWc4OiCq Mn\RSG1UVw>? MVfHTVkxRTdwNTFOwG0> MXWyN|A3OTN5Nh?=
MGC803 M{j3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\6fVhJPzJiaB?= NGD5dXJFVVOR NH74[XRIUTlyPUGwMlgh|ryP MVWyN|A3OTN5Nh?=
SGC7901 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHzO|IhcA>? MoPLSG1UVw>? NIW0[nZIUTlyPUmuOEDPxE1? M4LiNFI{ODZzM{e2
SKHEP1 M3rmXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnFUFl3PzJiaB?= MlrGSG1UVw>? NUjBOm1CT0l7ME2xO{DPxE1? M33N[lI{ODZzM{e2
SMMC7721 NETwWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i2RVczKGh? NWTpWXhFTE2VTx?= NGLjd3NIUTlyPUKwJO69VQ>? M3LxXlI{ODZzM{e2
NUGC3 NVLENVFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;ofosyOCEQvF2= NFm2RWxIUT1{Lkm0JO69VQ>? NEXaW3MzOzF4M{OzNi=>
A2780 CisR Mlm2T4lv[XOnIFHzd4F6 NHfwWJMyQCCq M{ezZWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? NV\DUWhiOjN{NUK2NFM>
CAL27 sens NXnrNYREU2mwYYPlJGF{e2G7 NYrrTVVzOThiaB?= MmS0TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? MoTpNlMzPTJ4MEO=
CAL27 CisR NIXmU4dMcW6jc3WgRZN{[Xl? M3TMdVE5KGh? MVXJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO M1nyUlI{OjV{NkCz
KYSE-510 CisR NVfkTZZDU2mwYYPlJGF{e2G7 MVuxPEBp NYj3d2p7UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= Mn;oNlMzPTJ4MEO=
KYSE-510 sens M1LiN2tqdmG|ZTDBd5NigQ>? NWjKdoFrOThiaB?= NIqyWYZKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? NIHkOpEzOzJ3Mk[wNy=>
MDA-MB-231 sens NFnnbWxMcW6jc3WgRZN{[Xl? NIjwcG8yQCCq NWnWSJlCUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MWeyN|I2OjZyMx?=
MDA-MB-231 CisR MWLLbY5ie2ViQYPzZZk> M{XPU|E5KGh? M1vUN2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NY[3XWs2OjN{NUK2NFM>
ES2 M{njT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELGdmc1QCCq MlnGSG1UVw>? NVv5XJo{UUN3ME2xNk44KM7:TR?= NEPteVgzOzR7M{S0PS=>
MDA-MB-231 MVLLbY5ie2ViQYPzZZk> MmDmNVAh|ryP NYnie2hTOzBibXnu MknKSG1UVw>? M2\T[WlvcGmkaYTpc44hd2ZiSFTBR|Ji NWToV25oOjN2OUO0OFk>
MDA-MB-231 NH7hO4NMcW6jc3WgRZN{[Xl? MkPuNUDPxE1? NEH1XlgzPCCq MWXEUXNQ MV3Jcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NHvybW0zOzR7M{S0PS=>
HS68 NHPzfmVEgXSxdH;4bYMhSXO|YYm= MnfsNVAh|ryP NUW3RYk{PzJiaB?= M1v2[mROW09? MV7JR|UxRTRwNjFOwG0> M3npdFI{PTdyNUSy
MEF MUPDfZRwfG:6aXOgRZN{[Xl? M3O4eVExKM7:TR?= NWDYeGw2PzJiaB?= MVjEUXNQ M1LweWlEPTB;ND60JO69VQ>? NFXRbmgzOzV5MEW0Ni=>
BGC823 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXQSG1UVw>? MoLhS2k2OD1|LkC5JO69VQ>? M1G1c|I{PjBzN{C2
High5 NYGzcWFoU2mwYYPlJGF{e2G7 NUfVcI9oOjRiaB?= MmjNTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? MnHJNlM3ODJ3MkO=
High5 MkLRT4lv[XOnIFHzd4F6 NETnZnAzPCCq M4Hyd2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP Mn\VNlM3ODJ3MkO=
High5 NX3NTFNzU2mwYYPlJGF{e2G7 NG\ZRWUzPCCq MoHrTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? NXz4Z45SOjN4MEK1NlM>
A549 NVnQW4FET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDGcFVwTE2VTx?= MWjJR|UxRTFwMEe5JO69VQ>? MUWyN|Y1PDJzMB?=
HCT116 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXEUXNQ MkPQTWM2OD1yLke1O{DPxE1? MkHNNlM3PDR{MUC=
K562 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36xOGROW09? NHTlb21KSzVyPUCuOlQ2KM7:TR?= NEn5VIgzOzZ2NEKxNC=>
GBC-SD M{Hjdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUSzSYVYPSEQvF2= NFrhZog4OiCq M1rJN2ROW09? M4[xSWlEPTB;MUSuPEDPxE1? NGi0[GIzOzdyN{K2NC=>
HGC27 NUjXfHd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfxZotrPSEQvF2= M3\qfFczKGh? MnT5SG1UVw>? NFS1RWtKSzVyPUWuOEDPxE1? MkfGNlM4ODd{NkC=
HL60 MVzLbY5ie2ViQYPzZZk> MXm1JO69VQ>? NEPINnczPCCq M3rQTGROW09? MVXJcohq[mm2aX;uJI9nKEiGQVO= MYSyN|cxPzJ4MB?=
Vero Mk\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDNO|IhcA>? MU\EUXNQ NE\ufI5KSzVyPUCuPUDPxE1? NYCxcmQ5OjN5OE[0OVI>
NCI60 MXPDfZRwfG:6aXOgRZN{[Xl? NXzSWlVsPDhiaB?= NFnSdVJFVVOR M1vW[mdKRTBwNUOg{txO NITLfnMzPDBzNUOyOy=>
SW620 NWrnPYo1S3m2b4TvfIlkKEG|c3H5 NYnXb2tmPDhiaB?= MUXEUXNQ NFrLV4tIUT1yLkW0JO69VQ>? NYrwU5F2OjRyMUWzNlc>
U251 NIDPSIREgXSxdH;4bYMhSXO|YYm= NIjNVlY1QCCq NWTwSJlPTE2VTx?= NWHE[mJGT0l;MT61N{DPxE1? MVuyOFAyPTN{Nx?=
KM12 M3q4TmN6fG:2b4jpZ{BCe3OjeR?= MUK0PEBp NWfq[ZB3TE2VTx?= NHz2WYRIUT1zLki4JO69VQ>? NVrVfHFIOjRyMUWzNlc>
Hs578T M4KyfmN6fG:2b4jpZ{BCe3OjeR?= MknROFghcA>? NHe5XVRFVVOR M4r5UGdKRTRwOEOg{txO MVuyOFAyPTN{Nx?=
MDA-MB-231 MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVW0PEBp M{LRZWlEPTB;MD6xOkDPxE1? M2eyVFI1ODl3MEG2
MCF7 NGPoPWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXK0PEBp M2rqemdKRTBwNEWg{txO NEewU2YzPDFzOUW1OS=>
MDA-MB-435 M1PPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnVOFghcA>? M2jaXWdKRTBwOEig{txO MnLrNlQyOTl3NUW=
AsPC1 NXH4[INpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[zNEDPxE1? MkG3OFghcA>? NGTL[phFVVOR MX7JR|UxRTNwNk[g{txO MXmyOFE5PTN5OB?=
Jurkat E6.1 MmPKT4lv[XOnIFHzd4F6 MXOyJIg> MYPEUXNQ MX7Jcohq[mm2aX;uJI9nKEiGQVO0JJdqfGhiSVO1NEBw\iByLkC0JO69VQ>? MmTnNlQzPjF6NkK=
KG1 M3TDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XORVQ5KGh? NIP3N3FKSzVyPUGuNVUh|ryP NYrYSm9ROjR3MkWwNFM>
HEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjpVIcyPDhiaB?= M4Lsb2ROW09? MXLJR|UxRTBwNEmg{txO NGfjS3UzPDZ7NEC1OS=>
HSC3 NHG0eJFEgXSxdH;4bYMhSXO|YYm= NH7pPIoyOiCq NUTFbFBnTE2VTx?= MlqxTWM2OD1yLkexJO69VQ>? MWqyOFc3PjV4MB?=
HT-29 NIjsN3pEgXSxdH;4bYMhSXO|YYm= MmrrNVIhcA>? M2fES2ROW09? MoXjTWM2OD1yLkeyJO69VQ>? M4TuTFI1PzZ4NU[w
KB NFLhT3VEgXSxdH;4bYMhSXO|YYm= NGX6ZZIyOiCq M4DHWWROW09? NG\UbItKSzVyPUCuO|Uh|ryP NHyxfWczPDd4NkW2NC=>
H460 NYTzU4pXS3m2b4TvfIlkKEG|c3H5 NVj3NJB5OTJiaB?= NHn3eGpFVVOR NFvz[4RKSzVyPUCuPFIh|ryP M1q5cFI1PzZ4NU[w
MONE1 NVHRZ3JWS3m2b4TvfIlkKEG|c3H5 MVKxNkBp Mn\0SG1UVw>? MYfJR|UxRTFwMUig{txO NVTiSod5OjR5Nk[1OlA>
MKN45 NYPZeZBDS3m2b4TvfIlkKEG|c3H5 MUKxNkBp NX74VJo5TE2VTx?= MVzJR|UxRTFwMkWg{txO M{LWTVI1PzZ4NU[w
TSGH NECySGtEgXSxdH;4bYMhSXO|YYm= NFrzZ2oyOiCq MUPEUXNQ Mo[0TWM2OD1{LkC5JO69VQ>? M3jNOVI1PzZ4NU[w
HL60 Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfiO|IhcA>? NHXWVJFFVVOR MmDuS2k2OD1yLkmzJO69VQ>? M3TvPFI1QTByNUCw
HEK293 NUnZXo9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILVUoo4OiCq NYXI[21JTE2VTx?= M2i0ZmdKPTB;MUOg{txO NWnXTHNGOjR7MEC1NFA>
Jurkat MYTDfZRwfG:6aXOgRZN{[Xl? MmnWNVAxKM7:TR?= MmOyO|IhcA>? NGTZZWtIUTVyPUCuPUDPxE1? MljFNlQ6ODB5NEO=
GM15850 Mly5T4lv[XOnIFHzd4F6 M2\YfFIvPSEQvF2= NYTacFdCQTZiaB?= M4nUU2ROW09? MoLr[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NIfK[owyPjl{MUO2Oy=>
GM15850 NGXUeVJMcW6jc3WgRZN{[Xl? M3u2elIvPSEQvF2= MVS5OkBp MnHVSG1UVw>? NWXTRoVE\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDViYXPleJlt[XSrb36gc4YhTliQIHflcoU> M3vtOVE3QTJzM{[3
GM15850 M3niOGtqdmG|ZTDBd5NigQ>? NWLwZYI3Oi53IN88US=> M{jaNFk3KGh? NWexW5UxTE2VTx?= NW\rbppz\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NXu0UVJWOTZ7MkGzOlc>
GM15850 MVnLbY5ie2ViQYPzZZk> NGP6[mkzNjVizszN M4HXVVk3KGh? NX3adIxoTE2VTx?= MlG4[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NF3KUVAyPjl{MUO2Oy=>
GM15850 M2W1WWtqdmG|ZTDBd5NigQ>? MV[yMlUh|ryP MkPUPVYhcA>? NGLUcIJFVVOR NInVbYFld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NH7uTWkyPjl{MUO2Oy=>
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NCI-H2052 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XwRmlEPTB;MUCuNVg5OiEQvF2= MVTTRW5ITVJ?
A375 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXTTJpKSzVyPUGwMlI1PTJizszN MnTxV2FPT0WU
HCC38 NUn6TVNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3kZlhHUUN3ME2xNE4{OjJizszN M3;WcnNCVkeHUh?=
LK-2 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFyLkSyNFgh|ryP M{f5bXNCVkeHUh?=
SF126 NW\lboI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3xT3BSUUN3ME2xNE41PzJ5IN88US=> NIjvNHBUSU6JRWK=
SK-MEL-1 NUX3TmJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG3Zoh6UUN3ME2xNE44QDN6IN88US=> NVuxPVZGW0GQR1XS
ACN MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTCTY4yUUN3ME2xNE45Pjd7IN88US=> MYjTRW5ITVJ?
BB30-HNC NYW3SGxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PwR2lEPTB;MUCuPFcyOSEQvF2= Ml7WV2FPT0WU
NCI-H747 M4HaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOxNGdKSzVyPUGwMlg4PDZizszN NGC5U5RUSU6JRWK=
KYSE-150 M2ToWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHyxUYpKSzVyPUGxMlA{QDdizszN NEnqeHJUSU6JRWK=
D-247MG MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjRb25KSzVyPUGxMlExODlizszN MojMV2FPT0WU
BxPC-3 NFz0OWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[0N2JKSzVyPUGxMlM4PDdizszN M2LoVnNCVkeHUh?=
SK-MEL-30 NHTGRpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfDNFhDUUN3ME2xNU41ODd7IN88US=> NH7CTlRUSU6JRWK=
CAS-1 NWPDbmVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r2fmlEPTB;MUGuOFExQSEQvF2= NXexZlRZW0GQR1XS
no-10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF{LkGyNVch|ryP NFfOSYpUSU6JRWK=
NCI-H2405 MkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPjTWM2OD1zMj6yNFM3KM7:TR?= NYXLcYFHW0GQR1XS
KGN NHjITIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ixVmlEPTB;MUKuNlkxOSEQvF2= NILBRYlUSU6JRWK=
BB49-HNC MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF{LkO5OVYh|ryP NGrUVZVUSU6JRWK=
NCI-H1693 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\BXWlEPTB;MUKuOVgyPiEQvF2= M2DQNnNCVkeHUh?=
RO82-W-1 NInhPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3kTXdKSzVyPUGzMlA3PDlizszN NEOzPIRUSU6JRWK=
CAL-85-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF|LkSzPVkh|ryP NHvsbVlUSU6JRWK=
H-EMC-SS NEjHXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vje2lEPTB;MUOuPVExPCEQvF2= NGnzWHJUSU6JRWK=
SW1783 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTh[GhKSzVyPUG0MlI{QTFizszN NVnJe4JyW0GQR1XS
LB771-HNC M3nqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TXcGlEPTB;MUSuOFE6KM7:TR?= M3qzRnNCVkeHUh?=
HCC70 M3PRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfqTWM2OD1zND60NlM{KM7:TR?= NUC4XGdOW0GQR1XS
KNS-81-FD NYLmfok4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nGWWlEPTB;MUSuO|A1PSEQvF2= MXrTRW5ITVJ?
KYSE-520 Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEizO3ZKSzVyPUG0MlkzPyEQvF2= M1\UNnNCVkeHUh?=
TGBC24TKB MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7WTHZKSzVyPUG0Mlk2OzlizszN NInGWI1USU6JRWK=
SNB75 NXnsPZQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\MUGpIUUN3ME2xOU4xPzJ7IN88US=> MYTTRW5ITVJ?
SW872 NIHnTIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvHVG1KSzVyPUG1MlIzOThizszN MY\TRW5ITVJ?
U031 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF3LkiwNlgh|ryP MVvTRW5ITVJ?
ChaGo-K-1 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXWZmhXUUN3ME2xOU45OzV7IN88US=> M4nObHNCVkeHUh?=
NCI-H441 NF\NUGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF4LkCwN|kh|ryP NGjOb|ZUSU6JRWK=
TE-12 M3jvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS4TWM2OD1zNj6xPFc{KM7:TR?= MoXTV2FPT0WU
NCI-H1755 NV;G[VdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXOxcZpLUUN3ME2xOk42PzNizszN MV;TRW5ITVJ?
KNS-42 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK3doZKSzVyPUG2MlY2QDlizszN MUHTRW5ITVJ?
SK-PN-DW NFS4Z3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKdG91UUN3ME2xO{41OjBzIN88US=> MVjTRW5ITVJ?
NCI-H226 NWG3TnRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T1cGlEPTB;MUeuPVM1PSEQvF2= NH\JTGRUSU6JRWK=
K-562 NYLNbFVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF6Lk[zNVch|ryP NYnV[2xvW0GQR1XS
A388 NHntSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rWVGlEPTB;MUmuNFMxOyEQvF2= MV\TRW5ITVJ?
ZR-75-30 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS3NXZKSzVyPUG5MlA6PjhizszN M{K1THNCVkeHUh?=
LU-135 NYrzfWJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiz[INnUUN3ME2xPU4zPjN4IN88US=> MlPhV2FPT0WU
NCI-H2029 M1HaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnrS4lKSzVyPUG5MlYxOjFizszN NV3TZWFvW0GQR1XS
HT-1197 MlTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\V[|BKSzVyPUG5MlkzOjdizszN NGHUWVNUSU6JRWK=
IGR-1 NESzcHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrTTWM2OD1{MD6zNVE4KM7:TR?= MUPTRW5ITVJ?
U-87-MG NHroPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLDTWM2OD1{MD62OFE{KM7:TR?= NIfrSG9USU6JRWK=
NCI-H1304 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrpR4JKSzVyPUKwMlc2ODFizszN NE\0U2pUSU6JRWK=
RCC10RGB NEf3eIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\JTWM2OD1{MT6yPFI6KM7:TR?= Mn;WV2FPT0WU
NCI-H520 NFLmR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvZTWM2OD1{Mj63OlEyKM7:TR?= MWPTRW5ITVJ?
SK-LU-1 M{i3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJ|LkC3NVgh|ryP MkXUV2FPT0WU
UACC-893 NHTnVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jFOGlEPTB;MkOuNVA{QCEQvF2= M3[0NHNCVkeHUh?=
NCI-H2347 NYnxSmhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ|LkK2O|Qh|ryP MoX5V2FPT0WU
U-118-MG NVXMcXY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P5S2lEPTB;MkOuO|IyPyEQvF2= MoTiV2FPT0WU
NCI-H596 M{jRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\wTWM2OD1{Mz65NFU2KM7:TR?= NIHKXY9USU6JRWK=
MZ1-PC NWPYblV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O2U2lEPTB;MkSuOlc2QSEQvF2= MVLTRW5ITVJ?
SW1417 NX\GTJROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\PemlEPTB;MkWuNlQ6QCEQvF2= NUOzOocxW0GQR1XS
NCI-H82 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL5UG5KSzVyPUK2MlQzQDhizszN Mn7SV2FPT0WU
COLO-678 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ5LkS5NVkh|ryP NHzYOGlUSU6JRWK=
KURAMOCHI MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\NdJVKSzVyPUK4MlEzPiEQvF2= MUXTRW5ITVJ?
NCI-H1650 M3nuSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTNyLkG5NlQh|ryP Mom3V2FPT0WU
HCC1954 NIHTR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO5TWM2OD1|MT6zOlY3KM7:TR?= M4i5bnNCVkeHUh?=
GAK MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml64TWM2OD1|Mj6yOlE3KM7:TR?= M1riW3NCVkeHUh?=
YAPC MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfxfnVKSzVyPUOzMlc3PDhizszN NFnmdlZUSU6JRWK=
NCI-H2228 NELUfHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK4c2R2UUN3ME2zOE4{PjB3IN88US=> M{\scnNCVkeHUh?=
VMRC-RCZ NFXXZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm2TWM2OD1|Nj6zNFIzKM7:TR?= M2\GPHNCVkeHUh?=
NMC-G1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnWc2FzUUN3ME2zO{4xPTJ7IN88US=> NUTRSVBEW0GQR1XS
D-336MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzrTFdKSzVyPUSxMlg1PDJizszN NWf1UpVmW0GQR1XS
UACC-62 NHrSWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTR{LkW1NFUh|ryP MYjTRW5ITVJ?
C-33-A MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzzTWM2OD12NT6zNlU3KM7:TR?= Ml22V2FPT0WU
HCC1937 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j0XWlEPTB;NEeuNVk2QCEQvF2= NYPsZVBFW0GQR1XS
HDLM-2 MonmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHXXmhKSzVyPUS3MlIzQDdizszN MmTkV2FPT0WU
NCI-H727 M4fPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTR5LkK0OVEh|ryP MWnTRW5ITVJ?
NY NW[1O5h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR7LkO5NFgh|ryP MWDTRW5ITVJ?
NCI-H2291 NXHk[pJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK4TWM2OD12OT64N|AyKM7:TR?= NVn2Wol4W0GQR1XS

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい
体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作（参考用のみ）

キナーゼ試験：

[1]
+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験：

[2]
+ 展開
  • 細胞株： LNCaP, PC-3, and TSU-Pr1
  • 濃度： Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間： 1, 2, 3 and 4 days
  • 実験の流れ：

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験：

[2]
+ 展開
  • 動物モデル： Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤： Dissolved in DMSO
  • 投薬量： ~100 mg/kg/day
  • 投与方法： Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。 		5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3
CAS No. 149647-78-9
保管 粉
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

総分子量：g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01281176 Active not recruiting Adult Solid Neoplasm National Cancer Institute (NCI) February 9 2011 Phase 1
NCT01189266 Active not recruiting Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Brain Stem Glioma|Childhood Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma|Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligoastrocytoma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Gliosarcoma National Cancer Institute (NCI) August 9 2010 Phase 1|Phase 2
NCT00703664 Completed Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma National Cancer Institute (NCI) July 9 2008 Phase 2
NCT03198559 Suspended HIV Infections The Peter Doherty Institute for Infection and Immunity|Merck Sharp & Dohme Corp.|The Alfred|University of Melbourne August 8 2017 Phase 1|Phase 2
NCT02538510 Active not recruiting Head and Neck Squamous Cell Carcinoma|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Salivary Gland Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage III Major Salivary Gland Carcinoma|Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage III Nasopharyngeal Carcinoma|Stage IV Nasopharyngeal Carcinoma|Stage IVA Major Salivary Gland Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Major Salivary Gland Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Major Salivary Gland Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma University of Washington|National Cancer Institute (NCI) October 8 2015 Phase 1|Phase 2
NCT01983969 Completed Advanced Cancers|Lymphoma M.D. Anderson Cancer Center November 7 2013 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問（FAQ）

  • 質問1：

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答：

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

selleck catalog

HDACシグナル伝達経路

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID