Vorinostat (SAHA)

For research use only. Not for use in humans.

製品コードS1047 別名:MK0683, Suberoylanilide hydroxamic acid

Vorinostat (SAHA)化学構造

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 33700
JPY 16000
JPY 26400
JPY 38500
最寄りの販売代理店を探す

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バルク問合せ

文献中Selleckの製品使用例(452)

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HT1080 NIS1eZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCzOGc3PzJiaB?= NFPqb2RFVVOR NHz4UIlKSzVyPUKuOEDPxE1? NHn2WGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkK3NFE4PSd-MUKyO|AyPzV:L3G+
K562 NWjTWW1JU2mwYYPlJGF{e2G7 MXq2JIg> MoC5SG1UVw>? Mn6wTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN NWfXdoZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0NVk{QDBpPkGyOFE6OzhyPD;hQi=>
A20 NEjKVG9McW6jc3WgRZN{[Xl? M3P1VFEhcA>? MXrEUXNQ M1mzTIFvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTl4MES4PUc,OTF7NkC0PFk9N2F-
Friend leukemic cell MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTSOVAh|ryP MY[3NkBp NWjXZmRjTE2VTx?= MkXMTWM2OD1yLkm5JO69VQ>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjFyOUmxN{c,OTJzMEm5NVM9N2F-
H1299 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L1eVczKGh? MnXuSG1UVw>? NWG2OFFLUUN3ME23MlI1KM7:TR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV{MUSyNkc,OTR3MkG0NlI9N2F-
HeLa MXLLbY5ie2ViQYPzZZk> M3jGRlMxKG2rbh?= M3\VNWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO Mme0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4MEO5OFkoRjF3NkCzPVQ6RC:jPh?=
LOX-IMVI M2O4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDFbHg6PDhiaB?= MnL0TWM2OD1zLkOg{txO MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O|A9N2F-
NCI-H226 MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVS0PEBp M2P5T2lEPTB;Mj62JO69VQ>? M3;2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{G1OFcxLz5zNUexOVQ4ODxxYU6=
RXF-631L MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHCNFc1QCCq NFzTemZKSzVyPUKg{txO MknaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5MUW0O|AoRjF3N{G1OFcxRC:jPh?=
SNB-78 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHrOFghcA>? NIfsdHRKSzVyPUG2JO69VQ>? NFf3WYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUexOVQ4OCd-MUW3NVU1PzB:L3G+
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CEM NUnnc5ZPU2mwYYPlJGF{e2G7 M3TzbVEhcA>? NWDBTYRJTE2VTx?= MnvlTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? NYPNR|RZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NlAxPjRpPkG2OFIxODZ2PD;hQi=>
HCT15 NWHYb4RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6wT4JZPDhiaB?= NYfyT2JzT0l3ME2wMlgzKM7:TR?= Mkj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5MkOyNlcoRjF4N{KzNlI4RC:jPh?=
NCI-H23 M1POdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLubpo1PDhiaB?= M1PUU2dKPTB;MD65NkDPxE1? MkPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5MkOyNlcoRjF4N{KzNlI4RC:jPh?=
GM15850 NVvIXo9iU2mwYYPlJGF{e2G7 NF\CRoozNjVizszN M1y0[lk3KGh? M3PUU2ROW09? NY\teWZ5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NVzZVGJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850 M{D3ZmtqdmG|ZTDBd5NigQ>? NVjsOHlGOi53IN88US=> NEC1eY86PiCq NUD6S|ZETE2VTx?= MmHLTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3L2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN|Y4Lz5zNkmyNVM3PzxxYU6=
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GM15850 MYLLbY5ie2ViQYPzZZk> MVOyMlUh|ryP M{S3T|k3KGh? NUfNS3NXTE2VTx?= NXzvOmFvUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M{jPSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN|Y4Lz5zNkmyNVM3PzxxYU6=
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U937 Mnz2SpVv[3Srb36gRZN{[Xl? NFrwUmUyKM7:TR?= MWqyOEBp NXjyd5JzTE2VTx?= Mn\OSYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= NHvjfWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0O|c2OCd-MUe0OFc4PTB:L3G+
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SKHEP1 NUnlXYZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUi3NkBp M4nHNGlEPTB;Mz60OkDPxE1? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O|g9N2F-
BJ MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNFAh|ryP NHi0[I01QCCq NHewVWZFVVOR MWnHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= NIOz[pQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|g1OCd-MkCxOFM5PDB:L3G+
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Caco-2 NWDEWm5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXsSXAyODBizszN MYm0PIg> MWHEUXNQ MonXTWM2OD16LkGg{txO Mlq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO4OFAoRjJyMUSzPFQxRC:jPh?=
Caco-2 MnTET4lv[XOnIFHzd4F6 NXLOT2xLPSEQvF2= NGq0O5g1KGh? NI\sUFVFVVOR MmW2TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvckBKSzVyIH;mJFAvODN5IN88US=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
Caco-2 M17wPGtqdmG|ZTDBd5NigQ>? NFXoR2kxNjNzNjDuUUB1dyB|MT62JO69VQ>? MUS0JIg> MkHISG1UVw>? M2Hab2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txO M2TjUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N|g1ODxxYU6=
Caco-2 MkPxT4lv[XOnIFHzd4F6 MYWwMlMyPiCwTTD0c{A{OS54IN88US=> MWe0JIg> M2P5OWROW09? M2PONGV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMzD3bZRpKEmFNUCgc4YhOC5zNEeg{txO MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
Caco-2 NVjVTWE5U2mwYYPlJGF{e2G7 MVW2MlMzKG6PIITvJFY{OiEQvF2= MWm0JIg> NUDXTWM2TE2VTx?= MnO3SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
Caco-2 NYfqW5p[U2mwYYPlJGF{e2G7 NUmyRYV6Pi5|MjDuUUB1dyB4M{Kg{txO MXm0JIg> M{\pdmROW09? M1PmO2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNzD3bZRpKEmFNUCgc4YhPDFizszN M1vPb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N|g1ODxxYU6=
Caco-2 M2DufWtqdmG|ZTDBd5NigQ>? M1ftZ|AvOzF4IH7NJJRwKDNzLk[g{txO NIrrXlQ1KGh? M{DNN2ROW09? NY\5dFlDTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO2 MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
HepG2 NGPU[JlMcW6jc3WgRZN{[Xl? MW[1JO69VQ>? NFnY[WI3cA>? NF:2bVZFVVOR MnT5TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvci=> NH7EbZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|g1OCd-MkCxOFM5PDB:L3G+
HepG2 NGfDbXNMcW6jc3WgRZN{[Xl? MlrJOUDPxE1? NFLheo83cA>? NVLxcHozTE2VTx?= MXvJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHj5dIVz[WOndInsZZRqd25? NXHGdIg6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
HepG2 MmjET4lv[XOnIFHzd4F6 NVjBPYdTPSEQvF2= NF7hVpI3cA>? NYnzOo9PTE2VTx?= MXHJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w NF3nbmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|g1OCd-MkCxOFM5PDB:L3G+
HepG2 NWPsUGR4U2mwYYPlJGF{e2G7 MlPtOUDPxE1? NFjETog3cA>? M4LKcGROW09? NIfBT2tKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBJOy:KNDDobZN1d26nIHHj[ZR6dGG2aX;u M4T1VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N|g1ODxxYU6=
COLO205 MlniT4lv[XOnIFHzd4F6 NYDMVIN2OTBizszN MYqyOEBp NFjORY9FVVOR MmnXTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NYjoUIxERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0OVE{PzhpPkKwOFUyOzd6PD;hQi=>
SCC4 M{f4ZWtqdmG|ZTDBd5NigQ>? MnP1NUDPxE1? NHHOV|czPGh? MlnUTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR3MkKyOUc,OjB2NUKyNlU9N2F-
SCC4 NF3pOmpMcW6jc3WgRZN{[Xl? NYj6O|V[OSEQvF2= MkfWNlRp MYfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCjY3X0fYxifGmxbh?= M3PDZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEWyNlI2Lz5{MES1NlIzPTxxYU6=
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A549 Ml21SpVv[3Srb36gRZN{[Xl? MljTOUDPxE1? MmfVN{Bp NVyzeFN[TE2VTx?= NGOzbWlKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3NUKwPEc,OjB6NUWyNFg9N2F-
HUT78 Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDCTHc4OiCq M2XINWROW09? M2XYVmdKPTB;MD6zJO69VQ>? NFPJUIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi4OFIxQCd-MkC4PFQzODh:L3G+
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A549 MW\DfZRwfG:6aXOgRZN{[Xl? M4jCU|czKGh? MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuPEDPxE1? MofVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
CAL27 M3\OXGN6fG:2b4jpZ{BCe3OjeR?= Ml\0O|IhcA>? M3XtOmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2= NYHENXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
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Sf21 M2ns[GtqdmG|ZTDBd5NigQ>? NGTV[ow{KGh? MUPJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= MnfwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
SKBR3 MWDDfZRwfG:6aXOgRZN{[Xl? MoTVO|IhcA>? NGLpVHJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszN NXTieXo1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
SKOV3 M2j6[2N6fG:2b4jpZ{BCe3OjeR?= NVPOTm5[PzJiaB?= NIrkRWdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN NYXVfJRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
COR-L23 M1XOWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C0dlExKM7:TR?= MoCwO|IhcA>? NWTmclQ1TE2VTx?= NH7HWpZIUTVyPUGuNUDPxE1? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
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MCR5-SV2 M3vwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;XWlExKM7:TR?= MoO3O|IhcA>? MXzEUXNQ NFzBV2lIUTVyPUKuNUDPxE1? NHzudlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFY1Pyd-MkGwPFA3PDd:L3G+
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COLO205 M1zhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H5U|k3KGh? M2PmVGROW09? M4TPW2lEPTB;Mj6xNkDPxE1? M{XJTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkO0OFMxLz5{MU[zOFQ{ODxxYU6=
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DU145 NH:xfFJMcW6jc3WgRZN{[Xl? MoKyNk42KM7:TR?= NITEW2szPCCq MYTEUXNQ M3TxN2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> MoqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkCxOlYoRjJ{Mk[wNVY3RC:jPh?=
DU145 M1\RO2tqdmG|ZTDBd5NigQ>? NXXYZVZGPSEQvF2= MXmyOEBp NIOw[oxFVVOR NHjPO5dKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKNDDhZ4V1gWyjdHnvci=> M3:yPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mk[wNVY3Lz5{MkK2NFE3PjxxYU6=
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A549/ATCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf0VoxqPi5{IN88US=> MYq3NkBp MXvEUXNQ MmDjS2k2OD1zLk[g{txO MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
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MALME-3M NYfCcXczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnpPWs3NjJizszN M1nZblczKGh? M2HrT2ROW09? MnmxS2k2OD1yLkOyJO69VQ>? NGTvcG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
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MDA-MB-435 MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3xcpk3NjJizszN NX;mTmJzPzJiaB?= M4DZO2ROW09? Mo\nS2k2OD1yLkWg{txO MnTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
MDA-MB-468 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3Q[IQ3NjJizszN MoHuO|IhcA>? MoHxSG1UVw>? NYrxdYxHT0l3ME2wMlY{KM7:TR?= MlfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
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NCI-H23 NV\udYFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7uXVBzPi5{IN88US=> NXjJdVZYPzJiaB?= NYO3eYFTTE2VTx?= NFvkenJIUTVyPUGg{txO NG\IflU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
NCI-H322M Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PwS|YvOiEQvF2= M4XYOFczKGh? M1jiZWROW09? NUjOVoNCT0l3ME2wMlc6KM7:TR?= MkftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
NCI-H460 NHHRRpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVG2MlIh|ryP M{jHV|czKGh? NV32ZZRCTE2VTx?= MkmwS2k2OD1yLke5JO69VQ>? NEfT[|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
NCI-H522 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTiOk4zKM7:TR?= NI\KXIY4OiCq MnfySG1UVw>? MYTHTVUxRTBwNTFOwG0> NGTnXm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
OVCAR3 NInxbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWK2MlIh|ryP Ml7RO|IhcA>? M3j0WWROW09? MWPHTVUxRTFwMzFOwG0> M4XQUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
OVCAR4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXW2MlIh|ryP Mnj1O|IhcA>? MmXrSG1UVw>? NVzGemdzT0l3ME20JO69VQ>? MmGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
OVCAR5 M{DBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfYVldOPi5{IN88US=> MXm3NkBp NHvTdlFFVVOR MXfHTVUxRTBwN{mg{txO MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
OVCAR8 M4nRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPySpRJPi5{IN88US=> NGrr[3U4OiCq NFyzTotFVVOR MXLHTVUxRTBwNTFOwG0> NXm0W3JbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
RXF393 NGDybYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnLSHo3NjJizszN MWi3NkBp M{HHO2ROW09? NYXGVHJZT0l3ME2xMlMh|ryP NEjWXGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
SF268 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLqelU3NjJizszN NVfGUFk6PzJiaB?= NITITYxFVVOR NIjEd4dIUTVyPUGuOkDPxE1? NGPJbYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
SF295 M4LIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrYNWY3NjJizszN NIrFfHg4OiCq NIfrfpVFVVOR MkHUS2k2OD1zLk[g{txO NFnhOFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
SF539 M2jaemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;sWZhFPi5{IN88US=> NFXLcXA4OiCq NInwXXpFVVOR NWfsOHJ1T0l3ME2yJO69VQ>? NF\MNWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
SK-MEL-2 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Xm[lYvOiEQvF2= Mm\HO|IhcA>? Mm\2SG1UVw>? NXzSN|BCT0l3ME2xMlMh|ryP Mn2wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
SK-MEL-28 M33OSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzQOk4zKM7:TR?= M4DnUVczKGh? MoTpSG1UVw>? NXiwTmZZT0l3ME2xJO69VQ>? NHXwNXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
SK-MEL-5 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\QOk4zKM7:TR?= Mon6O|IhcA>? NX;nbW9JTE2VTx?= M1zyTmdKPTB;MD62N{DPxE1? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
SKOV3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXq2MlIh|ryP MUm3NkBp MYPEUXNQ M3T0UmdKPTB;MTFOwG0> NUfKcGU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
SN12C NGfweI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYq2MlIh|ryP M3LjNlczKGh? MV7EUXNQ MoDUS2k2OD1{IN88US=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|NU[2PUc,OjJ2M{W2Olk9N2F-
SNB19 NGnpS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnWU5Q3NjJizszN NXH1OVllPzJiaB?= MoDCSG1UVw>? NVfDToxIT0l3ME2wMlY{KM7:TR?= MkLzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
SNB75 M3j0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr2Ok4zKM7:TR?= NHOxd5I4OiCq M1PKOGROW09? NHzFRlFIUTVyPUCuO|kh|ryP NV\BW3JJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|U3PjlpPkKyOFM2PjZ7PD;hQi=>
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T47D MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvmXYJzPi5{IN88US=> M33u[VczKGh? M2jJU2ROW09? NVnYZ4NWT0l3ME2wMlUh|ryP NGLN[oQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
TK10 MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTWVGg3NjJizszN MnuyO|IhcA>? M1TPbmROW09? M{L2R2dKPTB;MD62N{DPxE1? M2HYWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
UACC257 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[2MlIh|ryP Ml7vO|IhcA>? M4jMT2ROW09? M13G[mdKPTB;MD61JO69VQ>? NHj1NJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
UACC62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[2MlIh|ryP NWL4boloPzJiaB?= NUX2TJRnTE2VTx?= NVSwZmNNT0l3ME2wMlQh|ryP NIXxfYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N|U3Pjl:L3G+
UO31 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvYXG9SPi5{IN88US=> MXO3NkBp M3K0O2ROW09? M37CS2dKPTB;MD61JO69VQ>? MlLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
Hep3B NWGzSlJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjuOFghcA>? Mor1SG1UVw>? MXXHTVUxRTBwNkmg{txO MmPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m4OlMoRjJ{NEO5PFY{RC:jPh?=
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Bel7402 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHC[m04OiCq MkLuSG1UVw>? NFHNcJVIUTlyPUG3JO69VQ>? M{nnflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
Bel7404 M1TaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj2O|IhcA>? MnnWSG1UVw>? M4Tie2dKQTB;MUig{txO M2riR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
BGC823 NX7l[op6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV63NkBp MVHEUXNQ NYX6Zmo1T0l7ME23MlUh|ryP NVXNVmJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
MGC803 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTlSpQ4OiCq M1P2dWROW09? M4HI[WdKQTB;MUCuPEDPxE1? MoLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
SGC7901 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\uS2c4OiCq NV;pS3ZPTE2VTx?= NYrT[|ZDT0l7ME25MlQh|ryP MoHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkGzO|YoRjJ|ME[xN|c3RC:jPh?=
SKHEP1 NFvSUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjPOGo4OiCq M3X4UWROW09? NYfJRmszT0l7ME2xO{DPxE1? NUDrZ3hQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
SMMC7721 NHjlZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln4O|IhcA>? MnzRSG1UVw>? MoDOS2k6OD1{MDFOwG0> M33jZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[xN|c3Lz5{M{C2NVM4PjxxYU6=
NUGC3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLr[WQyOCEQvF2= MonOS2k:Oi57NDFOwG0> M1:wWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MU[zN|MzLz5{M{G2N|M{OjxxYU6=
A2780 CisR M4XKd2tqdmG|ZTDBd5NigQ>? MVyxPEBp M4jNeWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? NVzlfHRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB|PD;hQi=>
CAL27 sens NH72cmlMcW6jc3WgRZN{[Xl? Mn63NVghcA>? MXHJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
CAL27 CisR M4OybWtqdmG|ZTDBd5NigQ>? MnKxNVghcA>? NH\weoFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
KYSE-510 CisR NXPkN5gxU2mwYYPlJGF{e2G7 MmPINVghcA>? M3vFVGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? NFHhS5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
KYSE-510 sens NID2fVZMcW6jc3WgRZN{[Xl? MnPTNVghcA>? NYfqfmZsUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP M2HFW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
MDA-MB-231 sens NVHo[GNuU2mwYYPlJGF{e2G7 NIXXS5kyQCCq Mm\QTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M2fmNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
MDA-MB-231 CisR NXfYOGY3U2mwYYPlJGF{e2G7 NIL2PIMyQCCq M2jSWWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
ES2 NX3kRVJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDYOFghcA>? M{fHXmROW09? MVHJR|UxRTF{Lkeg{txO NH7YVWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N|Q1QSd-MkO0PVM1PDl:L3G+
MDA-MB-231 NEjIU5lMcW6jc3WgRZN{[Xl? M4SySlExKM7:TR?= Mme0N|AhdWmw M17yVGROW09? MW\Jcohq[mm2aX;uJI9nKEiGQVOyZS=> NELrRYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N|Q1QSd-MkO0PVM1PDl:L3G+
MDA-MB-231 NWXSNZFMU2mwYYPlJGF{e2G7 MlHlNUDPxE1? MnHLNlQhcA>? NXfOPI54TE2VTx?= MmnXTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= NX;1N|hQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVM1PDlpPkKzOFk{PDR7PD;hQi=>
HS68 MXvDfZRwfG:6aXOgRZN{[Xl? NH2xfYUyOCEQvF2= MXe3NkBp MkfRSG1UVw>? NITrXHZKSzVyPUSuOkDPxE1? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV5MEW0Nkc,OjN3N{C1OFI9N2F-
MEF NIfCcJZEgXSxdH;4bYMhSXO|YYm= M4m4TVExKM7:TR?= MkDOO|IhcA>? M1zPXmROW09? NGDkfpVKSzVyPUSuOEDPxE1? Ml71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3N{C1OFIoRjJ|NUewOVQzRC:jPh?=
BGC823 M1jSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLWSG1UVw>? M1nJSmdKPTB;Mz6wPUDPxE1? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMUewOkc,OjN4MEG3NFY9N2F-
High5 NILWfnBMcW6jc3WgRZN{[Xl? M4ThO|I1KGh? MUDJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkWyN{c,OjN4MEK1NlM9N2F-
High5 Mnf1T4lv[XOnIFHzd4F6 M3LvU|I1KGh? NILlRmdKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= NVztOYZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFI2OjNpPkKzOlAzPTJ|PD;hQi=>
High5 MVjLbY5ie2ViQYPzZZk> MoDaNlQhcA>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? M13TO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCyOVI{Lz5{M{[wNlUzOzxxYU6=
A549 MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjEUXNQ M1TkXmlEPTB;MT6wO|kh|ryP MmXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVAoRjJ|NkS0NlExRC:jPh?=
HCT116 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXrfZVlTE2VTx?= NF7sXI9KSzVyPUCuO|U4KM7:TR?= NHqwPYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[0OFIyOCd-MkO2OFQzOTB:L3G+
K562 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrET2RFVVOR MUfJR|UxRTBwNkS1JO69VQ>? NWfXOGhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OFQzOTBpPkKzOlQ1OjFyPD;hQi=>
GBC-SD NX7tWmNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT6dmhRPSEQvF2= M3\vclczKGh? Mn7WSG1UVw>? NUn1WIRlUUN3ME2xOE45KM7:TR?= M{PYRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{C3NlYxLz5{M{ewO|I3ODxxYU6=
HGC27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4e5W|Uh|ryP MUe3NkBp NGS3RmFFVVOR NYrNRXdqUUN3ME21MlQh|ryP M17yVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{C3NlYxLz5{M{ewO|I3ODxxYU6=
HL60 NIXRRVRMcW6jc3WgRZN{[Xl? MmXhOUDPxE1? MYSyOEBp M1;mOmROW09? NFLXcWdKdmirYnn0bY9vKG:oIFjERWM> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdyN{K2NEc,OjN5MEeyOlA9N2F-
Vero MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT6bVQ4OiCq MYrEUXNQ NV;TXZNJUUN3ME2wMlkh|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd6NkS1Nkc,OjN5OE[0OVI9N2F-
NCI60 NFrIfZFEgXSxdH;4bYMhSXO|YYm= NGLFdJg1QCCq MV;EUXNQ NEO3VJNIUT1yLkWzJO69VQ>? M1\iNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG1N|I4Lz5{NECxOVMzPzxxYU6=
SW620 MWfDfZRwfG:6aXOgRZN{[Xl? NVTVRYszPDhiaB?= Mnv1SG1UVw>? MkHZS2k:OC53NDFOwG0> NYPvNHp1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
U251 M1vme2N6fG:2b4jpZ{BCe3OjeR?= MmG2OFghcA>? M{L4RmROW09? M4LKV2dKRTFwNUOg{txO NXvVOXhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
KM12 MYTDfZRwfG:6aXOgRZN{[Xl? Mni5OFghcA>? MXTEUXNQ NH;BVJlIUT1zLki4JO69VQ>? NFy0[4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOVMzPyd-MkSwNVU{Ojd:L3G+
Hs578T NHXBO2FEgXSxdH;4bYMhSXO|YYm= M3PO[lQ5KGh? MYDEUXNQ NI\seW1IUT12LkizJO69VQ>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
MDA-MB-231 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVq0PEBp NWnQRoRRUUN3ME2wMlE3KM7:TR?= NWS4cmNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVUxOTZpPkK0NFk2ODF4PD;hQi=>
MCF7 NX[4PJMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvybW81QCCq MX3HTV0xNjR3IN88US=> NIW3c209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxPVU2PSd-MkSxNVk2PTV:L3G+
MDA-MB-435 NXHOdolYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\PS|Q5KGh? MUXHTV0xNjh6IN88US=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzOUW1OUc,OjRzMUm1OVU9N2F-
AsPC1 MoPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\sN|Ah|ryP MnjnOFghcA>? NIG4d|VFVVOR NHjrW|lKSzVyPUOuOlYh|ryP M2TPeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi1N|c5Lz5{NEG4OVM4QDxxYU6=
Jurkat E6.1 NUW4[4l5U2mwYYPlJGF{e2G7 NX;BOXBKOiCq NF;UV4JFVVOR NXq4VGl6UW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= MnT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NkG4OlIoRjJ2Mk[xPFYzRC:jPh?=
KG1 NYnXVW4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnWXYs1QCCq NV:1e|lCUUN3ME2xMlE2KM7:TR?= M4jkWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUK1NFA{Lz5{NEWyOVAxOzxxYU6=
HEL NWHMOoJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHQVGQ1QCCq M2DIV2ROW09? MXXJR|UxRTBwNEmg{txO M1;OWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nkm0NFU2Lz5{NE[5OFA2PTxxYU6=
HSC3 MXvDfZRwfG:6aXOgRZN{[Xl? MUWxNkBp NHfmOHpFVVOR M3POcGlEPTB;MD63NUDPxE1? NWjWTJFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
HT-29 M4fR[GN6fG:2b4jpZ{BCe3OjeR?= M1H6SVEzKGh? NHvBXVFFVVOR MUTJR|UxRTBwN{Kg{txO M3j2b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{[2OVYxLz5{NEe2OlU3ODxxYU6=
KB M{LESGN6fG:2b4jpZ{BCe3OjeR?= NFrNR2IyOiCq M1XhZmROW09? M2HzVGlEPTB;MD63OUDPxE1? NIXtOpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
H460 NV3nZ49jS3m2b4TvfIlkKEG|c3H5 MUGxNkBp MlrySG1UVw>? MVTJR|UxRTBwOEKg{txO NXXmVVNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O|Y3PTZyPD;hQi=>
MONE1 NFTiepdEgXSxdH;4bYMhSXO|YYm= NVq0W3NNOTJiaB?= MV\EUXNQ M1HkXGlEPTB;MT6xPEDPxE1? MmrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
MKN45 MnTOR5l1d3SxeHnjJGF{e2G7 MmPxNVIhcA>? MVzEUXNQ MVPJR|UxRTFwMkWg{txO NIfhVlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
TSGH NX3afIRTS3m2b4TvfIlkKEG|c3H5 MmDDNVIhcA>? NED6V4xFVVOR M2rKcmlEPTB;Mj6wPUDPxE1? MkS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
HL60 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzSZnB[PzJiaB?= MkW2SG1UVw>? NEnuNXBIUTVyPUCuPVMh|ryP MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEWwNEc,OjR7MEC1NFA9N2F-
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