Vorinostat (SAHA, MK0683)

製品コードS1047 別名：SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683)化学構造

分子量(MW)：264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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文献中Selleckの製品使用例(103)

カスタマーフィードバック(20)

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

製品安全説明書

HDAC阻害剤の選択性比較

生物活性

製品説明 Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
ターゲット
HDAC [1]
(Cell-free assay)
~10 nM
体外試験

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]
細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MXHLbY5ie2ViQYPzZZk> M3q2ZVEhcA>? NHzt[ppFVVOR NXXzOnV3[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN M1nzXVEyQTZyNEi5
Friend leukemic cell MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTGO4k2OCEQvF2= NXLQWYd6PzJiaB?= NH;RSWJFVVOR NEKySmpKSzVyPUCuPVkh|ryP MXexNlExQTlzMx?=
K562 MoTJT4lv[XOnIFHzd4F6 MkjaOkBp MnvFSG1UVw>? NHvOXXVKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> NXT2fHJEOTJ2MUmzPFA>
HT1080 NGjicm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j4W|czKGh? NYXoWnlMTE2VTx?= M2T1R2lEPTB;Mj60JO69VQ>? NGDnPXMyOjJ5MEG3OS=>
H1299 NXzQZ2ZZU2mwYYPlJGF{e2G7 Mn\MNlAhdWmw NX;sco0xTE2VTx?= M3zTZmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN NWTJ[nBHOTR3MkG0NlI>
H1299 NED0S2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTxXpk4OiCq NYXRR4VbTE2VTx?= MoOzTWM2OD15LkK0JO69VQ>? NEjvPY4yPDV{MUSyNi=>
HeLa MlfzT4lv[XOnIFHzd4F6 NUHMdWRnOzBibXnu Ml;QTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NX75NI96OTV4MEO5OFk>
LOX-IMVI M3jsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3mUVF4PDhiaB?= MmLoTWM2OD1zLkOg{txO M3jhelE2PzF3NEew
NCI-H226 M3;iVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jNWFQ5KGh? M1jjPGlEPTB;Mj62JO69VQ>? MnzzNVU4OTV2N{C=
RXF-631L NEW2XYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV20PEBp MkPnTWM2OD1{IN88US=> MoLNNVU4OTV2N{C=
SNB-78 M4\VbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTMUYo1QCCq MVHJR|UxRTF4IN88US=> MnLyNVU4OTV2N{C=
St-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVi0PEBp MmrMTWM2OD13LkKg{txO MW[xOVcyPTR5MB?=
ARP1 M4m4O2Z2dmO2aX;uJGF{e2G7 MUeyJO69VQ>? Mnz6OkBp MVvJcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= NXXRZ29KOTR5M{S4NFY>
CEM MkXpT4lv[XOnIFHzd4F6 NHnsU3UyKGh? MYDEUXNQ NImyVJZKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NXvuO|N4OTZ2MkCwOlQ>
HCT15 M4CzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr1OFghcA>? NXfmWFlQT0l3ME2wMlgzKM7:TR?= MWWxOlczOzJ{Nx?=
NCI-H23 MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WzXVQ5KGh? Ml[yS2k2OD1yLkmyJO69VQ>? M2jz[FE3PzJ|MkK3
GM15850 NVfp[GJ[U2mwYYPlJGF{e2G7 M1zGOVIvPSEQvF2= M{XtZ|k3KGh? Mln5SG1UVw>? MXLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NULmUmdSOTZ7MkGzOlc>
GM15850 MnTwT4lv[XOnIFHzd4F6 M2\rdlIvPSEQvF2= MmLjPVYhcA>? NH\aSIpFVVOR MXHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NFTUclcyPjl{MUO2Oy=>
GM15850 M4TiSWtqdmG|ZTDBd5NigQ>? MYmyMlUh|ryP NXXVWVY3QTZiaB?= NF;CRY9FVVOR M{fBbmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MkG0NVY6OjF|Nke=
GM15850 MlXHT4lv[XOnIFHzd4F6 MUiyMlUh|ryP MWm5OkBp NVjEdHZ6TE2VTx?= NX;LbnA{UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NG\QeowyPjl{MUO2Oy=>
GM15850 MkjxT4lv[XOnIFHzd4F6 NHvjNmMzNjVizszN M4TBWlk3KGh? NUXOdZFvTE2VTx?= NFfMeZZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M4q4Z|E3QTJzM{[3
GM15850 MnTTT4lv[XOnIFHzd4F6 M3nmTFIvPSEQvF2= NIDPc4g6PiCq M1yycWROW09? MUnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3vteFE3QTJzM{[3
U937 NVfibYNMTnWwY4Tpc44hSXO|YYm= NGDiWpE2KM7:TR?= MnrWNlQhcA>? NXvNVHlpTE2VTx?= M320UmNmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? MX[xO|AxPDdzOB?=
H661 Mn;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX20PEBp NHTQVHNKSzVyPUGg{txO MkfVNVcyPTdyMEm=
U937 NI\JcmJHfW6ldHnvckBCe3OjeR?= Mn3xOUDPxE1? NGqz[|EzPCCq NGjjVWxFVVOR Ml65TY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= Ml7HNVc1PDd5NUC=
U937 NHXxb49HfW6ldHnvckBCe3OjeR?= M3\xd|Eh|ryP NXT0eJdEOjRiaB?= NHnDU5FFVVOR NH7N[3VG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> NFzN[mcyPzR2N{e1NC=>
RAW264.7 NYrFdlRrTnWwY4Tpc44hSXO|YYm= M3PqTVExKM7:TR?= NXmwS5R2OjSq Mnvme4F1\XJ? NYLET3V3UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> Mk\6NVc1Pzd3MUi=
RAW264.7 MmHlSpVv[3Srb36gRZN{[Xl? MkHJNVAh|ryP MYOyOIg> NYjjXVVJf2G2ZYK= NVTtbJNtUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? Mn\PNVc1Pzd3MUi=
SC9 NWPyXW1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYK0PEBp MoXkTWM2OD1yLk[wOkDPxE1? M2jCT|E4PTB5MkG5
ST14A MXXGeY5kfGmxbjDBd5NigQ>? NF7tT242KG6P MXO3NkBp NGm0NlVKdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v M1SzcVE4PTZ3OUmz
ST14A NVKyclZ{TnWwY4Tpc44hSXO|YYm= Mlv5OUBvVQ>? NHXtfnY4OiCq NV\xSmlDUW6lcnXhd4UhcW5iRULGNUBuWk6DIHX4dJJme3Orb36= NYrRfI8yOTd3NkW5PVM>
PANC1 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnMNUDPxE1? MU\JR|UxRTBwNEWg{txO NFjwSI4yPzV6OEe0OC=>
PANC1 NGe5fHBHfW6ldHnvckBCe3OjeR?= NHHkXlEyKM7:TR?= NVjXW4lHOjRiaB?= M{\SOGlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? NXPxdIZkOTd3OEi3OFQ>
PANC1 MmTVSpVv[3Srb36gRZN{[Xl? M3y5OFEh|ryP MUCyOEBp MnrnTY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= MljXNVc2QDh5NES=
PT45 M4j2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml70TWM2OD12IN88US=> NIWwdFgyPzV6OEe0OC=>
ACHN M4HNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP2NlEhcA>? M4XyUWdKPTB;MD62OUDPxE1? NGjI[moyPzZ4Mk[wOi=>
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SCC25 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:3NkBp NH;pdZVKSzVyPUGuPVMh|ryP M3PC[lIxOTR|N{e4
SKHEP1 NU\ZR3FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33MZVczKGh? MXXJR|UxRTNwNE[g{txO NFv6SW8zODF2M{e3PC=>
BJ NFWzdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\LUlExOCEQvF2= MnnoOFghcA>? NXLLT3c6TE2VTx?= NHTOfoxIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> M2TVeVIxOTR|OESw
MUF MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvoVXEyODBizszN M33mcVQ5KGh? Moj3SG1UVw>? M{nySWdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN MV:yNFE1Ozh2MB?=
Caco-2 NVPTWZN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:0NVAxKM7:TR?= NVPzUWNrPDiq MW\EUXNQ NVHZ[lR7UUN3ME24MlEh|ryP NHjSeY0zODF2M{i0NC=>
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Caco-2 M4nNU2tqdmG|ZTDBd5NigQ>? Mkf0NE4{OTZibl2geI8hOzFwNjFOwG0> M4nMXFQhcA>? MmHJSG1UVw>? M4nkT2V5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMTD3bZRpKEmFNUCgc4YhOC5zMUmg{txO M1PUeVIxOTR|OESw
Caco-2 MULLbY5ie2ViQYPzZZk> NFjZZ4ExNjNzNjDuUUB1dyB|MT62JO69VQ>? MXe0JIg> MWTEUXNQ NIHhNYFGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>? M{TvZ|IxOTR|OESw
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HepG2 MWPLbY5ie2ViQYPzZZk> Mk\POUDPxE1? Mlz5Oog> MYrEUXNQ NFvVWoZKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIh6eGW{YXPleJlt[XSrb36= NVjQOZl3OjBzNEO4OFA>
HepG2 NFyyN|dMcW6jc3WgRZN{[Xl? NX;wTlhPPSEQvF2= Ml2wOog> MoXOSG1UVw>? M3\Ocmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NH7NcYszODF2M{i0NC=>
HepG2 NYX2PJdCU2mwYYPlJGF{e2G7 NELTTYc2KM7:TR?= MVu2bC=> MlL2SG1UVw>? MWHJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDIN{9JPCCqaYP0c45mKGGlZYT5cIF1cW:w NWjiW|J3OjBzNEO4OFA>
COLO205 MXHLbY5ie2ViQYPzZZk> MmnoNVAh|ryP Ml7RNlQhcA>? MoHGSG1UVw>? Ml;RTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= M1zvWVIxPDVzM{e4
SCC4 MnfUT4lv[XOnIFHzd4F6 NFLKdHcyKM7:TR?= MonJNlRp M{\HeGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjD0eYJ2dGmwIHHj[ZR6dGG2aX;u NWL0N|hMOjB2NUKyNlU>
SCC4 M{SwTmtqdmG|ZTDBd5NigQ>? M3jKb|Eh|ryP MWeyOIg> NWPObGpxUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> MUWyNFQ2OjJ{NR?=
SCC4 NX7Vfm1WTnWwY4Tpc44hSXO|YYm= MX:xJO69VQ>? MYq1JI1qdg>? NFHURWxC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u M3zuXlIxPDV{MkK1
NB4 NYf2NY9mTnWwY4Tpc44hSXO|YYm= NUXiXG5SPSEQvF2= NGTTdVIzPCCq MmG1SG1UVw>? MmjBR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPjeY12dGG2aX;uJIF1KHC{ZT3HNUBxcGG|ZR?= NVLUSJpbOjB2OUG0OFA>
NB4 Mn\UT4lv[XOnIFHzd4F6 NHzvRXo2KM7:TR?= MXWyOEBp NF33TINFVVOR NFLVdGNKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? NEjPZ3gzODR7MUS0NC=>
NB4 NVLBOVNzTnWwY4Tpc44hSXO|YYm= NHLNeJc2KM7:TR?= M4rUWVI1KGh? M1vTd2ROW09? MmXYTY5lfWO2aX;uJI9nKHB{MWfBSlEwS0mSMTDlfJBz\XO|aX;u NGrMdpAzODR7MUS0NC=>
NB4 NEPRbFhMcW6jc3WgRZN{[Xl? M{DRO|Uh|ryP NXTMeJJvOjRiaB?= NU\QWHU3TE2VTx?= NFHtOFJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdg>? MWOyNFQ6OTR2MB?=
NUGC3 NHfV[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT2fZFIUTVyPUKuPVQh|ryP MUWyNFg2ODl5MR?=
A549 NY\aWokxTnWwY4Tpc44hSXO|YYm= NWXlcGNjPSEQvF2= MUizJIg> M{e3b2ROW09? M1HsXmlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> MkDrNlA5PTV{MEi=
HUT78 NWT3NXNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LON|czKGh? MYXEUXNQ NX;temU5T0l3ME2wMlMh|ryP M3i3UFIxQDh2MkC4
U937 NETNZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUS3NkBp NVvI[GF2TE2VTx?= NYLHcItUT0l3ME2wMlM6KM7:TR?= NITYZYIzODh6NEKwPC=>
A431 M4XmZWN6fG:2b4jpZ{BCe3OjeR?= NHj0WIQ4OiCq NIfwUY1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= M{jhUFIyODhyNkK5
A549 MkPaR5l1d3SxeHnjJGF{e2G7 MlH3O|IhcA>? NGnkeGJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= NVvoOYx6OjFyOEC2Nlk>
CAL27 MnPRR5l1d3SxeHnjJGF{e2G7 MYe3NkBp NWq2RWl3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> NETBXlIzOTB6ME[yPS=>
HeLa NXPNSWFCS3m2b4TvfIlkKEG|c3H5 MUe3NkBp M4XwRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMhd3[ncnX4dJJme3OrbnegTGRCSyC5aYToJGlEPTBib3[gNU42KM7:TR?= MVeyNVA5ODZ{OR?=
Sf21 NGTRUGFMcW6jc3WgRZN{[Xl? M2HNflMhcA>? M4GxPWlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN MYmyNVA5ODZ{OR?=
SKBR3 MYnDfZRwfG:6aXOgRZN{[Xl? MVK3NkBp NVjSTJlYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> MUiyNVA5ODZ{OR?=
SKOV3 MYXDfZRwfG:6aXOgRZN{[Xl? MljvO|IhcA>? NXHUUoVGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NV\uO|NMOjFyOEC2Nlk>
COR-L23 NXnmUIE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;rWVExKM7:TR?= NWLGVnR5PzJiaB?= MV3EUXNQ NGG2U4hIUTVyPUGuNUDPxE1? NEXLS2QzOTB6ME[0Oy=>
DU145 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1uyXFExKM7:TR?= NF3Pfm84OiCq MUXEUXNQ NETMbYdIUTVyPUGuNFUh|ryP Mn;ONlExQDB4NEe=
LoVo Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkmyNVAh|ryP NXXvcJJwPzJiaB?= NETSNIJFVVOR M1vGVGdKPTB;MT63JO69VQ>? NH7mT4YzOTB6ME[0Oy=>
MCR5-SV2 NXq3fZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? MXi3NkBp M{n3PGROW09? NYX2RnRKT0l3ME2yMlEh|ryP M2jQXVIyODhyNkS3
HCT116 NYTSbFNwU2mwYYPlJGF{e2G7 NIjSSpg{OCEQvF2= NGDrd3M{OCCq NWn5c41FTE2VTx?= NYP1XHp5UW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> MYSyNVA5ODZ2Nx?=
HCT116 NIf2WoFMcW6jc3WgRZN{[Xl? M3\4VlMxKM7:TR?= M2TPNlMxKGh? MlP4SG1UVw>? NWfy[4dMUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u NY\MfpMzOjFyOEC2OFc>
U937 Mnj4T4lv[XOnIFHzd4F6 NGHWcYc2KM7:TR?= MUmyOEBp NWjPc|hETE2VTx?= NUG2WnR6UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= NEW4NnEzOTJ7MkS5Ni=>
U937 NY[2[XdwU2mwYYPlJGF{e2G7 Ml7iOUDPxE1? NHKyc2szPCCq MkLhSG1UVw>? NFfkWnpKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi= M{DnOlIyOjl{NEmy
U937 NFTOZXdMcW6jc3WgRZN{[Xl? MoPuOUDPxE1? NWHOcolJOjRiaB?= M2PJOWROW09? MmTOTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? M1S5fFIyOjl{NEmy
U937 M1ryW2tqdmG|ZTDBd5NigQ>? M4C0fVUh|ryP NGi1W2kyPSCvaX6= MoXCSG1UVw>? NFv1OHJKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? MnvWNlEzQTJ2OUK=
A2780 MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTHOXI6PiCq M{jGOWROW09? NXj6RlJKUUN3ME2xMlYzKM7:TR?= M4LvU|IyPjN2NEOw
COLO205 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfk[mc6PiCq MYXEUXNQ M4DxNWlEPTB;Mj6xNkDPxE1? M4XhclIyPjN2NEOw
Hep3B MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TqRlQ5KGh? NHe2XYlFVVOR Ml\HS2k2OD1zLkKxJO69VQ>? Ml;FNlE4OTJzNE[=
GM11272 M1nwU2Z2dmO2aX;uJGF{e2G7 NUfGZoxZOTByIH7N Mlm3O|IhcA>? MVHEUXNQ MVPS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N M2jMcVIyQDRyN{G2
CFBE41o NF:0eZFMcW6jc3WgRZN{[Xl? MnjEOUDPxE1? NHO3R49FVVOR NWTPNW5iTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP M4XPfFIyQTh2OUW4
CFBE41o NX\mZ2lZTnWwY4Tpc44hSXO|YYm= NUL6cmE1OSEQvF2= NIP3c2czPCCq NGPTTHpFVVOR MoTrVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| NIDDbHozOTl6NEm1PC=>
DU145 M4rRUGtqdmG|ZTDBd5NigQ>? M1PEdlIvPSEQvF2= NXH5dmhwOjRiaB?= NVXFUFZFTE2VTx?= M3nKT2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> NFzWSFMzOjJ4MEG2Oi=>
DU145 MoHRT4lv[XOnIFHzd4F6 MYK1JO69VQ>? NHXGXlkzPCCq NXS3WIdTTE2VTx?= NYXubVdPUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> MnrYNlIzPjBzNk[=
DU145 MofVT4lv[XOnIFHzd4F6 MnPqOUDPxE1? NX3BWnd4OjRiaB?= NUTjN5lMTE2VTx?= NFPONXFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKMzDofZBmemGlZYT5cIF1cW:w NVL0fVVCOjJ{NkCxOlY>
786-0 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm3Ok4zKM7:TR?= NGLBZok4OiCq NVvRU|UyTE2VTx?= MUjHTVUxRTNwMjFOwG0> MViyNlQ{PTZ4OR?=
A498 M1f5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWC2MlIh|ryP MnvFO|IhcA>? MX3EUXNQ Mn7KS2k2OD1zLk[g{txO NU[yRVBqOjJ2M{W2Olk>
A549/ATCC M3\1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTyXY43NjJizszN MWK3NkBp M1W0V2ROW09? MofOS2k2OD1zLk[g{txO MnHVNlI1OzV4Nkm=
ACHN NV;hcHR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L0NVYvOiEQvF2= MWe3NkBp NIXVNZpFVVOR MkjMS2k2OD1zLkOg{txO NFPMfXUzOjR|NU[2PS=>
BT549 M{nSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVS2MlIh|ryP MUW3NkBp M{XvemROW09? NVzGeIVCT0l3ME2xMlMh|ryP M4\pOFIzPDN3Nk[5
EKVX NVrPN3BmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S0V|YvOiEQvF2= NF\yZ244OiCq NIL2SZpFVVOR MmC3S2k2OD1zLkOg{txO MYeyNlQ{PTZ4OR?=
HCT15 NX\lPVB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLUU5c3NjJizszN NHPtPGk4OiCq M{f3UmROW09? NGqxXIVIUTVyPUKuOUDPxE1? NF30VlEzOjR|NU[2PS=>
HOP92 NIXROJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhWXo3NjJizszN MVe3NkBp MVjEUXNQ M1HRcmdKPTB;NDFOwG0> MlTKNlI1OzV4Nkm=
IGROV1 NWe1WXZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrsOk4zKM7:TR?= MlruO|IhcA>? Mn3oSG1UVw>? M4K5TGdKPTB;MT6zJO69VQ>? M4S0U|IzPDN3Nk[5
LOXIMVI Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:xWVYvOiEQvF2= NXHk[4E4PzJiaB?= NVPKV45VTE2VTx?= MVzHTVUxRTFizszN NYX5[WNzOjJ2M{W2Olk>
M14 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDXOGVIPi5{IN88US=> MX23NkBp NFfkZVBFVVOR MkPzS2k2OD1zLkOg{txO NHP3SXUzOjR|NU[2PS=>
MALME-3M NUTyO3ptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHHOk4zKM7:TR?= M361ZlczKGh? M1\RZmROW09? MV\HTVUxRTBwM{Kg{txO NVXYZ|E4OjJ2M{W2Olk>
MCF10A NYPzZlg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLTOk4zKM7:TR?= MmW4OFghcA>? MVrEUXNQ Mly5S2k2OD17Lk[g{txO NXfhdolGOjJ2M{W2Olk>
MDA-MB-435 M2fxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn4Ok4zKM7:TR?= NVXy[pdlPzJiaB?= NWDiepZxTE2VTx?= MVTHTVUxRTBwNTFOwG0> NFjvdnIzOjR|NU[2PS=>
MDA-MB-468 NWP5ZXdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DjZlYvOiEQvF2= MVu3NkBp NUC1TXlGTE2VTx?= NXHqV5g{T0l3ME2wMlY{KM7:TR?= MYqyNlQ{PTZ4OR?=
MOLT4 NF\mSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrMOk4zKM7:TR?= NHLoTlA4OiCq NELQWWVFVVOR M4TYW2dKPTB;MD60JO69VQ>? NWnuOHY3OjJ2M{W2Olk>
NCI-ADR-RES MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVO2MlIh|ryP M4rtZVczKGh? M{XYZmROW09? NXW5c45ET0l3ME2wMlE3KM7:TR?= NXTBTpFVOjJ2M{W2Olk>
NCI-H23 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH6zUXA3NjJizszN Mn\OO|IhcA>? MWPEUXNQ NXL6VFJjT0l3ME2xJO69VQ>? MVGyNlQ{PTZ4OR?=
NCI-H322M NYjqWXlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzUOk4zKM7:TR?= MorWO|IhcA>? M3fyNGROW09? NGO2epRIUTVyPUCuO|kh|ryP MWqyNlQ{PTZ4OR?=
NCI-H460 NXPZN|JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm2MlIh|ryP Mle5O|IhcA>? MofnSG1UVw>? MUXHTVUxRTBwN{mg{txO M1fWPVIzPDN3Nk[5
NCI-H522 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TNR|YvOiEQvF2= NX;VPItXPzJiaB?= NIPzNIVFVVOR NEHiZpZIUTVyPUCuOUDPxE1? M3XhVlIzPDN3Nk[5
OVCAR3 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrWcVJPPi5{IN88US=> NETCTIk4OiCq NFLJdY5FVVOR MV;HTVUxRTFwMzFOwG0> MXOyNlQ{PTZ4OR?=
OVCAR4 M3WzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUi2MlIh|ryP NWHqb4FXPzJiaB?= M3;6S2ROW09? NVzQc4FYT0l3ME20JO69VQ>? M2\ZeVIzPDN3Nk[5
OVCAR5 NVfYR4JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHYOk4zKM7:TR?= MmT0O|IhcA>? Mm\PSG1UVw>? NG\KU2pIUTVyPUCuO|kh|ryP MXqyNlQ{PTZ4OR?=
OVCAR8 NFLTfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PPfFYvOiEQvF2= MWC3NkBp M4XST2ROW09? MW\HTVUxRTBwNTFOwG0> M3qwU|IzPDN3Nk[5
RXF393 M{GyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHtdXBxPi5{IN88US=> MU[3NkBp MoC1SG1UVw>? NGrlc2tIUTVyPUGuN{DPxE1? NXnXRpdrOjJ2M{W2Olk>
SF268 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjOfGVXPi5{IN88US=> MkPTO|IhcA>? MYPEUXNQ M33pZWdKPTB;MT62JO69VQ>? MYeyNlQ{PTZ4OR?=
SF295 NGe5OohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWi2MlIh|ryP NXGxPI8yPzJiaB?= MUnEUXNQ MYDHTVUxRTFwNjFOwG0> MmX2NlI1OzV4Nkm=
SF539 NEL2bVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVu2MlIh|ryP M3XPNlczKGh? NUnuTWFETE2VTx?= MmLzS2k2OD1{IN88US=> MVKyNlQ{PTZ4OR?=
SK-MEL-2 NWHPNI14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj3XWc3NjJizszN NH\xW3E4OiCq MX;EUXNQ MXjHTVUxRTFwMzFOwG0> NIfBRWkzOjR|NU[2PS=>
SK-MEL-28 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jMWlYvOiEQvF2= NWnW[G9WPzJiaB?= NVPpdnBHTE2VTx?= NEfO[21IUTVyPUGg{txO M{LTVFIzPDN3Nk[5
SK-MEL-5 MnfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTlVnFSPi5{IN88US=> MX23NkBp MYLEUXNQ NUPFbHYxT0l3ME2wMlY{KM7:TR?= MmTvNlI1OzV4Nkm=
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SN12C NH3sPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi2MlIh|ryP M2rTPFczKGh? MUjEUXNQ MUnHTVUxRTJizszN NV;JOm5kOjJ2M{W2Olk>
SNB19 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTITZY3NjJizszN M3;CRlczKGh? MUHEUXNQ M2jFR2dKPTB;MD62N{DPxE1? MnvRNlI1OzV4Nkm=
SNB75 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7IRXM3NjJizszN NYXG[29DPzJiaB?= MXHEUXNQ NFXOTY5IUTVyPUCuO|kh|ryP NYnhd5pWOjJ2M{W2Olk>
SR NUfjPFVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XEVlYvOiEQvF2= M{fER|czKGh? NX;pOIxMTE2VTx?= MlXiS2k2OD1yLkSg{txO MVSyNlQ{PTZ4OR?=
T47D M{nE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P2XlYvOiEQvF2= NHLi[ZE4OiCq MnvESG1UVw>? NFvXVVJIUTVyPUCuOUDPxE1? MnzSNlI1OzV4Nkm=
TK10 NVPINWh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmqzOk4zKM7:TR?= NEj6bGk4OiCq MXXEUXNQ MWrHTVUxRTBwNkOg{txO M{nlSFIzPDN3Nk[5
UACC257 M{nuR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGewOow3NjJizszN MVW3NkBp NXq5cVh[TE2VTx?= M4j1bWdKPTB;MD61JO69VQ>? MkLsNlI1OzV4Nkm=
UACC62 NHq4[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PCSVYvOiEQvF2= NXnpbGJYPzJiaB?= MUjEUXNQ MmPDS2k2OD1yLkSg{txO MoDpNlI1OzV4Nkm=
UO31 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvh[ZB7Pi5{IN88US=> MVu3NkBp M2m4[GROW09? MXjHTVUxRTBwNTFOwG0> NHXZUFUzOjR|NU[2PS=>
Hep3B MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTCOFghcA>? NVm4dpB5TE2VTx?= NFvDfGhIUTVyPUCuOlkh|ryP M3K3UVIzPDN7OE[z
BE(2)-C NYLUboRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHIO|IhcA>? NHXYbJlFVVOR MXzJR|cxRTJizszN NILC[IkzOjl|MkOxOi=>
Bel7402 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L1VFczKGh? MWDEUXNQ NX7CPJZpT0l7ME2xO{DPxE1? NV\zXIxMOjNyNkGzO|Y>
Bel7404 NYfyTmtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnteFE4OiCq MU\EUXNQ MYrHTVkxRTF6IN88US=> MlrRNlMxPjF|N{[=
BGC823 NV;veI9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXsZ2Y4OiCq MoHSSG1UVw>? M2i5[mdKQTB;Nz61JO69VQ>? MYCyN|A3OTN5Nh?=
MGC803 M1jueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\5N|lXPzJiaB?= NV\h[ZE{TE2VTx?= NUXRZXo4T0l7ME2xNE45KM7:TR?= NVTERpVPOjNyNkGzO|Y>
SGC7901 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7YV2Q4OiCq NF3uV4pFVVOR NIixVlRIUTlyPUmuOEDPxE1? NXPhflh4OjNyNkGzO|Y>
SKHEP1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFToU2M4OiCq MXzEUXNQ NEPONIxIUTlyPUG3JO69VQ>? NUPqXGd3OjNyNkGzO|Y>
SMMC7721 MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;UV|c4OiCq NW\qfppYTE2VTx?= NWDIW3hOT0l7ME2yNEDPxE1? NX;Ie4JNOjNyNkGzO|Y>
NUGC3 NH\GW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnezNVAh|ryP NXzKSGhZT0l;Mj65OEDPxE1? Ml\pNlMyPjN|M{K=
A2780 CisR MoPIT4lv[XOnIFHzd4F6 MkTQNVghcA>? MlThTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? NHTlR4gzOzJ3Mk[wNy=>
CAL27 sens NIDQbWFMcW6jc3WgRZN{[Xl? MXyxPEBp NWjXdnhSUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= MWSyN|I2OjZyMx?=
CAL27 CisR NVnkOXFoU2mwYYPlJGF{e2G7 NGX6elgyQCCq MWrJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO M33Kb|I{OjV{NkCz
KYSE-510 CisR M1nVVWtqdmG|ZTDBd5NigQ>? MWKxPEBp M2Gwb2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? M2XWblI{OjV{NkCz
KYSE-510 sens MmD0T4lv[XOnIFHzd4F6 NVi2OZdOOThiaB?= MnKyTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO NV\iPXRFOjN{NUK2NFM>
MDA-MB-231 sens NHjVV3BMcW6jc3WgRZN{[Xl? M37MRVE5KGh? NWDpUpRuUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MUGyN|I2OjZyMx?=
MDA-MB-231 CisR M2TyS2tqdmG|ZTDBd5NigQ>? NYe0eW1xOThiaB?= NHHuWGpKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NVXDfmlwOjN{NUK2NFM>
ES2 NEfiUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HIVVQ5KGh? MonLSG1UVw>? M3\NW2lEPTB;MUKuO{DPxE1? M4TkcFI{PDl|NES5
MDA-MB-231 MojQT4lv[XOnIFHzd4F6 M3j1VVExKM7:TR?= MlXvN|AhdWmw NGLDRYJFVVOR M{nSc2lvcGmkaYTpc44hd2ZiSFTBR|Ji NUDRNVNsOjN2OUO0OFk>
MDA-MB-231 MoDyT4lv[XOnIFHzd4F6 M4TlclEh|ryP M1PD[|I1KGh? MlLCSG1UVw>? NVzrPId[UW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NHi0dJMzOzR7M{S0PS=>
HS68 M4PkWWN6fG:2b4jpZ{BCe3OjeR?= NHq2V2wyOCEQvF2= NGrSTng4OiCq NH\ZclZFVVOR MkfBTWM2OD12Lk[g{txO MkTTNlM2PzB3NEK=
MEF MVjDfZRwfG:6aXOgRZN{[Xl? MYmxNEDPxE1? NUG3Z2hFPzJiaB?= NE\vVYFFVVOR NWLrSHh7UUN3ME20MlQh|ryP NUL2c|BlOjN3N{C1OFI>
BGC823 M{nhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\EUXNQ NUDjb4lrT0l3ME2zMlA6KM7:TR?= MnL2NlM3ODF5ME[=
High5 NF2zNYZMcW6jc3WgRZN{[Xl? Mn\oNlQhcA>? M4rJR2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP Ml;JNlM3ODJ3MkO=
High5 M1LxT2tqdmG|ZTDBd5NigQ>? MYSyOEBp MUfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NIjqTHczOzZyMkWyNy=>
High5 M{SxWWtqdmG|ZTDBd5NigQ>? MoD5NlQhcA>? NIO3Z5hKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= MoX4NlM3ODJ3MkO=
A549 NXjNPG9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPEUXNQ MX;JR|UxRTFwMEe5JO69VQ>? M2DHc|I{PjR2MkGw
HCT116 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHjdoJFVVOR NHL6RodKSzVyPUCuO|U4KM7:TR?= M4H3XFI{PjR2MkGw
K562 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPF[|lbTE2VTx?= MVHJR|UxRTBwNkS1JO69VQ>? NUPXZmhyOjN4NESyNVA>
GBC-SD NFjGNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfINWQ2KM7:TR?= MWG3NkBp NG\3[JNFVVOR MVvJR|UxRTF2Lkig{txO NVj4TpNwOjN5MEeyOlA>
HGC27 Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf4OUDPxE1? MXK3NkBp MlLJSG1UVw>? NFGwd5dKSzVyPUWuOEDPxE1? M4HnXVI{PzB5Mk[w
HL60 M1HKe2tqdmG|ZTDBd5NigQ>? M3vud|Uh|ryP MmnhNlQhcA>? NUnTcId6TE2VTx?= Mke1TY5pcWKrdHnvckBw\iCKRFHD NX;HS29COjN5MEeyOlA>
Vero NF62Z4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLKZZVvPzJiaB?= NID4RZlFVVOR M3fBemlEPTB;MD65JO69VQ>? MnS1NlM4QDZ2NUK=
NCI60 MXjDfZRwfG:6aXOgRZN{[Xl? NY\lU4RoPDhiaB?= MWHEUXNQ M3nQZ2dKRTBwNUOg{txO MnraNlQxOTV|Mke=
SW620 M3jxVmN6fG:2b4jpZ{BCe3OjeR?= NVTlPHpXPDhiaB?= MmPQSG1UVw>? NX;jeWhyT0l;MD61OEDPxE1? NYDuU2w{OjRyMUWzNlc>
U251 MX3DfZRwfG:6aXOgRZN{[Xl? MWW0PEBp MVPEUXNQ NH31S|dIUT1zLkWzJO69VQ>? MoPYNlQxOTV|Mke=
KM12 M2rr[GN6fG:2b4jpZ{BCe3OjeR?= NIXz[mY1QCCq M4i1Z2ROW09? Mn61S2k:OS56ODFOwG0> NEiw[HYzPDBzNUOyOy=>
Hs578T MkDjR5l1d3SxeHnjJGF{e2G7 MVq0PEBp MkDESG1UVw>? MWfHTV01Njh|IN88US=> M{fmS|I1ODF3M{K3
MDA-MB-231 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj2OFghcA>? NUnTW5VwUUN3ME2wMlE3KM7:TR?= M4C2PFI1ODl3MEG2
MCF7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrDOFghcA>? NVH2dJdCT0l;MD60OUDPxE1? NFjNbHAzPDFzOUW1OS=>
MDA-MB-435 NIrUT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWm0PEBp NIrjc2lIUT1yLki4JO69VQ>? NVzOfpZJOjRzMUm1OVU>
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Jurkat E6.1 MU\LbY5ie2ViQYPzZZk> MVeyJIg> MoXGSG1UVw>? NXm0T28yUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= NXzTN3JrOjR{NkG4OlI>
KG1 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\FZXY1QCCq NXjye29SUUN3ME2xMlE2KM7:TR?= MlLlNlQ2OjVyMEO=
HEL NH7IcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljDOFghcA>? NHjsVJNFVVOR NV3tZW45UUN3ME2wMlQ6KM7:TR?= NV;TbJpROjR4OUSwOVU>
HSC3 NHvBW|VEgXSxdH;4bYMhSXO|YYm= MkLzNVIhcA>? MVLEUXNQ MoDHTWM2OD1yLkexJO69VQ>? NXvk[YxUOjR5Nk[1OlA>
HT-29 MWTDfZRwfG:6aXOgRZN{[Xl? NXvLR2JkOTJiaB?= NHPPNZBFVVOR MnjsTWM2OD1yLkeyJO69VQ>? NWXyNYt7OjR5Nk[1OlA>
KB NFXUOFZEgXSxdH;4bYMhSXO|YYm= NGj2[FgyOiCq Mnm1SG1UVw>? NXPKe21KUUN3ME2wMlc2KM7:TR?= M4G4flI1PzZ4NU[w
H460 NF;SVJhEgXSxdH;4bYMhSXO|YYm= Mn7aNVIhcA>? MWPEUXNQ NIDC[VRKSzVyPUCuPFIh|ryP NFXFZ2MzPDd4NkW2NC=>
MONE1 MYTDfZRwfG:6aXOgRZN{[Xl? NXrmclRKOTJiaB?= MUPEUXNQ M2PqSmlEPTB;MT6xPEDPxE1? NGrxdYQzPDd4NkW2NC=>
MKN45 M4\Pe2N6fG:2b4jpZ{BCe3OjeR?= M37GV|EzKGh? MXvEUXNQ MlHDTWM2OD1zLkK1JO69VQ>? M33iRlI1PzZ4NU[w
TSGH M2[wc2N6fG:2b4jpZ{BCe3OjeR?= M2fQRVEzKGh? NV7xWZZETE2VTx?= NELPSndKSzVyPUKuNFkh|ryP NIHzXnAzPDd4NkW2NC=>
HL60 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{ftZ|czKGh? MnLJSG1UVw>? MmfBS2k2OD1yLkmzJO69VQ>? M1:zZ|I1QTByNUCw
HEK293 M3Swb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWW3NkBp M4nWZ2ROW09? MnLBS2k2OD1zMzFOwG0> NHTwZ5YzPDlyMEWwNC=>
Jurkat NEL2Z2xEgXSxdH;4bYMhSXO|YYm= MVixNFAh|ryP MW[3NkBp NGOyWJBIUTVyPUCuPUDPxE1? M4fJOlI1QTByN{Sz
GM15850 MXzLbY5ie2ViQYPzZZk> MUGyMlUh|ryP M3TFZ|k3KGh? NH;0OWhFVVOR MmHN[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NFPlNFMyPjl{MUO2Oy=>
GM15850 MnjIT4lv[XOnIFHzd4F6 MoPRNk42KM7:TR?= MkDFPVYhcA>? NF\kNoxFVVOR MX3kc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MWqxOlkzOTN4Nx?=
GM15850 MoHUT4lv[XOnIFHzd4F6 NV;lVXpKOi53IN88US=> M3Hxblk3KGh? M3fkUmROW09? NXXIW5Jx\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NYTrOY1ROTZ7MkGzOlc>
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MC-IXC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV70NI04UUN3ME2xMlE4QDhzIN88US=> NXuwVmdYW0GQR1XS
LB1047-RCC NWrW[WFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTFwMUizNVIh|ryP M4HOSXNCVkeHUh?=
VM-CUB-1 M1G3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\6N|lvUUN3ME2xMlE6OTB6IN88US=> MnmwV2FPT0WU
NB5 NUmxbIhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rkb2lEPTB;MT6xPVg2PiEQvF2= NXjKPHNKW0GQR1XS
SKG-IIIa Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;0TWM2OD1zLkKzOFY1KM7:TR?= M33rPXNCVkeHUh?=
HO-1-N-1 M3TLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWxT4FKSzVyPUGuNlM5OzVizszN NHnk[m1USU6JRWK=
EFO-27 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXXcW1pUUN3ME2xMlI2ODR|IN88US=> NVOzdpJpW0GQR1XS
MHH-NB-11 NIrYWmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\BNXFKSzVyPUGuNlg{OjlizszN MmrzV2FPT0WU
SW620 NUnPZohQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PK[2lEPTB;MT6yPVAyQCEQvF2= MUTTRW5ITVJ?
MOLT-16 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;6TGlEPTB;MT6yPVc6PyEQvF2= NH;RbFVUSU6JRWK=
NTERA-S-cl-D1 M3jySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlm3TWM2OD1zLkOxO|YyKM7:TR?= NV;Jd|JlW0GQR1XS
VA-ES-BJ MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDxfm5KSzVyPUGuN|I1PzdizszN NI\3cYhUSU6JRWK=
HCC1419 NE\JT|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwM{SwNlch|ryP NGnVe2tUSU6JRWK=
NCI-H69 MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[wSmlEPTB;MT6zOFEyOiEQvF2= MU\TRW5ITVJ?
DEL MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILZdYpKSzVyPUGuN|UyPjJizszN M33SSnNCVkeHUh?=
LXF-289 MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PT[GlEPTB;MT6zOVI1KM7:TR?= M170O3NCVkeHUh?=
EW-11 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHCTWM2OD1zLkO2NFI3KM7:TR?= MX3TRW5ITVJ?
KP-4 M3j0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXmWHBbUUN3ME2xMlM4ODh3IN88US=> MXHTRW5ITVJ?
NOS-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS2VFR{UUN3ME2xMlQyOTl2IN88US=> MXnTRW5ITVJ?
SK-NEP-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO5R5hKSzVyPUGuOFE3QTNizszN NHnsVpdUSU6JRWK=
LAMA-84 NGDSUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwNEO5OFUh|ryP NFqxOYNUSU6JRWK=
ES5 NHe0TnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwNESzJO69VQ>? MnS1V2FPT0WU
HuO9 NVHEN5RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nseWlEPTB;MT60OVM3OiEQvF2= NUPLVot2W0GQR1XS
COLO-684 M1;VZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTt[VRjUUN3ME2xMlQ3OTF6IN88US=> NIrEZWJUSU6JRWK=
EW-24 M3nMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwNE[1N|Eh|ryP MYDTRW5ITVJ?
BV-173 NGXMOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vxfmlEPTB;MT60O|I6OSEQvF2= Mn:zV2FPT0WU
NCI-H1770 M4P1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DUN2lEPTB;MT60PFU{PiEQvF2= MkPNV2FPT0WU
HuP-T4 NIrFW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTFwNEmzJO69VQ>? NV\PWllJW0GQR1XS
TYK-nu NUXYSZBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwNEm4OVEh|ryP MkTFV2FPT0WU
YH-13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TrcWlEPTB;MT60PVg6PCEQvF2= NHLNWHlUSU6JRWK=
H4 NXHpdmE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XUd2lEPTB;MT61NFkyOiEQvF2= M2HJSXNCVkeHUh?=
OVCAR-8 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HCS2lEPTB;MT61OFQ4PyEQvF2= M4jCVnNCVkeHUh?=
NCI-H23 MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzwcXZKSzVyPUGuOVQ3PDVizszN M1Pw[nNCVkeHUh?=
ES7 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwNUS3O|Mh|ryP MYDTRW5ITVJ?
COR-L88 M2\QWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSySYJqUUN3ME2xMlU3PDJ2IN88US=> Mn3pV2FPT0WU
TI-73 NXjoUm9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwNUmwOkDPxE1? NIXreG9USU6JRWK=
RT-112 NEnKTFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjIOVdKSzVyPUGuOVkzQDRizszN MlvzV2FPT0WU
HuO-3N1 NX\sNZhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\2TWM2OD1zLkW5N|g2KM7:TR?= NWH2TIpVW0GQR1XS
HC-1 M3e2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLm[GhDUUN3ME2xMlU6QDZ4IN88US=> MVHTRW5ITVJ?
HT55 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXyTWM2OD1zLk[1NVMyKM7:TR?= MWTTRW5ITVJ?
IA-LM M3;nUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHnXIJvUUN3ME2xMlY6Ojd6IN88US=> NF;XendUSU6JRWK=
EM-2 NVrLXoJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwN{CwNVQh|ryP M3fKZnNCVkeHUh?=
MHH-ES-1 M1K3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFwN{C0N|Uh|ryP MUPTRW5ITVJ?
CAL-27 NWSyN5NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTHNnlKSzVyPUGuO|A3OjFizszN NGP4SFZUSU6JRWK=
COLO-800 M13pcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[zTWM2OD1zLkexNVc6KM7:TR?= M1nBN3NCVkeHUh?=
HCE-T MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nJc2lEPTB;MT63NVUh|ryP NX7uS5JXW0GQR1XS
CAMA-1 NYP2RXJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHITWM2OD1zLkexPVcyKM7:TR?= NXniU3FWW0GQR1XS
LOXIMVI NHHDOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwN{KxNUDPxE1? MoexV2FPT0WU
NH-12 NUjXXpZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\QRooyUUN3ME2xMlczPjlzIN88US=> MlvsV2FPT0WU
TCCSUP MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;rO2FKSzVyPUGuO|I5OjlizszN NFPoWHhUSU6JRWK=
MDA-MB-361 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfaeFdKSzVyPUGuO|MyPTdizszN NWfTSG9QW0GQR1XS
EW-16 M3nCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\JfWlEPTB;MT63OFExPyEQvF2= NF\G[ZlUSU6JRWK=
SNU-423 M3;q[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwN{W4Nlch|ryP M1q3enNCVkeHUh?=
Daoy MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwN{[zNVkh|ryP NF\2UXFUSU6JRWK=
ES4 M2T6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwN{i3OFEh|ryP NYHGTm1pW0GQR1XS
PFSK-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PWUWlEPTB;MT64NFM4KM7:TR?= MnyyV2FPT0WU
ES3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq5TWM2OD1zLkiyOlgyKM7:TR?= Mlq4V2FPT0WU
ONS-76 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFwOEK4PVch|ryP MoDHV2FPT0WU
JVM-3 M3TLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zJW2lEPTB;MT64OVQ2OSEQvF2= NG\MXFBUSU6JRWK=
OS-RC-2 NHradXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTLXJVuUUN3ME2xMlg4OTVzIN88US=> NXXJOHRFW0GQR1XS
COLO-320-HSR M3m0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTkTWM2OD1zLki4NVk4KM7:TR?= NUXUWZRTW0GQR1XS
HN M4TVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3NTWM2OD1zLki4O|I2KM7:TR?= MXTTRW5ITVJ?
HT MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy2bmVPUUN3ME2xMlg5QTR5IN88US=> MVnTRW5ITVJ?
LoVo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LmemlEPTB;MT64PVgyKM7:TR?= MkP4V2FPT0WU
CGTH-W-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVbo57UUN3ME2xMlg6QTR4IN88US=> M4m0[nNCVkeHUh?=
NB6 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwOUGyPVgh|ryP MYfTRW5ITVJ?
EW-22 NInGTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwOUK4PFch|ryP NYrmN4pSW0GQR1XS
ES6 M2jIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonVTWM2OD1zLkmzOlMyKM7:TR?= M3njdnNCVkeHUh?=
SCC-15 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlyzTWM2OD1zLkmzPFE6KM7:TR?= MYfTRW5ITVJ?
HL-60 M4Kw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PFZmlEPTB;MT65N|kxOiEQvF2= Mlz0V2FPT0WU
human HOP-92 M2nkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfsXYFKSzVyPUGuPVQxPjVizszN MULTRW5ITVJ?
SW626 MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\6R|ZKSzVyPUGuPVQ5QTlizszN NUDBOXg3W0GQR1XS
HEC-1 M3;0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjCSmdKSzVyPUGuPVU{PiEQvF2= M{XIbnNCVkeHUh?=
LB2241-RCC NGW4RZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfpTmZKSzVyPUGuPVgzOzFizszN NHTXZnhUSU6JRWK=
Ramos-2G6-4C10 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jzSWlEPTB;MT65PVQ6OyEQvF2= NF3RZohUSU6JRWK=
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NCI-H446 M4ficWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnYTWM2OD1{LkC0OVk6KM7:TR?= NFLHbHhUSU6JRWK=
SBC-5 NVXITZJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwME[xOFch|ryP NYTPTYJJW0GQR1XS
HOS NETXcmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJwMEe2OVMh|ryP NIXUOXpUSU6JRWK=
K5 NX21SWp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJwMEe4NVEh|ryP M3u0d3NCVkeHUh?=
HLE NILYeoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHaWnVtUUN3ME2yMlA5PTJ7IN88US=> M3nRcHNCVkeHUh?=
HSC-2 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHlTWM2OD1{LkGyPFk5KM7:TR?= M3XVbHNCVkeHUh?=
LCLC-97TM1 NFO1V5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\uTndtUUN3ME2yMlE1PTh|IN88US=> NIf1SmpUSU6JRWK=
DMS-273 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonOTWM2OD1{LkG0PFM4KM7:TR?= NHr3fo5USU6JRWK=
TE-8 M4izW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCzTWM2OD1{LkG1O|Y2KM7:TR?= NEPKfXdUSU6JRWK=
DSH1 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwMU[zPVgh|ryP NVPmS5AzW0GQR1XS
CAL-51 NFm0boVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUiwbmZvUUN3ME2yMlE3Pjl7IN88US=> M{HyZ3NCVkeHUh?=
IST-SL1 M4PhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwMU[4OFQh|ryP MoHqV2FPT0WU
GCT NVHqSG9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXOTXhKSzVyPUKuNVc4PyEQvF2= MV3TRW5ITVJ?
SW948 MmDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjXTWM2OD1{LkG4OFU3KM7:TR?= MlzhV2FPT0WU
NOMO-1 M1rVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T6SGlEPTB;Mj6xPVMyPyEQvF2= M13GPXNCVkeHUh?=
C8166 NX\CWWtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH6V4lKSzVyPUKuNlE{OzRizszN NGr1ZXRUSU6JRWK=
OC-314 M2ra[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLsVmpLUUN3ME2yMlI{OjV7IN88US=> Mor3V2FPT0WU
CAL-39 NIjxfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHWWppKSzVyPUKuNlM3OjZizszN M4e3eHNCVkeHUh?=
MDA-MB-453 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\MTWM2OD1{LkK0Nlc2KM7:TR?= NV3wWHlIW0GQR1XS
A673 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\2VYFnUUN3ME2yMlI2QDZ{IN88US=> MXXTRW5ITVJ?
HTC-C3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13BeWlEPTB;Mj6yOlg2KM7:TR?= NYThd5BZW0GQR1XS
NCI-H1666 MoLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLyfHBLUUN3ME2yMlI5OTFzIN88US=> MmTmV2FPT0WU
PSN1 M4faUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\kTWM2OD1{LkK4PVE{KM7:TR?= NV;pWWV5W0GQR1XS
GI-1 NFG5XIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\DTWM2OD1{LkOwOVQ{KM7:TR?= NYe0bms4W0GQR1XS
HuH-7 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[2TWM2OD1{LkOwOlM4KM7:TR?= Mmq4V2FPT0WU
JAR MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHFUlhKSzVyPUKuN|E6QDdizszN MY\TRW5ITVJ?
5637 M2ntPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jx[mlEPTB;Mj6zNlEzQSEQvF2= MlvmV2FPT0WU
GB-1 NV\FXGh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jMRmlEPTB;Mj6zNlM{PSEQvF2= M{D3VHNCVkeHUh?=
KP-N-YS MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\IbWlEPTB;Mj6zNlYyPSEQvF2= MWrTRW5ITVJ?
OAW-42 NH;UO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJwM{O0NVYh|ryP MXrTRW5ITVJ?
8-MG-BA M2PWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrFS3I6UUN3ME2yMlM{QTB4IN88US=> NHroXmlUSU6JRWK=
RH-18 NVvWO45ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\hTWM2OD1{LkO1NFIzKM7:TR?= MXPTRW5ITVJ?
NCI-H1155 NH7Ic3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJwM{[3NlUh|ryP NVL4SWYxW0GQR1XS
NB17 M1OyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwM{iyOFMh|ryP NF7y[5hUSU6JRWK=
NCI-H1437 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLXTWM2OD1{LkSxPFc{KM7:TR?= NWPrcGRUW0GQR1XS
SN12C M1TwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID6d5lKSzVyPUKuOFMzOTRizszN NH:3dVhUSU6JRWK=
HSC-3 NW\LdGFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX5TWM2OD1{LkS0OVA6KM7:TR?= MYTTRW5ITVJ?
GAMG M2e5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGGzSFNKSzVyPUKuOFQ2PjFizszN NGHTRXBUSU6JRWK=
HT-1080 NE\0d5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7MemxKUUN3ME2yMlQ1QDZ2IN88US=> M4Ln[HNCVkeHUh?=
A549 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHuTWM2OD1{LkS0PFk{KM7:TR?= NXLqUnN6W0GQR1XS
KNS-62 NUG5WYFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fBfGlEPTB;Mj60OVA3OSEQvF2= MnvCV2FPT0WU
YKG-1 NXTjeHVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrsc4pKSzVyPUKuOFU1OzdizszN MorqV2FPT0WU
LU-134-A NG\BZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT4TWM2OD1{LkS3NFA5KM7:TR?= MkfTV2FPT0WU
FADU Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPGTWM2OD1{LkS3NVYzKM7:TR?= NHXZXYJUSU6JRWK=
TGBC11TKB MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwNEexO|ch|ryP MWXTRW5ITVJ?
HT-3 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDHTWM2OD1{LkS5OVM2KM7:TR?= MnfOV2FPT0WU
NCI-H2170 NVT1b3R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TIXGlEPTB;Mj61NFU1QSEQvF2= NFTLZYJUSU6JRWK=
Mo-T NFnDWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTzR3RbUUN3ME2yMlUxQTJ5IN88US=> MUDTRW5ITVJ?
CCRF-CEM M3vFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHi0SXJKSzVyPUKuOVMxPDNizszN NGjJO5JUSU6JRWK=
KU-19-19 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXwVVZKSzVyPUKuOVM2OTNizszN Mn75V2FPT0WU
NCI-H1048 M2XsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zL[GlEPTB;Mj61OVAzPSEQvF2= M{\NdnNCVkeHUh?=
KOSC-2 NEXsWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHsT3lKSzVyPUKuOVYxPzZizszN NU[5TJdGW0GQR1XS
A431 M4LGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwNU[zN|Uh|ryP MkfPV2FPT0WU
COR-L23 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJwNUi1OlYh|ryP MWTTRW5ITVJ?
MKN28 MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJwNUmwN|ch|ryP NVn0R2doW0GQR1XS
22RV1 MnPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHjTWM2OD1{LkW5Nlc1KM7:TR?= Mk\mV2FPT0WU
ABC-1 M2XkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XuNGlEPTB;Mj62NFQ3KM7:TR?= NFn3U4FUSU6JRWK=
NCI-H2126 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H0T2lEPTB;Mj62NFk5PCEQvF2= NIrp[IJUSU6JRWK=
DoTc2-4510 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\YblVKSzVyPUKuOlIyQDVizszN MYrTRW5ITVJ?
SCC-4 NH;iUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqxTWM2OD1{Lk[zNFEzKM7:TR?= NInjRllUSU6JRWK=
NCI-H661 NHq5NpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJwNkSwPFUh|ryP M4jSZXNCVkeHUh?=
RPMI-2650 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXOTWM2OD1{Lk[0NVQ{KM7:TR?= MoPuV2FPT0WU
NCI-H510A Ml;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPpTWM2OD1{Lk[0OFI3KM7:TR?= MlvvV2FPT0WU
BPH-1 NFj1NVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;od4dsUUN3ME2yMlY2QDVizszN Mme4V2FPT0WU
M14 Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36zNGlEPTB;Mj62Olk6OyEQvF2= MmPlV2FPT0WU
G-402 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP5PYxKSzVyPUKuO|A1PTFizszN MkHOV2FPT0WU
AsPC-1 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzVb|lKSzVyPUKuO|EyPyEQvF2= MXnTRW5ITVJ?
NB12 NFrVPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwN{G3NUDPxE1? NIT0[VJUSU6JRWK=
SK-HEP-1 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTJwN{SzPVEh|ryP NWSxfZBZW0GQR1XS
U-266 M{nlPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\vUoRKSzVyPUKuO|cyOjFizszN M3HtdHNCVkeHUh?=
AM-38 M3nvVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP5R5FKSzVyPUKuO|c{PTVizszN MV7TRW5ITVJ?
PC-14 NVnyTJZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHpSlRpUUN3ME2yMlgxPTFizszN NIiyeZJUSU6JRWK=
EGI-1 NXGwfYN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvQU4dPUUN3ME2yMlgyPzR|IN88US=> M3j4fnNCVkeHUh?=
LS-411N NHTlb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j1ZWlEPTB;Mj64NlM{KM7:TR?= NUe4SlBxW0GQR1XS
BFTC-905 NUH5dmRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P0RmlEPTB;Mj64OVUzOyEQvF2= NH;aO2RUSU6JRWK=
CaR-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3vc2EzUUN3ME2yMlg3KM7:TR?= MmTyV2FPT0WU
NCI-H292 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwOE[1PVYh|ryP MXzTRW5ITVJ?
8305C MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwOE[2OFUh|ryP MVPTRW5ITVJ?
SNU-449 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLZ2lEPTB;Mj64PVE5OiEQvF2= NF7PN2FUSU6JRWK=
LCLC-103H NIrERZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjmSlFKSzVyPUKuPVA1OzhizszN NVzPOm5RW0GQR1XS
SW1573 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnzTWM2OD1{Lkm2NFgzKM7:TR?= M{XZb3NCVkeHUh?=
MLMA M3PEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO2[lJXUUN3ME2yMlk3PzF5IN88US=> NW\GRXllW0GQR1XS
NCI-H1355 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D1cGlEPTB;Mz6wNFc6PiEQvF2= M1vvZXNCVkeHUh?=
RMG-I Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnU[ZNsUUN3ME2zMlAzPTl{IN88US=> MnHkV2FPT0WU
BB65-RCC NH62WXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTNwMEOzNVQh|ryP NWHQOmxvW0GQR1XS
PC-3 NHj4c4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fEU2lEPTB;Mz6wN|g4PCEQvF2= NXXLR5JXW0GQR1XS
SF268 NHP4VHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H5fGlEPTB;Mz6wOFUzOyEQvF2= MnmwV2FPT0WU
NCI-H810 NFTm[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHJVI1KSzVyPUOuNFQ5OjNizszN MoLDV2FPT0WU
MEG-01 NHnUZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKzTWM2OD1|LkC2NVY1KM7:TR?= MoCzV2FPT0WU
SW13 NVuyTW93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNwMEe4OFch|ryP M3rzcnNCVkeHUh?=
RH-1 M1fTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnm[203UUN3ME2zMlExOjd6IN88US=> MmSyV2FPT0WU
GT3TKB MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInBc3BKSzVyPUOuNVEzQDNizszN NIrpboJUSU6JRWK=
TK10 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL6cYtKSzVyPUOuNVM4OjRizszN M1WzdXNCVkeHUh?=
T-24 M17ibWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XpN2lEPTB;Mz6xOVA4KM7:TR?= M2XnNXNCVkeHUh?=
A498 M3P6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;jTGlEPTB;Mz6yNFg4OSEQvF2= MnvZV2FPT0WU
GR-ST NY\4XoN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X5XWlEPTB;Mz6yNlE{QSEQvF2= Mk\xV2FPT0WU
LB2518-MEL NEjTUZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNwMkKzPVgh|ryP NHqxOHVUSU6JRWK=
T47D MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrmTWM2OD1|LkKzOlI4KM7:TR?= NVm3NWpOW0GQR1XS
NCI-H1651 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TXVWlEPTB;Mz6yOFY1PCEQvF2= MmX3V2FPT0WU
EC-GI-10 NGjK[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TvcmlEPTB;Mz6yOlE2OyEQvF2= M1PhSXNCVkeHUh?=
HT-29 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[4TWM2OD1|LkK2OlE1KM7:TR?= MWTTRW5ITVJ?
GI-ME-N NV3CZolZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHXOG5KSzVyPUOuNlk2OTFizszN Ml3ZV2FPT0WU
SW756 M1K4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfkTWM2OD1|LkK5OlI6KM7:TR?= M2jhe3NCVkeHUh?=
RKO MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLFdY5KSzVyPUOuN|A4PTdizszN NFzVUnJUSU6JRWK=
NCI-H1563 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H4U2lEPTB;Mz6zN|AyQCEQvF2= MXTTRW5ITVJ?
DJM-1 NVfhe2NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HGcWlEPTB;Mz6zO|Y4PCEQvF2= MnvkV2FPT0WU
L-428 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Ls[GlEPTB;Mz60NFA1PSEQvF2= M4TXW3NCVkeHUh?=
NCI-H2122 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\Jd2lEPTB;Mz60NVMyOiEQvF2= MoL2V2FPT0WU
Ca-Ski NXHZS|F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\5fo5KSzVyPUOuOFU1OyEQvF2= M2\MVnNCVkeHUh?=
639-V MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm4TWM2OD1|LkS2NFU4KM7:TR?= M{LBVXNCVkeHUh?=
SW1116 M1XPemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj4WVBEUUN3ME2zMlQ3OjZ7IN88US=> MVfTRW5ITVJ?
DMS-114 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNwNEewOlYh|ryP MlTCV2FPT0WU
MZ2-MEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV70eZNFUUN3ME2zMlQ4PjhzIN88US=> NGLOe49USU6JRWK=
COLO-829 NX;0bYtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNwNUCwO|Mh|ryP NEHLUm9USU6JRWK=
J82 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr4eXNKSzVyPUOuOVA2PyEQvF2= NWe4eHJQW0GQR1XS
EW-13 NV\FbGNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TINWlEPTB;Mz61NlUyKM7:TR?= NWfZ[nNSW0GQR1XS
RXF393 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX61fFdGUUN3ME2zMlU{Ojl2IN88US=> NFrZTlhUSU6JRWK=
CAL-62 M{[5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXPTWM2OD1|LkW0OVE1KM7:TR?= MkH0V2FPT0WU
OCUB-M NVLDR21HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSyTWM2OD1|LkW0OlY2KM7:TR?= NHu4XY5USU6JRWK=
BT-474 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTNwNkOzNUDPxE1? Mn7PV2FPT0WU
KYSE-180 M3LKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;FTWM2OD1|Lk[zN|czKM7:TR?= MV;TRW5ITVJ?
NCI-H650 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDGTWM2OD1|Lk[0Nlg4KM7:TR?= M1n0[XNCVkeHUh?=
Detroit562 M1zSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn5TWM2OD1|Lk[1NFIzKM7:TR?= MVTTRW5ITVJ?
SW48 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTNwNkW2OVch|ryP MlnyV2FPT0WU
KYSE-450 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13yOmlEPTB;Mz62PFU5OiEQvF2= NEfTR3RUSU6JRWK=
KYSE-510 M2XIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFiwZ5VKSzVyPUOuO|IyQDFizszN MVPTRW5ITVJ?
GP5d MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHETWM2OD1|LkeyPVUh|ryP MW\TRW5ITVJ?
RPMI-7951 NE\nfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HDVWlEPTB;Mz63OFczOyEQvF2= M3LabnNCVkeHUh?=
Becker NELLTFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTjTnRUUUN3ME2zMlc2ODF{IN88US=> M4LXXXNCVkeHUh?=
WM-115 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNwN{ixPVUh|ryP NH\Rc|JUSU6JRWK=
G-401 M17Jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkSzTWM2OD1|Lke5NFg2KM7:TR?= Mon4V2FPT0WU
PANC-08-13 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TBcmlEPTB;Mz63PVYxOiEQvF2= NVyx[JNMW0GQR1XS
SW982 NG[3b3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xab2lEPTB;Mz64NFU2OSEQvF2= NWjacWhxW0GQR1XS
D-263MG NXu5XpRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT1NXhZUUN3ME2zMlgzODVzIN88US=> NHnCfYtUSU6JRWK=
KM-H2 NFTqZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT4cWFvUUN3ME2zMlgzPjJ2IN88US=> M2[zWXNCVkeHUh?=
SK-MEL-3 NFjCWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTNwOEK4OFEh|ryP NV[1UHI3W0GQR1XS
NCI-H1581 NGfzU4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD1OJBuUUN3ME2zMlg1PDh6IN88US=> M2nHbnNCVkeHUh?=
LS-123 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPKWVlKSzVyPUOuPFc6ODlizszN NFP2bHJUSU6JRWK=
CAKI-1 MnrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK1dZNKSzVyPUOuPFkxPTJizszN NX:yN2lZW0GQR1XS
MEL-JUSO MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwOEmxOVMh|ryP MkTPV2FPT0WU
HCE-4 M{T0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwOUG2OlMh|ryP Ml;ZV2FPT0WU
TE-10 M4C3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwOUKwNUDPxE1? NVu0PJVVW0GQR1XS
OVCAR-4 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvVe2dKSzVyPUOuPVI5QDlizszN NW\3eZY{W0GQR1XS
ETK-1 NY\o[YQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPz[nhlUUN3ME2zMlk1PjN3IN88US=> M13yT3NCVkeHUh?=
A2780 MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Lp[GlEPTB;ND6wOVk3PiEQvF2= NIm5XWhUSU6JRWK=
LU-65 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M325XmlEPTB;ND6wO|Y{OyEQvF2= M2XMVXNCVkeHUh?=
BHY M4\yTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfXS3ZKSzVyPUSuNVI1QTVizszN M4DNenNCVkeHUh?=
COR-L105 NEnhb4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTRwMUOwOVEh|ryP NXjX[JVxW0GQR1XS
CAL-12T M1vzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPHTWM2OD12LkGzNVA{KM7:TR?= NGLmOVJUSU6JRWK=
SCH M2n1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwMUW3OFMh|ryP MWDTRW5ITVJ?
CW-2 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\hXWlEPTB;ND6xPVAxOSEQvF2= M3P5cXNCVkeHUh?=
HCC1806 NUfEPJR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTRwMkCzNVIh|ryP MUjTRW5ITVJ?
KP-N-YN NXvPWHVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PCUWlEPTB;ND6yNFkzPyEQvF2= NV6xWnVoW0GQR1XS
T98G NYHISnJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHZTWM2OD12LkKyNVU4KM7:TR?= NFXROGhUSU6JRWK=
CAL-54 NEL0eWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqzPHJKSzVyPUSuNlI{QDFizszN NHjrbVFUSU6JRWK=
CAL-33 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T0dGlEPTB;ND6yN|A3PCEQvF2= NX34PHRDW0GQR1XS
SNU-C2B NXy5elhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4UHRVUUN3ME20MlI1PzZ7IN88US=> NGSyZWNUSU6JRWK=
NUGC-3 NVHQdVd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvaTWM2OD12LkK1OVA2KM7:TR?= Mk\XV2FPT0WU
DOK NWXrUY1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rQcWlEPTB;ND6yOlU6OyEQvF2= NUftOYJsW0GQR1XS
MMAC-SF NX\xWIJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7OTWM2OD12LkK2PFU6KM7:TR?= NU\SfJZ[W0GQR1XS
KYSE-70 NVLTRVNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTRwMkmzOEDPxE1? NIT2cWNUSU6JRWK=
A204 NXHtOlVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H3c2lEPTB;ND6zOVgxOyEQvF2= NFTjV4pUSU6JRWK=
SCC-25 NWLweFBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTRwM{W4NVkh|ryP MY\TRW5ITVJ?
EPLC-272H M{Gxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTRwM{i5OUDPxE1? NWe1S49wW0GQR1XS
CAL-120 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTRwM{i5PVIh|ryP MYHTRW5ITVJ?
LS-513 M2C5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\PTWM2OD12LkSyNVk5KM7:TR?= MoHFV2FPT0WU
CAPAN-1 M3fo[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3JTWM2OD12LkSyN|gzKM7:TR?= NYroNGNsW0GQR1XS
ESS-1 NF;s[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;aXGxKSzVyPUSuOFI4OjRizszN MYfTRW5ITVJ?
GMS-10 MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\2bYFKSzVyPUSuOFI5OTlizszN M4WzUHNCVkeHUh?=
NCI-N87 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPFb4N6UUN3ME20MlUxQDZ6IN88US=> MkHPV2FPT0WU
HMV-II NI\y[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnnTWM2OD12LkWxO|Mh|ryP MnqwV2FPT0WU
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CP50-MEL-B MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTlwOUK0N|Ih|ryP NHT3XpdUSU6JRWK=
SK-MEL-28 Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFyLkCxPVMh|ryP NHPqPYJUSU6JRWK=
NCI-H2452 NXXyc2dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFyLkG2JO69VQ>? MUnTRW5ITVJ?
NCI-H1395 M2Lndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITQT2FKSzVyPUGwMlE4QCEQvF2= MYHTRW5ITVJ?
NCI-H2052 MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFyLkG4PFIh|ryP M3\lNXNCVkeHUh?=
A375 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXKTWM2OD1zMD6yOFUzKM7:TR?= NXjCTIw{W0GQR1XS
HCC38 M1LOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom5TWM2OD1zMD6zNlIh|ryP NXfieWhqW0GQR1XS
LK-2 M3\DR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPvbmVwUUN3ME2xNE41OjB6IN88US=> MXPTRW5ITVJ?
SF126 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWzTGtUUUN3ME2xNE41PzJ5IN88US=> NUDqSpJbW0GQR1XS
SK-MEL-1 NYDsdlRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnTTWM2OD1zMD63PFM5KM7:TR?= NWTYc3hEW0GQR1XS
ACN MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi4b3hKSzVyPUGwMlg3PzlizszN M37UZnNCVkeHUh?=
BB30-HNC MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4roOmlEPTB;MUCuPFcyOSEQvF2= M{jzN3NCVkeHUh?=
NCI-H747 NVrjc45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFyLki3OFYh|ryP NFzsNIpUSU6JRWK=
KYSE-150 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi4XnVKSzVyPUGxMlA{QDdizszN MoHUV2FPT0WU
D-247MG MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;qT2lEPTB;MUGuNVAxQSEQvF2= MonZV2FPT0WU
BxPC-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TYSGlEPTB;MUGuN|c1PyEQvF2= Mmm1V2FPT0WU
SK-MEL-30 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnDbnJuUUN3ME2xNU41ODd7IN88US=> MkHLV2FPT0WU
CAS-1 NXq5Z|k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L2NmlEPTB;MUGuOFExQSEQvF2= MoX2V2FPT0WU
no-10 NUnhNnNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPyVYtNUUN3ME2xNk4yOjF5IN88US=> MnL3V2FPT0WU
NCI-H2405 M4PTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TXOmlEPTB;MUKuNlA{PiEQvF2= NFGwR2dUSU6JRWK=
KGN NFPBTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC2TWM2OD1zMj6yPVAyKM7:TR?= MYHTRW5ITVJ?
BB49-HNC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF{LkO5OVYh|ryP NYDpd|VpW0GQR1XS
NCI-H1693 M1\BS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DDVWlEPTB;MUKuOVgyPiEQvF2= NGLRTYpUSU6JRWK=
RO82-W-1 M1zXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW5WpFKSzVyPUGzMlA3PDlizszN NIHBRYJUSU6JRWK=
CAL-85-1 Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF|LkSzPVkh|ryP NGnTbHhUSU6JRWK=
H-EMC-SS NWO4[Jg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3lTWM2OD1zMz65NVA1KM7:TR?= MWrTRW5ITVJ?
SW1783 NUGwRXI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF2LkKzPVEh|ryP MmXSV2FPT0WU
LB771-HNC MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX1O5kzUUN3ME2xOE41OTlizszN NXrS[HNxW0GQR1XS
HCC70 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF2LkSyN|Mh|ryP NHfGboNUSU6JRWK=
KNS-81-FD MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vwfGlEPTB;MUSuO|A1PSEQvF2= M3LkTHNCVkeHUh?=
KYSE-520 NYri[|lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;sdYRKSzVyPUG0MlkzPyEQvF2= M4nwR3NCVkeHUh?=
TGBC24TKB NXnnSXA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPoWYQ6UUN3ME2xOE46PTN7IN88US=> NFrVVYxUSU6JRWK=
SNB75 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHXTWM2OD1zNT6wO|I6KM7:TR?= NVH6dHBMW0GQR1XS
SW872 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLaXXcyUUN3ME2xOU4zOjF6IN88US=> NHnpR5JUSU6JRWK=
U031 M3fkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF3LkiwNlgh|ryP MoXyV2FPT0WU
ChaGo-K-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\nTWM2OD1zNT64N|U6KM7:TR?= MUTTRW5ITVJ?
NCI-H441 NH\FUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTydXVKSzVyPUG2MlAxOzlizszN NHXNfnlUSU6JRWK=
TE-12 M{PrPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTsTWM2OD1zNj6xPFc{KM7:TR?= NIW0clRUSU6JRWK=
NCI-H1755 NIPwNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TSbGlEPTB;MU[uOVc{KM7:TR?= M{TqUHNCVkeHUh?=
KNS-42 NYnae2NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33Ec2lEPTB;MU[uOlU5QSEQvF2= M2TSSHNCVkeHUh?=
SK-PN-DW NFi1SIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nXVmlEPTB;MUeuOFIxOSEQvF2= NXXVT29xW0GQR1XS
NCI-H226 NXLSO5djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;NTWM2OD1zNz65N|Q2KM7:TR?= NXvw[Wx6W0GQR1XS
K-562 NG\obHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPPV3o{UUN3ME2xPE43OzF5IN88US=> NVXlcZFnW0GQR1XS
A388 MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvvTWM2OD1zOT6wN|A{KM7:TR?= M17nZnNCVkeHUh?=
ZR-75-30 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF7LkC5Olgh|ryP NFPHXIlUSU6JRWK=
LU-135 NHf0ZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3FTWM2OD1zOT6yOlM3KM7:TR?= M4O1dXNCVkeHUh?=
NCI-H2029 NXPWUIoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF7Lk[wNlEh|ryP MnHOV2FPT0WU
HT-1197 NYDSOIR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF7LkmyNlch|ryP NWrZZldUW0GQR1XS
IGR-1 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTIT4JxUUN3ME2yNE4{OTF5IN88US=> M1;4UnNCVkeHUh?=
U-87-MG NXvXUoRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJyLk[0NVMh|ryP MnvKV2FPT0WU
NCI-H1304 NUHydpN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TIe2lEPTB;MkCuO|UxOSEQvF2= NVXXTo4zW0GQR1XS
RCC10RGB MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfwUoV1UUN3ME2yNU4zQDJ7IN88US=> MnH2V2FPT0WU
NCI-H520 M3[xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ{Lke2NVEh|ryP MXfTRW5ITVJ?
SK-LU-1 M2PMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ|LkC3NVgh|ryP MVvTRW5ITVJ?
UACC-893 NU\vdJRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorBTWM2OD1{Mz6xNFM5KM7:TR?= M3m0O3NCVkeHUh?=
NCI-H2347 M4T3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHVV41KSzVyPUKzMlI3PzRizszN NFv3ZoZUSU6JRWK=
U-118-MG M1y0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDZWpR2UUN3ME2yN{44OjF5IN88US=> NUSxe3ZMW0GQR1XS
NCI-H596 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHmTWM2OD1{Mz65NFU2KM7:TR?= NGS2TpNUSU6JRWK=
MZ1-PC NXPSXpRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj6OHpKSzVyPUK0MlY4PTlizszN M{noSnNCVkeHUh?=
SW1417 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M130fWlEPTB;MkWuNlQ6QCEQvF2= NWX4XmRSW0GQR1XS
NCI-H82 MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJ4LkSyPFgh|ryP M{\oenNCVkeHUh?=
COLO-678 NHnVS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP6TWM2OD1{Nz60PVE6KM7:TR?= M1:yUnNCVkeHUh?=
KURAMOCHI MoLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;ub|ZKSzVyPUK4MlEzPiEQvF2= MlvLV2FPT0WU
NCI-H1650 NXzrN5FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXB[VRKSzVyPUOwMlE6OjRizszN MXfTRW5ITVJ?
HCC1954 NHTJe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXCVmJKSzVyPUOxMlM3PjZizszN NH\XcWFUSU6JRWK=
GAK MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInCRnZKSzVyPUOyMlI3OTZizszN M1LzbnNCVkeHUh?=
YAPC NXvUXFVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPrTWM2OD1|Mz63OlQ5KM7:TR?= MmPCV2FPT0WU
NCI-H2228 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj0dGlKSzVyPUO0MlM3ODVizszN NWjVWHVKW0GQR1XS
VMRC-RCZ MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zlcWlEPTB;M{[uN|AzOiEQvF2= NEjzOXlUSU6JRWK=
NMC-G1 NIK5Uo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTN5LkC1Nlkh|ryP MUXTRW5ITVJ?
D-336MG NFTaNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3wTWM2OD12MT64OFQzKM7:TR?= NWrBNmltW0GQR1XS
UACC-62 Ml3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fMd2lEPTB;NEKuOVUxPSEQvF2= NGrsU3pUSU6JRWK=
C-33-A M4\lfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH4TWM2OD12NT6zNlU3KM7:TR?= Mkn2V2FPT0WU
HCC1937 NVu1c4Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG5TWM2OD12Nz6xPVU5KM7:TR?= M13SOHNCVkeHUh?=
HDLM-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR5LkKyPFch|ryP Ml70V2FPT0WU
NCI-H727 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLxTWM2OD12Nz6yOFUyKM7:TR?= MVrTRW5ITVJ?
NY NVS4bWhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn2WWlGUUN3ME20PU4{QTB6IN88US=> M4P5WXNCVkeHUh?=
NCI-H2291 MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvleHNKSzVyPUS5Mlg{ODFizszN NI\uUFFUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい
体内試験 Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

お薦めの試験操作（参考用のみ）

キナーゼ試験：

[1]
+ 展開

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
細胞試験：

[2]
+ 展開
  • 細胞株： LNCaP, PC-3, and TSU-Pr1
  • 濃度： Dissolved in DMSO, final concentrations ~7.5 μM
  • 反応時間： 1, 2, 3 and 4 days
  • 実験の流れ：

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (参考用のみ)
動物試験：

[2]
+ 展開
  • 動物モデル： Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • 製剤： Dissolved in DMSO
  • 投薬量： ~100 mg/kg/day
  • 投与方法： Injection i.p.
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。 		5mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 264.3
化学式

C14H20N2O3
CAS No. 149647-78-9
保管 粉
in solvent
別名 SAHA, MK0683, suberoylanilide hydroxamic acid

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

総分子量：g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System March 1 2019 Phase 1
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center December 2018 Early Phase 1
NCT03263533 Recruiting Schizophrenia Virginia Commonwealth University December 1 2018 Early Phase 1
NCT03259503 Not yet recruiting Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic|Lymphoma M.D. Anderson Cancer Center|AstraZeneca November 2018 Phase 1|Phase 2
NCT03713320 Recruiting Cutaneous T-Cell Lymphoma/Mycosis Fungoides miRagen Therapeutics Inc. October 2018 Phase 2
NCT03382834 Active not recruiting HIV Infections National Institute of Allergy and Infectious Diseases (NIAID) April 26 2018 Early Phase 1

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問（FAQ）

  • 質問1：

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答：

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

selleck catalog

HDACシグナル伝達経路

HDAC Inhibitors with Unique Features

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  • 4SC-202

    4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.

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Tags: Vorinostat (SAHA, MK0683)を買う | Vorinostat (SAHA, MK0683) ic50 | Vorinostat (SAHA, MK0683)供給者 | Vorinostat (SAHA, MK0683)を購入する | Vorinostat (SAHA, MK0683)費用 | Vorinostat (SAHA, MK0683)生産者 | オーダーVorinostat (SAHA, MK0683) | Vorinostat (SAHA, MK0683)化学構造 | Vorinostat (SAHA, MK0683)分子量 | Vorinostat (SAHA, MK0683)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID