HDAC9 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S7324 TMP269 TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Pan HDAC9, IC50: 23 nM; HDAC9, IC50: 23 nM
S1096 Quisinostat (JNJ-26481585) Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. Pan HDAC9, IC50: 32.1 nM
S1194 CUDC-101 CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. Pan HDAC9, IC50: 67.2 nM
S1515 Pracinostat (SB939) Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Phase 2. Pan HDAC9, IC50: 70 nM
S2759 CUDC-907 CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. Phase 1. Pan HDAC9, IC50: 554 nM
Tags: HDAC9 mutation | HDAC9 cancer | HDAC9 signaling pathway | HDAC9 kinase inhibitor
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