Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

文献中Selleckの製品使用例(31)

カスタマーフィードバック(6)

  • Immunoblot of H23 cells treated with trametinib (25 nM), ponatinib (750 nM), or their combination for the times shown.

    Nature, 2016, 534(7609):647-51. Ponatinib (AP24534) purchased from Selleck.

     

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

  • Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

    The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

  • Western blot analysis of lysates of Ba/F3 cells expressing BCR/ABL and BCR/ABL-T315I using antibodies directed against: c-ABL, ABL-Y245 (anti-phospho-ABL), Crkl, phosphorylated Crkl, STAT5, phosphorylated STAT5 (anti-phospho-STAT5) and β-tubulin (anti-β-tubulin). Molecular mass references (kDa) are presented, and c-ABL and β-Tubulin were used as a loading control.

    Leukemia, 2015, 29(5):1104-14. Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHISZVKSzVyPUCuNFAxODByMEO1PUDPxE1? MkTlV2FPT0WU
MV-4-11 M1nUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HUZmlEPTB;MD6wNFAxQTV4IN88US=> NX;lPJZjW0GQR1XS
MEG-01 NFf6XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTJNJE5UUN3ME2wMlAxODF{ODFOwG0> MXTTRW5ITVJ?
LAMA-84 Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMECwNVY2KM7:TR?= MVTTRW5ITVJ?
CGTH-W-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXUOXRKSzVyPUCuNFAyPjlizszN M{TObHNCVkeHUh?=
KASUMI-1 NH:0PWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnIUHVKSzVyPUCuNFAzOTdizszN NIP6TXJUSU6JRWK=
BE-13 NH73ZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMECyOVkh|ryP MlPvV2FPT0WU
CTV-1 M1vKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PofmlEPTB;MD6wNFUzOSEQvF2= MYrTRW5ITVJ?
NKM-1 M4PnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTjdnd3UUN3ME2wMlAxPjV3IN88US=> MVHTRW5ITVJ?
MONO-MAC-6 NXLxW2ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHpRY9KSzVyPUCuNFA5OzdizszN NHzPXHRUSU6JRWK=
A204 NYjkb3V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnWO5lsUUN3ME2wMlAyOjF6IN88US=> MljPV2FPT0WU
GDM-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPIV|JJUUN3ME2wMlAyQDN|IN88US=> MVLTRW5ITVJ?
AN3-CA M3\Y[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEG4O|Mh|ryP MmryV2FPT0WU
BL-70 NXj1flNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\HbZBYUUN3ME2wMlAzOTl7IN88US=> MUDTRW5ITVJ?
Daudi NVr5c|dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPGNmhKSzVyPUCuNFI2OzdizszN NXTyN3lUW0GQR1XS
KU812 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIezR5BKSzVyPUCuNFI5PDhizszN MnLLV2FPT0WU
KG-1 NEftUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrpNmkxUUN3ME2wMlA{Ojl2IN88US=> NFLCVFJUSU6JRWK=
DOHH-2 NFLJOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XWSmlEPTB;MD6wOFgxOyEQvF2= M{ji[XNCVkeHUh?=
HuO9 M4LkVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e0XWlEPTB;MD6wOVQ1QCEQvF2= NI\nT|BUSU6JRWK=
EB2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEW1O|Yh|ryP NUjOTG9nW0GQR1XS
G-402 NESwSFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\YTWM2OD1yLkC2N|QyKM7:TR?= Mn3DV2FPT0WU
SU-DHL-1 NG[2bYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzqUVNKSzVyPUCuNFY{PzlizszN NXPQ[lM3W0GQR1XS
NCI-H719 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO3O|ZKSzVyPUCuNFc5QDhizszN MnnTV2FPT0WU
MLMA NHPsflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXPTWM2OD1yLkC5NFYh|ryP NUS4ZpB1W0GQR1XS
KM12 M1TTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17ZSmlEPTB;MD6wPVc{PyEQvF2= MoPUV2FPT0WU
SUP-T1 NWP0So5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj3OplKSzVyPUCuNFk6QDJizszN NHPEV3NUSU6JRWK=
MZ1-PC NGf1WVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHvSY1TUUN3ME2wMlEyOzN4IN88US=> NWm5VZhSW0GQR1XS
MFE-296 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq4dllDUUN3ME2wMlEyQDN7IN88US=> Mk\BV2FPT0WU
ALL-PO NIrqcXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zE[mlEPTB;MD6xNlQ1OyEQvF2= NHHrPG5USU6JRWK=
GB-1 NVewT2ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LRbWlEPTB;MD6xNlUyOiEQvF2= M2q4RXNCVkeHUh?=
SIG-M5 M1;Ld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILiUlRKSzVyPUCuNVM{PyEQvF2= NEfIN4ZUSU6JRWK=
P30-OHK NXXrN|VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vROGlEPTB;MD6xOVY4OiEQvF2= M162U3NCVkeHUh?=
NCI-H716 MlrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nFemlEPTB;MD6xOlI3PiEQvF2= NUnQXoRHW0GQR1XS
MPP-89 MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPidmFKSzVyPUCuNVY6OzNizszN NWnMOnlLW0GQR1XS
SF126 NX;yOWlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMUewOlMh|ryP MYjTRW5ITVJ?
CTB-1 NFT2UIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\BPIFnUUN3ME2wMlE4OzF4IN88US=> Mo\mV2FPT0WU
CA46 NHrPSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jFdGlEPTB;MD6xO|Q5QSEQvF2= MYfTRW5ITVJ?
NCI-H520 NGi3[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W5W2lEPTB;MD6xO|c{OiEQvF2= M4HGU3NCVkeHUh?=
CAL-85-1 M1i3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLxUpNKSzVyPUCuNVc6OjdizszN MoDtV2FPT0WU
NCI-H2342 M3rmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMUi1O|ch|ryP MoPSV2FPT0WU
697 M3\Xe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHNXGhKSzVyPUCuNVg5PzFizszN NF\uXWxUSU6JRWK=
NY MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMUmyPFch|ryP MWHTRW5ITVJ?
T98G MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PofmlEPTB;MD6xPVMyQCEQvF2= NW\ZZ2M6W0GQR1XS
NCI-H1703 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXkd4NKSzVyPUCuNVk3OTVizszN NVPn[VE6W0GQR1XS
NCI-H2087 NEXJVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHVVIUyUUN3ME2wMlIxPDN7IN88US=> M4HmfHNCVkeHUh?=
PF-382 NHL6XWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXpOWlqUUN3ME2wMlIxQDd|IN88US=> Ml;4V2FPT0WU
HCT-116 NEXxVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\yXXp4UUN3ME2wMlIyODZ7IN88US=> MYLTRW5ITVJ?
CAKI-1 NXzt[Iw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PLZWlEPTB;MD6yNVY3PiEQvF2= MVjTRW5ITVJ?
CCF-STTG1 NVjrc|ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjiToVHUUN3ME2wMlIzPDd3IN88US=> M3Pr[nNCVkeHUh?=
D-392MG MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq1VnlKSzVyPUCuNlMyPzdizszN MljZV2FPT0WU
RT-112 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TQdWlEPTB;MD6yN|c6PSEQvF2= MojrV2FPT0WU
MES-SA Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zUS2lEPTB;MD6yOFE5PyEQvF2= MVfTRW5ITVJ?
LC-2-ad M2DERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XtRWlEPTB;MD6yOFI3PSEQvF2= MUXTRW5ITVJ?
NOS-1 NHvoeo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmroTWM2OD1yLkK0N|Y4KM7:TR?= MoHaV2FPT0WU
NALM-6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMkW1OFMh|ryP NFGxUHdUSU6JRWK=
TE-15 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf6PXptUUN3ME2wMlI3ODlzIN88US=> M2\CWnNCVkeHUh?=
786-0 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvCTWM2OD1yLkK2NlI5KM7:TR?= MniwV2FPT0WU
IST-MES1 NHu4WplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS2TWM2OD1yLkK2PFI6KM7:TR?= NVjSdlF[W0GQR1XS
KYSE-180 NXLLR3hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;pUGlEPTB;MD6yOlg6OSEQvF2= NVfxOXhtW0GQR1XS
YT NVLURnZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HOeGlEPTB;MD6yOlk4PCEQvF2= MVHTRW5ITVJ?
A427 NYrXOZg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\yeGlEPTB;MD6yO|I3PCEQvF2= NU\qe5FKW0GQR1XS
KYSE-450 MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPrTWM2OD1yLkK3N|I6KM7:TR?= MmPDV2FPT0WU
HuH-7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrUbmt[UUN3ME2wMlI4PzZ|IN88US=> NXKyU5REW0GQR1XS
CAS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMkizNFMh|ryP M1v5bnNCVkeHUh?=
KURAMOCHI MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGyPWdKSzVyPUCuNlg1OTlizszN NHLsZ3dUSU6JRWK=
ACHN NXHFTGpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO3RndKSzVyPUCuNlk{OjNizszN MWDTRW5ITVJ?
HGC-27 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETWeYtKSzVyPUCuNlk{PTNizszN M1HJWHNCVkeHUh?=
A172 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDqSoRjUUN3ME2wMlI6PTd5IN88US=> NIOyWpZUSU6JRWK=
SNU-449 NXP3enQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH4TWM2OD1yLkK5PVY1KM7:TR?= M2riSnNCVkeHUh?=
SW982 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LIVWlEPTB;MD6yPVk4QCEQvF2= MV7TRW5ITVJ?
EFO-21 M3jNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwM{C0NVEh|ryP NELNbW5USU6JRWK=
NCI-H2030 M2rjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHiS|A2UUN3ME2wMlMyOTZ2IN88US=> M2W2enNCVkeHUh?=
HT-144 NY\4[Y4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzKXG9bUUN3ME2wMlMyOjhizszN NFTHWJhUSU6JRWK=
MFE-280 NXT4TpZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwM{G0OVMh|ryP M17kOnNCVkeHUh?=
SK-LU-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvWdGVKSzVyPUCuN|E1PjZizszN M4P2XHNCVkeHUh?=
NCI-H2052 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HXVWlEPTB;MD6zNVQ5PCEQvF2= NVzpXJpqW0GQR1XS
SK-HEP-1 NULjb2EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rpNWlEPTB;MD6zN|M3QCEQvF2= M{\zTnNCVkeHUh?=
QIMR-WIL NHrOWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwM{O0NlQh|ryP NIqzdYlUSU6JRWK=
A2780 M3HqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DUT2lEPTB;MD6zOFMxPCEQvF2= MUnTRW5ITVJ?
ACN NIK3S4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\CTWM2OD1yLkO0PFc{KM7:TR?= MoXvV2FPT0WU
BxPC-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWyXXJKUUN3ME2wMlM1QTh7IN88US=> NFzDNpBUSU6JRWK=
BCPAP MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PuXWlEPTB;MD6zOlAxOSEQvF2= M1L5PXNCVkeHUh?=
HOP-62 NILrN49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXZeHBKSzVyPUCuN|YyODZizszN MXnTRW5ITVJ?
SW1710 M1PkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHux[VRKSzVyPUCuN|Y1PTVizszN M{PIWXNCVkeHUh?=
OPM-2 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;KdmZKSzVyPUCuN|Y1PzNizszN NGfZdo5USU6JRWK=
DBTRG-05MG M2r3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwM{iwOVQh|ryP MmjTV2FPT0WU
SK-MEL-24 M1XVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DhU2lEPTB;MD6zPVc6OSEQvF2= NYrGU|ZuW0GQR1XS
8305C MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXhTWM2OD1yLkO5O|k{KM7:TR?= NYLjXG44W0GQR1XS
OVCAR-4 M172SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwNEG1PFYh|ryP NF3WOlRUSU6JRWK=
HLE M32wUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLETWM2OD1yLkSxPFYh|ryP NYXHcpdxW0GQR1XS
NCI-H747 NFjxWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNEKxN|ch|ryP NU\ETm5ZW0GQR1XS
SW780 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rYTWlEPTB;MD60NlM1PiEQvF2= M4\YXHNCVkeHUh?=
KYSE-150 NVjyW5FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXreJZSUUN3ME2wMlQzPDF3IN88US=> MnL2V2FPT0WU
H4 NFvEVY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moi2TWM2OD1yLkSyOFUyKM7:TR?= NUfTOlhXW0GQR1XS
SW1088 NFGwdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDJTWM2OD1yLkS0N|kh|ryP MVnTRW5ITVJ?
SF268 M4\VN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNES4OkDPxE1? M2PMdnNCVkeHUh?=
RT4 NWToNFc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDTV5lKSzVyPUCuOFUyOTFizszN MWXTRW5ITVJ?
NCI-H522 M3GwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC5XodKSzVyPUCuOFUzPyEQvF2= NFz4RZpUSU6JRWK=
LCLC-97TM1 NUDK[G1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTudZN7UUN3ME2wMlQ3OTl3IN88US=> M3vZXHNCVkeHUh?=
CAL-39 NF6zc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rxNGlEPTB;MD60OlUyQSEQvF2= NH7tTWpUSU6JRWK=
CAL-120 NF\q[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf0[2R1UUN3ME2wMlQ4PjR|IN88US=> MYjTRW5ITVJ?
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NCI-H810 MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPXcGtlUUN3ME2xMlgyPjB4IN88US=> M1WzVHNCVkeHUh?=
SK-NEP-1 NEfXdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHDZoV2UUN3ME2xMlg{PzZ5IN88US=> NEnKR3hUSU6JRWK=
D-542MG NFW3OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jrRWlEPTB;MT64OVg2OSEQvF2= NXq4SYNtW0GQR1XS
KNS-42 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwOE[yOlYh|ryP M1jF[nNCVkeHUh?=
NCI-H2452 NVjBSJRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwOEmwO|Qh|ryP Mn3VV2FPT0WU
SK-MEL-2 M{LYN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTFwOUCyO|Eh|ryP NYfkVYlrW0GQR1XS
OVCAR-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPsTWM2OD1zLkmwOlc2KM7:TR?= NGfrVJRUSU6JRWK=
SNG-M MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDmXXlKSzVyPUGuPVU5PThizszN NIX4NYlUSU6JRWK=
A673 NYLGOmV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlizTWM2OD1zLkm3OVE3KM7:TR?= MWnTRW5ITVJ?
L-428 NEnNNIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwOUmxO|kh|ryP NX3MbpFjW0GQR1XS
KM-H2 M2\pbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJwMEGwPUDPxE1? MYTTRW5ITVJ?
MC-IXC NV7oOYhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJwMEKyO|Mh|ryP MYHTRW5ITVJ?
COLO-678 NH7YcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnzTWM2OD1{LkC0NlA4KM7:TR?= MYfTRW5ITVJ?
MEL-JUSO MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO2TWM2OD1{LkC3PFUyKM7:TR?= MYDTRW5ITVJ?
HCC38 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjIbIZKSzVyPUKuNFg1OzNizszN M1PwOXNCVkeHUh?=
UACC-62 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK4TWM2OD1{LkC4PFU2KM7:TR?= MXPTRW5ITVJ?
OAW-42 Mly3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknkTWM2OD1{LkC5O|EyKM7:TR?= NYC1[ppnW0GQR1XS
LB996-RCC NWrENotWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK5TWM2OD1{LkGzPFE4KM7:TR?= MWXTRW5ITVJ?
COR-L105 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;hTWM2OD1{LkG2N|c{KM7:TR?= MUjTRW5ITVJ?
RCC10RGB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXMWGlKSzVyPUKuNVg2PzZizszN MnrEV2FPT0WU
A431 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHjTWM2OD1{LkG5NFE6KM7:TR?= MnznV2FPT0WU
NCI-H292 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO4WHA5UUN3ME2yMlI{QTVzIN88US=> NHv2SoFUSU6JRWK=
SK-UT-1 M1T5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DlRmlEPTB;Mj6zN|E5PCEQvF2= NX\sWFdUW0GQR1XS
PANC-08-13 NWLTN3FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL5bodKSzVyPUKuN|MzOzVizszN MoPCV2FPT0WU
ST486 NIX5Z2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jpTGlEPTB;Mj60NVA1QCEQvF2= M3nFRXNCVkeHUh?=
SJSA-1 NWjzfVB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fpcmlEPTB;Mj60NVI4OSEQvF2= M3TJSXNCVkeHUh?=
RKO NVrncGY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwNEKwNlkh|ryP MUfTRW5ITVJ?
NCI-H1793 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3ZTHI6UUN3ME2yMlQ1ODJ7IN88US=> M13IdnNCVkeHUh?=
639-V Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInmSJJKSzVyPUKuOFU{QDJizszN MnfLV2FPT0WU
ES3 M1nudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHzdHdpUUN3ME2yMlQ6PzN5IN88US=> NI\rWXFUSU6JRWK=
NCI-H1792 NF7SeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C2OmlEPTB;Mj61OlgzPiEQvF2= MlzBV2FPT0WU
NCI-H1651 NUKzNVRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjCelBwUUN3ME2yMlU5OjFizszN M{ntXXNCVkeHUh?=
SN12C NWrhV|dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;MTWM2OD1{LkW4OFg4KM7:TR?= NIjXV5VUSU6JRWK=
COLO-679 NIjp[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwNUi2NFUh|ryP M4\DT3NCVkeHUh?=
U-118-MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKwS4JKSzVyPUKuOVg5PzJizszN M2LLd3NCVkeHUh?=
Ramos-2G6-4C10 NIP3RoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rFXWlEPTB;Mj62OFgxPyEQvF2= MlTWV2FPT0WU
HCT-15 M3fie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfDTWM2OD1{Lk[4O|kzKM7:TR?= NWrSUHFTW0GQR1XS
MDA-MB-157 MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHXTWM2OD1{LkewO|Q4KM7:TR?= NFG2cFdUSU6JRWK=
K5 NELqVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;nV4JnUUN3ME2yMlcyQDR3IN88US=> NVK5UFJ7W0GQR1XS
MKN45 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzhTWM2OD1{LkezN|Y3KM7:TR?= NVOxSG5RW0GQR1XS
DMS-273 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\udFNKSzVyPUKuO|U3OzJizszN MkjKV2FPT0WU
C8166 NY\peFVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jVTGlEPTB;Mj63PFUyOyEQvF2= M1i1THNCVkeHUh?=
Calu-3 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPSTWM2OD1{Lke4PVY6KM7:TR?= NYLWPI1jW0GQR1XS
SNB75 M2fabWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S2WGlEPTB;Mj64PFU{PSEQvF2= M2XCT3NCVkeHUh?=
BFTC-905 NWjxU|hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTBOWFRUUN3ME2yMlkxOTlzIN88US=> MWfTRW5ITVJ?
C-4-II MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTK[4ZJUUN3ME2yMlkyOzV|IN88US=> MUPTRW5ITVJ?
MS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFewWZFKSzVyPUKuPVY4PjlizszN NGLyToxUSU6JRWK=
A375 M2rhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwMEixPFQh|ryP MoLlV2FPT0WU
KYSE-70 NITUNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNwMEi4PFIh|ryP MXzTRW5ITVJ?
KYSE-510 NGq0RmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfKU3RsUUN3ME2zMlExQTl3IN88US=> MoHiV2FPT0WU
LN-405 M{Xybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNwMUO1NVgh|ryP MnrNV2FPT0WU
BOKU NXTR[mRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\5WWlEPTB;Mz6xOFI2PiEQvF2= NF3aOG9USU6JRWK=
TE-10 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknPTWM2OD1|LkG3N|YzKM7:TR?= NFTESGtUSU6JRWK=
MKN1 NHrYbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\oUHFPUUN3ME2zMlE5PDh|IN88US=> MnLFV2FPT0WU
M059J NVT0cWlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHlVXdKSzVyPUOuNlAyPzNizszN NWX2bJdQW0GQR1XS
GOTO M1[0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT5TWM2OD1|LkKyNFM6KM7:TR?= Mlr4V2FPT0WU
DK-MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPBTWM2OD1|LkK1PVc3KM7:TR?= M4TsUnNCVkeHUh?=
NCI-H727 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\rTWM2OD1|LkK2OVgh|ryP M{\3T3NCVkeHUh?=
NB12 NUjJZmhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D4PWlEPTB;Mz6zN|IzPCEQvF2= MnjSV2FPT0WU
DOK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTFTWM2OD1|LkO2NVg3KM7:TR?= NHvXZnBUSU6JRWK=
KYSE-410 MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q5TmlEPTB;Mz6zOlI5PyEQvF2= NUnOVGM5W0GQR1XS
AM-38 NYDqWVNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnTVHZKSzVyPUOuN|gxPTFizszN MoS3V2FPT0WU
GR-ST M4WyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjJTWM2OD1|LkS1O|MzKM7:TR?= MYXTRW5ITVJ?
D-247MG NIW5e5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO3TWM2OD1|LkS4NlY{KM7:TR?= NHrsN|BUSU6JRWK=
TE-8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\sfWlEPTB;Mz60PVM{OyEQvF2= MlLqV2FPT0WU
LS-411N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG0TWM2OD1|LkS5OlkzKM7:TR?= MV;TRW5ITVJ?
SK-MES-1 M3jZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrsW2FKSzVyPUOuOVY1OzNizszN MnfvV2FPT0WU
SF295 NYrYSY9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu2TWM2OD1|Lk[xOVUzKM7:TR?= NIPjS2NUSU6JRWK=
SK-MEL-30 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXsUGZKSzVyPUOuOlU6OjFizszN NGKzR4RUSU6JRWK=
LB2241-RCC NGr5NlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLETWM2OD1|Lk[2NlYh|ryP NYTmZnc5W0GQR1XS
PC-14 NUfKdIp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfubJVKSzVyPUOuOlY1OzdizszN MlXrV2FPT0WU
EW-7 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwNke2PVMh|ryP MVfTRW5ITVJ?
NMC-G1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvhXlJQUUN3ME2zMlcyQDN5IN88US=> NUGxZXhoW0GQR1XS
TE-441-T NXvJ[o1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPmTWM2OD1|LkezNFI5KM7:TR?= M3uzVnNCVkeHUh?=
NCI-H1618 NHvpPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnQTFc{UUN3ME2zMlgyQDd3IN88US=> MYDTRW5ITVJ?
PANC-03-27 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\ETWM2OD1|LkixPVE3KM7:TR?= M2HFVnNCVkeHUh?=
NCI-H2228 NFfYeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W0TmlEPTB;Mz64N|EzPiEQvF2= NE\HPFNUSU6JRWK=
CAPAN-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNwOEewNFkh|ryP M4LsSHNCVkeHUh?=
KLE NHrtT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLSSZFnUUN3ME2zMlkxPjdizszN NWnxRZhoW0GQR1XS
Becker NIHL[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTNwOUK4OFkh|ryP NWT0XXNwW0GQR1XS
SK-PN-DW M3;4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK1TWM2OD12LkC3PVc1KM7:TR?= Mn2wV2FPT0WU
Hs-578-T MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwMEizNFYh|ryP NHfxWFFUSU6JRWK=
RS4-11 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTRwMUGyOVUh|ryP NVe2T2dHW0GQR1XS
D-502MG NF:zUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTRwMU[5PVch|ryP M{j5ZnNCVkeHUh?=
GI-1 M4izVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnGcIdWUUN3ME20MlI5Ojl7IN88US=> NELhPW5USU6JRWK=
NCI-H209 MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTRwM{O3PEDPxE1? M3u5[HNCVkeHUh?=
SK-OV-3 NVvubFRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LMOGlEPTB;ND60PFE1QSEQvF2= MofEV2FPT0WU
LOUCY MoexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn0e4liUUN3ME20MlQ5PDN{IN88US=> MV3TRW5ITVJ?
NCI-H69 M4fDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkToTWM2OD12LkWxO|k{KM7:TR?= MmGxV2FPT0WU
SCC-9 NHy1ToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXnTWM2OD12LkWzNVczKM7:TR?= M4LEW3NCVkeHUh?=
NCI-H526 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHkelRKSzVyPUSuOVkzQTNizszN NHvDWYlUSU6JRWK=
NCI-H2170 MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml70TWM2OD12Lk[2O|cyKM7:TR?= NELXT2FUSU6JRWK=
SR NF3lVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M134emlEPTB;ND63NFA1QCEQvF2= MnS4V2FPT0WU
CMK M17NeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTRwN{KxNFEh|ryP M2PlRnNCVkeHUh?=
COLO-829 NFjrS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTRwN{ewOFMh|ryP M3Xn[XNCVkeHUh?=
HuO-3N1 NWrsbnpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nIO2lEPTB;ND64N|I5OSEQvF2= MX7TRW5ITVJ?
5637 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTGWJVQUUN3ME20MlkxPDh5IN88US=> M1;VWXNCVkeHUh?=
A253 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTRwOUe3NFgh|ryP NG\TXoFUSU6JRWK=
NB10 M2LuPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Lob2lEPTB;NT6wO|Q6PyEQvF2= NXjVRm9KW0GQR1XS
SF539 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDkSolyUUN3ME21MlA6QTV7IN88US=> M1Lo[3NCVkeHUh?=
HAL-01 NX\PcoQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVwMUS2OFUh|ryP MYDTRW5ITVJ?
MHH-ES-1 NETRWJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Gz[mlEPTB;NT6xOlkzPSEQvF2= MXPTRW5ITVJ?
DEL M1TuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXZTWM2OD13LkK3OVgzKM7:TR?= M1uxPHNCVkeHUh?=
NCI-H1299 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnH[2VKSzVyPUWuN|UxODdizszN NHrNXpJUSU6JRWK=
ChaGo-K-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjwS25oUUN3ME21MlM2OTB5IN88US=> M3Lw[XNCVkeHUh?=
HMV-II MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLQRoJKSzVyPUWuN|k1OyEQvF2= NX;WR3FTW0GQR1XS
NB69 NXLFXZNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX1fnNVUUN3ME21MlM6PjNzIN88US=> M1j6VnNCVkeHUh?=
NCI-H1882 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnoTWM2OD13LkSzN|Y1KM7:TR?= M4rq[nNCVkeHUh?=
SNU-475 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X4WWlEPTB;NT60O|E4OSEQvF2= MX\TRW5ITVJ?
RXF393 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HqUGlEPTB;NT60PFQ6PCEQvF2= NH76WJlUSU6JRWK=
CAL-51 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrBcJlKSzVyPUWuOlI5PTNizszN Mli3V2FPT0WU
SW1573 MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv4[YlIUUN3ME21MlY{PTN2IN88US=> NFrjbplUSU6JRWK=
GCT NF\zTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfNfXd5UUN3ME21Mlc2QTJ7IN88US=> NGPqco1USU6JRWK=
COR-L88 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDNTWM2OD13Lke2PFQ3KM7:TR?= M3rLZnNCVkeHUh?=
MDA-MB-134-VI Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXIc|ZOUUN3ME21Mlg4PTN4IN88US=> MknVV2FPT0WU
NB5 NE\iS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnWSXp1UUN3ME21MlkzPDRizszN M1vKZnNCVkeHUh?=
GMS-10 M3fsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX31S4pZUUN3ME21Mlk3QDZzIN88US=> MlHMV2FPT0WU
CHP-212 M3TKemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG1fnhKSzVyPU[uOFgzPjdizszN MV7TRW5ITVJ?
TE-11 NGPpTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7MTWM2OD14LkW1NVgzKM7:TR?= MY\TRW5ITVJ?
SW962 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvyTWM2OD14Lk[1O|c1KM7:TR?= Ml7oV2FPT0WU
MZ2-MEL MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTZwOEKwNVEh|ryP NUDLRWhkW0GQR1XS
C-33-A M3LUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTZwOUG2PFgh|ryP MXfTRW5ITVJ?
IGR-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPQUFZKSzVyPU[uPVc5OjZizszN MnfWV2FPT0WU
MOLT-4 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL3dmpKSzVyPUeuNVU1ODZizszN MVnTRW5ITVJ?
NCI-H1650 MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTTSXdRUUN3ME23MlI4ODR4IN88US=> Mn;3V2FPT0WU
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NCI-H630 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn4fJdKSzVyPUKyMlU{PjNizszN MYjTRW5ITVJ?
LU-165 MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PFT2lEPTB;MkKuOVU1KM7:TR?= M4rMdnNCVkeHUh?=
COLO-792 NUDHVlg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HMdWlEPTB;MkKuO|EyOSEQvF2= MknFV2FPT0WU
CAL-62 M1PYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O2fmlEPTB;MkKuO|UyPyEQvF2= NX7QcGhjW0GQR1XS
HCE-T MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD3TWM2OD1{Mj64OlA3KM7:TR?= NYC4[|NVW0GQR1XS
BB65-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJ|LkCzOFQh|ryP MVzTRW5ITVJ?
SiHa NFXaWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPDe3FKSzVyPUKzMlM6PjhizszN M1XPb3NCVkeHUh?=
NCI-H2081 M4L2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHlTWM2OD1{ND6wOlQyKM7:TR?= M4rlcHNCVkeHUh?=
U251 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPNTWM2OD1{ND6wOlY5KM7:TR?= NYXhbFRkW0GQR1XS
LoVo NWXVZYF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrPT4hGUUN3ME2yOE46Ojh{IN88US=> M2jN[3NCVkeHUh?=
GCIY NYDzSVNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPaTWM2OD1{NT6yPFc4KM7:TR?= MUfTRW5ITVJ?
NUGC-3 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm1TWM2OD1{NT6zN|E3KM7:TR?= NIj6WpZUSU6JRWK=
LNCaP-Clone-FGC NX;CfpBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy5NpBKSzVyPUK1MlM1QThizszN MoLiV2FPT0WU
PA-1 NEe0c|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX1WWxDUUN3ME2yOU43QDN|IN88US=> NIXYbYtUSU6JRWK=
OE33 NH[zR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;sd3JKSzVyPUK1MlY5PTNizszN NF3JS|BUSU6JRWK=
HT-29 NHPUS4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[1PWlEPTB;MkWuO|g4QSEQvF2= M{LBd3NCVkeHUh?=
RCM-1 NWW3WWdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\qTWM2OD1{NT65OlU3KM7:TR?= NUHndZdtW0GQR1XS
NCI-H1522 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ3Lkm5NVEh|ryP MoflV2FPT0WU
LB373-MEL-D NHXLNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX0TWM2OD1{Nj6xO|A5KM7:TR?= M4\NZXNCVkeHUh?=
NCI-H1436 NFGx[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPUVVhxUUN3ME2yOk4zPzN6IN88US=> NXTqc3hyW0GQR1XS
COLO-824 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ4LkSwNFIh|ryP MVvTRW5ITVJ?
CP50-MEL-B MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe5WmdKSzVyPUK2MlU3PzVizszN MYfTRW5ITVJ?
EGI-1 NF73OIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ5LkK2PVgh|ryP MX7TRW5ITVJ?
LAN-6 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfIZ41MUUN3ME2yO{4{PTl6IN88US=> NHGwXW5USU6JRWK=
GAK M1fMU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3Fe3pKSzVyPUK3MlQzOjVizszN MUTTRW5ITVJ?
MDA-MB-175-VII M4HVb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJ5LkWwOVMh|ryP Mn\HV2FPT0WU
JVM-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHWWoxKSzVyPUK3MlY3OjJizszN MY\TRW5ITVJ?
UACC-257 M3;XR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJ5Lk[4O|gh|ryP NHTBTYlUSU6JRWK=
SW1783 NGn4dXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPsemczUUN3ME2yO{44Pzh|IN88US=> MlqyV2FPT0WU
HT-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfGTWM2OD1{OD6yNVY3KM7:TR?= M4q3O3NCVkeHUh?=
RL NWTVc4pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHvWnlKSzVyPUK4MlU6OTFizszN M3HVS3NCVkeHUh?=
TK10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHNeGZKSzVyPUK4MlY2OzVizszN MlrGV2FPT0WU
HT55 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX1e5RqUUN3ME2yPU4xPTZ3IN88US=> MVnTRW5ITVJ?
BT-20 NID3UFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljDTWM2OD1{OT6wOVg3KM7:TR?= NX25NIpJW0GQR1XS
TGBC24TKB Mlf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfBOnFKSzVyPUK5MlE5OzFizszN M3TjN3NCVkeHUh?=
HSC-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\PVmNlUUN3ME2yPU4{ODBzIN88US=> M162O3NCVkeHUh?=
COLO-205 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnB[HBKSzVyPUK5MlM6PDRizszN M1LRTXNCVkeHUh?=
GT3TKB M{fwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvCTWM2OD1{OT62PFc4KM7:TR?= M1\wdnNCVkeHUh?=
T47D MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrtRndKSzVyPUK5Mlg2QDJizszN MYXTRW5ITVJ?
OMC-1 M3TwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTNyLkG5NVkh|ryP NVnPSWhUW0GQR1XS
PFSK-1 MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTNzLkK2OVkh|ryP NWnCN|hiW0GQR1XS
JEG-3 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TmNmlEPTB;M{GuN|U3OSEQvF2= MW\TRW5ITVJ?
RD MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD1|MT61NVE2KM7:TR?= MWTTRW5ITVJ?
NCI-H64 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN{LkSxO|kh|ryP MYrTRW5ITVJ?
DMS-114 M4Hidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTN{LkSxPFIh|ryP MoLHV2FPT0WU
NCI-H661 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDDeZVXUUN3ME2zNk43PTBzIN88US=> NIfWcZBUSU6JRWK=
CAL-148 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN{Lk[2OlUh|ryP MULTRW5ITVJ?
HuP-T3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPiVVl3UUN3ME2zNk46OzN6IN88US=> MmXpV2FPT0WU
ES4 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW2TWM2OD1|Mz6xO|A2KM7:TR?= M1SwenNCVkeHUh?=
Ca9-22 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTsV4JWUUN3ME2zN{41PjBzIN88US=> M{LDfnNCVkeHUh?=
LP-1 NWH1[Yl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHZZZVKSzVyPUO0MlA6KM7:TR?= NVHyVVB[W0GQR1XS
AU565 NIfPc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SzTWlEPTB;M{SuOVA3QSEQvF2= NWLTPJQyW0GQR1XS
MDA-MB-453 NVPmSXVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1|NT6xOFI3KM7:TR?= NWKzUZh{W0GQR1XS
SNU-C1 NGTEOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmxVmlKSzVyPUO1MlE4OSEQvF2= Mmj2V2FPT0WU
SW13 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjvOpRxUUN3ME2zOU41ODd4IN88US=> NFnOUmVUSU6JRWK=
NCI-H2122 M17wXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3QfWxKSzVyPUO1MlU2QThizszN NYn3Tmp[W0GQR1XS
NCI-H1395 M1:2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL2TWM2OD1|NT62OlkyKM7:TR?= NFrzTIZUSU6JRWK=
J-RT3-T3-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoWxTWM2OD1|Nj6wNlk1KM7:TR?= MUnTRW5ITVJ?
COR-L279 NXvrOYFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37tdmlEPTB;M{[uNVk5OSEQvF2= NFfVfWxUSU6JRWK=
ATN-1 M3Hy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHJdFVOUUN3ME2zOk45PTF4IN88US=> M{jXSHNCVkeHUh?=
HCC2998 M2L4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXTb3BKSzVyPUO2Mlg2PzFizszN MWjTRW5ITVJ?
UM-UC-3 NHXFN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN4Lki2O|Uh|ryP M3zNPHNCVkeHUh?=
DV-90 NHTLc4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\CSZJIUUN3ME2zOk46ODZ5IN88US=> MXXTRW5ITVJ?
ES8 M4G2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DWfmlEPTB;M{[uPVMyQCEQvF2= NGLQSlRUSU6JRWK=
YAPC Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn2wTWM2OD1|Nj65OlU1KM7:TR?= M1m1bHNCVkeHUh?=
HCC1599 M1W5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfiTWM2OD1|Nz6xOlE5KM7:TR?= MXfTRW5ITVJ?
UMC-11 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLDTWM2OD1|Nz6yOVA{KM7:TR?= MXzTRW5ITVJ?
THP-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPM[ZNKSzVyPUO3MlI5PjhizszN NGHybpZUSU6JRWK=
OCUB-M NG[w[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTN5LkK4PVEh|ryP Mn\qV2FPT0WU
NCI-H1693 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrVNXA5UUN3ME2zO{4{OjN|IN88US=> M33PZnNCVkeHUh?=
NCI-H345 NFrOTJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjMTWM2OD1|Nz6zOlI1KM7:TR?= NUPOe4Z[W0GQR1XS
COLO-800 NGK4[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LXPWlEPTB;M{euOVY4KM7:TR?= NUnPbHJEW0GQR1XS
COLO-320-HSR MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTN6LkO0PVIh|ryP MlnSV2FPT0WU
NCI-H596 M2C4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTN6LkS0PFkh|ryP MkOzV2FPT0WU
NCI-H187 MnThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HNUWlEPTB;M{iuO|M1PCEQvF2= M1zSRXNCVkeHUh?=
ECC4 M4K4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PKfGlEPTB;M{muNFgyPCEQvF2= Mkf4V2FPT0WU
KP-4 NVyzRlZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnoTWM2OD1|OT6xNlM2KM7:TR?= M3f1OXNCVkeHUh?=
NCI-H2227 M3rvbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN7LkO5OFkh|ryP NHfCTFZUSU6JRWK=
22RV1 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPPSoxHUUN3ME2zPU45Ozl6IN88US=> M2HHXnNCVkeHUh?=
SAS NX65OFNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKwTWM2OD12MD6wPVYh|ryP MlfSV2FPT0WU
PANC-10-05 NI\KSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPmTWM2OD12MD6xPFI5KM7:TR?= MYjTRW5ITVJ?
MDA-MB-468 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XlRmlEPTB;NECuOVM1PiEQvF2= MVvTRW5ITVJ?
RPMI-7951 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nybWlEPTB;NEGuNlA4PSEQvF2= Mnm0V2FPT0WU
BB49-HNC NXHLeIJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:0[JpVUUN3ME20NU4zOTd7IN88US=> MXnTRW5ITVJ?
23132-87 NVWxcZlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\KVGlEPTB;NEGuNlc{OiEQvF2= M{jNWnNCVkeHUh?=
HCC1569 NUnsO2dvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL2O3diUUN3ME20NU4zQDh3IN88US=> MXHTRW5ITVJ?
CP66-MEL NV\3UodjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTR{LkG4PFYh|ryP M120b3NCVkeHUh?=
K-562 NF3xOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HYXGlEPTB;NEKuNlg2PCEQvF2= M2XlWnNCVkeHUh?=
OCI-AML2 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvu[|hKSzVyPUSyMlg6PzRizszN NHjuZXdUSU6JRWK=
SW756 NFrPTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR|LkCzPFgh|ryP MmS2V2FPT0WU
M14 NIXkSoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7OTWM2OD12Mz6zNVg6KM7:TR?= M4PyTXNCVkeHUh?=
NCI-H1623 NHW3T4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvDTJhmUUN3ME20N{41PjRizszN M2rUNnNCVkeHUh?=
KNS-81-FD NVnURlVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W0c2lEPTB;NEOuO|YzKM7:TR?= NYr6bnc3W0GQR1XS
TGBC1TKB NVHVT45tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjkTmdKSzVyPUSzMlkxQTlizszN NEO5N3ZUSU6JRWK=
RERF-LC-MS MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH1c25CUUN3ME20N{46OjhzIN88US=> NHe5NFNUSU6JRWK=
PC-3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvFTWM2OD12ND60N|Q4KM7:TR?= NHTORoZUSU6JRWK=
HuP-T4 NICyUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTR2LkS0O|Qh|ryP Ml7pV2FPT0WU
NCI-H510A NHrtdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\hcmlEPTB;NESuO|A5KM7:TR?= MmHJV2FPT0WU
LB2518-MEL NV7UcmhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;RTWM2OD12ND63PVM4KM7:TR?= NHvKSplUSU6JRWK=
TE-5 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f0[2lEPTB;NEWuPVU5OSEQvF2= NWXC[FVlW0GQR1XS
EW-24 NV\IcVhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXlZYpRUUN3ME20Ok4yPzJ|IN88US=> NIf3b49USU6JRWK=
LB647-SCLC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL5[nZqUUN3ME20Ok4zOTV3IN88US=> NXzQRog1W0GQR1XS
NCI-H524 M2Tiemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HvSGlEPTB;NE[uO|E5PSEQvF2= MnzwV2FPT0WU
EW-11 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnIcYo2UUN3ME20Ok46Ozd|IN88US=> MXLTRW5ITVJ?
KALS-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X2dmlEPTB;NEeuNlA3PiEQvF2= MUXTRW5ITVJ?
BT-474 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe4eYhKSzVyPUS3MlQzOTZizszN NHrr[W9USU6JRWK=
SK-N-AS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nWc2lEPTB;NEeuPFg5KM7:TR?= MV3TRW5ITVJ?
HCC2157 NYXYNGV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{myT2lEPTB;NEiuNFc3KM7:TR?= MV;TRW5ITVJ?
HCC1954 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR6LkG3NFQh|ryP NXXuc|VoW0GQR1XS
FADU NImyPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnvVGN5UUN3ME20PE4{ODNzIN88US=> MmjxV2FPT0WU
S-117 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XGc2lEPTB;NEiuN|gyPSEQvF2= MmDHV2FPT0WU
LS-1034 M4XmWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR6LkewOlch|ryP MYnTRW5ITVJ?
CAMA-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3ibI43UUN3ME20PU42PTR|IN88US=> MkTEV2FPT0WU
LU-134-A NYGzfm5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q5NGlEPTB;NEmuPFA5PSEQvF2= M33ZfnNCVkeHUh?=
NCI-H1838 NWDKXlYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\VTWM2OD12OT64NFg4KM7:TR?= M2q0PHNCVkeHUh?=

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体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Ablシグナル伝達経路

Bcr-Abl Inhibitors with Unique Features

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Tags: Ponatinib (AP24534)を買う | Ponatinib (AP24534) ic50 | Ponatinib (AP24534)供給者 | Ponatinib (AP24534)を購入する | Ponatinib (AP24534)費用 | Ponatinib (AP24534)生産者 | オーダーPonatinib (AP24534) | Ponatinib (AP24534)化学構造 | Ponatinib (AP24534)分子量 | Ponatinib (AP24534)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID