Ponatinib (AP24534)

For research use only. Not for use in humans.

製品コードS1490

Ponatinib (AP24534)化学構造

CAS No. 943319-70-8

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.

サイズ 価格(税別) 在庫  
10mM (1mL in DMSO) JPY 18600 あり
JPY 20200 あり
JPY 63400 あり
JPY 163000 あり
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文献中Selleckの製品使用例(132)

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NYGzT|J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXixXmFvUUN3ME2wMlAxODByMECzOVkh|ryP NVm1[21iW0GQR1XS
MV-4-11 M3HwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMECwNFk2PiEQvF2= MULTRW5ITVJ?
MEG-01 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILBbnJKSzVyPUCuNFAxOTJ6IN88US=> MkCyV2FPT0WU
LAMA-84 NWewXY5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7vPZZKSzVyPUCuNFAxOTZ3IN88US=> M1K1RXNCVkeHUh?=
CGTH-W-1 NV7XUWhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjRcHRKSzVyPUCuNFAyPjlizszN MVrTRW5ITVJ?
KASUMI-1 NEXXbZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7rTWM2OD1yLkCwNlE4KM7:TR?= MUnTRW5ITVJ?
BE-13 M1ftW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO0Z4dKSzVyPUCuNFAzPTlizszN NEm1OYVUSU6JRWK=
CTV-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEC1NlEh|ryP MUDTRW5ITVJ?
NKM-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[xTWM2OD1yLkCwOlU2KM7:TR?= MnGyV2FPT0WU
MONO-MAC-6 M3n3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:zOWlEPTB;MD6wNFg{PyEQvF2= NG\zclRUSU6JRWK=
A204 M2DzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEGyNVgh|ryP M4P5cXNCVkeHUh?=
GDM-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEG4N|Mh|ryP Ml\aV2FPT0WU
AN3-CA MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHzTWM2OD1yLkCxPFc{KM7:TR?= NWn3Wm01W0GQR1XS
BL-70 NEnZcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXxd|Y4UUN3ME2wMlAzOTl7IN88US=> NIfEVW5USU6JRWK=
Daudi NXnuZ5pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3SyVWlEPTB;MD6wNlU{PyEQvF2= MYXTRW5ITVJ?
KU812 NXTVT3UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;1UGlEPTB;MD6wNlg1QCEQvF2= M{TienNCVkeHUh?=
KG-1 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LUXmlEPTB;MD6wN|I6PCEQvF2= M1nlbXNCVkeHUh?=
DOHH-2 Mnv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHMXYE4UUN3ME2wMlA1QDB|IN88US=> NVi2THVsW0GQR1XS
HuO9 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX64NW8zUUN3ME2wMlA2PDR6IN88US=> Mme1V2FPT0WU
EB2 M3rSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7GR4Z5UUN3ME2wMlA2PTd4IN88US=> MXrTRW5ITVJ?
G-402 M3W4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwME[zOFEh|ryP M37rUXNCVkeHUh?=
SU-DHL-1 MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwME[zO|kh|ryP NHfCVW1USU6JRWK=
NCI-H719 M3HkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEe4PFgh|ryP M1TWPXNCVkeHUh?=
MLMA MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjoXXQyUUN3ME2wMlA6ODZizszN NU\xcmVjW0GQR1XS
KM12 NFrsXoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEm3N|ch|ryP NV\wSXZ3W0GQR1XS
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MZ1-PC NYjFXmpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfTU5JKSzVyPUCuNVE{OzZizszN M3:3THNCVkeHUh?=
MFE-296 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMUG4N|kh|ryP MkjtV2FPT0WU
ALL-PO M4fuR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrPTWM2OD1yLkGyOFQ{KM7:TR?= NFnRR|RUSU6JRWK=
GB-1 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMUK1NVIh|ryP MkHzV2FPT0WU
SIG-M5 NVXiPYR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHOTWM2OD1yLkGzN|ch|ryP M{HvfXNCVkeHUh?=
P30-OHK NH35fYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXETWM2OD1yLkG1OlczKM7:TR?= MXLTRW5ITVJ?
NCI-H716 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMU[yOlYh|ryP MmHlV2FPT0WU
MPP-89 NWfOWFR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K2VGlEPTB;MD6xOlk{OyEQvF2= M2W3c3NCVkeHUh?=
SF126 M2m2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe4ZmptUUN3ME2wMlE4ODZ|IN88US=> NGm4eXlUSU6JRWK=
CTB-1 M{DiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDae|Z[UUN3ME2wMlE4OzF4IN88US=> MWfTRW5ITVJ?
CA46 NVnLNpplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMUe0PFkh|ryP NH7zd4hUSU6JRWK=
NCI-H520 NViwXVdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMUe3N|Ih|ryP NFP0[pVUSU6JRWK=
CAL-85-1 NVjuWW5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr6VoVKSzVyPUCuNVc6OjdizszN NFrPRnZUSU6JRWK=
NCI-H2342 NFjTRYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVGxRnFqUUN3ME2wMlE5PTd5IN88US=> MWnTRW5ITVJ?
697 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;aZ4M3UUN3ME2wMlE5QDdzIN88US=> NFvzXmRUSU6JRWK=
NY NEXsOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKR5VKSzVyPUCuNVkzQDdizszN MoPrV2FPT0WU
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NCI-H1703 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonMTWM2OD1yLkG5OlE2KM7:TR?= Mo\kV2FPT0WU
NCI-H2087 M{jBR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i4TGlEPTB;MD6yNFQ{QSEQvF2= M{LjSXNCVkeHUh?=
PF-382 M4D4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPhTWM2OD1yLkKwPFc{KM7:TR?= Mmq2V2FPT0WU
HCT-116 M2jiZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXmw[FduUUN3ME2wMlIyODZ7IN88US=> M3jOPHNCVkeHUh?=
CAKI-1 MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n6UWlEPTB;MD6yNVY3PiEQvF2= MXrTRW5ITVJ?
CCF-STTG1 NHPDRppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTUTWM2OD1yLkKyOFc2KM7:TR?= M2T0NHNCVkeHUh?=
D-392MG MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Lte2lEPTB;MD6yN|E4PyEQvF2= MmrBV2FPT0WU
RT-112 M37r[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rXbmlEPTB;MD6yN|c6PSEQvF2= MVXTRW5ITVJ?
MES-SA MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDVTWM2OD1yLkK0NVg4KM7:TR?= M{\IZ3NCVkeHUh?=
LC-2-ad NGfic5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofmTWM2OD1yLkK0NlY2KM7:TR?= M1P0fnNCVkeHUh?=
NOS-1 M{\6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3uNnVKSzVyPUCuNlQ{PjdizszN NWHwZVRrW0GQR1XS
NALM-6 NEezRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\ac2lEPTB;MD6yOVU1OyEQvF2= M{W0XXNCVkeHUh?=
TE-15 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPBTWM2OD1yLkK2NFkyKM7:TR?= MXHTRW5ITVJ?
786-0 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nxWWlEPTB;MD6yOlIzQCEQvF2= NYDocWg4W0GQR1XS
IST-MES1 NFnJ[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\5TWM2OD1yLkK2PFI6KM7:TR?= NXrG[Id4W0GQR1XS
KYSE-180 NFXQcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TDeWlEPTB;MD6yOlg6OSEQvF2= MoLRV2FPT0WU
YT M2TQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXmdGxSUUN3ME2wMlI3QTd2IN88US=> Mo\VV2FPT0WU
A427 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom0TWM2OD1yLkK3NlY1KM7:TR?= NVfZTJFwW0GQR1XS
KYSE-450 NXfUS4dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e0eWlEPTB;MD6yO|MzQSEQvF2= MmjaV2FPT0WU
HuH-7 NITtOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMke3OlMh|ryP MXrTRW5ITVJ?
CAS-1 M3rpcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHjTWM2OD1yLkK4N|A{KM7:TR?= NWTJO5FkW0GQR1XS
KURAMOCHI M4jrc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\2[|hKSzVyPUCuNlg1OTlizszN MVfTRW5ITVJ?
ACHN Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXrTWM2OD1yLkK5N|I{KM7:TR?= NXj5fVZ6W0GQR1XS
HGC-27 NWDZWpl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS0VGhSUUN3ME2wMlI6OzV|IN88US=> M2LR[nNCVkeHUh?=
A172 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfyTWM2OD1yLkK5OVc4KM7:TR?= M2rpcHNCVkeHUh?=
SNU-449 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSwcYZKSzVyPUCuNlk6PjRizszN MnLxV2FPT0WU
SW982 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHVTWM2OD1yLkK5PVc5KM7:TR?= MXfTRW5ITVJ?
EFO-21 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwM{C0NVEh|ryP MYDTRW5ITVJ?
NCI-H2030 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkOzTWM2OD1yLkOxNVY1KM7:TR?= M3PyXHNCVkeHUh?=
HT-144 NVL0W3RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnJPIxDUUN3ME2wMlMyOjhizszN NIPsOYFUSU6JRWK=
MFE-280 NXP6NnBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvBTWM2OD1yLkOxOFU{KM7:TR?= NILtcJFUSU6JRWK=
SK-LU-1 NHLhWYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfkS3BUUUN3ME2wMlMyPDZ4IN88US=> NULDd4ZUW0GQR1XS
NCI-H2052 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XG[WlEPTB;MD6zNVQ5PCEQvF2= MkT5V2FPT0WU
SK-HEP-1 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjETWM2OD1yLkOzN|Y5KM7:TR?= MXzTRW5ITVJ?
QIMR-WIL M4r5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjWNFhKSzVyPUCuN|M1OjRizszN NUfFU4VjW0GQR1XS
A2780 Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\HTWM2OD1yLkO0N|A1KM7:TR?= MlzhV2FPT0WU
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BxPC-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwM{S5PFkh|ryP NX3R[2RNW0GQR1XS
BCPAP M2TNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7PRYVKSzVyPUCuN|YxODFizszN M1;2b3NCVkeHUh?=
HOP-62 MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTveWpkUUN3ME2wMlM3OTB4IN88US=> Mn[xV2FPT0WU
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OPM-2 MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{[0O|Mh|ryP NITO[FBUSU6JRWK=
DBTRG-05MG MmTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnJSoRKSzVyPUCuN|gxPTRizszN MVLTRW5ITVJ?
SK-MEL-24 M3\pZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zNN2lEPTB;MD6zPVc6OSEQvF2= MoDEV2FPT0WU
8305C MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPwTWM2OD1yLkO5O|k{KM7:TR?= NG[5eXVUSU6JRWK=
OVCAR-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjzSYpKSzVyPUCuOFE2QDZizszN NETGRXNUSU6JRWK=
HLE NFPoXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnxeFVKSzVyPUCuOFE5PiEQvF2= MnqyV2FPT0WU
NCI-H747 NHz0VoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XsNWlEPTB;MD60NlE{PyEQvF2= MYLTRW5ITVJ?
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KYSE-150 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37pcmlEPTB;MD60NlQyPSEQvF2= NX;HcFF4W0GQR1XS
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SW1088 M2jNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwNESzPUDPxE1? M3nxfXNCVkeHUh?=
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LCLC-97TM1 NIjSfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnMRYsyUUN3ME2wMlQ3OTl3IN88US=> MVjTRW5ITVJ?
CAL-39 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\SZmlEPTB;MD60OlUyQSEQvF2= MXTTRW5ITVJ?
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ESS-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwNEe4NlEh|ryP Mnz4V2FPT0WU
KARPAS-45 M17rSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzlbYJvUUN3ME2wMlQ5QTN|IN88US=> NXjWXXB[W0GQR1XS
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VMRC-RCZ NVG2Xo5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwNEm5NFQh|ryP M2nUVXNCVkeHUh?=
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MOLT-16 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zmTWlEPTB;MD61NVgxQCEQvF2= MVfTRW5ITVJ?
RPMI-6666 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwNUKxN|Uh|ryP NEHRdWZUSU6JRWK=
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CAL-12T M3myfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmxTVBjUUN3ME2wMlc{QDd5IN88US=> NWDXOIw3W0GQR1XS
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NCI-H1581 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwOEmyPVch|ryP M37nOHNCVkeHUh?=
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NCI-H2347 M33Bfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i3[GlEPTB;MD65N|I6OiEQvF2= MkHVV2FPT0WU
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HCC1395 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjRdWliUUN3ME2wMlk2PDZzIN88US=> M1\2WnNCVkeHUh?=
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HDLM-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7kTWM2OD1zLkCxNlUzKM7:TR?= M1HZWXNCVkeHUh?=
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HT-1197 NH6y[VlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3TZVJpUUN3ME2xMlEyPDN6IN88US=> MoDaV2FPT0WU
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MHH-NB-11 NUXXWYFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmq2TWM2OD1zLkG1N|Y5KM7:TR?= MUjTRW5ITVJ?
NCI-H2405 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37FfGlEPTB;MT6xOlE3KM7:TR?= NX\sfYQ6W0GQR1XS
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MKN28 NGH4TnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn4TWM2OD1zLkK1OlM3KM7:TR?= MWnTRW5ITVJ?
KS-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvnR|dbUUN3ME2xMlI5OjZ7IN88US=> NIq0d4NUSU6JRWK=
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NCI-H838 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fVe2lEPTB;MT6zNFYyPSEQvF2= M3[wbnNCVkeHUh?=
HEC-1 NH3lXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTDR5ExUUN3ME2xMlM{PzV3IN88US=> NFjG[2dUSU6JRWK=
ME-180 NUjVT45iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\MXWlEPTB;MT6zO|k6OyEQvF2= NI\N[nhUSU6JRWK=
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SIMA MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPkSnlKSzVyPUGuOFg3QDdizszN NFHMbGZUSU6JRWK=
NCI-H1770 NWDU[FdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVGzXIw{UUN3ME2xMlUzODV2IN88US=> NX;wUFVXW0GQR1XS
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LB771-HNC Ml:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL1[ploUUN3ME2xMlU{QTB4IN88US=> MnzXV2FPT0WU
SW48 M2XXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\vTWM2OD1zLkW0NlQ{KM7:TR?= M{PmWnNCVkeHUh?=
KYSE-140 NGr3WplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\TeWZwUUN3ME2xMlU2PzRzIN88US=> M2[wPXNCVkeHUh?=
SW626 NWjvSmdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwNUixOkDPxE1? NX\3VYhrW0GQR1XS
MC-CAR MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rvNGlEPTB;MT61PFY3OyEQvF2= MWHTRW5ITVJ?
D-336MG NF;xS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT1TWM2OD1zLk[yPVQh|ryP NUfkVZF2W0GQR1XS
SK-MEL-3 NYjxRllXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXyyV29yUUN3ME2xMlY{QTB{IN88US=> Mn;wV2FPT0WU
MHH-PREB-1 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrGTWM2OD1zLk[0OFc{KM7:TR?= M3iySHNCVkeHUh?=
Calu-1 M{HGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPPTWM2OD1zLk[1N|g3KM7:TR?= M{Lid3NCVkeHUh?=
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A101D MnXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DRbGlEPTB;MT62Olc5OSEQvF2= MUjTRW5ITVJ?
A704 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofzTWM2OD1zLk[4N|EyKM7:TR?= NUnJOlI5W0GQR1XS
LB831-BLC MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwNkm4OVQh|ryP Mlm2V2FPT0WU
RL95-2 NETwcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPUTWM2OD1zLkexOFY{KM7:TR?= MULTRW5ITVJ?
RPMI-2650 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwN{K3NVkh|ryP MUPTRW5ITVJ?
NH-12 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu2TWM2OD1zLkezOFI4KM7:TR?= NXTrWIFDW0GQR1XS
AGS NEf3OlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHsNIVKSzVyPUGuO|Y{PThizszN MonYV2FPT0WU
NEC8 MlnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn0T2hKSzVyPUGuO|g6QTVizszN NWPJS241W0GQR1XS
NCI-H2009 MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\wdlZKSzVyPUGuO|k4OjFizszN MU\TRW5ITVJ?
A498 NELlRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT4RlNzUUN3ME2xMlgyOjh{IN88US=> MYjTRW5ITVJ?
NCI-H810 NW\qV4dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3iTWM2OD1zLkixOlA3KM7:TR?= NWCw[I5IW0GQR1XS
SK-NEP-1 NFXmcJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwOEO3Olch|ryP NHfNUGdUSU6JRWK=
D-542MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwOEW4OVEh|ryP NXLGXXNbW0GQR1XS
KNS-42 NWjGXYptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnq2TWM2OD1zLki2NlY3KM7:TR?= MXTTRW5ITVJ?
NCI-H2452 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDQNVNKSzVyPUGuPFkxPzRizszN NVP5c2RvW0GQR1XS
SK-MEL-2 NILLcFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LIdmlEPTB;MT65NFI4OSEQvF2= NGnUU21USU6JRWK=
OVCAR-5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnibndiUUN3ME2xMlkxPjd3IN88US=> NUe1cFZXW0GQR1XS
SNG-M M4rR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\t[2lEPTB;MT65OVg2QCEQvF2= NVr3c5U{W0GQR1XS
A673 M2T6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPTTWM2OD1zLkm3OVE3KM7:TR?= MWfTRW5ITVJ?
L-428 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjQc3hvUUN3ME2xMlk6OTd7IN88US=> MorkV2FPT0WU
KM-H2 M1LNTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\sRmlEPTB;Mj6wNVA6KM7:TR?= NVLS[GZVW0GQR1XS
MC-IXC NFHu[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7aTXFKSzVyPUKuNFIzPzNizszN NFLZUFdUSU6JRWK=
COLO-678 NUDaXpVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwMESyNFch|ryP NILQVGNUSU6JRWK=
MEL-JUSO M1\vS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHtdINpUUN3ME2yMlA4QDVzIN88US=> MlPmV2FPT0WU
HCC38 MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i1ZmlEPTB;Mj6wPFQ{OyEQvF2= MV;TRW5ITVJ?
UACC-62 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TuR2lEPTB;Mj6wPFg2PSEQvF2= NH;Tb4dUSU6JRWK=
OAW-42 NYXHXmhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJwMEm3NVEh|ryP MXLTRW5ITVJ?
LB996-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWWweHVuUUN3ME2yMlE{QDF5IN88US=> MlPBV2FPT0WU
COR-L105 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJwMU[zO|Mh|ryP M{XVOnNCVkeHUh?=
RCC10RGB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3pTWM2OD1{LkG4OVc3KM7:TR?= MYfTRW5ITVJ?
A431 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fEfWlEPTB;Mj6xPVAyQSEQvF2= NYPuOGNzW0GQR1XS
NCI-H292 NIfTZnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DKfmlEPTB;Mj6yN|k2OSEQvF2= MmTHV2FPT0WU
SK-UT-1 NV\Se41[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LTemlEPTB;Mj6zN|E5PCEQvF2= MmixV2FPT0WU
PANC-08-13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW2Nm9jUUN3ME2yMlM{OjN3IN88US=> NHPTTnFUSU6JRWK=
ST486 M3TQ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LXmlEPTB;Mj60NVA1QCEQvF2= M33tOHNCVkeHUh?=
SJSA-1 NXThVJprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu3TWM2OD1{LkSxNlcyKM7:TR?= Mn;qV2FPT0WU
RKO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLxTWM2OD1{LkSyNFI6KM7:TR?= MlHTV2FPT0WU
NCI-H1793 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TXbWlEPTB;Mj60OFAzQSEQvF2= NV3RUnZRW0GQR1XS
639-V M3\OUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHzTWM2OD1{LkS1N|gzKM7:TR?= MV3TRW5ITVJ?
ES3 NHTVOoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PoXWlEPTB;Mj60PVc{PyEQvF2= M3LZenNCVkeHUh?=
NCI-H1792 Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjL[Y5KSzVyPUKuOVY5OjZizszN NUTDPIFrW0GQR1XS
NCI-H1651 M3TaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\YUWpKSzVyPUKuOVgzOSEQvF2= NV60[YNlW0GQR1XS
SN12C NIjNd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUOxPWluUUN3ME2yMlU5PDh5IN88US=> NWO5SHkyW0GQR1XS
COLO-679 NW\wNIVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:yWmlEPTB;Mj61PFYxPSEQvF2= NYWxRYVvW0GQR1XS
U-118-MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjQTWM2OD1{LkW4PFczKM7:TR?= M{XudnNCVkeHUh?=
Ramos-2G6-4C10 M1Gwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwNkS4NFch|ryP MoH1V2FPT0WU
HCT-15 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrMWINKSzVyPUKuOlg4QTJizszN NV7FPI5KW0GQR1XS
MDA-MB-157 NFfwfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3wTWM2OD1{LkewO|Q4KM7:TR?= MnXWV2FPT0WU
K5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofUTWM2OD1{LkexPFQ2KM7:TR?= NU\mTJBmW0GQR1XS
MKN45 M{e4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jmSGlEPTB;Mj63N|M3PiEQvF2= MlzNV2FPT0WU
DMS-273 Mmj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13LcWlEPTB;Mj63OVY{OiEQvF2= Mmj2V2FPT0WU
C8166 NEXvfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwN{i1NVMh|ryP MoHyV2FPT0WU
Calu-3 M2POTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjsXXIyUUN3ME2yMlc5QTZ7IN88US=> NF\NT|JUSU6JRWK=
SNB75 NUK5WVYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnjb2JKSzVyPUKuPFg2OzVizszN MYrTRW5ITVJ?
BFTC-905 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv4dplKSzVyPUKuPVAyQTFizszN M3TxOHNCVkeHUh?=
C-4-II NVnseY1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLQ[5ltUUN3ME2yMlkyOzV|IN88US=> Mmf1V2FPT0WU
MS-1 M1rndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJwOU[3Olkh|ryP M{HDe3NCVkeHUh?=
A375 NETDTVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHqeGRKSzVyPUOuNFgyQDRizszN MWXTRW5ITVJ?
KYSE-70 NH:3[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTNwMEi4PFIh|ryP NVvwTI0{W0GQR1XS
KYSE-510 NGnGc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwMUC5PVUh|ryP M2C1N3NCVkeHUh?=
LN-405 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHiTodmUUN3ME2zMlE{PTF6IN88US=> Mnj4V2FPT0WU
BOKU NHLkbVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPnTWM2OD1|LkG0NlU3KM7:TR?= MnfqV2FPT0WU
TE-10 NGi0c|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml25TWM2OD1|LkG3N|YzKM7:TR?= NXLoPZNnW0GQR1XS
MKN1 MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVO4WXpZUUN3ME2zMlE5PDh|IN88US=> NHPabnhUSU6JRWK=
M059J Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTNwMkCxO|Mh|ryP NIm0[W9USU6JRWK=
GOTO NIHwcIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTNwMkKwN|kh|ryP MYfTRW5ITVJ?
DK-MG MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwMkW5O|Yh|ryP NEfHd4xUSU6JRWK=
NCI-H727 NHfh[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml74TWM2OD1|LkK2OVgh|ryP Ml;sV2FPT0WU
NB12 M36ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7DV29{UUN3ME2zMlM{OjJ2IN88US=> MkLNV2FPT0WU
DOK MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNwM{[xPFYh|ryP MnH2V2FPT0WU
KYSE-410 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjocIMxUUN3ME2zMlM3Ojh5IN88US=> MVHTRW5ITVJ?
AM-38 NH\NUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrH[FZ4UUN3ME2zMlM5ODVzIN88US=> M{XPTXNCVkeHUh?=
GR-ST M2XzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPWeJJKSzVyPUOuOFU4OzJizszN NWm1RodIW0GQR1XS
D-247MG M3vPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwNEiyOlMh|ryP MoWxV2FPT0WU
TE-8 NYf3eIwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwNEmzN|Mh|ryP MkflV2FPT0WU
LS-411N NGDYd3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnId5dKSzVyPUOuOFk3QTJizszN MnTIV2FPT0WU
SK-MES-1 NIj3UHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPHTWM2OD1|LkW2OFM{KM7:TR?= NUj0fpVYW0GQR1XS
SF295 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL4TWM2OD1|Lk[xOVUzKM7:TR?= MnzyV2FPT0WU
SK-MEL-30 NV\EXolGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTNwNkW5NlEh|ryP NIPhT4pUSU6JRWK=
LB2241-RCC NFzBfXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnyPGdWUUN3ME2zMlY3OjZizszN M4\CO3NCVkeHUh?=
PC-14 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXizOpVxUUN3ME2zMlY3PDN5IN88US=> MoCxV2FPT0WU
EW-7 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwNke2PVMh|ryP NYDKSXNUW0GQR1XS
NMC-G1 M1jld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj4Z3hjUUN3ME2zMlcyQDN5IN88US=> NYHDUnpUW0GQR1XS
TE-441-T M1Tj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33HcWlEPTB;Mz63N|AzQCEQvF2= NIn6dmJUSU6JRWK=
NCI-H1618 M2XRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXVSItjUUN3ME2zMlgyQDd3IN88US=> NUTTSHhTW0GQR1XS
PANC-03-27 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNwOEG5NVYh|ryP MnzSV2FPT0WU
NCI-H2228 NIXsVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\T[mlEPTB;Mz64N|EzPiEQvF2= NGfwdpNUSU6JRWK=
CAPAN-1 M{DY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXHN|FKSzVyPUOuPFcxODlizszN NIXzOmRUSU6JRWK=
KLE MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLmTWM2OD1|LkmwOlch|ryP NF\RSIdUSU6JRWK=
Becker MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzY[41KSzVyPUOuPVI5PDlizszN MnH3V2FPT0WU
SK-PN-DW MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTRwMEe5O|Qh|ryP NVPY[XJnW0GQR1XS
Hs-578-T M1rwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rtNGlEPTB;ND6wPFMxPiEQvF2= MXfTRW5ITVJ?
RS4-11 MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fwWWlEPTB;ND6xNVI2PSEQvF2= M2DJUHNCVkeHUh?=
D-502MG M{PWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nRemlEPTB;ND6xOlk6PyEQvF2= MYnTRW5ITVJ?
GI-1 NF7zdZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTRwMkiyPVkh|ryP MmHmV2FPT0WU
NCI-H209 NHPIUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXL3TmdPUUN3ME20MlM{PzhizszN MYnTRW5ITVJ?
SK-OV-3 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTkUWM{UUN3ME20MlQ5OTR7IN88US=> NE\XfI9USU6JRWK=
LOUCY NIC1OYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTRwNEi0N|Ih|ryP M{i5T3NCVkeHUh?=
NCI-H69 NVfGWIxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH0TWM2OD12LkWxO|k{KM7:TR?= M{nwUnNCVkeHUh?=
SCC-9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf5bXVKSzVyPUSuOVMyPzJizszN MoLPV2FPT0WU
NCI-H526 NEDKNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTRwNUmyPVMh|ryP M1rxb3NCVkeHUh?=
NCI-H2170 NV33VHI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXI[|NKSzVyPUSuOlY4PzFizszN NVzzUXFZW0GQR1XS
SR NFHKRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HSUmlEPTB;ND63NFA1QCEQvF2= MmPXV2FPT0WU
CMK M1PydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPSTWM2OD12LkeyNVAyKM7:TR?= M3fvNHNCVkeHUh?=
COLO-829 NYPjW3BFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmyNWZpUUN3ME20Mlc4ODR|IN88US=> NUnIOZN[W0GQR1XS
HuO-3N1 M2n1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTRwOEOyPFEh|ryP NILacnNUSU6JRWK=
5637 M{Cwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWySZFKSzVyPUSuPVA1QDdizszN MlfOV2FPT0WU
A253 M2jmUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LzV2lEPTB;ND65O|cxQCEQvF2= NYLRfnNWW0GQR1XS
NB10 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HKfGlEPTB;NT6wO|Q6PyEQvF2= MkHZV2FPT0WU
SF539 NVznd5FFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjsbYpKSzVyPUWuNFk6PTlizszN M2SwN3NCVkeHUh?=
HAL-01 NIHxU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXkTWM2OD13LkG0OlQ2KM7:TR?= Mk\pV2FPT0WU
MHH-ES-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HMRWlEPTB;NT6xOlkzPSEQvF2= NGfzWlBUSU6JRWK=
DEL NHLE[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS4TWM2OD13LkK3OVgzKM7:TR?= NGfk[m1USU6JRWK=
NCI-H1299 NYrCZ25ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTVwM{WwNFch|ryP NXPxUXN5W0GQR1XS
ChaGo-K-1 M4Ox[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3UT2xKSzVyPUWuN|UyODdizszN NVvFUINTW0GQR1XS
HMV-II NX;E[4JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTSXoYzUUN3ME21MlM6PDNizszN MVrTRW5ITVJ?
NB69 NYS2TmUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmzTWM2OD13LkO5OlMyKM7:TR?= NFXTOFdUSU6JRWK=
NCI-H1882 MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPJTWM2OD13LkSzN|Y1KM7:TR?= M1nYenNCVkeHUh?=
SNU-475 M3G4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrpenVKSzVyPUWuOFcyPzFizszN M1XEbHNCVkeHUh?=
RXF393 M1;GWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq5cFZKSzVyPUWuOFg1QTRizszN NEDT[nJUSU6JRWK=
CAL-51 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rLXWlEPTB;NT62Nlg2OyEQvF2= NHzKSZJUSU6JRWK=
SW1573 NYK3TW4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TFbWlEPTB;NT62N|U{PCEQvF2= NELsV4ZUSU6JRWK=
GCT Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M335R2lEPTB;NT63OVkzQSEQvF2= NFHBbIJUSU6JRWK=
COR-L88 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj5T2tKSzVyPUWuO|Y5PDZizszN NF\6UW5USU6JRWK=
MDA-MB-134-VI MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\2cmR1UUN3ME21Mlg4PTN4IN88US=> MmfVV2FPT0WU
NB5 NWC4[pptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzuTWM2OD13LkmyOFQh|ryP NIXoUJJUSU6JRWK=
GMS-10 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;sS3JnUUN3ME21Mlk3QDZzIN88US=> MmOyV2FPT0WU
CHP-212 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkKxTWM2OD14LkS4NlY4KM7:TR?= NIHPSppUSU6JRWK=
TE-11 NVTMOHR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DZRmlEPTB;Nj61OVE5OiEQvF2= NF70VZNUSU6JRWK=
SW962 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zGU2lEPTB;Nj62OVc4PCEQvF2= MV\TRW5ITVJ?
MZ2-MEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC0cnJKSzVyPU[uPFIxOTFizszN MUTTRW5ITVJ?
C-33-A MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\h[nY3UUN3ME22MlkyPjh6IN88US=> NUjGTWx6W0GQR1XS
IGR-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULifWhVUUN3ME22Mlk4QDJ4IN88US=> M1TUenNCVkeHUh?=
MOLT-4 NVeyRW12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTdwMUW0NFYh|ryP MWLTRW5ITVJ?
NCI-H1650 M4LPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTdwMkewOFYh|ryP NVPGeJRHW0GQR1XS
AsPC-1 NWPMS|BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlntTWM2OD15LkK4OlA2KM7:TR?= MWXTRW5ITVJ?
SNU-C2B NWHkR4Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPXTWM2OD15LkK5OVcyKM7:TR?= MkPiV2FPT0WU
MKN7 NITZdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHUPI1KSzVyPUeuN|czOzVizszN NGXGXmVUSU6JRWK=
SW620 NF24[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTdwM{iyNFUh|ryP M3Trc3NCVkeHUh?=
SK-MEL-28 NHHwZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\2R3pnUUN3ME23MlQxPzl6IN88US=> NVywWoR2W0GQR1XS
TE-6 NWnOdoh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;XRmlEPTB;Nz60OFkxQCEQvF2= M3f5T3NCVkeHUh?=
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CAL-62 NXjhbFJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr2c2NKSzVyPUKyMlc2OTdizszN NInHenpUSU6JRWK=
HCE-T NFHLWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInwNlFKSzVyPUKyMlg3ODZizszN MoixV2FPT0WU
BB65-RCC M{XCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvGfIVuUUN3ME2yN{4xOzR2IN88US=> M1rWNHNCVkeHUh?=
SiHa MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLxWndKSzVyPUKzMlM6PjhizszN Ml3FV2FPT0WU
NCI-H2081 M3LRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTJ2LkC2OFEh|ryP M1fpeXNCVkeHUh?=
U251 M2i5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrOSVdDUUN3ME2yOE4xPjZ6IN88US=> M2fNVXNCVkeHUh?=
LoVo M1HadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHOTWM2OD1{ND65NlgzKM7:TR?= MlS2V2FPT0WU
GCIY MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q4[WlEPTB;MkWuNlg4PyEQvF2= MXvTRW5ITVJ?
NUGC-3 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;5cGlEPTB;MkWuN|MyPiEQvF2= NXPqfnJWW0GQR1XS
LNCaP-Clone-FGC M2PJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrhRpZKSzVyPUK1MlM1QThizszN NFPMfmxUSU6JRWK=
PA-1 NX3nT29yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnyRXNOUUN3ME2yOU43QDN|IN88US=> M3\E[3NCVkeHUh?=
OE33 NYj1WItsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP1TWM2OD1{NT62PFU{KM7:TR?= MXXTRW5ITVJ?
HT-29 NFfj[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ3Lke4O|kh|ryP M2jIcXNCVkeHUh?=
RCM-1 NEPOPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnTTWM2OD1{NT65OlU3KM7:TR?= NIHoVIRUSU6JRWK=
NCI-H1522 NWHZc2c1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKxfYhKSzVyPUK1Mlk6OTFizszN MoraV2FPT0WU
LB373-MEL-D NITOc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jhUmlEPTB;Mk[uNVcxQCEQvF2= M2jld3NCVkeHUh?=
NCI-H1436 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLibYxDUUN3ME2yOk4zPzN6IN88US=> NV\SNlA5W0GQR1XS
COLO-824 NXnwbYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jBdGlEPTB;Mk[uOFAxOiEQvF2= MnvUV2FPT0WU
CP50-MEL-B NHrKPXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jDVmlEPTB;Mk[uOVY4PSEQvF2= MkfuV2FPT0WU
EGI-1 M2DYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;BTWM2OD1{Nz6yOlk5KM7:TR?= M1TsR3NCVkeHUh?=
LAN-6 NVrxUoVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ5LkO1PVgh|ryP M13NN3NCVkeHUh?=
GAK NWrHcVdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7hOWFKSzVyPUK3MlQzOjVizszN MV\TRW5ITVJ?
MDA-MB-175-VII M1:4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLSOWhzUUN3ME2yO{42ODV|IN88US=> MoLzV2FPT0WU
JVM-2 NITNU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJTHBKSzVyPUK3MlY3OjJizszN MoG3V2FPT0WU
UACC-257 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ5Lk[4O|gh|ryP NELSNpdUSU6JRWK=
SW1783 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7uTWM2OD1{Nz63O|g{KM7:TR?= MnzXV2FPT0WU
HT-3 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfwW3NKSzVyPUK4MlIyPjZizszN MVLTRW5ITVJ?
RL NU\5fZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4THT2lEPTB;MkiuOVkyOSEQvF2= MmHWV2FPT0WU
TK10 NHPFUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrUTWM2OD1{OD62OVM2KM7:TR?= NHi4XWlUSU6JRWK=
HT55 NWfXfVlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTxZ2ZKSzVyPUK5MlA2PjVizszN NXu5So5CW0GQR1XS
BT-20 MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HvUWlEPTB;MkmuNFU5PiEQvF2= NEDNOZBUSU6JRWK=
TGBC24TKB MlfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLETWM2OD1{OT6xPFMyKM7:TR?= MWPTRW5ITVJ?
HSC-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOwcpFKSzVyPUK5MlMxODFizszN NFfqeWZUSU6JRWK=
COLO-205 NH\mR3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13Y[2lEPTB;MkmuN|k1PCEQvF2= M1LaWHNCVkeHUh?=
GT3TKB NXrsN|YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK1TWM2OD1{OT62PFc4KM7:TR?= NYq4[m1SW0GQR1XS
T47D M2Tmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3abVgzUUN3ME2yPU45PTh{IN88US=> MnjpV2FPT0WU
OMC-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNyLkG5NVkh|ryP M3zhW3NCVkeHUh?=
PFSK-1 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PKfmlEPTB;M{GuNlY2QSEQvF2= M1TxVnNCVkeHUh?=
JEG-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjBUpNyUUN3ME2zNU4{PTZzIN88US=> M3;pbXNCVkeHUh?=
RD NWnkT49WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHyfVBDUUN3ME2zNU42OTF3IN88US=> M3TE[XNCVkeHUh?=
NCI-H64 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvLTWM2OD1|Mj60NVc6KM7:TR?= MW\TRW5ITVJ?
DMS-114 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LCSGlEPTB;M{KuOFE5OiEQvF2= M3\wOnNCVkeHUh?=
NCI-H661 NYTCb5dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37wSWlEPTB;M{KuOlUxOSEQvF2= MlHkV2FPT0WU
CAL-148 M136b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnHZm9iUUN3ME2zNk43PjZ3IN88US=> MlT4V2FPT0WU
HuP-T3 NVHob4s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGxTlRPUUN3ME2zNk46OzN6IN88US=> NELzXFBUSU6JRWK=
ES4 MoXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN|LkG3NFUh|ryP MnXSV2FPT0WU
Ca9-22 NYG3R2JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPNTWM2OD1|Mz60OlAyKM7:TR?= M{PTVXNCVkeHUh?=
LP-1 MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTTeFlFUUN3ME2zOE4xQSEQvF2= Ml3NV2FPT0WU
AU565 NYHaUVcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\XTWM2OD1|ND61NFY6KM7:TR?= MUHTRW5ITVJ?
MDA-MB-453 NYHjU4VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvlTWM2OD1|NT6xOFI3KM7:TR?= MWXTRW5ITVJ?
SNU-C1 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO0TWM2OD1|NT6xO|Eh|ryP NVPUelMxW0GQR1XS
SW13 NF7SdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\F[2lEPTB;M{WuOFA4PiEQvF2= M3zGWHNCVkeHUh?=
NCI-H2122 NF;ZRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInqbFRKSzVyPUO1MlU2QThizszN Ml;CV2FPT0WU
NCI-H1395 M4L1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHZUo9KSzVyPUO1MlY3QTFizszN MYjTRW5ITVJ?
J-RT3-T3-5 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XnTGlEPTB;M{[uNFI6PCEQvF2= MmXPV2FPT0WU
COR-L279 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjSWFJZUUN3ME2zOk4yQThzIN88US=> M3X1U3NCVkeHUh?=
ATN-1 NF73OXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnqTWM2OD1|Nj64OVE3KM7:TR?= NYrqXohUW0GQR1XS
HCC2998 MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;MV2VKSzVyPUO2Mlg2PzFizszN NYKxelYyW0GQR1XS
UM-UC-3 M1fnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTN4Lki2O|Uh|ryP MoDQV2FPT0WU
DV-90 M4TyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHm[nI5UUN3ME2zOk46ODZ5IN88US=> Mm\xV2FPT0WU
ES8 NWjaRY5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32yZ2lEPTB;M{[uPVMyQCEQvF2= MULTRW5ITVJ?
YAPC NW\wVlVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;MfWQ{UUN3ME2zOk46PjV2IN88US=> NFXISXlUSU6JRWK=
HCC1599 M3rhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfHd5hKSzVyPUO3MlE3OThizszN MWHTRW5ITVJ?
UMC-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvwTWM2OD1|Nz6yOVA{KM7:TR?= MXvTRW5ITVJ?
THP-1 M17qRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN5LkK4Olgh|ryP NV7vZmc4W0GQR1XS
OCUB-M MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i1XmlEPTB;M{euNlg6OSEQvF2= MXHTRW5ITVJ?
NCI-H1693 NG\ZdXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HleGlEPTB;M{euN|I{OyEQvF2= NX3wZ|dyW0GQR1XS
NCI-H345 M2DVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TBTGlEPTB;M{euN|YzPCEQvF2= M2KzXXNCVkeHUh?=
COLO-800 NYTpe2pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILxTHRKSzVyPUO3MlU3PyEQvF2= MmPLV2FPT0WU
COLO-320-HSR M4ryNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT6TmpDUUN3ME2zPE4{PDl{IN88US=> NI\XeGVUSU6JRWK=
NCI-H596 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPqTWhiUUN3ME2zPE41PDh7IN88US=> NWnMb5NUW0GQR1XS
NCI-H187 NWe5dlM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3rTWM2OD1|OD63N|Q1KM7:TR?= MmjqV2FPT0WU
ECC4 MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nyNmlEPTB;M{muNFgyPCEQvF2= NH[ybZpUSU6JRWK=
KP-4 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fiZmlEPTB;M{muNVI{PSEQvF2= MVrTRW5ITVJ?
NCI-H2227 M4PN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\IbmVKSzVyPUO5MlM6PDlizszN NX3ob21{W0GQR1XS
22RV1 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXhb4tKSzVyPUO5Mlg{QThizszN NH3xOGtUSU6JRWK=
SAS NUP3N5RTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3DXHpKSzVyPUSwMlA6PiEQvF2= MXHTRW5ITVJ?
PANC-10-05 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHhTWM2OD12MD6xPFI5KM7:TR?= MlnSV2FPT0WU
MDA-MB-468 M2\YfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;ITWM2OD12MD61N|Q3KM7:TR?= NYC5O2NFW0GQR1XS
RPMI-7951 NInuNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;tUVRKSzVyPUSxMlIxPzVizszN NW\0N4EyW0GQR1XS
BB49-HNC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLPTWM2OD12MT6yNVc6KM7:TR?= MYXTRW5ITVJ?
23132-87 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHYTWM2OD12MT6yO|MzKM7:TR?= M{HzNnNCVkeHUh?=
HCC1569 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fZRWlEPTB;NEGuNlg5PSEQvF2= M3u2RXNCVkeHUh?=
CP66-MEL NVr2PWR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPjSZVKSzVyPUSyMlE5QDZizszN MkH5V2FPT0WU
K-562 MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HYOWlEPTB;NEKuNlg2PCEQvF2= MWTTRW5ITVJ?
OCI-AML2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvkOJJMUUN3ME20Nk45QTd2IN88US=> NF7xUnlUSU6JRWK=
SW756 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknETWM2OD12Mz6wN|g5KM7:TR?= MXrTRW5ITVJ?
M14 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn4TWM2OD12Mz6zNVg6KM7:TR?= NF76ZWtUSU6JRWK=
NCI-H1623 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTSOmwxUUN3ME20N{41PjRizszN NIf5NHFUSU6JRWK=
KNS-81-FD M{frOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR|Lke2NkDPxE1? M13EeHNCVkeHUh?=
TGBC1TKB NFPFfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q1cGlEPTB;NEOuPVA6QSEQvF2= M{fobnNCVkeHUh?=
RERF-LC-MS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn61TWM2OD12Mz65NlgyKM7:TR?= NIS2SpNUSU6JRWK=
PC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:5PVdKSzVyPUS0MlQ{PDdizszN NF7BcVJUSU6JRWK=
HuP-T4 NVmwfWpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR2LkS0O|Qh|ryP MorUV2FPT0WU
NCI-H510A M3nEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR2LkewPEDPxE1? NIHETINUSU6JRWK=
LB2518-MEL NYjvUWVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTR2Lke5N|ch|ryP NHTENFRUSU6JRWK=
TE-5 NVvTflBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DJW2lEPTB;NEWuPVU5OSEQvF2= MV3TRW5ITVJ?
EW-24 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO2SmxKSzVyPUS2MlE4OjNizszN M{Dme3NCVkeHUh?=
LB647-SCLC NFrBU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TnXGlEPTB;NE[uNlE2PSEQvF2= NXX0PJJFW0GQR1XS
NCI-H524 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvyRXZKSzVyPUS2MlcyQDVizszN MlTsV2FPT0WU
EW-11 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTR4LkmzO|Mh|ryP NVHpdVQzW0GQR1XS
KALS-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTR5LkKwOlYh|ryP MYrTRW5ITVJ?
BT-474 NFX3OFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrpUoZKSzVyPUS3MlQzOTZizszN NYrUcXlqW0GQR1XS
SK-N-AS NEHkbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELjbVlKSzVyPUS3Mlg5QCEQvF2= NF;GUGRUSU6JRWK=
HCC2157 NULVOHB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR6LkC3OkDPxE1? MWnTRW5ITVJ?
HCC1954 NFj5cFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL1doZvUUN3ME20PE4yPzB2IN88US=> M3;rOXNCVkeHUh?=
FADU NWLjVZhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\SV21[UUN3ME20PE4{ODNzIN88US=> NHrMWpRUSU6JRWK=
S-117 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPBb5hKSzVyPUS4MlM5OTVizszN M1\vOnNCVkeHUh?=
LS-1034 NVm3PJdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTR6LkewOlch|ryP NGGxWWlUSU6JRWK=
CAMA-1 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3ZUlI4UUN3ME20PU42PTR|IN88US=> NYnIPHY6W0GQR1XS
LU-134-A MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXjT4xKSzVyPUS5MlgxQDVizszN NFzy[XFUSU6JRWK=
NCI-H1838 M3nDSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rUVWlEPTB;NEmuPFA5PyEQvF2= M4LRNnNCVkeHUh?=

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Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
- 合併

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
- 合併
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
- 合併
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
別名 N/A
Smiles CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04554459 Not yet recruiting Drug: Ponatinib 15 MG Oral Tablet Acute Lymphoblastic Leukemia Adult|Ph+ ALL|Newly Diagnosed Institute of Hematology and Blood Transfusion Czech Republic|CZECRIN - Czech Clinical Research Infrastructure Network October 30 2020 Phase 2
NCT04160546 Recruiting Drug: Ponatinib 15 MG|Drug: Acetylsalicylic acid 100 MG Chronic Myeloid Leukemia Chronic Phase Fundacion CRIS de Investigación para Vencer el Cáncer|Incyte Biosciences UK|Apices Soluciones S.L. January 17 2020 Phase 2
NCT03934372 Recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation January 29 2020 Phase 1|Phase 2
NCT04070443 Recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard November 13 2019 Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Ablシグナル伝達経路

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