Ponatinib (AP24534)

For research use only. Not for use in humans.

製品コードS1490

CAS No. 943319-70-8

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.

サイズ

価格(税別)

10mM (1mL in DMSO)	JPY 18600
10mg	JPY 20200
50mg	JPY 63400
200mg	JPY 163000

最寄りの販売代理店を探す

東京
北海道
東北
北関東
南関東
東海
北信越
近畿
中国
四国
九州

お探しのディーラーが見当たらない場合は直接こちらのメールアドレスまでお問い合わせください：[email protected]

バルク問合せ

代表番号: 03-5615-9297 | 電子メール：[email protected]

文献中Selleckの製品使用例(139)

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明

ターゲット

Abl ^[1] (Cell-free assay)	PDGFRα ^[1] (Cell-free assay)	VEGFR2 ^[1] (Cell-free assay)	FGFR1 ^[1] (Cell-free assay)	c-Src ^[1] (Cell-free assay)	もっとクリックする
0.37 nM	1.1 nM	1.5 nM	2.2 nM	5.4 nM	もっとクリックする

体外試験

AP24534 potently inhibits native Abl, Abl^T315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. ^[1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. ^[3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. ^[4]

細胞データ

Cell Lines	Assay Type	Activity Description	PMID
EoL-1-cell	M1nLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHfJOYJKSzVyPUCuNFAxODByMEO1PUDPxE1?	NHyxeIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
MV-4-11	NX3Hb2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3P5ZmlEPTB;MD6wNFAxQTV4IN88US=>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MEG-01	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDFTWM2OD1yLkCwNFEzQCEQvF2=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LAMA-84	MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXHS[JpJUUN3ME2wMlAxODF4NTFOwG0>	NX25SppkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
CGTH-W-1	NIm4O4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1u4emlEPTB;MD6wNFE3QSEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
KASUMI-1	NIjIfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEfmXYtKSzVyPUCuNFAzOTdizszN	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
BE-13	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUm5PGN5UUN3ME2wMlAxOjV7IN88US=>	MnrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
CTV-1	MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoPtTWM2OD1yLkCwOVIyKM7:TR?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NKM-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnXlTWM2OD1yLkCwOlU2KM7:TR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MONO-MAC-6	NFXOXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrQPFJKSzVyPUCuNFA5OzdizszN	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
A204	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;vZmlEPTB;MD6wNVIyQCEQvF2=	NH3Tdm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
GDM-1	M2XEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmHGTWM2OD1yLkCxPFM{KM7:TR?=	Mlz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
AN3-CA	Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYTETpVJUUN3ME2wMlAyQDd\|IN88US=>	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
BL-70	NFHKfG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWfJR\|UxRTBwMEKxPVkh\|ryP	NX;PdVU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
Daudi	NUi3cI9lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGmwWoVKSzVyPUCuNFI2OzdizszN	NVHnfFNtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
KU812	NEi1NYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF32e3hKSzVyPUCuNFI5PDhizszN	Ml3zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
KG-1	M1jMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmnETWM2OD1yLkCzNlk1KM7:TR?=	M3LCelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
DOHH-2	M17NWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWnJR\|UxRTBwMES4NFMh\|ryP	NW\FZnppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
HuO9	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVz2XoVtUUN3ME2wMlA2PDR6IN88US=>	Mk\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
EB2	M4XXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwMEW1O\|Yh\|ryP	M3j5PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
G-402	M{nibWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUXJR\|UxRTBwME[zOFEh\|ryP	M4TydFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SU-DHL-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUfJR\|UxRTBwME[zO\|kh\|ryP	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H719	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4rnPGlEPTB;MD6wO\|g5QCEQvF2=	MmjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
MLMA	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHLtUpJKSzVyPUCuNFkxPiEQvF2=	Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
KM12	MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEfDOWtKSzVyPUCuNFk4OzdizszN	NIXONYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
SUP-T1	NE\GT\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{DvS2lEPTB;MD6wPVk5OiEQvF2=	M2XMTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
MZ1-PC	NYTtPZVUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoPVTWM2OD1yLkGxN\|M3KM7:TR?=	NEnXbXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
MFE-296	NVXQ[29[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DtN2lEPTB;MD6xNVg{QSEQvF2=	M4TX[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
ALL-PO	NHrybFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTBwMUK0OFMh\|ryP	MoPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
GB-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTBwMUK1NVIh\|ryP	M{LSNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SIG-M5	NUOxdVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnztTWM2OD1yLkGzN\|ch\|ryP	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
P30-OHK	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEfTbohKSzVyPUCuNVU3PzJizszN	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H716	NI\wSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;JZpB{UUN3ME2wMlE3OjZ4IN88US=>	MnTCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
MPP-89	MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTBwMU[5N\|Mh\|ryP	NFvpZWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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LB1047-RCC	MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTBwN{O1N\|gh\|ryP	NFPacYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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KYSE-270	NXLiUIp{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1ThNmlEPTB;MD64NFUzQSEQvF2=	M1HZRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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MFM-223	MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1;CTWlEPTB;MD64NVQxPyEQvF2=	NXn1dIdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
G-361	NYXYT3pST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\iRXFKSzVyPUCuPFE5QTdizszN	NFzaelM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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HT-1376	NF;WdpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnm4TWM2OD1yLki2NFUyKM7:TR?=	NVP5c2N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
COLO-680N	MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTBwOEe5N\|Mh\|ryP	NYXldJdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H1581	MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTBwOEmyPVch\|ryP	NYHmU4MyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
HuCCT1	NVHY[FBvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVrCVVl4UUN3ME2wMlg6PTR6IN88US=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
BB30-HNC	Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3TTb2lEPTB;MD65NlQ3QSEQvF2=	NIjkcHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H2347	MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYT5bXpxUUN3ME2wMlk{Ojl{IN88US=>	NYTifo5DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
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HCC1395	NXKwNJVzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3LrbWlEPTB;MD65OVQ3OSEQvF2=	NGHqPGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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KE-37	MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4m4SWlEPTB;MD65OlM5PyEQvF2=	NWX3TG1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NOMO-1	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mmm4TWM2OD1yLkm2OVY1KM7:TR?=	M2PCdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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SW872	NWLjclIzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3HHe2lEPTB;MD65PVc4PSEQvF2=	NI\4VYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
KYSE-520	NHj4dmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1y2NWlEPTB;MT6wNFQ6PCEQvF2=	M1nNXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
HL-60	Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTFwMEC5O{DPxE1?	NHPacYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HDLM-2	MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUnJR\|UxRTFwMEGyOVIh\|ryP	MljGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
MIA-PaCa-2	NEHGcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH;0eXVKSzVyPUGuNFE{PzVizszN	MmW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
TCCSUP	NVfETIk2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVPlNnZ1UUN3ME2xMlAyPzN{IN88US=>	M{DRVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SH-4	M4DndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrXcmNKSzVyPUGuNFIzPDRizszN	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MG-63	M1nq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGDoOIxKSzVyPUGuNFI3OTZizszN	M{X3V\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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CAL-54	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHK5bFNKSzVyPUGuNFM6PTlizszN	MmL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
DU-145	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoDkTWM2OD1zLkC4NFc{KM7:TR?=	M3LaZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
HCE-4	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIrQOJlKSzVyPUGuNFkzQDZizszN	NG\UWmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
U-266	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH3oPZpKSzVyPUGuNFk3OzNizszN	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
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NCI-H2452	NHzRZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTFwOEmwO\|Qh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SK-MEL-2	NWn1b3RKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF3hfHJKSzVyPUGuPVAzPzFizszN	Ml7hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
OVCAR-5	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF3LVlhKSzVyPUGuPVA3PzVizszN	NG\F[m89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
SNG-M	MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nNSmlEPTB;MT65OVg2QCEQvF2=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
A673	M2nVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTBTWM2OD1zLkm3OVE3KM7:TR?=	NHLSSmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
L-428	M1KyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXrKcJo6UUN3ME2xMlk6OTd7IN88US=>	NFrJPYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
KM-H2	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3PSbWlEPTB;Mj6wNVA6KM7:TR?=	NFnVZ\|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
MC-IXC	MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHriOm9KSzVyPUKuNFIzPzNizszN	M1nQSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
COLO-678	NID3OWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEHib5VKSzVyPUKuNFQzODdizszN	NEjpcZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
MEL-JUSO	M3r2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGnITIlKSzVyPUKuNFc5PTFizszN	NGDMZ5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCC38	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGjBbYlKSzVyPUKuNFg1OzNizszN	M3LiR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
UACC-62	NVLNS5pqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTJwMEi4OVUh\|ryP	NXvPNZV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
OAW-42	M2jMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVXJR\|UxRTJwMEm3NVEh\|ryP	M4W5cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
LB996-RCC	MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;iO49KSzVyPUKuNVM5OTdizszN	NHTiRno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
COR-L105	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYDJR\|UxRTJwMU[zO\|Mh\|ryP	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
RCC10RGB	NHvvb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4P4O2lEPTB;Mj6xPFU4PiEQvF2=	M4HuVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
A431	M3zrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoTwTWM2OD1{LkG5NFE6KM7:TR?=	M2jsOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H292	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHrSRlRKSzVyPUKuNlM6PTFizszN	NWnDRmpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SK-UT-1	NYPGXXk6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUPWTopVUUN3ME2yMlM{OTh2IN88US=>	NFni[XA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
PANC-08-13	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIXv[VVKSzVyPUKuN\|MzOzVizszN	M2\CSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
ST486	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{j2bGlEPTB;Mj60NVA1QCEQvF2=	NWLxXI16RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SJSA-1	M3ThdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1n6RWlEPTB;Mj60NVI4OSEQvF2=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
RKO	M4nZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3PQOWlEPTB;Mj60NlAzQSEQvF2=	NXHJS\|BxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H1793	M3fzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTJwNESwNlkh\|ryP	M4\zZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
639-V	NIPMb25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LxbmlEPTB;Mj60OVM5OiEQvF2=	NXHEboJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
ES3	NGHyVItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTJwNEm3N\|ch\|ryP	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H1792	M4HJWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkHsTWM2OD1{LkW2PFI3KM7:TR?=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H1651	NIH3VIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3nUcWlEPTB;Mj61PFIyKM7:TR?=	NIrqfFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
SN12C	Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIr2NHRKSzVyPUKuOVg1QDdizszN	NXXYe2poRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
COLO-679	NEXYRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoTTTWM2OD1{LkW4OlA2KM7:TR?=	MoW3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
U-118-MG	NHvncWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHQcXZ2UUN3ME2yMlU5QDd{IN88US=>	NHrQZWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
Ramos-2G6-4C10	MkO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLlTWM2OD1{Lk[0PFA4KM7:TR?=	NXTIUnZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
HCT-15	Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXzpXZRIUUN3ME2yMlY5Pzl{IN88US=>	NXLnfolJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
MDA-MB-157	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTJwN{C3OFch\|ryP	NFz2W4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
K5	NWDGT\|lsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnHLTWM2OD1{LkexPFQ2KM7:TR?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MKN45	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIDPbpJKSzVyPUKuO\|M{PjZizszN	Mn3BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
DMS-273	M3zueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2jWeWlEPTB;Mj63OVY{OiEQvF2=	MkfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
C8166	NUHRUWNLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkDOTWM2OD1{Lke4OVE{KM7:TR?=	MlHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
Calu-3	M3vrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEj1Um5KSzVyPUKuO\|g6PjlizszN	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SNB75	MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTJwOEi1N\|Uh\|ryP	NH;iVWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
BFTC-905	Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGXHRmhKSzVyPUKuPVAyQTFizszN	MlrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
C-4-II	M1rGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NY\vVmtpUUN3ME2yMlkyOzV\|IN88US=>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MS-1	M1ezNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2r4PGlEPTB;Mj65Olc3QSEQvF2=	Mnz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
A375	NG\KUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLCcJNGUUN3ME2zMlA5OTh2IN88US=>	M{HqeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
KYSE-70	M37xZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml\MTWM2OD1\|LkC4PFgzKM7:TR?=	NWjhS\|dbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
KYSE-510	MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4PrbGlEPTB;Mz6xNFk6PSEQvF2=	NWH1b3B6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
LN-405	M1z1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIfRZnBKSzVyPUOuNVM2OThizszN	MnznQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
BOKU	NFfnNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2S0PGlEPTB;Mz6xOFI2PiEQvF2=	M3fkZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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Saos-2	NFLp[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYLJR\|UxRTJyLkm1OVYh\|ryP	MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
CHP-126	NE\sPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{PDfGlEPTB;MkGuOFQ3OiEQvF2=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SW837	NXPvfFZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWLJR\|UxRTJzLkS5N\|kh\|ryP	NXToZYJPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SHP-77	NUe0UGJJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlzqTWM2OD1{MT62NVIzKM7:TR?=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
DB	NXnnO4xLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYLrOVJXUUN3ME2yNU43OTR{IN88US=>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
ES5	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHThbm9KSzVyPUKxMlY5PjRizszN	NGjZcY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
COR-L23	M1TWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGW1bY1KSzVyPUKxMlgxPTFizszN	NULTN5FlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
KU-19-19	NVLHc3ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWr3VpBKUUN3ME2yNU45QTh{IN88US=>	MoKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
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NCI-H630	M3XnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkX5TWM2OD1{Mj61N\|Y{KM7:TR?=	NEj3[Yk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
LU-165	MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXz1TI1GUUN3ME2yNk42PTRizszN	M2LLWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
COLO-792	NHLPVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPkNIRCUUN3ME2yNk44OTFzIN88US=>	NHT3e2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
CAL-62	MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1PiV2lEPTB;MkKuO\|UyPyEQvF2=	NFXSeog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCE-T	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3rWRmlEPTB;MkKuPFYxPiEQvF2=	M3K5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
BB65-RCC	MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjLbYxKSzVyPUKzMlA{PDRizszN	M3T1V\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SiHa	NFPZUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2S2bmlEPTB;MkOuN\|k3QCEQvF2=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H2081	NUDTOm82T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTJ2LkC2OFEh\|ryP	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
U251	NX7NXXRRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\UeYFKSzVyPUK0MlA3PjhizszN	NUfnRXl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
LoVo	NU\D[FB{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmrqTWM2OD1{ND65NlgzKM7:TR?=	NXuwSHNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
GCIY	MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1XjPGlEPTB;MkWuNlg4PyEQvF2=	M4XQNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NUGC-3	MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF2zU21KSzVyPUK1MlM{OTZizszN	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LNCaP-Clone-FGC	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmnDTWM2OD1{NT6zOFk5KM7:TR?=	NYC1T\|hFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
PA-1	NXPVeWZbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnfTTWM2OD1{NT62PFM{KM7:TR?=	NXTK[4hwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
OE33	NFL6V\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTJ3Lk[4OVMh\|ryP	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
HT-29	NWrz[FZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTJ3Lke4O\|kh\|ryP	Mk\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
RCM-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkK5TWM2OD1{NT65OlU3KM7:TR?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H1522	M3TaXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUXJR\|UxRTJ3Lkm5NVEh\|ryP	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LB373-MEL-D	M13MZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTJ4LkG3NFgh\|ryP	NUfZfZN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H1436	NFO5VZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXI[IZKSzVyPUK2MlI4OzhizszN	M2Ty[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
COLO-824	NXnmbo1TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTJ4LkSwNFIh\|ryP	MlPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
CP50-MEL-B	NX:ycVdkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlHTTWM2OD1{Nj61Olc2KM7:TR?=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
EGI-1	NEi0TpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33DUmlEPTB;MkeuNlY6QCEQvF2=	MkTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
LAN-6	NFXhbIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoHzTWM2OD1{Nz6zOVk5KM7:TR?=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
GAK	NHzzfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2PLdGlEPTB;MkeuOFIzPSEQvF2=	MnXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
MDA-MB-175-VII	NEXid4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTJ5LkWwOVMh\|ryP	NEjJN2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
JVM-2	Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M371N2lEPTB;MkeuOlYzOiEQvF2=	MlrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
UACC-257	NHfMRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWD0UJV6UUN3ME2yO{43QDd6IN88US=>	M{PtNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SW1783	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH3hcoFKSzVyPUK3Mlc4QDNizszN	NGfY[lM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HT-3	NXz6flB{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXVWVhKUUN3ME2yPE4zOTZ4IN88US=>	MlS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
RL	NUDQ[GNpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlrUTWM2OD1{OD61PVEyKM7:TR?=	M2PTblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
TK10	M3HITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1PPdmlEPTB;MkiuOlU{PSEQvF2=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
HT55	M13PT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFnDPINKSzVyPUK5MlA2PjVizszN	M2Xhd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
BT-20	M36z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYrJR\|UxRTJ7LkC1PFYh\|ryP	NFrTSmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
TGBC24TKB	NEjOZ\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGfKXo5KSzVyPUK5MlE5OzFizszN	NIjZepQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HSC-2	NULZc\|hlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPiV4FKSzVyPUK5MlMxODFizszN	NUf0TllVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
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23132-87	NGHMOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkHCTWM2OD12MT6yO\|MzKM7:TR?=	MlLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
HCC1569	NWe0fVVqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjqOXpKSzVyPUSxMlI5QDVizszN	MlzDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
CP66-MEL	M4DJcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTR{LkG4PFYh\|ryP	NHzEXWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
K-562	MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX6wVXM3UUN3ME20Nk4zQDV2IN88US=>	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
OCI-AML2	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXHJR\|UxRTR{Lki5O\|Qh\|ryP	M2DJWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SW756	NWXldHJST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUTB[VVtUUN3ME20N{4xOzh6IN88US=>	MnLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
M14	M4XVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfjfXBKSzVyPUSzMlMyQDlizszN	NGfsSVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H1623	NVfoU4M3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGHhc4dKSzVyPUSzMlQ3PCEQvF2=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
KNS-81-FD	NETxV4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LDPWlEPTB;NEOuO\|YzKM7:TR?=	NHjBV4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
TGBC1TKB	NX7x[JBTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIfC[VBKSzVyPUSzMlkxQTlizszN	NEnvdWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
RERF-LC-MS	NEHPfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYXiUYxSUUN3ME20N{46OjhzIN88US=>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
PC-3	M3jaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4POXGlEPTB;NESuOFM1PyEQvF2=	MoHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
HuP-T4	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHvx[nNKSzVyPUS0MlQ1PzRizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H510A	NWHtdW01T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF;tSGxKSzVyPUS0MlcxQCEQvF2=	Mle1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
LB2518-MEL	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{jRTWlEPTB;NESuO\|k{PyEQvF2=	NHzz[WQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
TE-5	M1jVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3viR2lEPTB;NEWuPVU5OSEQvF2=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
EW-24	Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTjTWM2OD12Nj6xO\|I{KM7:TR?=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LB647-SCLC	NUDvT5VuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\vd49KSzVyPUS2MlIyPTVizszN	M{XTNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H524	NV7vTWtrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3;VemlEPTB;NE[uO\|E5PSEQvF2=	NFj3N289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
EW-11	M37VcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3O0O2lEPTB;NE[uPVM4OyEQvF2=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
KALS-1	NWTqdlhbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTR5LkKwOlYh\|ryP	NVf3cWd3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
BT-474	NYjsWopOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2XrbGlEPTB;NEeuOFIyPiEQvF2=	NFPEOok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
SK-N-AS	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1j5S2lEPTB;NEeuPFg5KM7:TR?=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
HCC2157	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkG3TWM2OD12OD6wO\|Yh\|ryP	NEDSdY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCC1954	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTR6LkG3NFQh\|ryP	NY\s[mNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
FADU	NXnBNmxmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\6WZNpUUN3ME20PE4{ODNzIN88US=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
S-117	M{\TRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jnNmlEPTB;NEiuN\|gyPSEQvF2=	MlyzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
LS-1034	M{fwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmXJTWM2OD12OD63NFY4KM7:TR?=	M1\GOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
CAMA-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;FTWM2OD12OT61OVQ{KM7:TR?=	M3\YSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
LU-134-A	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XldmlEPTB;NEmuPFA5PSEQvF2=	NHXORYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H1838	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTR7LkiwPFch\|ryP	M{TxUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

アッセイ

Methods	Test Index	PMID
Western blot	pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; PubMed: 22781593 Leukemia In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1. pFGFR1(pY20) / FGFR1; PubMed: 22781593 Leukemia Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; PubMed: 30959969 Molecules Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells. p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; PubMed: 30959969 Molecules Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. RAD51; PubMed: 30959969 Molecules The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells. p-MEK / MEK / p-ERK / ERK; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. c-Jun / p-JNK(T183/Y185) / JNK; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. p-p38 MAPK / p38 MAPK; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. p-JAK2 / JAK2 / p-STAT3 / STAT3; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; PubMed: 30959969 Molecules Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. p-PDGFRα / PDGFRα; PubMed: 24472312 Mol Cancer Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h. PARP / Caspase-3 / Active Caspase-3; PubMed: 24472312 Mol Cancer The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting. AIF / Cyto C ; PubMed: 24472312 Mol Cancer Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting. Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; PubMed: 24472312 Mol Cancer Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h. β-catenin ; PubMed: 24472312 Mol Cancer Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting. β-catenin; PubMed: 24472312 Mol Cancer Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). ABL; PubMed: 19878872 Cancer Cell In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.	22781593 30959969 24472312 19878872
Growth inhibition assay	Cell viability; PubMed: 30174789 Oncotarget (A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.	30174789

体内試験

In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-Abl^T315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. ^[2]

お薦めの試験操作（参考用のみ）

キナーゼ試験：^[1]	- 合併 Peptide substrate phosphorylation assays with GST-Abl kinase domains: The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl₂, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-³²[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験： ^[2]	- 合併細胞株： Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl 濃度： 0-625 nM 反応時間： 72 hours 実験の流れ： Ba/F3 cell lines are distributed in 96-well plates (4 × 10³ cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat (参考用のみ)
動物試験：^[1]	- 合併動物モデル： Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-Abl^T315I 投薬量： 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-Abl^T315I 投与方法： Oral gavage once daily (参考用のみ)

参考

- 合併

溶解度 (25°C)

体外	DMSO	30 mg/mL (56.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ): 1% CMC Na 混合させたのち直ちに使用することを推奨します。	30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報 Ponatinib (AP24534) SDFをダウンロードする

分子量	532.56
化学式	C₂₉H₂₇F₃N₆O
CAS No.	943319-70-8
Storage	3 years-20°C powder 2 years-80°C in solvent
別名	N/A
Smiles	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

投与溶媒組成計算器(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量

mg/kg

動物平均体重

投与体積（動物毎）

動物数

匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO+ % + % Tween 80+ % ddH₂O

計算リセット

計算結果:

投与溶媒濃度： mg/ml；

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL，注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。）

投与溶媒調製方法：μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

質量

濃度

体積

分子量
=

×

×

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力出力 )

C1

V1

C2

V2
×

=

×

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

連続希釈剤
初めの濃度：
稀釈倍数：

計算結果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

臨床試験 (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04554459	Not yet recruiting	Drug: Ponatinib 15 MG Oral Tablet	Acute Lymphoblastic Leukemia Adult\|Ph+ ALL\|Newly Diagnosed	Institute of Hematology and Blood Transfusion Czech Republic\|CZECRIN - Czech Clinical Research Infrastructure Network	October 30 2020	Phase 2
NCT04160546	Recruiting	Drug: Ponatinib 15 MG\|Drug: Acetylsalicylic acid 100 MG	Chronic Myeloid Leukemia Chronic Phase	Fundacion CRIS de Investigación para Vencer el Cáncer\|Incyte Biosciences UK\|Apices Soluciones S.L.	January 17 2020	Phase 2
NCT03934372	Recruiting	Drug: Ponatinib	Acute Myeloid Leukemia\|Accelerated Phase Chronic Myeloid Leukemia\|Blast Phase Chronic Myeloid Leukemia\|Chronic Phase Chronic Myeloid Leukemia\|Acute Lymphoblastic Leukemia\|Acute Lymphocytic Leukemia\|Leukemia\|Lymphoma\|Solid Tumors	Incyte Biosciences International Sàrl\|Incyte Corporation	January 29 2020	Phase 1\|Phase 2
NCT04070443	Recruiting	Drug: Ponatinib\|Drug: Imatinib	Philadelphia Chromosome Positive CML\|BCR-ABL Positive Chronic Myelogenous Leukemia	Centre Leon Berard	November 13 2019	Phase 2
NCT03895671	Recruiting	Drug: Ponatinib\|Drug: Azacitidine	CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE\|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS	Versailles Hospital	June 19 2019	Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須
*大学・企業名:
*名前:
*電子メール:
*電話番号:
*内容:

よくある質問（FAQ）

質問1：
Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?
回答：
Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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FDA-approved Bcr-Abl Inhibitor

Dasatinib : Approved by FDA for CML and Ph+ ALL.
Newest Bcr-Abl Inhibitor

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

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研究分野別

製品類型

Ponatinib (AP24534)

文献中Selleckの製品使用例(139)

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

お薦めの試験操作（参考用のみ）

参考

溶解度 (25°C)

化学情報 Ponatinib (AP24534) SDFをダウンロードする

投与溶媒組成計算器(クリア溶液)

便利ツール

モル濃度計算器

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

希釈計算器

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

連続希釈計算器方程式

連続希釈剤

計算結果

分子量计算器

総分子量：g/mol

モル濃度計算器

臨床試験 (data from https://clinicaltrials.gov, updated on 2021-01-06)

技術サポート

よくある質問（FAQ）

Bcr-Ablシグナル伝達経路

Bcr-Abl Inhibitors with Unique Features

相関Bcr-Abl製品