Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW)：532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00
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文献中Selleckの製品使用例(26)

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 FGFR1 [1]
(Cell-free assay)		 c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUG1e2llUUN3ME2wMlAxODByMECzOVkh|ryP Mn7SV2FPT0WU
MV-4-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMECwNFk2PiEQvF2= NUHEeXY5W0GQR1XS
MEG-01 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC3TWM2OD1yLkCwNFEzQCEQvF2= M{XnWnNCVkeHUh?=
LAMA-84 NW\X[nNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMECwNVY2KM7:TR?= NUD0XIxWW0GQR1XS
CGTH-W-1 NFz5clJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\X[o9UUUN3ME2wMlAxOTZ7IN88US=> MVjTRW5ITVJ?
KASUMI-1 NU\FOZJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXLUVRKSzVyPUCuNFAzOTdizszN Mn6wV2FPT0WU
BE-13 MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECyOVkh|ryP NVP3NW1NW0GQR1XS
CTV-1 NFKzN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17sS2lEPTB;MD6wNFUzOSEQvF2= MlfnV2FPT0WU
NKM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW2[4N4UUN3ME2wMlAxPjV3IN88US=> M{DVVnNCVkeHUh?=
MONO-MAC-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jBUGlEPTB;MD6wNFg{PyEQvF2= MV;TRW5ITVJ?
A204 M{\CSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID0SGxKSzVyPUCuNFEzOThizszN NFe0ZYdUSU6JRWK=
GDM-1 NECzUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEG4N|Mh|ryP M1nLOXNCVkeHUh?=
AN3-CA NF;EWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq0eoFKSzVyPUCuNFE5PzNizszN M1r2bnNCVkeHUh?=
BL-70 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHjSZFjUUN3ME2wMlAzOTl7IN88US=> NXnXd4FwW0GQR1XS
Daudi MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHKwOYRKSzVyPUCuNFI2OzdizszN MkfFV2FPT0WU
KU812 NIrwZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LmUGlEPTB;MD6wNlg1QCEQvF2= MX\TRW5ITVJ?
KG-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6wVJQ{UUN3ME2wMlA{Ojl2IN88US=> M37xfXNCVkeHUh?=
DOHH-2 MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMES4NFMh|ryP M2TJS3NCVkeHUh?=
HuO9 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrBT5pKSzVyPUCuNFU1PDhizszN MlPNV2FPT0WU
EB2 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon1TWM2OD1yLkC1OVc3KM7:TR?= NG\Ge2FUSU6JRWK=
G-402 NH7mfm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7LSIRpUUN3ME2wMlA3OzRzIN88US=> MUHTRW5ITVJ?
SU-DHL-1 MnvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HIU2lEPTB;MD6wOlM4QSEQvF2= MnLTV2FPT0WU
NCI-H719 NHnSS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe4WXhpUUN3ME2wMlA4QDh6IN88US=> MnzYV2FPT0WU
MLMA NH7sfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO5TWM2OD1yLkC5NFYh|ryP M1WwXHNCVkeHUh?=
KM12 NIL0VVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PqPWlEPTB;MD6wPVc{PyEQvF2= NXX4b3ZHW0GQR1XS
SUP-T1 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEm5PFIh|ryP NYnwO4hJW0GQR1XS
MZ1-PC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELTXoFKSzVyPUCuNVE{OzZizszN NUHNNIFIW0GQR1XS
MFE-296 NVSxepBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMUG4N|kh|ryP Mmq2V2FPT0WU
ALL-PO NYHwd2c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\HPGlEPTB;MD6xNlQ1OyEQvF2= Mo\hV2FPT0WU
GB-1 M4\kcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Fe4Y{UUN3ME2wMlEzPTF{IN88US=> NFzHWIdUSU6JRWK=
SIG-M5 NGXle2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELSOGNKSzVyPUCuNVM{PyEQvF2= NIr0[o1USU6JRWK=
P30-OHK MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\zPItKSzVyPUCuNVU3PzJizszN MUnTRW5ITVJ?
NCI-H716 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP5TWM2OD1yLkG2NlY3KM7:TR?= M4nqbXNCVkeHUh?=
MPP-89 NES3b25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jwVmlEPTB;MD6xOlk{OyEQvF2= MXPTRW5ITVJ?
SF126 Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVexWFk2UUN3ME2wMlE4ODZ|IN88US=> NYXUW3F3W0GQR1XS
CTB-1 MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr3TWM2OD1yLkG3N|E3KM7:TR?= NFW5c|ZUSU6JRWK=
CA46 M1ni[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LvVmlEPTB;MD6xO|Q5QSEQvF2= NGTNTllUSU6JRWK=
NCI-H520 NX31eJNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe0eWxKSzVyPUCuNVc4OzJizszN M164dXNCVkeHUh?=
CAL-85-1 NHLRTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDBRVFKSzVyPUCuNVc6OjdizszN NI\Sd4dUSU6JRWK=
NCI-H2342 M{X2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\ETWM2OD1yLkG4OVc4KM7:TR?= M1PSfnNCVkeHUh?=
697 M2XzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLwTWM2OD1yLkG4PFcyKM7:TR?= MXLTRW5ITVJ?
NY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rGRWlEPTB;MD6xPVI5PyEQvF2= NHTKT5BUSU6JRWK=
T98G NHLVdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMUmzNVgh|ryP NIjCT5NUSU6JRWK=
NCI-H1703 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMUm2NVUh|ryP MX3TRW5ITVJ?
NCI-H2087 M1PIPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMkC0N|kh|ryP M2K3cXNCVkeHUh?=
PF-382 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMkC4O|Mh|ryP NXjhN2JxW0GQR1XS
HCT-116 M1\neGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:wTWM2OD1yLkKxNFY6KM7:TR?= MkTTV2FPT0WU
CAKI-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvGW5ZKSzVyPUCuNlE3PjZizszN NUGyT4VPW0GQR1XS
CCF-STTG1 NX7UOIhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jiVmlEPTB;MD6yNlQ4PSEQvF2= MX3TRW5ITVJ?
D-392MG MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv1eZVjUUN3ME2wMlI{OTd5IN88US=> M3zCbXNCVkeHUh?=
RT-112 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jQbmlEPTB;MD6yN|c6PSEQvF2= NVrL[mJTW0GQR1XS
MES-SA M4XMO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDZTWM2OD1yLkK0NVg4KM7:TR?= MX;TRW5ITVJ?
LC-2-ad MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfZWGZKSzVyPUCuNlQzPjVizszN MWXTRW5ITVJ?
NOS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LufGlEPTB;MD6yOFM3PyEQvF2= MknqV2FPT0WU
NALM-6 NV;iWIVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfTTWM2OD1yLkK1OVQ{KM7:TR?= M2Tn[XNCVkeHUh?=
TE-15 NFOwR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMk[wPVEh|ryP M2H4V3NCVkeHUh?=
786-0 Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\WSIpnUUN3ME2wMlI3OjJ6IN88US=> NVjxSINLW0GQR1XS
IST-MES1 NF;ZT|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDFTWM2OD1yLkK2PFI6KM7:TR?= MWDTRW5ITVJ?
KYSE-180 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3BNFAzUUN3ME2wMlI3QDlzIN88US=> NGfmXo9USU6JRWK=
YT MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnuc|ZKSzVyPUCuNlY6PzRizszN MlPnV2FPT0WU
A427 M1LKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TY[mlEPTB;MD6yO|I3PCEQvF2= NVexbG5YW0GQR1XS
KYSE-450 NX7KR21GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXDTmpKSzVyPUCuNlc{OjlizszN M{[3THNCVkeHUh?=
HuH-7 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHU[YIxUUN3ME2wMlI4PzZ|IN88US=> MmniV2FPT0WU
CAS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P3OGlEPTB;MD6yPFMxOyEQvF2= NGr4WVZUSU6JRWK=
KURAMOCHI MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPTW5JKSzVyPUCuNlg1OTlizszN MULTRW5ITVJ?
ACHN NET5dpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ZTWM2OD1yLkK5N|I{KM7:TR?= MmnkV2FPT0WU
HGC-27 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFroNWFKSzVyPUCuNlk{PTNizszN M3T5WnNCVkeHUh?=
A172 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDvTWM2OD1yLkK5OVc4KM7:TR?= MV3TRW5ITVJ?
SNU-449 NX2yPWQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PSbGlEPTB;MD6yPVk3PCEQvF2= MkH1V2FPT0WU
SW982 MlH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMkm5O|gh|ryP NEnJPHlUSU6JRWK=
EFO-21 M2W1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXiwT3pnUUN3ME2wMlMxPDFzIN88US=> M2PVWXNCVkeHUh?=
NCI-H2030 M2LsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3zTWM2OD1yLkOxNVY1KM7:TR?= MknqV2FPT0WU
HT-144 NVLyPJFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwM{GyPEDPxE1? MYfTRW5ITVJ?
MFE-280 Mo\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXZTWM2OD1yLkOxOFU{KM7:TR?= M2XZTHNCVkeHUh?=
SK-LU-1 NXLL[45CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwM{G0OlYh|ryP MYDTRW5ITVJ?
NCI-H2052 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jpVWlEPTB;MD6zNVQ5PCEQvF2= MnrqV2FPT0WU
SK-HEP-1 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV23N3Z7UUN3ME2wMlM{OzZ6IN88US=> MXfTRW5ITVJ?
QIMR-WIL MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NECwdW5KSzVyPUCuN|M1OjRizszN MVjTRW5ITVJ?
A2780 MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XLO2lEPTB;MD6zOFMxPCEQvF2= M4nMTHNCVkeHUh?=
ACN M4PY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKwNHRKSzVyPUCuN|Q5PzNizszN NIPNTmVUSU6JRWK=
BxPC-3 Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjE[pZ1UUN3ME2wMlM1QTh7IN88US=> MoX2V2FPT0WU
BCPAP NFnKXmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;tb2NlUUN3ME2wMlM3ODBzIN88US=> MVnTRW5ITVJ?
HOP-62 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPBTWM2OD1yLkO2NVA3KM7:TR?= M4q5fHNCVkeHUh?=
SW1710 MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvFVYtKSzVyPUCuN|Y1PTVizszN M{\SVXNCVkeHUh?=
OPM-2 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17IdmlEPTB;MD6zOlQ4OyEQvF2= MUnTRW5ITVJ?
DBTRG-05MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;ETWM2OD1yLkO4NFU1KM7:TR?= NFW3clFUSU6JRWK=
SK-MEL-24 NXzxS5NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzFe2dKSzVyPUCuN|k4QTFizszN M1flT3NCVkeHUh?=
8305C NYiyO3VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf4XFJKSzVyPUCuN|k4QTNizszN NGrRVm1USU6JRWK=
OVCAR-4 NFe1fGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HyZWlEPTB;MD60NVU5PiEQvF2= MX7TRW5ITVJ?
HLE M2jRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrZNIJKSzVyPUCuOFE5PiEQvF2= M4LzPHNCVkeHUh?=
NCI-H747 NH;nU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrnTWM2OD1yLkSyNVM4KM7:TR?= MlzlV2FPT0WU
SW780 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjmTWM2OD1yLkSyN|Q3KM7:TR?= MnvhV2FPT0WU
KYSE-150 NGPHfoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwNEK0NVUh|ryP NUXudFdqW0GQR1XS
H4 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDMN5lKUUN3ME2wMlQzPDVzIN88US=> NFrOUINUSU6JRWK=
SW1088 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwNESzPUDPxE1? NVK5UGM{W0GQR1XS
SF268 M4jLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LjOGlEPTB;MD60OFg3KM7:TR?= MmL4V2FPT0WU
RT4 NUXM[201T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLRb3NKSzVyPUCuOFUyOTFizszN NXPiTpByW0GQR1XS
NCI-H522 M4jIO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT6dJZvUUN3ME2wMlQ2OjdizszN M{G4TXNCVkeHUh?=
LCLC-97TM1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrQfoxKSzVyPUCuOFYyQTVizszN M3TtdXNCVkeHUh?=
CAL-39 MlLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\tTWM2OD1yLkS2OVE6KM7:TR?= MmHhV2FPT0WU
CAL-120 NGDafWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwNEe2OFMh|ryP MUTTRW5ITVJ?
ESS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXjSJJ4UUN3ME2wMlQ4QDJzIN88US=> NXj5SWlOW0GQR1XS
KARPAS-45 MkH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q5NGlEPTB;MD60PFk{OyEQvF2= MXTTRW5ITVJ?
DU-4475 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rzdmlEPTB;MD60PVUyOSEQvF2= M3W5TXNCVkeHUh?=
VMRC-RCZ NULKPYlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTtTWM2OD1yLkS5PVA1KM7:TR?= NVXFS4NzW0GQR1XS
HOS NF\3c21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nrZmlEPTB;MD61NFM3PSEQvF2= MmjKV2FPT0WU
MOLT-16 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLwNlZ1UUN3ME2wMlUyQDB6IN88US=> M4G1NHNCVkeHUh?=
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NCI-H2452 NG\2XnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\5R|ZKSzVyPUGuPFkxPzRizszN NGDQZ4ZUSU6JRWK=
SK-MEL-2 NV7QeJlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XofmlEPTB;MT65NFI4OSEQvF2= MXPTRW5ITVJ?
OVCAR-5 NWTyNYNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Id5FyUUN3ME2xMlkxPjd3IN88US=> NWTBblNnW0GQR1XS
SNG-M M1;FeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHlWo1LUUN3ME2xMlk2QDV6IN88US=> MkS5V2FPT0WU
A673 M2jZc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;tbWlEPTB;MT65O|UyPiEQvF2= M2rxfHNCVkeHUh?=
L-428 NH7ZdYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLjXoZ7UUN3ME2xMlk6OTd7IN88US=> NIjq[W5USU6JRWK=
KM-H2 NGfkOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPzTWM2OD1{LkCxNFkh|ryP NYLKPFVOW0GQR1XS
MC-IXC Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfrfHROUUN3ME2yMlAzOjd|IN88US=> MV3TRW5ITVJ?
COLO-678 NFjSSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwMESyNFch|ryP NV[5eHp4W0GQR1XS
MEL-JUSO NVLqTIRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDhTWM2OD1{LkC3PFUyKM7:TR?= M3TPb3NCVkeHUh?=
HCC38 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTEfFFKSzVyPUKuNFg1OzNizszN M{fYVnNCVkeHUh?=
UACC-62 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXnTWM2OD1{LkC4PFU2KM7:TR?= M4fu[HNCVkeHUh?=
OAW-42 Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrvdWVuUUN3ME2yMlA6PzFzIN88US=> MXnTRW5ITVJ?
LB996-RCC NFS2fItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\qZWlEPTB;Mj6xN|gyPyEQvF2= NXjRSJJmW0GQR1XS
COR-L105 M2H5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojWTWM2OD1{LkG2N|c{KM7:TR?= MkTEV2FPT0WU
RCC10RGB Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonTTWM2OD1{LkG4OVc3KM7:TR?= M2nN[HNCVkeHUh?=
A431 NUPM[FJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTuWHFIUUN3ME2yMlE6ODF7IN88US=> MlH5V2FPT0WU
NCI-H292 NIHxflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\WNWlEPTB;Mj6yN|k2OSEQvF2= M4DGfnNCVkeHUh?=
SK-UT-1 NGjsb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJwM{OxPFQh|ryP MkPLV2FPT0WU
PANC-08-13 M37pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHWd2w6UUN3ME2yMlM{OjN3IN88US=> NUXxS2xoW0GQR1XS
ST486 NIK3UI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn2TWM2OD1{LkSxNFQ5KM7:TR?= NF3ncnJUSU6JRWK=
SJSA-1 NGjvN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD0TWM2OD1{LkSxNlcyKM7:TR?= M1TjSXNCVkeHUh?=
RKO NYTy[oxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXUc5RXUUN3ME2yMlQzODJ7IN88US=> MXvTRW5ITVJ?
NCI-H1793 NVT2OJptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q0[2lEPTB;Mj60OFAzQSEQvF2= MV7TRW5ITVJ?
639-V NIntcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XucWlEPTB;Mj60OVM5OiEQvF2= MUHTRW5ITVJ?
ES3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn6PJZKSzVyPUKuOFk4OzdizszN NYjyVFBDW0GQR1XS
NCI-H1792 NYfIRohLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJwNU[4NlYh|ryP NIG4Z2RUSU6JRWK=
NCI-H1651 NUW5UIJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX6fYh3UUN3ME2yMlU5OjFizszN M37JenNCVkeHUh?=
SN12C NWPjbpBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX5VYVIUUN3ME2yMlU5PDh5IN88US=> MXvTRW5ITVJ?
COLO-679 NXLqVXlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP1UY53UUN3ME2yMlU5PjB3IN88US=> MUDTRW5ITVJ?
U-118-MG NGjuZ5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;lcmlEPTB;Mj61PFg4OiEQvF2= MlrzV2FPT0WU
Ramos-2G6-4C10 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwNkS4NFch|ryP M1LLenNCVkeHUh?=
HCT-15 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnid5F6UUN3ME2yMlY5Pzl{IN88US=> MVXTRW5ITVJ?
MDA-MB-157 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHSeI9KSzVyPUKuO|A4PDdizszN NHezfZhUSU6JRWK=
K5 M1XZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHudI9KSzVyPUKuO|E5PDVizszN NWT0W3d4W0GQR1XS
MKN45 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTJV2E3UUN3ME2yMlc{OzZ4IN88US=> NHTjPHpUSU6JRWK=
DMS-273 NEi1OXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nzbWlEPTB;Mj63OVY{OiEQvF2= NFTG[|JUSU6JRWK=
C8166 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jYUWlEPTB;Mj63PFUyOyEQvF2= MULTRW5ITVJ?
Calu-3 NI\SSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jNU2lEPTB;Mj63PFk3QSEQvF2= NYLRbWhxW0GQR1XS
SNB75 MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Da[2lEPTB;Mj64PFU{PSEQvF2= NXrjeGpHW0GQR1XS
BFTC-905 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwOUCxPVEh|ryP NXPpRWMyW0GQR1XS
C-4-II MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XOT2lEPTB;Mj65NVM2OyEQvF2= NH7OV3dUSU6JRWK=
MS-1 Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7DTWM2OD1{Lkm2O|Y6KM7:TR?= MVLTRW5ITVJ?
A375 MmPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfxcWJKSzVyPUOuNFgyQDRizszN NFzldJFUSU6JRWK=
KYSE-70 NWDuVY1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNwMEi4PFIh|ryP NIPNTlhUSU6JRWK=
KYSE-510 M4CwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\BTWM2OD1|LkGwPVk2KM7:TR?= MmjXV2FPT0WU
LN-405 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfMTWM2OD1|LkGzOVE5KM7:TR?= NV62fWw1W0GQR1XS
BOKU NFHWe5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnrbJpnUUN3ME2zMlE1OjV4IN88US=> NWDIbHdbW0GQR1XS
TE-10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\2SJp{UUN3ME2zMlE4OzZ{IN88US=> MXLTRW5ITVJ?
MKN1 NWrUXZdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD1|LkG4OFg{KM7:TR?= NWXWbVRnW0GQR1XS
M059J NUXudXJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4GzZ2lEPTB;Mz6yNFE4OyEQvF2= M{fncnNCVkeHUh?=
GOTO MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrCNopKSzVyPUOuNlIxOzlizszN NWW3SFkzW0GQR1XS
DK-MG M1zsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTlTm9bUUN3ME2zMlI2QTd4IN88US=> MojpV2FPT0WU
NCI-H727 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe2dIJ[UUN3ME2zMlI3PThizszN NWC1dnd2W0GQR1XS
NB12 NY\TZ4Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW4TWM2OD1|LkOzNlI1KM7:TR?= M1zxSnNCVkeHUh?=
DOK MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LoR2lEPTB;Mz6zOlE5PiEQvF2= MW\TRW5ITVJ?
KYSE-410 NH3J[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK0TWM2OD1|LkO2Nlg4KM7:TR?= Mm\xV2FPT0WU
AM-38 NFfDVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\nNmJKSzVyPUOuN|gxPTFizszN M2G1fnNCVkeHUh?=
GR-ST NVH0XFJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHIdZhRUUN3ME2zMlQ2PzN{IN88US=> NIr6RY9USU6JRWK=
D-247MG Moj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfDZo5KSzVyPUOuOFgzPjNizszN NYPXfY5RW0GQR1XS
TE-8 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf4RY1KSzVyPUOuOFk{OzNizszN M1\kOHNCVkeHUh?=
LS-411N NX36c|U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvDNopDUUN3ME2zMlQ6Pjl{IN88US=> M2XuTXNCVkeHUh?=
SK-MES-1 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNwNU[0N|Mh|ryP NGH0bXFUSU6JRWK=
SF295 NGHweoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTUTWM2OD1|Lk[xOVUzKM7:TR?= MoLSV2FPT0WU
SK-MEL-30 M3n0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrqTWM2OD1|Lk[1PVIyKM7:TR?= M1XsVXNCVkeHUh?=
LB2241-RCC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\wPGlEPTB;Mz62OlI3KM7:TR?= NF[3NXdUSU6JRWK=
PC-14 Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SwUWlEPTB;Mz62OlQ{PyEQvF2= M4HIO3NCVkeHUh?=
EW-7 NYXScnRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fNRmlEPTB;Mz62O|Y6OyEQvF2= MV3TRW5ITVJ?
NMC-G1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNwN{G4N|ch|ryP MXjTRW5ITVJ?
TE-441-T MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnxUG4yUUN3ME2zMlc{ODJ6IN88US=> NHOwVmlUSU6JRWK=
NCI-H1618 NXnmT5pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNwOEG4O|Uh|ryP NI\VeVVUSU6JRWK=
PANC-03-27 NI\KVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LFU2lEPTB;Mz64NVkyPiEQvF2= MkHJV2FPT0WU
NCI-H2228 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i2ZmlEPTB;Mz64N|EzPiEQvF2= MVHTRW5ITVJ?
CAPAN-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y3cmlEPTB;Mz64O|AxQSEQvF2= MYHTRW5ITVJ?
KLE M{K1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XQXGlEPTB;Mz65NFY4KM7:TR?= MYDTRW5ITVJ?
Becker MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe0VFNrUUN3ME2zMlkzQDR7IN88US=> M4X6TnNCVkeHUh?=
SK-PN-DW NEDEdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTRwMEe5O|Qh|ryP NH72Z4ZUSU6JRWK=
Hs-578-T Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3STWM2OD12LkC4N|A3KM7:TR?= M2HpbXNCVkeHUh?=
RS4-11 NUjDRphMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vmVmlEPTB;ND6xNVI2PSEQvF2= NHu5XYtUSU6JRWK=
D-502MG NXu4eJpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjOe4tpUUN3ME20MlE3QTl5IN88US=> NH34ZodUSU6JRWK=
GI-1 NIDubnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;jUWlEPTB;ND6yPFI6QSEQvF2= NVHIdm02W0GQR1XS
NCI-H209 NGXveZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fSfWlEPTB;ND6zN|c5KM7:TR?= NH;jXXFUSU6JRWK=
SK-OV-3 NV3DfXF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjOWohKSzVyPUSuOFgyPDlizszN NXKzbGhjW0GQR1XS
LOUCY NIDrW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LoXWlEPTB;ND60PFQ{OiEQvF2= MXnTRW5ITVJ?
NCI-H69 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTRwNUG3PVMh|ryP NV\3d5NGW0GQR1XS
SCC-9 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L5ZWlEPTB;ND61N|E4OiEQvF2= M1mxT3NCVkeHUh?=
NCI-H526 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HTN2lEPTB;ND61PVI6OyEQvF2= NE\wNXlUSU6JRWK=
NCI-H2170 NYjiUpdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\vSWNzUUN3ME20MlY3PzdzIN88US=> M{HDeXNCVkeHUh?=
SR M2m4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHtTWM2OD12LkewNFQ5KM7:TR?= NGD2[IFUSU6JRWK=
CMK MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTRwN{KxNFEh|ryP M1nTdnNCVkeHUh?=
COLO-829 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ZVVRuUUN3ME20Mlc4ODR|IN88US=> MY\TRW5ITVJ?
HuO-3N1 M4fET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTRwOEOyPFEh|ryP M4f3OnNCVkeHUh?=
5637 NIHTN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ntdmlEPTB;ND65NFQ5PyEQvF2= NGTsNplUSU6JRWK=
A253 NF7XRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrNNlNxUUN3ME20Mlk4PzB6IN88US=> M{Gy[HNCVkeHUh?=
NB10 M4PpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e4VWlEPTB;NT6wO|Q6PyEQvF2= NVrmTlBiW0GQR1XS
SF539 NGXtTItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor3TWM2OD13LkC5PVU6KM7:TR?= M3;L[XNCVkeHUh?=
HAL-01 M2fn[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHlTWM2OD13LkG0OlQ2KM7:TR?= MUnTRW5ITVJ?
MHH-ES-1 M4nabGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTzTWM2OD13LkG2PVI2KM7:TR?= NIrrdZBUSU6JRWK=
DEL NW\wbmFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfwZ2lKSzVyPUWuNlc2QDJizszN MmHpV2FPT0WU
NCI-H1299 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvLOXJKSzVyPUWuN|UxODdizszN M3e1UXNCVkeHUh?=
ChaGo-K-1 NHqyPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfQT|JKSzVyPUWuN|UyODdizszN NVjXPGttW0GQR1XS
HMV-II NXPuUWFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTVwM{m0N{DPxE1? NFLiXIhUSU6JRWK=
NB69 NYq1eXZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PDemlEPTB;NT6zPVY{OSEQvF2= NWLxNI1PW0GQR1XS
NCI-H1882 NF7yZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYG5cWZpUUN3ME21MlQ{OzZ2IN88US=> MmrrV2FPT0WU
SNU-475 NW\LVGlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnOUoRKSzVyPUWuOFcyPzFizszN M4f1dXNCVkeHUh?=
RXF393 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTVwNEi0PVQh|ryP MXfTRW5ITVJ?
CAL-51 NX:yfJY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHmZ4FKSzVyPUWuOlI5PTNizszN M4XFe3NCVkeHUh?=
SW1573 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrpTWM2OD13Lk[zOVM1KM7:TR?= MY\TRW5ITVJ?
GCT MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DZTWlEPTB;NT63OVkzQSEQvF2= MYrTRW5ITVJ?
COR-L88 M1Tp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLrVnhKSzVyPUWuO|Y5PDZizszN NHHRdllUSU6JRWK=
MDA-MB-134-VI MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ztSmlEPTB;NT64O|U{PiEQvF2= M{jHTXNCVkeHUh?=
NB5 MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3OXItKSzVyPUWuPVI1PCEQvF2= MVLTRW5ITVJ?
GMS-10 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTVwOU[4OlEh|ryP M{XWZnNCVkeHUh?=
CHP-212 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn0[WVKSzVyPU[uOFgzPjdizszN M2LLcXNCVkeHUh?=
TE-11 M2Pn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHqyNnZKSzVyPU[uOVUyQDJizszN M1;hT3NCVkeHUh?=
SW962 NYrad|FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTZwNkW3O|Qh|ryP MkfRV2FPT0WU
MZ2-MEL MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rqW2lEPTB;Nj64NlAyOSEQvF2= MlTpV2FPT0WU
C-33-A NITqXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHexdmNKSzVyPU[uPVE3QDhizszN NXuyOmdzW0GQR1XS
IGR-1 M{TGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDrWIlKSzVyPU[uPVc5OjZizszN MV3TRW5ITVJ?
MOLT-4 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTdwMUW0NFYh|ryP MYXTRW5ITVJ?
NCI-H1650 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PjWGlEPTB;Nz6yO|A1PiEQvF2= NGXtVHhUSU6JRWK=
AsPC-1 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTdwMki2NFUh|ryP NG\a[phUSU6JRWK=
SNU-C2B Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K0b2lEPTB;Nz6yPVU4OSEQvF2= NFHmOlZUSU6JRWK=
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T84 NWnMNm57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrsTWM2OD1{MT65PFE6KM7:TR?= MXfTRW5ITVJ?
NCI-H630 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJ{LkWzOlMh|ryP M4X2bnNCVkeHUh?=
LU-165 NFfQUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor1TWM2OD1{Mj61OVQh|ryP NFr3ZlVUSU6JRWK=
COLO-792 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHMWHE{UUN3ME2yNk44OTFzIN88US=> MYTTRW5ITVJ?
CAL-62 NIHCNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJ{Lke1NVch|ryP M1fWdXNCVkeHUh?=
HCE-T MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ{Lki2NFYh|ryP M3TXfnNCVkeHUh?=
BB65-RCC NYHlNFJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfjVYtKSzVyPUKzMlA{PDRizszN M3i4[XNCVkeHUh?=
SiHa NVPYWnhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHIe2x5UUN3ME2yN{4{QTZ6IN88US=> MnrLV2FPT0WU
NCI-H2081 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXzfGdTUUN3ME2yOE4xPjRzIN88US=> NWCyT|RvW0GQR1XS
U251 M2[xPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjjTWM2OD1{ND6wOlY5KM7:TR?= NEHpU2FUSU6JRWK=
LoVo MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULq[pl4UUN3ME2yOE46Ojh{IN88US=> NWf5T3BRW0GQR1XS
GCIY NYrle4JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPwTWM2OD1{NT6yPFc4KM7:TR?= NFTiR5RUSU6JRWK=
NUGC-3 NXLDZlJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV36dZJJUUN3ME2yOU4{OzF4IN88US=> Mm\IV2FPT0WU
LNCaP-Clone-FGC NGr0TYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO1TWM2OD1{NT6zOFk5KM7:TR?= M1rydHNCVkeHUh?=
PA-1 NH23eJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHkTWM2OD1{NT62PFM{KM7:TR?= MVzTRW5ITVJ?
OE33 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly4TWM2OD1{NT62PFU{KM7:TR?= MnLNV2FPT0WU
HT-29 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnJUoxsUUN3ME2yOU44QDd7IN88US=> M2r5RnNCVkeHUh?=
RCM-1 M1jhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j2N2lEPTB;MkWuPVY2PiEQvF2= NE[zellUSU6JRWK=
NCI-H1522 NFnuT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Cw[GlEPTB;MkWuPVkyOSEQvF2= M1;UTXNCVkeHUh?=
LB373-MEL-D NVXoe3BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn2fHJnUUN3ME2yOk4yPzB6IN88US=> MUHTRW5ITVJ?
NCI-H1436 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M331dmlEPTB;Mk[uNlc{QCEQvF2= M4jRdHNCVkeHUh?=
COLO-824 MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXjRpk3UUN3ME2yOk41ODB{IN88US=> Ml;iV2FPT0WU
CP50-MEL-B MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PMUWlEPTB;Mk[uOVY4PSEQvF2= M4Hn[3NCVkeHUh?=
EGI-1 NHzPfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET1VlBKSzVyPUK3MlI3QThizszN M4nQPXNCVkeHUh?=
LAN-6 NVLqZmVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJ5LkO1PVgh|ryP NEfKZplUSU6JRWK=
GAK MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvTTWM2OD1{Nz60NlI2KM7:TR?= MlLwV2FPT0WU
MDA-MB-175-VII Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXrTJpKSzVyPUK3MlUxPTNizszN NYq4NpFVW0GQR1XS
JVM-2 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vGeWlEPTB;MkeuOlYzOiEQvF2= NF3GWVNUSU6JRWK=
UACC-257 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P1XWlEPTB;MkeuOlg4QCEQvF2= NVXrfYdSW0GQR1XS
SW1783 NFzzWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOwWVBKSzVyPUK3Mlc4QDNizszN MXLTRW5ITVJ?
HT-3 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ6LkKxOlYh|ryP M4TabnNCVkeHUh?=
RL NE\GTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTQbolKSzVyPUK4MlU6OTFizszN M3q2NnNCVkeHUh?=
TK10 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvoTIdKSzVyPUK4MlY2OzVizszN Mo\oV2FPT0WU
HT55 NF\yPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6N4FsUUN3ME2yPU4xPTZ3IN88US=> Mo\lV2FPT0WU
BT-20 MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHVTWM2OD1{OT6wOVg3KM7:TR?= M2q5VHNCVkeHUh?=
TGBC24TKB MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHjTWM2OD1{OT6xPFMyKM7:TR?= NH65fZdUSU6JRWK=
HSC-2 NVHTO|MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\3TWM2OD1{OT6zNFAyKM7:TR?= MoPEV2FPT0WU
COLO-205 NX\oOZlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TI[mlEPTB;MkmuN|k1PCEQvF2= M3S3enNCVkeHUh?=
GT3TKB NYHxNXJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELxN3JKSzVyPUK5MlY5PzdizszN NV[2SYMxW0GQR1XS
T47D Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S5WmlEPTB;MkmuPFU5OiEQvF2= M{HvNXNCVkeHUh?=
OMC-1 NYTHWIZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLwe|JKSzVyPUOwMlE6OTlizszN M1zqTHNCVkeHUh?=
PFSK-1 M4K3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jIVmlEPTB;M{GuNlY2QSEQvF2= M2jBOnNCVkeHUh?=
JEG-3 M4rkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvENXVKSzVyPUOxMlM2PjFizszN MmHEV2FPT0WU
RD M17hSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jiTmlEPTB;M{GuOVEyPSEQvF2= NWnzXYxDW0GQR1XS
NCI-H64 MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX3TWM2OD1|Mj60NVc6KM7:TR?= NV:2fmNHW0GQR1XS
DMS-114 NXPodI5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHXfZVKSzVyPUOyMlQyQDJizszN NXj1dmpiW0GQR1XS
NCI-H661 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i2O2lEPTB;M{KuOlUxOSEQvF2= M{SxNnNCVkeHUh?=
CAL-148 NGT2UplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqzNoVKSzVyPUOyMlY3PjVizszN MVfTRW5ITVJ?
HuP-T3 NUDLbohrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv4VodlUUN3ME2zNk46OzN6IN88US=> M2fOdXNCVkeHUh?=
ES4 MkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjkTWM2OD1|Mz6xO|A2KM7:TR?= NYXSXVQ2W0GQR1XS
Ca9-22 NG\mR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnLSGNIUUN3ME2zN{41PjBzIN88US=> MW\TRW5ITVJ?
LP-1 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLoTWNvUUN3ME2zOE4xQSEQvF2= MkL4V2FPT0WU
AU565 NH3Ge4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDFUpdKSzVyPUO0MlUxPjlizszN MYTTRW5ITVJ?
MDA-MB-453 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnUO|JKSzVyPUO1MlE1OjZizszN NH[zOYpUSU6JRWK=
SNU-C1 M4\ZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvscHdQUUN3ME2zOU4yPzFizszN M2TTUHNCVkeHUh?=
SW13 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LsZmlEPTB;M{WuOFA4PiEQvF2= M4\yXXNCVkeHUh?=
NCI-H2122 NVjlOWVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;ETWM2OD1|NT61OVk5KM7:TR?= NIfBNpJUSU6JRWK=
NCI-H1395 NGjBOItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jYU2lEPTB;M{WuOlY6OSEQvF2= NETBO3VUSU6JRWK=
J-RT3-T3-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\LWYExUUN3ME2zOk4xOjl2IN88US=> MWTTRW5ITVJ?
COR-L279 NXrPN3ZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;uTWM2OD1|Nj6xPVgyKM7:TR?= M1uxOHNCVkeHUh?=
ATN-1 NFntfnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTN4Lki1NVYh|ryP M4PTZ3NCVkeHUh?=
HCC2998 MnfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK4TWM2OD1|Nj64OVcyKM7:TR?= NYXl[WoxW0GQR1XS
UM-UC-3 Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M321OmlEPTB;M{[uPFY4PSEQvF2= M3\LWHNCVkeHUh?=
DV-90 NFrMfoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fQfGlEPTB;M{[uPVA3PyEQvF2= NVu5[nVMW0GQR1XS
ES8 NXLlWY9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWTWM2OD1|Nj65N|E5KM7:TR?= NFLqTJBUSU6JRWK=
YAPC MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfETWM2OD1|Nj65OlU1KM7:TR?= M{W2[3NCVkeHUh?=
HCC1599 NHHNepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTpcpVKSzVyPUO3MlE3OThizszN MlXuV2FPT0WU
UMC-11 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfSTWM2OD1|Nz6yOVA{KM7:TR?= Mk\RV2FPT0WU
THP-1 NHq5TG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTN5LkK4Olgh|ryP MV\TRW5ITVJ?
OCUB-M MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7ldZlKSzVyPUO3MlI5QTFizszN NIXB[m5USU6JRWK=
NCI-H1693 MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nDTWlEPTB;M{euN|I{OyEQvF2= NW\J[XdwW0GQR1XS
NCI-H345 M4PpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;QdoRXUUN3ME2zO{4{PjJ2IN88US=> M4T0enNCVkeHUh?=
COLO-800 NFPxTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W3S2lEPTB;M{euOVY4KM7:TR?= NIPTc5RUSU6JRWK=
COLO-320-HSR M2ey[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrOeJRKSzVyPUO4MlM1QTJizszN NWDYUXVoW0GQR1XS
NCI-H596 NH7SNINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH0TWM2OD1|OD60OFg6KM7:TR?= M2fJPHNCVkeHUh?=
NCI-H187 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN6LkezOFQh|ryP NEmxe2RUSU6JRWK=
ECC4 M1v5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:wZmtKSzVyPUO5MlA5OTRizszN M{jFeHNCVkeHUh?=
KP-4 M3PpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULlRllqUUN3ME2zPU4yOjN3IN88US=> M{LGR3NCVkeHUh?=
NCI-H2227 M3TBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTN7LkO5OFkh|ryP NEfWcHpUSU6JRWK=
22RV1 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljrTWM2OD1|OT64N|k5KM7:TR?= NUPpO5piW0GQR1XS
SAS MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i4bmlEPTB;NECuNFk3KM7:TR?= MXXTRW5ITVJ?
PANC-10-05 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnruTWM2OD12MD6xPFI5KM7:TR?= NIjOdXBUSU6JRWK=
MDA-MB-468 NX7JZZhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTKcJEyUUN3ME20NE42OzR4IN88US=> MnHRV2FPT0WU
RPMI-7951 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle1TWM2OD12MT6yNFc2KM7:TR?= NUHFPW51W0GQR1XS
BB49-HNC NXfuXJE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTQOodZUUN3ME20NU4zOTd7IN88US=> NXnleIgxW0GQR1XS
23132-87 NHS2ZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTRzLkK3N|Ih|ryP NIXuUFJUSU6JRWK=
HCC1569 NYTvbVlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfre4Z4UUN3ME20NU4zQDh3IN88US=> MoOwV2FPT0WU
CP66-MEL MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnGXpVCUUN3ME20Nk4yQDh4IN88US=> MkfNV2FPT0WU
K-562 MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLrTWM2OD12Mj6yPFU1KM7:TR?= MlLmV2FPT0WU
OCI-AML2 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Wwb2lEPTB;NEKuPFk4PCEQvF2= M1nTSHNCVkeHUh?=
SW756 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfpbmhKSzVyPUSzMlA{QDhizszN MXfTRW5ITVJ?
M14 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;EdIhKSzVyPUSzMlMyQDlizszN NVr1ZYZpW0GQR1XS
NCI-H1623 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjiWJR7UUN3ME20N{41PjRizszN NX60Sm5{W0GQR1XS
KNS-81-FD NHzvPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XSR2lEPTB;NEOuO|YzKM7:TR?= NEDTbHpUSU6JRWK=
TGBC1TKB Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTR|LkmwPVkh|ryP MnnnV2FPT0WU
RERF-LC-MS M3v2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojwTWM2OD12Mz65NlgyKM7:TR?= MkX2V2FPT0WU
PC-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPzc2pEUUN3ME20OE41OzR5IN88US=> Mlv2V2FPT0WU
HuP-T4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTR2LkS0O|Qh|ryP M3;IdXNCVkeHUh?=
NCI-H510A NGrRR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSwR2lKSzVyPUS0MlcxQCEQvF2= M3zNcnNCVkeHUh?=
LB2518-MEL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M173dWlEPTB;NESuO|k{PyEQvF2= NFT4XHdUSU6JRWK=
TE-5 M1vvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGntOpZKSzVyPUS1Mlk2QDFizszN NWTBV|RlW0GQR1XS
EW-24 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\PT|BKSzVyPUS2MlE4OjNizszN MnnuV2FPT0WU
LB647-SCLC NUP2dHBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqxUGl{UUN3ME20Ok4zOTV3IN88US=> M1Tac3NCVkeHUh?=
NCI-H524 NFPQd2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTR4LkexPFUh|ryP NYXneoVPW0GQR1XS
EW-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;CRWlEPTB;NE[uPVM4OyEQvF2= MWnTRW5ITVJ?
KALS-1 NXLwc3plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnGTWM2OD12Nz6yNFY3KM7:TR?= NWnTZpd4W0GQR1XS
BT-474 NGTWdItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfSTWM2OD12Nz60NlE3KM7:TR?= NYLPdIFQW0GQR1XS
SK-N-AS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XyV2lEPTB;NEeuPFg5KM7:TR?= MlLrV2FPT0WU
HCC2157 MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f2UGlEPTB;NEiuNFc3KM7:TR?= MW\TRW5ITVJ?
HCC1954 NGqw[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq2dmJKSzVyPUS4MlE4ODRizszN NFTUeIFUSU6JRWK=
FADU NULDeZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnFfmFKSzVyPUS4MlMxOzFizszN M2nwSXNCVkeHUh?=
S-117 M2jhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS2WnRKSzVyPUS4MlM5OTVizszN NHnUTnVUSU6JRWK=
LS-1034 M1zL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrTdXlFUUN3ME20PE44ODZ5IN88US=> MmfuV2FPT0WU
CAMA-1 NF7jcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvFUnZoUUN3ME20PU42PTR|IN88US=> NH7jR21USU6JRWK=
LU-134-A MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTR7LkiwPFUh|ryP NEHw[JNUSU6JRWK=
NCI-H1838 NUj3coZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nVXmlEPTB;NEmuPFA5PyEQvF2= NInpd5JUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい
体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作（参考用のみ）

キナーゼ試験：[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験： [2]
+ 展開
  • 細胞株： Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度： 0-625 nM
  • 反応時間： 72 hours
  • 実験の流れ： Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験：[1]
+ 展開
  • 動物モデル： Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤： Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量： 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法： Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。 		30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O
CAS No. 943319-70-8
保管 粉
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

総分子量：g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2
NCT01874665 Completed GIST Ariad Pharmaceuticals|Takeda June 5 2013 Phase 2
NCT01424982 Recruiting Acute Lymphoblastic Leukemia|Adult Acute Lymphoblastic Leukemia in Complete Remission|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Philadelphia Chromosome Positive|Untreated Adult Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) October 5 2011 Phase 2
NCT02627677 Active not recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals|Takeda December 31 2015 Phase 3
NCT01667133 Completed Chronic Myeloid Leukemia (CML)|Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Ariad Pharmaceuticals|Takeda August 31 2012 Phase 1|Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問（FAQ）

  • 質問1：

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答：

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

selleck catalog

Bcr-Ablシグナル伝達経路

Bcr-Abl Inhibitors with Unique Features

  • Selective Bcr-Abl Inhibitor

    Nilotinib (AMN-107) ： Bcr-Abl-selective, IC50<30 nM.

  • Most Potent Bcr-Abl Inhibitor

    GZD824 ： Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.

  • FDA-approved Bcr-Abl Inhibitor

    Dasatinib ： Approved by FDA for CML and Ph+ ALL.

  • Newest Bcr-Abl Inhibitor

    GZD824 ： Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

相関Bcr-Abl製品

  • PX-478 2HCl

    PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. Phase 1.

  • Defactinib (VS-6063, PF-04554878)

    Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.

  • SU6656

    SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.

  • Imatinib Mesylate (STI571)

    Imatinib Mesylate (STI571) is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.

  • Nilotinib (AMN-107)

    Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells.

    Features:A selective inhibitor of native and mutant Bcr-Abl.

  • Bafetinib (INNO-406)

    Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.

    Features:Dual Bcr-Abl/Lyn inhibitor.

  • Rebastinib (DCC-2036)

    Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.

    Features:A conformational control inhibitor of Abl1 and T315I Abl1.

Tags: Ponatinib (AP24534)を買う | Ponatinib (AP24534) ic50 | Ponatinib (AP24534)供給者 | Ponatinib (AP24534)を購入する | Ponatinib (AP24534)費用 | Ponatinib (AP24534)生産者 | オーダーPonatinib (AP24534) | Ponatinib (AP24534)化学構造 | Ponatinib (AP24534)分子量 | Ponatinib (AP24534)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID