Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

文献中Selleckの製品使用例(31)

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NX\0U4tKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;nTHlGUUN3ME2wMlAxODByMECzOVkh|ryP MWrTRW5ITVJ?
MV-4-11 NXG0cpJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMECwNFk2PiEQvF2= M4LnTnNCVkeHUh?=
MEG-01 NUPEOm1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jDWWlEPTB;MD6wNFAyOjhizszN NELBVIxUSU6JRWK=
LAMA-84 NETTSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzOZYZKSzVyPUCuNFAxOTZ3IN88US=> MVrTRW5ITVJ?
CGTH-W-1 NULNXlBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnqTWM2OD1yLkCwNVY6KM7:TR?= Mn\XV2FPT0WU
KASUMI-1 NV;ST3hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjScYRZUUN3ME2wMlAxOjF5IN88US=> MlPiV2FPT0WU
BE-13 Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zvWGlEPTB;MD6wNFI2QSEQvF2= MkPNV2FPT0WU
CTV-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;ZTWM2OD1yLkCwOVIyKM7:TR?= MWfTRW5ITVJ?
NKM-1 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfFUWtuUUN3ME2wMlAxPjV3IN88US=> M2TsbHNCVkeHUh?=
MONO-MAC-6 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjsSGNKSzVyPUCuNFA5OzdizszN NYr5dVdCW0GQR1XS
A204 NV\aTWs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fnZ2lEPTB;MD6wNVIyQCEQvF2= MXHTRW5ITVJ?
GDM-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEG4N|Mh|ryP MUHTRW5ITVJ?
AN3-CA NYjFPYhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEG4O|Mh|ryP NVmxS4NPW0GQR1XS
BL-70 NHzkXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrub3gyUUN3ME2wMlAzOTl7IN88US=> MYLTRW5ITVJ?
Daudi M{PNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHSSmRKSzVyPUCuNFI2OzdizszN M1XOXHNCVkeHUh?=
KU812 M37Ob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M371bmlEPTB;MD6wNlg1QCEQvF2= NFTlR5JUSU6JRWK=
KG-1 NV3wRWtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrZTWM2OD1yLkCzNlk1KM7:TR?= NIfqbYlUSU6JRWK=
DOHH-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrTbZhKSzVyPUCuNFQ5ODNizszN Mm\BV2FPT0WU
HuO9 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTkTWM2OD1yLkC1OFQ5KM7:TR?= NGDrV3FUSU6JRWK=
EB2 NXXveJZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTFeotKSzVyPUCuNFU2PzZizszN NF3DOnVUSU6JRWK=
G-402 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\NOWlEPTB;MD6wOlM1OSEQvF2= NGXqOFFUSU6JRWK=
SU-DHL-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf2cYhKSzVyPUCuNFY{PzlizszN M3nQXnNCVkeHUh?=
NCI-H719 NEXsTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\nNmlEPTB;MD6wO|g5QCEQvF2= NVvrZYc{W0GQR1XS
MLMA M3zLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYewWI1RUUN3ME2wMlA6ODZizszN NYjm[Vl{W0GQR1XS
KM12 NYntOXFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni0TWM2OD1yLkC5O|M4KM7:TR?= MWLTRW5ITVJ?
SUP-T1 M{H4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz1NZdKSzVyPUCuNFk6QDJizszN M4DvR3NCVkeHUh?=
MZ1-PC MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TWOWlEPTB;MD6xNVM{PiEQvF2= NHfGTFJUSU6JRWK=
MFE-296 NYi4OoJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMUG4N|kh|ryP NIL4SmdUSU6JRWK=
ALL-PO NHe2VY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HXSmlEPTB;MD6xNlQ1OyEQvF2= MWjTRW5ITVJ?
GB-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMUK1NVIh|ryP MXnTRW5ITVJ?
SIG-M5 NVXhSmNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMUOzO{DPxE1? M{DJenNCVkeHUh?=
P30-OHK NE\iNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvKVZBKSzVyPUCuNVU3PzJizszN NF;uXpZUSU6JRWK=
NCI-H716 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMU[yOlYh|ryP M4fMfHNCVkeHUh?=
MPP-89 NIXNZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMU[5N|Mh|ryP M{\GcnNCVkeHUh?=
SF126 NGHXd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnWOIdzUUN3ME2wMlE4ODZ|IN88US=> MlPQV2FPT0WU
CTB-1 M2ixOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WyeGlEPTB;MD6xO|MyPiEQvF2= MoHZV2FPT0WU
CA46 NUG2O|k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PNW2lEPTB;MD6xO|Q5QSEQvF2= M2noXnNCVkeHUh?=
NCI-H520 M3PWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki1TWM2OD1yLkG3O|MzKM7:TR?= MVvTRW5ITVJ?
CAL-85-1 NXHvVFJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjsSHdCUUN3ME2wMlE4QTJ5IN88US=> M2jPW3NCVkeHUh?=
NCI-H2342 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLkTWM2OD1yLkG4OVc4KM7:TR?= MU\TRW5ITVJ?
697 NVfFeIdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMUi4O|Eh|ryP MlX6V2FPT0WU
NY M2riPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnzTWM2OD1yLkG5Nlg4KM7:TR?= MnfBV2FPT0WU
T98G MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMUmzNVgh|ryP M1HyT3NCVkeHUh?=
NCI-H1703 NE\zXmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;XeYk1UUN3ME2wMlE6PjF3IN88US=> M1\sfHNCVkeHUh?=
NCI-H2087 NWrUd2lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHFZnlKSzVyPUCuNlA1OzlizszN MXPTRW5ITVJ?
PF-382 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMkC4O|Mh|ryP NGPoXWNUSU6JRWK=
HCT-116 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMkGwOlkh|ryP NYS4dWp4W0GQR1XS
CAKI-1 M2q3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHOTWM2OD1yLkKxOlY3KM7:TR?= NFfKNXFUSU6JRWK=
CCF-STTG1 M4HOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7PTWM2OD1yLkKyOFc2KM7:TR?= M4\sU3NCVkeHUh?=
D-392MG NVrwe5ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMkOxO|ch|ryP NVznZWlSW0GQR1XS
RT-112 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2njemlEPTB;MD6yN|c6PSEQvF2= M{fuTXNCVkeHUh?=
MES-SA MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfuWVhrUUN3ME2wMlI1OTh5IN88US=> MlnwV2FPT0WU
LC-2-ad MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXToRopbUUN3ME2wMlI1OjZ3IN88US=> MoXiV2FPT0WU
NOS-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\ITWM2OD1yLkK0N|Y4KM7:TR?= NEDz[3BUSU6JRWK=
NALM-6 NUfZcoxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon0TWM2OD1yLkK1OVQ{KM7:TR?= NXT0S2tUW0GQR1XS
TE-15 MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[2TWM2OD1yLkK2NFkyKM7:TR?= NVfCZW9RW0GQR1XS
786-0 M2XCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMk[yNlgh|ryP NGO5VlZUSU6JRWK=
IST-MES1 M3XVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTZUFRxUUN3ME2wMlI3QDJ7IN88US=> NEPhZVBUSU6JRWK=
KYSE-180 NUTRRZRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD6dXpoUUN3ME2wMlI3QDlzIN88US=> Mne5V2FPT0WU
YT NVPaPZluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr3V3ZKSzVyPUCuNlY6PzRizszN NHTSeo1USU6JRWK=
A427 NUXlZWk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2wcYFKSzVyPUCuNlczPjRizszN NWfsdFF5W0GQR1XS
KYSE-450 NGLxRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMkezNlkh|ryP NUnvNGgzW0GQR1XS
HuH-7 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPPTWM2OD1yLkK3O|Y{KM7:TR?= MnjMV2FPT0WU
CAS-1 NWXhO2JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j3e2lEPTB;MD6yPFMxOyEQvF2= MkHhV2FPT0WU
KURAMOCHI MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT5TWM2OD1yLkK4OFE6KM7:TR?= MmjaV2FPT0WU
ACHN M4q1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\tZpFJUUN3ME2wMlI6OzJ|IN88US=> Mn3mV2FPT0WU
HGC-27 NEjkbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLqWHI2UUN3ME2wMlI6OzV|IN88US=> MXnTRW5ITVJ?
A172 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMkm1O|ch|ryP NXfy[|Z6W0GQR1XS
SNU-449 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTKTWM2OD1yLkK5PVY1KM7:TR?= MUfTRW5ITVJ?
SW982 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPJZnJKSzVyPUCuNlk6PzhizszN MXXTRW5ITVJ?
EFO-21 NF:yO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDjUZNCUUN3ME2wMlMxPDFzIN88US=> MkXSV2FPT0WU
NCI-H2030 M2PpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLOTWM2OD1yLkOxNVY1KM7:TR?= NYDZcoVrW0GQR1XS
HT-144 NHXQRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H4[2lEPTB;MD6zNVI5KM7:TR?= MULTRW5ITVJ?
MFE-280 NH30SGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\GeXA2UUN3ME2wMlMyPDV|IN88US=> M4\scHNCVkeHUh?=
SK-LU-1 NUnQU|lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwM{G0OlYh|ryP NH3LcXZUSU6JRWK=
NCI-H2052 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjnZYtKSzVyPUCuN|E1QDRizszN NWXrTIZoW0GQR1XS
SK-HEP-1 NGTDbFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\0ellKSzVyPUCuN|M{PjhizszN NVniVWt2W0GQR1XS
QIMR-WIL NFLObnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17SWWlEPTB;MD6zN|QzPCEQvF2= NG\abZBUSU6JRWK=
A2780 M{n6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36wW2lEPTB;MD6zOFMxPCEQvF2= MmDiV2FPT0WU
ACN MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHBTWM2OD1yLkO0PFc{KM7:TR?= M1LBRXNCVkeHUh?=
BxPC-3 M4\xdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTrTWM2OD1yLkO0PVg6KM7:TR?= MXrTRW5ITVJ?
BCPAP M4nucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmSyTWM2OD1yLkO2NFAyKM7:TR?= Mn;5V2FPT0WU
HOP-62 MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwM{[xNFYh|ryP NFXOS4VUSU6JRWK=
SW1710 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlKxTWM2OD1yLkO2OFU2KM7:TR?= NH;HSHBUSU6JRWK=
OPM-2 M4f6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi4TWM2OD1yLkO2OFc{KM7:TR?= MWLTRW5ITVJ?
DBTRG-05MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPZTWM2OD1yLkO4NFU1KM7:TR?= NWDMfXluW0GQR1XS
SK-MEL-24 NIfhRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwM{m3PVEh|ryP NVLiVHlHW0GQR1XS
8305C NG\qfohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLUc5ZKSzVyPUCuN|k4QTNizszN NUi1cFZYW0GQR1XS
OVCAR-4 NFvwbmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwNEG1PFYh|ryP NVe3VmROW0GQR1XS
HLE MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf4XJFjUUN3ME2wMlQyQDZizszN MW\TRW5ITVJ?
NCI-H747 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGzTWM2OD1yLkSyNVM4KM7:TR?= NX;kN2JCW0GQR1XS
SW780 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\BPXRpUUN3ME2wMlQzOzR4IN88US=> Mmr0V2FPT0WU
KYSE-150 NXvR[mtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf1RVNKSzVyPUCuOFI1OTVizszN NX3hU|BmW0GQR1XS
H4 MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rzOWlEPTB;MD60NlQ2OSEQvF2= MmPKV2FPT0WU
SW1088 M1HPPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XWe2lEPTB;MD60OFM6KM7:TR?= MkK3V2FPT0WU
SF268 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\xRmlEPTB;MD60OFg3KM7:TR?= MlS3V2FPT0WU
RT4 M{LPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNEWxNVEh|ryP NVvEbXo3W0GQR1XS
NCI-H522 M{fp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwNEWyO{DPxE1? NH60e4NUSU6JRWK=
LCLC-97TM1 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PkbGlEPTB;MD60OlE6PSEQvF2= M1nFWnNCVkeHUh?=
CAL-39 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPSTWM2OD1yLkS2OVE6KM7:TR?= MW\TRW5ITVJ?
CAL-120 NVjnWYR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNEe2OFMh|ryP MlnkV2FPT0WU
ESS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnCb49NUUN3ME2wMlQ4QDJzIN88US=> NX7lUZZuW0GQR1XS
KARPAS-45 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj3XllKSzVyPUCuOFg6OzNizszN NVz5R5JjW0GQR1XS
DU-4475 NHjlOY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwNEm1NVEh|ryP MnXyV2FPT0WU
VMRC-RCZ M4DqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXoTWM2OD1yLkS5PVA1KM7:TR?= M2XBcnNCVkeHUh?=
HOS M3;peGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNUCzOlUh|ryP M3jHVHNCVkeHUh?=
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NH-12 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rrUWlEPTB;MT63N|QzPyEQvF2= MYrTRW5ITVJ?
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NCI-H2009 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jPTWlEPTB;MT63PVczOSEQvF2= M{W1[HNCVkeHUh?=
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NCI-H810 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSz[Y9[UUN3ME2xMlgyPjB4IN88US=> MWTTRW5ITVJ?
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KNS-42 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnSTWM2OD1zLki2NlY3KM7:TR?= MXjTRW5ITVJ?
NCI-H2452 M2nBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrI[JpzUUN3ME2xMlg6ODd2IN88US=> M3;IN3NCVkeHUh?=
SK-MEL-2 M4i3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVmw[oVXUUN3ME2xMlkxOjdzIN88US=> NImwVoNUSU6JRWK=
OVCAR-5 NG\uVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknETWM2OD1zLkmwOlc2KM7:TR?= NUDmU4NJW0GQR1XS
SNG-M NWTnRWI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HVdWlEPTB;MT65OVg2QCEQvF2= M2rmSXNCVkeHUh?=
A673 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;Me2lEPTB;MT65O|UyPiEQvF2= Ml7ZV2FPT0WU
L-428 NVTVfY9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvjfZdKSzVyPUGuPVkyPzlizszN Mm\KV2FPT0WU
KM-H2 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC5VmpKSzVyPUKuNFExQSEQvF2= NHjpeo5USU6JRWK=
MC-IXC NXfHe2htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETqS|FKSzVyPUKuNFIzPzNizszN MmP2V2FPT0WU
COLO-678 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnvb2ZKSzVyPUKuNFQzODdizszN NFPGOVJUSU6JRWK=
MEL-JUSO NYHVeJFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHyOpc5UUN3ME2yMlA4QDVzIN88US=> NUewTXlRW0GQR1XS
HCC38 M4TOVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Xz[mlEPTB;Mj6wPFQ{OyEQvF2= NGLlRZBUSU6JRWK=
UACC-62 NHPod5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj2N|FLUUN3ME2yMlA5QDV3IN88US=> MXrTRW5ITVJ?
OAW-42 M136XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknITWM2OD1{LkC5O|EyKM7:TR?= NFP2N5FUSU6JRWK=
LB996-RCC NWGxXYY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITMUVdKSzVyPUKuNVM5OTdizszN MX3TRW5ITVJ?
COR-L105 NEHRWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rpdWlEPTB;Mj6xOlM4OyEQvF2= Mk\aV2FPT0WU
RCC10RGB MonOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X3dmlEPTB;Mj6xPFU4PiEQvF2= MVfTRW5ITVJ?
A431 NVfGd49UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwMUmwNVkh|ryP MWnTRW5ITVJ?
NCI-H292 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj6TWM2OD1{LkKzPVUyKM7:TR?= NHLjSJpUSU6JRWK=
SK-UT-1 NF;WfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki5TWM2OD1{LkOzNVg1KM7:TR?= MUfTRW5ITVJ?
PANC-08-13 NHziSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LnfWlEPTB;Mj6zN|I{PSEQvF2= MlvUV2FPT0WU
ST486 MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwNEGwOFgh|ryP NGjrPYVUSU6JRWK=
SJSA-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S4dGlEPTB;Mj60NVI4OSEQvF2= NIrBU|RUSU6JRWK=
RKO NGjkNHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJwNEKwNlkh|ryP MkHmV2FPT0WU
NCI-H1793 MoT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvSTmtKSzVyPUKuOFQxOjlizszN NWriUWZFW0GQR1XS
639-V NES5e29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn2ZZNvUUN3ME2yMlQ2Ozh{IN88US=> NYXvW41oW0GQR1XS
ES3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7ybW17UUN3ME2yMlQ6PzN5IN88US=> MUDTRW5ITVJ?
NCI-H1792 NIPvSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLwTWM2OD1{LkW2PFI3KM7:TR?= MVjTRW5ITVJ?
NCI-H1651 M135TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwNUiyNUDPxE1? MoK1V2FPT0WU
SN12C NED6fnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwNUi0PFch|ryP NWTZcotjW0GQR1XS
COLO-679 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW2fJZKSzVyPUKuOVg3ODVizszN NI\iepJUSU6JRWK=
U-118-MG M{TZdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYezXJVkUUN3ME2yMlU5QDd{IN88US=> MmfEV2FPT0WU
Ramos-2G6-4C10 NW\HS4dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwNkS4NFch|ryP MX7TRW5ITVJ?
HCT-15 MnizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmyXpJOUUN3ME2yMlY5Pzl{IN88US=> MXnTRW5ITVJ?
MDA-MB-157 NF\SSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXRZ|BsUUN3ME2yMlcxPzR5IN88US=> M{SxXHNCVkeHUh?=
K5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfGN3FKSzVyPUKuO|E5PDVizszN M33nPXNCVkeHUh?=
MKN45 NGL5U41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i1UGlEPTB;Mj63N|M3PiEQvF2= MnnuV2FPT0WU
DMS-273 NV\CXFNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj2TWM2OD1{Lke1OlMzKM7:TR?= Mk[xV2FPT0WU
C8166 NYf0W2JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\OWWlEPTB;Mj63PFUyOyEQvF2= M1XnPHNCVkeHUh?=
Calu-3 M1fqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm5TWM2OD1{Lke4PVY6KM7:TR?= M{H1WHNCVkeHUh?=
SNB75 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD0TWM2OD1{Lki4OVM2KM7:TR?= Ml3FV2FPT0WU
BFTC-905 NVPRVYVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH1TWM2OD1{LkmwNVkyKM7:TR?= NV65R3Z4W0GQR1XS
C-4-II MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3OTWM2OD1{LkmxN|U{KM7:TR?= NHzxN5ZUSU6JRWK=
MS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS1PHNqUUN3ME2yMlk3PzZ7IN88US=> NVX3[4U1W0GQR1XS
A375 Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwMEixPFQh|ryP NYj4cZdkW0GQR1XS
KYSE-70 NV7kXVduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH2[pBKSzVyPUOuNFg5QDJizszN MkTwV2FPT0WU
KYSE-510 NIqyc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTNwMUC5PVUh|ryP NVzrc|l7W0GQR1XS
LN-405 M3XRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvFOWNKSzVyPUOuNVM2OThizszN MkG2V2FPT0WU
BOKU NVG3WZNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;p[GlEPTB;Mz6xOFI2PiEQvF2= M3\OO3NCVkeHUh?=
TE-10 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnYfmlkUUN3ME2zMlE4OzZ{IN88US=> NX[2eYN6W0GQR1XS
MKN1 NV:3OmwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrXWW9KSzVyPUOuNVg1QDNizszN NV7z[4RvW0GQR1XS
M059J MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwMkCxO|Mh|ryP NEXiZodUSU6JRWK=
GOTO NFHLZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDjVIlKSzVyPUOuNlIxOzlizszN NEH0XY1USU6JRWK=
DK-MG M2n6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDeFBKSzVyPUOuNlU6PzZizszN NX2zOYJJW0GQR1XS
NCI-H727 NFX5bnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;Ld4dPUUN3ME2zMlI3PThizszN M4nVcXNCVkeHUh?=
NB12 NXm0V2Q3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3KdpVQUUN3ME2zMlM{OjJ2IN88US=> MXXTRW5ITVJ?
DOK NG\1fm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDHd45KSzVyPUOuN|YyQDZizszN NIfOfmVUSU6JRWK=
KYSE-410 M4rpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\3TWM2OD1|LkO2Nlg4KM7:TR?= M4nveHNCVkeHUh?=
AM-38 MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTNwM{iwOVEh|ryP NHnhXlBUSU6JRWK=
GR-ST MmfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nPb2lEPTB;Mz60OVc{OiEQvF2= NITCVZFUSU6JRWK=
D-247MG MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwNEiyOlMh|ryP Mmq1V2FPT0WU
TE-8 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTNwNEmzN|Mh|ryP M1jucnNCVkeHUh?=
LS-411N NYjsVFJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;wSoJXUUN3ME2zMlQ6Pjl{IN88US=> Mn[2V2FPT0WU
SK-MES-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG3VlJKSzVyPUOuOVY1OzNizszN NHTQfpJUSU6JRWK=
SF295 NHr4OIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPmcYFKSzVyPUOuOlE2PTJizszN NX[1[npVW0GQR1XS
SK-MEL-30 NFjKSG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTNwNkW5NlEh|ryP NWmxbYlRW0GQR1XS
LB2241-RCC NIfW[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLnc2xRUUN3ME2zMlY3OjZizszN MWfTRW5ITVJ?
PC-14 M2DDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPwdHZKSzVyPUOuOlY1OzdizszN M{TiPXNCVkeHUh?=
EW-7 M333NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnGZmZoUUN3ME2zMlY4Pjl|IN88US=> M2rx[nNCVkeHUh?=
NMC-G1 M1:3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jEbGlEPTB;Mz63NVg{PyEQvF2= MkPtV2FPT0WU
TE-441-T NIrpfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK5c3dKSzVyPUOuO|MxOjhizszN NXPLRYZ7W0GQR1XS
NCI-H1618 M3znXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK3TWM2OD1|LkixPFc2KM7:TR?= MnjFV2FPT0WU
PANC-03-27 NVi5OlM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnL2TWM2OD1|LkixPVE3KM7:TR?= M3fscXNCVkeHUh?=
NCI-H2228 Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTNwOEOxNlYh|ryP NX\oR5pUW0GQR1XS
CAPAN-1 MoXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\FTWM2OD1|Lki3NFA6KM7:TR?= M3XZZ3NCVkeHUh?=
KLE NWO1S4NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLSNVNyUUN3ME2zMlkxPjdizszN MV;TRW5ITVJ?
Becker NIjISGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXSOYw1UUN3ME2zMlkzQDR7IN88US=> NEjlNGtUSU6JRWK=
SK-PN-DW MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTRwMEe5O|Qh|ryP NED0[mtUSU6JRWK=
Hs-578-T MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe1OlBKSzVyPUSuNFg{ODZizszN M{jRZXNCVkeHUh?=
RS4-11 M3HBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rPO2lEPTB;ND6xNVI2PSEQvF2= M{jHPXNCVkeHUh?=
D-502MG NGHMN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofSTWM2OD12LkG2PVk4KM7:TR?= MYjTRW5ITVJ?
GI-1 M17rWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLv[HZKSzVyPUSuNlgzQTlizszN NYrpOHpLW0GQR1XS
NCI-H209 M33COGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPNNnNKSzVyPUSuN|M4QCEQvF2= NH3hWXhUSU6JRWK=
SK-OV-3 M1jodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnroTWM2OD12LkS4NVQ6KM7:TR?= NYezenRWW0GQR1XS
LOUCY NUe5eG13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjTTWM2OD12LkS4OFMzKM7:TR?= MVfTRW5ITVJ?
NCI-H69 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HTcWlEPTB;ND61NVc6OyEQvF2= MYHTRW5ITVJ?
SCC-9 M1\LXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC3fHBKSzVyPUSuOVMyPzJizszN MlrJV2FPT0WU
NCI-H526 NFzzc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK0TWM2OD12LkW5Nlk{KM7:TR?= M3zaO3NCVkeHUh?=
NCI-H2170 NH\qTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[0[WlEPTB;ND62Olc4OSEQvF2= NXTIfHR4W0GQR1XS
SR M{G1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofDTWM2OD12LkewNFQ5KM7:TR?= MWPTRW5ITVJ?
CMK M3vrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf0XZlMUUN3ME20MlczOTBzIN88US=> MVzTRW5ITVJ?
COLO-829 M{LPeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrycY9EUUN3ME20Mlc4ODR|IN88US=> MoTRV2FPT0WU
HuO-3N1 M3PucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTRwOEOyPFEh|ryP NXHjVoI3W0GQR1XS
5637 NUKwfoRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rPc2lEPTB;ND65NFQ5PyEQvF2= NULORo14W0GQR1XS
A253 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TjemlEPTB;ND65O|cxQCEQvF2= Ml\xV2FPT0WU
NB10 M4HSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTVwMEe0PVch|ryP MXHTRW5ITVJ?
SF539 NV6wZ4ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DGTmlEPTB;NT6wPVk2QSEQvF2= NYPTdIkzW0GQR1XS
HAL-01 M4nkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTVwMUS2OFUh|ryP MXvTRW5ITVJ?
MHH-ES-1 M{TXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe5NVFKSzVyPUWuNVY6OjVizszN M2f1NHNCVkeHUh?=
DEL NGGwRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTVwMke1PFIh|ryP NV3TNJhkW0GQR1XS
NCI-H1299 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnvWHhKSzVyPUWuN|UxODdizszN MXrTRW5ITVJ?
ChaGo-K-1 MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXNNGNKSzVyPUWuN|UyODdizszN MUXTRW5ITVJ?
HMV-II MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonqTWM2OD13LkO5OFMh|ryP M{myRnNCVkeHUh?=
NB69 NEjUVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i1bmlEPTB;NT6zPVY{OSEQvF2= NYTi[INLW0GQR1XS
NCI-H1882 M{nPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTVwNEOzOlQh|ryP NXjOeGZwW0GQR1XS
SNU-475 M3jKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz0d3BJUUN3ME21MlQ4OTdzIN88US=> M2fkTXNCVkeHUh?=
RXF393 NYLpNVZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HzNmlEPTB;NT60PFQ6PCEQvF2= MlfjV2FPT0WU
CAL-51 NYX3ZVJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr4ZndKSzVyPUWuOlI5PTNizszN MWTTRW5ITVJ?
SW1573 M1vSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;BbGlEPTB;NT62N|U{PCEQvF2= NF7jUIlUSU6JRWK=
GCT MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7H[odbUUN3ME21Mlc2QTJ7IN88US=> MlHLV2FPT0WU
COR-L88 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTVwN{[4OFYh|ryP NV\wdXpEW0GQR1XS
MDA-MB-134-VI NID4[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTVwOEe1N|Yh|ryP NXT3ZnF2W0GQR1XS
NB5 M2nJTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{THdWlEPTB;NT65NlQ1KM7:TR?= MnjRV2FPT0WU
GMS-10 M{HXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInie|dKSzVyPUWuPVY5PjFizszN MVjTRW5ITVJ?
CHP-212 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTZwNEiyOlch|ryP NILxb3BUSU6JRWK=
TE-11 M3n4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\4ZYQ1UUN3ME22MlU2OTh{IN88US=> MVvTRW5ITVJ?
SW962 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTZwNkW3O|Qh|ryP MWPTRW5ITVJ?
MZ2-MEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL5UldKSzVyPU[uPFIxOTFizszN MlnGV2FPT0WU
C-33-A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7GTWM2OD14LkmxOlg5KM7:TR?= M131cHNCVkeHUh?=
IGR-1 NHHaUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnuW5hkUUN3ME22Mlk4QDJ4IN88US=> NWTxVY01W0GQR1XS
MOLT-4 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzVNllKSzVyPUeuNVU1ODZizszN MlvPV2FPT0WU
NCI-H1650 NW\NRZIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTdwMkewOFYh|ryP NV\2O3JxW0GQR1XS
AsPC-1 NFHpbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPtUHJkUUN3ME23MlI5PjB3IN88US=> MV7TRW5ITVJ?
SNU-C2B MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonpTWM2OD15LkK5OVcyKM7:TR?= NIDIbYtUSU6JRWK=
MKN7 NF7rSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjOTWM2OD15LkO3NlM2KM7:TR?= M4rx[3NCVkeHUh?=
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LU-165 NGrqVohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HVPGlEPTB;MkKuOVU1KM7:TR?= NWG0blk5W0GQR1XS
COLO-792 NH3kS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zwU2lEPTB;MkKuO|EyOSEQvF2= M{HEcXNCVkeHUh?=
CAL-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmy[4xKSzVyPUKyMlc2OTdizszN M2n5UHNCVkeHUh?=
HCE-T Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYGzWlhlUUN3ME2yNk45PjB4IN88US=> NYXkVHpkW0GQR1XS
BB65-RCC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnQcYpKSzVyPUKzMlA{PDRizszN MV3TRW5ITVJ?
SiHa M{KxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELWXFZKSzVyPUKzMlM6PjhizszN Mm[3V2FPT0WU
NCI-H2081 NX;UUG82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjUTWM2OD1{ND6wOlQyKM7:TR?= NE[1UJRUSU6JRWK=
U251 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDzT|RKSzVyPUK0MlA3PjhizszN NF\WfpFUSU6JRWK=
LoVo NH\XN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jSW2lEPTB;MkSuPVI5OiEQvF2= NGnVbYlUSU6JRWK=
GCIY MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHRbHFKSzVyPUK1MlI5PzdizszN NVvIZXVkW0GQR1XS
NUGC-3 NIDLZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWOxeW5VUUN3ME2yOU4{OzF4IN88US=> M3HycXNCVkeHUh?=
LNCaP-Clone-FGC M1G1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTmTWM2OD1{NT6zOFk5KM7:TR?= M2rpcXNCVkeHUh?=
PA-1 NH7ESm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\4UoRKSzVyPUK1MlY5OzNizszN MY\TRW5ITVJ?
OE33 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D4VGlEPTB;MkWuOlg2OyEQvF2= MmDsV2FPT0WU
HT-29 NITWZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jtNGlEPTB;MkWuO|g4QSEQvF2= NGC1OphUSU6JRWK=
RCM-1 NVHlV2xFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPB[IlKSzVyPUK1Mlk3PTZizszN NUnlN49GW0GQR1XS
NCI-H1522 MnK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ3Lkm5NVEh|ryP NF7KNJdUSU6JRWK=
LB373-MEL-D NWG5Tm5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rGVmlEPTB;Mk[uNVcxQCEQvF2= MnPDV2FPT0WU
NCI-H1436 MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi0TWM2OD1{Nj6yO|M5KM7:TR?= NF21VHRUSU6JRWK=
COLO-824 MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjUTWM2OD1{Nj60NFAzKM7:TR?= MWPTRW5ITVJ?
CP50-MEL-B NHHyNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojBTWM2OD1{Nj61Olc2KM7:TR?= M3q2c3NCVkeHUh?=
EGI-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn3NGlPUUN3ME2yO{4zPjl6IN88US=> MV\TRW5ITVJ?
LAN-6 NEj1b5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6yTWM2OD1{Nz6zOVk5KM7:TR?= MoDMV2FPT0WU
GAK NYTNclFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPMO4FQUUN3ME2yO{41OjJ3IN88US=> M2\nOnNCVkeHUh?=
MDA-MB-175-VII MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELEdlNKSzVyPUK3MlUxPTNizszN MXjTRW5ITVJ?
JVM-2 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\QW5Q6UUN3ME2yO{43PjJ{IN88US=> MkH4V2FPT0WU
UACC-257 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TjTmlEPTB;MkeuOlg4QCEQvF2= M3ntXXNCVkeHUh?=
SW1783 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfkTWM2OD1{Nz63O|g{KM7:TR?= NYDtVJdGW0GQR1XS
HT-3 NUntU4dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rsOWlEPTB;MkiuNlE3PiEQvF2= MUjTRW5ITVJ?
RL NF7rSpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfpbJRKUUN3ME2yPE42QTFzIN88US=> MmTzV2FPT0WU
TK10 NEHJb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrUTWM2OD1{OD62OVM2KM7:TR?= MnXQV2FPT0WU
HT55 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLRephKSzVyPUK5MlA2PjVizszN NFLoRXRUSU6JRWK=
BT-20 NHXUXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHUTWM2OD1{OT6wOVg3KM7:TR?= MmH3V2FPT0WU
TGBC24TKB NFnaTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DBW2lEPTB;MkmuNVg{OSEQvF2= NHzmS5pUSU6JRWK=
HSC-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDJTWM2OD1{OT6zNFAyKM7:TR?= NUexfpVFW0GQR1XS
COLO-205 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;1NVR2UUN3ME2yPU4{QTR2IN88US=> NH;Hb4tUSU6JRWK=
GT3TKB MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXqSHYzUUN3ME2yPU43QDd5IN88US=> MXXTRW5ITVJ?
T47D Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ7Lki1PFIh|ryP Ml3rV2FPT0WU
OMC-1 NGjGXFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj1TWM2OD1|MD6xPVE6KM7:TR?= NVO1R3Q2W0GQR1XS
PFSK-1 NHLiRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTNzLkK2OVkh|ryP NX\OUJd3W0GQR1XS
JEG-3 NFrDd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nZN2lEPTB;M{GuN|U3OSEQvF2= M{T1T3NCVkeHUh?=
RD MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy3Z3VKSzVyPUOxMlUyOTVizszN NGD3PZpUSU6JRWK=
NCI-H64 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTN{LkSxO|kh|ryP NVf5V5BYW0GQR1XS
DMS-114 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDXeG5KSzVyPUOyMlQyQDJizszN NF3Hb3lUSU6JRWK=
NCI-H661 MmPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXl[mhKSzVyPUOyMlY2ODFizszN NXn4bnRMW0GQR1XS
CAL-148 NITlN4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PWbmlEPTB;M{KuOlY3PSEQvF2= MnXJV2FPT0WU
HuP-T3 NFWzToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTN{LkmzN|gh|ryP NGi2b4NUSU6JRWK=
ES4 M2\GZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfuWXZKSzVyPUOzMlE4ODVizszN NX3wOllJW0GQR1XS
Ca9-22 NX6wemVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fxXGlEPTB;M{OuOFYxOSEQvF2= M4DGNXNCVkeHUh?=
LP-1 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluxTWM2OD1|ND6wPUDPxE1? MWfTRW5ITVJ?
AU565 NGT3bYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTN2LkWwOlkh|ryP MoG2V2FPT0WU
MDA-MB-453 MkGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTN3LkG0NlYh|ryP MYTTRW5ITVJ?
SNU-C1 NU\UOoY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfj[2pKSzVyPUO1MlE4OSEQvF2= NUTLOpp[W0GQR1XS
SW13 NV\BcpBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHe5PWpKSzVyPUO1MlQxPzZizszN M4T3O3NCVkeHUh?=
NCI-H2122 NHHZS5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTN3LkW1PVgh|ryP MmHIV2FPT0WU
NCI-H1395 M3[5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPFTWM2OD1|NT62OlkyKM7:TR?= NYnRUJV2W0GQR1XS
J-RT3-T3-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P1NGlEPTB;M{[uNFI6PCEQvF2= M4jxc3NCVkeHUh?=
COR-L279 NIrmTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTKTWM2OD1|Nj6xPVgyKM7:TR?= MlLkV2FPT0WU
ATN-1 M3PZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTN4Lki1NVYh|ryP M1vzNXNCVkeHUh?=
HCC2998 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX5TWM2OD1|Nj64OVcyKM7:TR?= M2j5fXNCVkeHUh?=
UM-UC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLpTVlUUUN3ME2zOk45Pjd3IN88US=> NIL2S|RUSU6JRWK=
DV-90 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12xVmlEPTB;M{[uPVA3PyEQvF2= MXPTRW5ITVJ?
ES8 NUfjbYZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXRTZIzUUN3ME2zOk46OzF6IN88US=> MX7TRW5ITVJ?
YAPC NI\sNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjmVXBxUUN3ME2zOk46PjV2IN88US=> MX3TRW5ITVJ?
HCC1599 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXqxeWNmUUN3ME2zO{4yPjF6IN88US=> Mn\rV2FPT0WU
UMC-11 NFrGZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHhTWM2OD1|Nz6yOVA{KM7:TR?= NXrB[WRiW0GQR1XS
THP-1 MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi4XI1xUUN3ME2zO{4zQDZ6IN88US=> NInRNGRUSU6JRWK=
OCUB-M MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[1fGtFUUN3ME2zO{4zQDlzIN88US=> NWnVXGVzW0GQR1XS
NCI-H1693 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljqTWM2OD1|Nz6zNlM{KM7:TR?= NGfHVJFUSU6JRWK=
NCI-H345 NGThOYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrPcnZZUUN3ME2zO{4{PjJ2IN88US=> MXTTRW5ITVJ?
COLO-800 NF\2N29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\FdHNXUUN3ME2zO{42PjdizszN NV7IRnFiW0GQR1XS
COLO-320-HSR Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfmOldDUUN3ME2zPE4{PDl{IN88US=> NHzab4JUSU6JRWK=
NCI-H596 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD3TWM2OD1|OD60OFg6KM7:TR?= NYDtSWl5W0GQR1XS
NCI-H187 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\KfGFKSzVyPUO4Mlc{PDRizszN NU\STY5jW0GQR1XS
ECC4 NIW4T4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrrTWM2OD1|OT6wPFE1KM7:TR?= M{LBVHNCVkeHUh?=
KP-4 NUPDZ3dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTN7LkGyN|Uh|ryP NGfjT5JUSU6JRWK=
NCI-H2227 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjQSpVKSzVyPUO5MlM6PDlizszN NGHzWHVUSU6JRWK=
22RV1 NFixc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfoW3JCUUN3ME2zPU45Ozl6IN88US=> Mn;xV2FPT0WU
SAS NUPKcFY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX2OIlKSzVyPUSwMlA6PiEQvF2= MXnTRW5ITVJ?
PANC-10-05 NHnGTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7pTWM2OD12MD6xPFI5KM7:TR?= MXnTRW5ITVJ?
MDA-MB-468 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTRyLkWzOFYh|ryP NVXwOIwyW0GQR1XS
RPMI-7951 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rFdGlEPTB;NEGuNlA4PSEQvF2= M4Hib3NCVkeHUh?=
BB49-HNC MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTRzLkKxO|kh|ryP NH\EbYlUSU6JRWK=
23132-87 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni4TWM2OD12MT6yO|MzKM7:TR?= MlXvV2FPT0WU
HCC1569 NGj3XlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXPTWM2OD12MT6yPFg2KM7:TR?= NGjVOWJUSU6JRWK=
CP66-MEL NWD6XVE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR{LkG4PFYh|ryP NYDNNHJSW0GQR1XS
K-562 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fKPGlEPTB;NEKuNlg2PCEQvF2= NFXFOVlUSU6JRWK=
OCI-AML2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\QSGlEPTB;NEKuPFk4PCEQvF2= NYfkNYpbW0GQR1XS
SW756 NGGw[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfOUXdKSzVyPUSzMlA{QDhizszN NVvMeoR4W0GQR1XS
M14 NUjZZ2w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Cy[GlEPTB;NEOuN|E5QSEQvF2= MYHTRW5ITVJ?
NCI-H1623 NV3Ke5BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOzTWM2OD12Mz60OlQh|ryP MXzTRW5ITVJ?
KNS-81-FD MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHEWJBOUUN3ME20N{44PjJizszN NG\vVmlUSU6JRWK=
TGBC1TKB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[xR2lEPTB;NEOuPVA6QSEQvF2= NGTZdohUSU6JRWK=
RERF-LC-MS M3TY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3DTWM2OD12Mz65NlgyKM7:TR?= M1mxR3NCVkeHUh?=
PC-3 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f3VWlEPTB;NESuOFM1PyEQvF2= MV7TRW5ITVJ?
HuP-T4 M2Hhe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDmdJBKSzVyPUS0MlQ1PzRizszN NUCweZhjW0GQR1XS
NCI-H510A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K5bGlEPTB;NESuO|A5KM7:TR?= NHizZZpUSU6JRWK=
LB2518-MEL MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Xsd2lEPTB;NESuO|k{PyEQvF2= M4LBZ3NCVkeHUh?=
TE-5 NIHmNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljOTWM2OD12NT65OVgyKM7:TR?= M3vEPHNCVkeHUh?=
EW-24 M3TP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml60TWM2OD12Nj6xO|I{KM7:TR?= MmjSV2FPT0WU
LB647-SCLC NEfzXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e4dWlEPTB;NE[uNlE2PSEQvF2= MnrrV2FPT0WU
NCI-H524 NHTnfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7rclVKSzVyPUS2MlcyQDVizszN NXP6eJNYW0GQR1XS
EW-11 M{LzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4myT2lEPTB;NE[uPVM4OyEQvF2= NY[wPY4{W0GQR1XS
KALS-1 NFLBd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHkZYNKSzVyPUS3MlIxPjZizszN MXTTRW5ITVJ?
BT-474 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi4fWllUUN3ME20O{41OjF4IN88US=> NXfTR4VmW0GQR1XS
SK-N-AS NF;mV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjTRllKSzVyPUS3Mlg5QCEQvF2= MkDKV2FPT0WU
HCC2157 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPlcG5UUUN3ME20PE4xPzZizszN MmSwV2FPT0WU
HCC1954 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvpTWM2OD12OD6xO|A1KM7:TR?= NYHwZ4pIW0GQR1XS
FADU NEPSWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:wWFdKSzVyPUS4MlMxOzFizszN MUnTRW5ITVJ?
S-117 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPROlBKSzVyPUS4MlM5OTVizszN MX;TRW5ITVJ?
LS-1034 NVrINJZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTR6LkewOlch|ryP NHvTcpBUSU6JRWK=
CAMA-1 NFfWUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;nOWlEPTB;NEmuOVU1OyEQvF2= MWjTRW5ITVJ?
LU-134-A M1P4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr5TWM2OD12OT64NFg2KM7:TR?= M2q4eHNCVkeHUh?=
NCI-H1838 NUj6clY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTR7LkiwPFch|ryP MV3TRW5ITVJ?

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体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709017 Recruiting Chronic Myeloid Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Korea Otsuka Pharmaceutical Co. Ltd. October 2018 --
NCT03690115 Not yet recruiting Leukemia Myeloid Acute Versailles Hospital October 2018 Phase 2
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03589326 Recruiting Lymphoblastic Leukemia Acute Adult|Acute Lymphoid Leukemia|Leukemia Acute Lymphoblastic|Leukemia Lymphoblastic|Ph1 Chromosome|Leukemia Lymphoblastic Acute Philadelphia-Positive Millennium Pharmaceuticals Inc.|Takeda August 10 2018 Phase 3
NCT03576547 Recruiting Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|t(9;22) M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 26 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Ablシグナル伝達経路

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID