Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

文献中Selleckの製品使用例(31)

カスタマーフィードバック(6)

  • Immunoblot of H23 cells treated with trametinib (25 nM), ponatinib (750 nM), or their combination for the times shown.

    Nature, 2016, 534(7609):647-51. Ponatinib (AP24534) purchased from Selleck.

     

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

  • Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

    The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

  • Western blot analysis of lysates of Ba/F3 cells expressing BCR/ABL and BCR/ABL-T315I using antibodies directed against: c-ABL, ABL-Y245 (anti-phospho-ABL), Crkl, phosphorylated Crkl, STAT5, phosphorylated STAT5 (anti-phospho-STAT5) and β-tubulin (anti-β-tubulin). Molecular mass references (kDa) are presented, and c-ABL and β-Tubulin were used as a loading control.

    Leukemia, 2015, 29(5):1104-14. Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NV7xe2x{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH3dIFKSzVyPUCuNFAxODByMEO1PUDPxE1? NX\YSmFKW0GQR1XS
MV-4-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy4R2dKSzVyPUCuNFAxODl3NjFOwG0> NEH4epZUSU6JRWK=
MEG-01 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zNbmlEPTB;MD6wNFAyOjhizszN M2PXU3NCVkeHUh?=
LAMA-84 NWW1TVJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT4TWRKSzVyPUCuNFAxOTZ3IN88US=> MoraV2FPT0WU
CGTH-W-1 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED4NpBKSzVyPUCuNFAyPjlizszN MWHTRW5ITVJ?
KASUMI-1 NHnpdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrLTWM2OD1yLkCwNlE4KM7:TR?= NFfrXYRUSU6JRWK=
BE-13 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMECyOVkh|ryP NGL0W3lUSU6JRWK=
CTV-1 M3fHTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEC1NlEh|ryP NET3RnpUSU6JRWK=
NKM-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfUTWM2OD1yLkCwOlU2KM7:TR?= M4fiPHNCVkeHUh?=
MONO-MAC-6 MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\DTWM2OD1yLkCwPFM4KM7:TR?= NH;iRVVUSU6JRWK=
A204 NXj4Npg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkiyTWM2OD1yLkCxNlE5KM7:TR?= MV\TRW5ITVJ?
GDM-1 NIm2eFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV36Z2h5UUN3ME2wMlAyQDN|IN88US=> M2LDNXNCVkeHUh?=
AN3-CA M3LNdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PBV2lEPTB;MD6wNVg4OyEQvF2= NXjVRmg2W0GQR1XS
BL-70 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zIS2lEPTB;MD6wNlE6QSEQvF2= M4DIU3NCVkeHUh?=
Daudi M3vQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrOe5VKSzVyPUCuNFI2OzdizszN M1vsV3NCVkeHUh?=
KU812 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LXWWlEPTB;MD6wNlg1QCEQvF2= NVS5V5FMW0GQR1XS
KG-1 M3K4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEOyPVQh|ryP MYXTRW5ITVJ?
DOHH-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMES4NFMh|ryP MmPPV2FPT0WU
HuO9 NIPzcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXreG5KSzVyPUCuNFU1PDhizszN M3nv[nNCVkeHUh?=
EB2 NY\DUndMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvnTWM2OD1yLkC1OVc3KM7:TR?= MWrTRW5ITVJ?
G-402 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKxdWo2UUN3ME2wMlA3OzRzIN88US=> NEjMSpdUSU6JRWK=
SU-DHL-1 NWT3[mh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fMdGlEPTB;MD6wOlM4QSEQvF2= NXTiXIFbW0GQR1XS
NCI-H719 NH3Lb5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjETWM2OD1yLkC3PFg5KM7:TR?= M{G4b3NCVkeHUh?=
MLMA Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PkZ2lEPTB;MD6wPVA3KM7:TR?= M2LUbXNCVkeHUh?=
KM12 M4S5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEm3N|ch|ryP MoPvV2FPT0WU
SUP-T1 NFTHepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrNTWM2OD1yLkC5PVgzKM7:TR?= M1LLOnNCVkeHUh?=
MZ1-PC NVLYenJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfnU4xKSzVyPUCuNVE{OzZizszN MoXjV2FPT0WU
MFE-296 MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzFd2c2UUN3ME2wMlEyQDN7IN88US=> M{Ta[3NCVkeHUh?=
ALL-PO M13F[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDOdHlKSzVyPUCuNVI1PDNizszN NEn0RmhUSU6JRWK=
GB-1 M1nwTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rxVmlEPTB;MD6xNlUyOiEQvF2= M2rMSnNCVkeHUh?=
SIG-M5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPScJRKSzVyPUCuNVM{PyEQvF2= NH;K[JRUSU6JRWK=
P30-OHK NGXQU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M123VmlEPTB;MD6xOVY4OiEQvF2= NF;4UYtUSU6JRWK=
NCI-H716 NXfWR4dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjrTWM2OD1yLkG2NlY3KM7:TR?= NGXuO3NUSU6JRWK=
MPP-89 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMU[5N|Mh|ryP MYXTRW5ITVJ?
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS4O4hKSzVyPUCuNVcxPjNizszN Mln2V2FPT0WU
CTB-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPKdm1KSzVyPUCuNVc{OTZizszN NGrScoxUSU6JRWK=
CA46 NVHtXJVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDCfoJjUUN3ME2wMlE4PDh7IN88US=> MUHTRW5ITVJ?
NCI-H520 M2LCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfzTWM2OD1yLkG3O|MzKM7:TR?= M4fBXXNCVkeHUh?=
CAL-85-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\OTWM2OD1yLkG3PVI4KM7:TR?= MYTTRW5ITVJ?
NCI-H2342 M1;ofGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz6TWM2OD1yLkG4OVc4KM7:TR?= NYL0NYNDW0GQR1XS
697 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX4SY9nUUN3ME2wMlE5QDdzIN88US=> MXHTRW5ITVJ?
NY MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLETWM2OD1yLkG5Nlg4KM7:TR?= M4rpOXNCVkeHUh?=
T98G Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMUmzNVgh|ryP M{e0VXNCVkeHUh?=
NCI-H1703 NVfBc4g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu0XYJGUUN3ME2wMlE6PjF3IN88US=> Moq3V2FPT0WU
NCI-H2087 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMkC0N|kh|ryP M1TofXNCVkeHUh?=
PF-382 NGDnbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rLcmlEPTB;MD6yNFg4OyEQvF2= M17hcXNCVkeHUh?=
HCT-116 MkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHjTWM2OD1yLkKxNFY6KM7:TR?= Mn\NV2FPT0WU
CAKI-1 MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofXTWM2OD1yLkKxOlY3KM7:TR?= MkPiV2FPT0WU
CCF-STTG1 NUPlR5dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnmTWM2OD1yLkKyOFc2KM7:TR?= NXK1XI1bW0GQR1XS
D-392MG NV;aN4Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG0Z2tKSzVyPUCuNlMyPzdizszN M{\EfnNCVkeHUh?=
RT-112 M3P4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LjNGlEPTB;MD6yN|c6PSEQvF2= NUDVbIxVW0GQR1XS
MES-SA M4nIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfMUIVKSzVyPUCuNlQyQDdizszN M3r1dHNCVkeHUh?=
LC-2-ad NHnF[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVux[Wd5UUN3ME2wMlI1OjZ3IN88US=> MYjTRW5ITVJ?
NOS-1 NUDkOGk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrhTWM2OD1yLkK0N|Y4KM7:TR?= MWDTRW5ITVJ?
NALM-6 NHjCPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMkW1OFMh|ryP M3vhSXNCVkeHUh?=
TE-15 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInEWYFKSzVyPUCuNlYxQTFizszN NW\JR5dxW0GQR1XS
786-0 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfWTWM2OD1yLkK2NlI5KM7:TR?= Mn\NV2FPT0WU
IST-MES1 M4nLZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMk[4Nlkh|ryP NWrjWHp2W0GQR1XS
KYSE-180 NH7BT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jNZ2lEPTB;MD6yOlg6OSEQvF2= M2TM[XNCVkeHUh?=
YT NU\Pc5huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETS[YxKSzVyPUCuNlY6PzRizszN NIGzeodUSU6JRWK=
A427 NGXZZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojNTWM2OD1yLkK3NlY1KM7:TR?= NVnwTIE1W0GQR1XS
KYSE-450 NHjnVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMkezNlkh|ryP NYfiU|c4W0GQR1XS
HuH-7 M{GwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjWeVJKSzVyPUCuNlc4PjNizszN MmG4V2FPT0WU
CAS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\mN2lEPTB;MD6yPFMxOyEQvF2= MnqwV2FPT0WU
KURAMOCHI NXjJdm1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPINYJKSzVyPUCuNlg1OTlizszN MUPTRW5ITVJ?
ACHN NHXGTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL5U45KSzVyPUCuNlk{OjNizszN NULVfll3W0GQR1XS
HGC-27 NVvIZZd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMkmzOVMh|ryP MmXXV2FPT0WU
A172 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMkm1O|ch|ryP NUX3RmNEW0GQR1XS
SNU-449 M4DhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMkm5OlQh|ryP NGXYWlRUSU6JRWK=
SW982 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMkm5O|gh|ryP MmrEV2FPT0WU
EFO-21 M{HFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3FdIJUUUN3ME2wMlMxPDFzIN88US=> NVHSbpVmW0GQR1XS
NCI-H2030 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwM{GxOlQh|ryP MkDoV2FPT0WU
HT-144 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTtcopKSzVyPUCuN|EzQCEQvF2= MXHTRW5ITVJ?
MFE-280 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP3eHlUUUN3ME2wMlMyPDV|IN88US=> M1S3e3NCVkeHUh?=
SK-LU-1 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq0V4pzUUN3ME2wMlMyPDZ4IN88US=> MYHTRW5ITVJ?
NCI-H2052 NV\lcoZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwM{G0PFQh|ryP NVfYXFF[W0GQR1XS
SK-HEP-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjWTWM2OD1yLkOzN|Y5KM7:TR?= NI\GRVVUSU6JRWK=
QIMR-WIL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\1PYRDUUN3ME2wMlM{PDJ2IN88US=> M37JV3NCVkeHUh?=
A2780 MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\TUZNKSzVyPUCuN|Q{ODRizszN M{XkS3NCVkeHUh?=
ACN MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfzSplRUUN3ME2wMlM1QDd|IN88US=> MYXTRW5ITVJ?
BxPC-3 NGLwcppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwM{S5PFkh|ryP NH\EZYhUSU6JRWK=
BCPAP NYn6OoxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjJZ|RKSzVyPUCuN|YxODFizszN NWPHdlNRW0GQR1XS
HOP-62 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\0TWM2OD1yLkO2NVA3KM7:TR?= MXjTRW5ITVJ?
SW1710 M4TST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[1OGlEPTB;MD6zOlQ2PSEQvF2= M{HxZXNCVkeHUh?=
OPM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOxTWM2OD1yLkO2OFc{KM7:TR?= NITafm5USU6JRWK=
DBTRG-05MG NWrj[nIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LpcmlEPTB;MD6zPFA2PCEQvF2= NWr3SoJOW0GQR1XS
SK-MEL-24 MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PLNmlEPTB;MD6zPVc6OSEQvF2= MXLTRW5ITVJ?
8305C NYryW4R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn2Rm1ZUUN3ME2wMlM6Pzl|IN88US=> NV3y[oFHW0GQR1XS
OVCAR-4 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDC[VVKSzVyPUCuOFE2QDZizszN NEjyW4VUSU6JRWK=
HLE NXXPZmhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TlRWlEPTB;MD60NVg3KM7:TR?= M2n4RXNCVkeHUh?=
NCI-H747 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;yTYtMUUN3ME2wMlQzOTN5IN88US=> Mki3V2FPT0WU
SW780 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\1[mxFUUN3ME2wMlQzOzR4IN88US=> M{\KfHNCVkeHUh?=
KYSE-150 NIXndpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwNEK0NVUh|ryP NWXuTJRwW0GQR1XS
H4 NE\ZdW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;uTWM2OD1yLkSyOFUyKM7:TR?= M3fUVXNCVkeHUh?=
SW1088 M3PRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUftZ5NCUUN3ME2wMlQ1OzlizszN MXvTRW5ITVJ?
SF268 M4jjXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnoTWM2OD1yLkS0PFYh|ryP NYDRW4x2W0GQR1XS
RT4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrQOYtKSzVyPUCuOFUyOTFizszN M1zlUnNCVkeHUh?=
NCI-H522 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PPc2lEPTB;MD60OVI4KM7:TR?= NIL6cFVUSU6JRWK=
LCLC-97TM1 MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfHOYxKSzVyPUCuOFYyQTVizszN NHPwOWNUSU6JRWK=
CAL-39 M3;2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzpcnpKUUN3ME2wMlQ3PTF7IN88US=> NUOxb256W0GQR1XS
CAL-120 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnRW5lKSzVyPUCuOFc3PDNizszN MlLMV2FPT0WU
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NCI-H810 M3ewUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:5XmlEPTB;MT64NVYxPiEQvF2= MVHTRW5ITVJ?
SK-NEP-1 NUL5OWtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwOEO3Olch|ryP NHLyZ|ZUSU6JRWK=
D-542MG NV2zNpRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XodWlEPTB;MT64OVg2OSEQvF2= MXzTRW5ITVJ?
KNS-42 MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFwOE[yOlYh|ryP Mnv1V2FPT0WU
NCI-H2452 NHyyXGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFwOEmwO|Qh|ryP NVOwSId[W0GQR1XS
SK-MEL-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrGNIdZUUN3ME2xMlkxOjdzIN88US=> NUPsbXV6W0GQR1XS
OVCAR-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q5PGlEPTB;MT65NFY4PSEQvF2= NFjtRWdUSU6JRWK=
SNG-M M4DFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOUW4OVgh|ryP M3vW[nNCVkeHUh?=
A673 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn0UYdKSzVyPUGuPVc2OTZizszN M17PVXNCVkeHUh?=
L-428 M2SybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe1WWxKSzVyPUGuPVkyPzlizszN M2HXN3NCVkeHUh?=
KM-H2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TiV2lEPTB;Mj6wNVA6KM7:TR?= MXzTRW5ITVJ?
MC-IXC M4PTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkizTWM2OD1{LkCyNlc{KM7:TR?= M{L6VHNCVkeHUh?=
COLO-678 NUfqV|RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfLSnBOUUN3ME2yMlA1OjB5IN88US=> NVLYeY5tW0GQR1XS
MEL-JUSO Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqzTWM2OD1{LkC3PFUyKM7:TR?= M4mzSHNCVkeHUh?=
HCC38 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITHW|dKSzVyPUKuNFg1OzNizszN NXz3TFlHW0GQR1XS
UACC-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{eyTGlEPTB;Mj6wPFg2PSEQvF2= MnjjV2FPT0WU
OAW-42 NU[3NnkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHQZnVTUUN3ME2yMlA6PzFzIN88US=> MorOV2FPT0WU
LB996-RCC NWnCNWs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zzWmlEPTB;Mj6xN|gyPyEQvF2= NH62dnRUSU6JRWK=
COR-L105 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[5OpBKSzVyPUKuNVY{PzNizszN M2P6UnNCVkeHUh?=
RCC10RGB MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjLRXVKSzVyPUKuNVg2PzZizszN MUPTRW5ITVJ?
A431 NH3FbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvTdVBZUUN3ME2yMlE6ODF7IN88US=> Mm\yV2FPT0WU
NCI-H292 NVz1ZXFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nGZ2lEPTB;Mj6yN|k2OSEQvF2= NXfkSGloW0GQR1XS
SK-UT-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P6XWlEPTB;Mj6zN|E5PCEQvF2= MlfaV2FPT0WU
PANC-08-13 Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;0SWlEPTB;Mj6zN|I{PSEQvF2= NH;DTWdUSU6JRWK=
ST486 NXHzPHVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfCTItKSzVyPUKuOFExPDhizszN NVmzelVvW0GQR1XS
SJSA-1 MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLYTWM2OD1{LkSxNlcyKM7:TR?= NIX0clBUSU6JRWK=
RKO M4HOW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;IeFJJUUN3ME2yMlQzODJ7IN88US=> MknoV2FPT0WU
NCI-H1793 MkO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwNESwNlkh|ryP MXTTRW5ITVJ?
639-V MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnkTWM2OD1{LkS1N|gzKM7:TR?= MWXTRW5ITVJ?
ES3 M4K4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\2eGtKSzVyPUKuOFk4OzdizszN MVHTRW5ITVJ?
NCI-H1792 NYPrd29JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHiUZdKSzVyPUKuOVY5OjZizszN MoDiV2FPT0WU
NCI-H1651 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSzRWhPUUN3ME2yMlU5OjFizszN MnTHV2FPT0WU
SN12C M1GwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm1fmFPUUN3ME2yMlU5PDh5IN88US=> NXGwVIR4W0GQR1XS
COLO-679 NHfVPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwNUi2NFUh|ryP MnHpV2FPT0WU
U-118-MG NYnyTFhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJwNUi4O|Ih|ryP MkDyV2FPT0WU
Ramos-2G6-4C10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXHTWM2OD1{Lk[0PFA4KM7:TR?= M3[3VHNCVkeHUh?=
HCT-15 NYjkTmNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;XWnhKSzVyPUKuOlg4QTJizszN M{\LU3NCVkeHUh?=
MDA-MB-157 M4XLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1voWGlEPTB;Mj63NFc1PyEQvF2= M3X1THNCVkeHUh?=
K5 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjGTWM2OD1{LkexPFQ2KM7:TR?= MnTGV2FPT0WU
MKN45 M2rJO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkSxTWM2OD1{LkezN|Y3KM7:TR?= NWLQOm51W0GQR1XS
DMS-273 M3jMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fnXGlEPTB;Mj63OVY{OiEQvF2= Ml3nV2FPT0WU
C8166 NHzVRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwN{i1NVMh|ryP NE\WfWlUSU6JRWK=
Calu-3 M3H0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLpTWM2OD1{Lke4PVY6KM7:TR?= M3HtcHNCVkeHUh?=
SNB75 NVjTVoRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrJTWM2OD1{Lki4OVM2KM7:TR?= NVPjSYk2W0GQR1XS
BFTC-905 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTGTWM2OD1{LkmwNVkyKM7:TR?= NYHUU2kyW0GQR1XS
C-4-II MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfxUG1KSzVyPUKuPVE{PTNizszN M361enNCVkeHUh?=
MS-1 NF7Zc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P2dGlEPTB;Mj65Olc3QSEQvF2= MWjTRW5ITVJ?
A375 NYHPcYVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PDSmlEPTB;Mz6wPFE5PCEQvF2= Mmr2V2FPT0WU
KYSE-70 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXycG5KSzVyPUOuNFg5QDJizszN NFPXcYlUSU6JRWK=
KYSE-510 NULY[FY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;WXGlEPTB;Mz6xNFk6PSEQvF2= MlTBV2FPT0WU
LN-405 NGC4fpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jKcGlEPTB;Mz6xN|UyQCEQvF2= M1TI[XNCVkeHUh?=
BOKU MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWwXG5KSzVyPUOuNVQzPTZizszN M{POUnNCVkeHUh?=
TE-10 NEK1eHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17nUGlEPTB;Mz6xO|M3OiEQvF2= NFrV[G1USU6JRWK=
MKN1 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGwXJZKSzVyPUOuNVg1QDNizszN MorzV2FPT0WU
M059J Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj0TJJsUUN3ME2zMlIxOTd|IN88US=> MYDTRW5ITVJ?
GOTO NUG4RpVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\5N3BKSzVyPUOuNlIxOzlizszN M4D2WXNCVkeHUh?=
DK-MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwMkW5O|Yh|ryP NFixRYdUSU6JRWK=
NCI-H727 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTNwMk[1PEDPxE1? NUj0OJRSW0GQR1XS
NB12 M4fSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkezTWM2OD1|LkOzNlI1KM7:TR?= NHLoNJVUSU6JRWK=
DOK NU\0VJQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfrNXVKSzVyPUOuN|YyQDZizszN NXLpdppGW0GQR1XS
KYSE-410 NXnwOGtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInDXoxKSzVyPUOuN|YzQDdizszN MUPTRW5ITVJ?
AM-38 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\oRnBtUUN3ME2zMlM5ODVzIN88US=> NXLIRVlIW0GQR1XS
GR-ST NEjWXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:3VFZKSzVyPUOuOFU4OzJizszN MU\TRW5ITVJ?
D-247MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTNwNEiyOlMh|ryP NITNPWhUSU6JRWK=
TE-8 NHnuZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTNwNEmzN|Mh|ryP MVHTRW5ITVJ?
LS-411N NIjUS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP0c3BKSzVyPUOuOFk3QTJizszN NX[1ZVRVW0GQR1XS
SK-MES-1 NX31V4k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNwNU[0N|Mh|ryP Mny3V2FPT0WU
SF295 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHUTWM2OD1|Lk[xOVUzKM7:TR?= NV\iUWRKW0GQR1XS
SK-MEL-30 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLtTWM2OD1|Lk[1PVIyKM7:TR?= MUjTRW5ITVJ?
LB2241-RCC NVmyRZU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOyTWM2OD1|Lk[2NlYh|ryP NF7WTGJUSU6JRWK=
PC-14 NGLDbXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3zUYJxUUN3ME2zMlY3PDN5IN88US=> MoHEV2FPT0WU
EW-7 M{fJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonoTWM2OD1|Lk[3Olk{KM7:TR?= MkD1V2FPT0WU
NMC-G1 NVLhNll5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfqTWM2OD1|LkexPFM4KM7:TR?= MnTIV2FPT0WU
TE-441-T MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTNwN{OwNlgh|ryP MUPTRW5ITVJ?
NCI-H1618 MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rp[GlEPTB;Mz64NVg4PSEQvF2= NF:zVHVUSU6JRWK=
PANC-03-27 NWn1eGpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT3TWM2OD1|LkixPVE3KM7:TR?= NFfScGZUSU6JRWK=
NCI-H2228 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XzZWlEPTB;Mz64N|EzPiEQvF2= M2fhd3NCVkeHUh?=
CAPAN-1 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nTe2lEPTB;Mz64O|AxQSEQvF2= NFTWe3NUSU6JRWK=
KLE MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\JVVhKSzVyPUOuPVA3PyEQvF2= MnrtV2FPT0WU
Becker NVW0e3d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwOUK4OFkh|ryP M{\le3NCVkeHUh?=
SK-PN-DW NHHzVohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRwMEe5O|Qh|ryP NIDke41USU6JRWK=
Hs-578-T M3n2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF30TmRKSzVyPUSuNFg{ODZizszN NEPweZhUSU6JRWK=
RS4-11 M4WySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjJNW1KSzVyPUSuNVEzPTVizszN NVix[ZpVW0GQR1XS
D-502MG MlfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrITWM2OD12LkG2PVk4KM7:TR?= NF65c4JUSU6JRWK=
GI-1 NWPocldZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDVUFBKSzVyPUSuNlgzQTlizszN NUfkRZNwW0GQR1XS
NCI-H209 NYrqXWM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XNPGlEPTB;ND6zN|c5KM7:TR?= MXjTRW5ITVJ?
SK-OV-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M173PGlEPTB;ND60PFE1QSEQvF2= MW\TRW5ITVJ?
LOUCY M1uyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn35TWM2OD12LkS4OFMzKM7:TR?= MkPIV2FPT0WU
NCI-H69 NXj5ZnJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTRwNUG3PVMh|ryP MkLyV2FPT0WU
SCC-9 M2\vXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTRwNUOxO|Ih|ryP MXPTRW5ITVJ?
NCI-H526 NUHYRZBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorrTWM2OD12LkW5Nlk{KM7:TR?= MoHYV2FPT0WU
NCI-H2170 NI\WRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRwNk[3O|Eh|ryP MYPTRW5ITVJ?
SR MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHoS3ZKSzVyPUSuO|AxPDhizszN M3y1T3NCVkeHUh?=
CMK NV\vOXBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTRwN{KxNFEh|ryP MXXTRW5ITVJ?
COLO-829 NE\SZ49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3YTWM2OD12Lke3NFQ{KM7:TR?= MlLkV2FPT0WU
HuO-3N1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlryTWM2OD12LkizNlgyKM7:TR?= M2j5V3NCVkeHUh?=
5637 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rzcWlEPTB;ND65NFQ5PyEQvF2= M3\TbHNCVkeHUh?=
A253 M1;iUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC0fIM3UUN3ME20Mlk4PzB6IN88US=> M3XEUXNCVkeHUh?=
NB10 MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG1dIxKSzVyPUWuNFc1QTdizszN MlPuV2FPT0WU
SF539 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDGe21tUUN3ME21MlA6QTV7IN88US=> MmrRV2FPT0WU
HAL-01 NFnBOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\wTWM2OD13LkG0OlQ2KM7:TR?= NHmyWItUSU6JRWK=
MHH-ES-1 NXzRfnJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTzTWM2OD13LkG2PVI2KM7:TR?= M3PvenNCVkeHUh?=
DEL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;YNmlEPTB;NT6yO|U5OiEQvF2= MVvTRW5ITVJ?
NCI-H1299 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDudYtKSzVyPUWuN|UxODdizszN NYS1d3lkW0GQR1XS
ChaGo-K-1 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTVwM{WxNFch|ryP NHTTeJVUSU6JRWK=
HMV-II MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\hcGlEPTB;NT6zPVQ{KM7:TR?= MnzTV2FPT0WU
NB69 NYjWW2hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTiN5BjUUN3ME21MlM6PjNzIN88US=> NIDiZ5ZUSU6JRWK=
NCI-H1882 NX\tNGxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwNEOzOlQh|ryP MlPRV2FPT0WU
SNU-475 M3LuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTVwNEexO|Eh|ryP NGrXd3JUSU6JRWK=
RXF393 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorqTWM2OD13LkS4OFk1KM7:TR?= M1\pdHNCVkeHUh?=
CAL-51 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX0TWM2OD13Lk[yPFU{KM7:TR?= NEHPS49USU6JRWK=
SW1573 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vPU2lEPTB;NT62N|U{PCEQvF2= NF3vTm5USU6JRWK=
GCT NYnsNI51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zK[2lEPTB;NT63OVkzQSEQvF2= M2\CTnNCVkeHUh?=
COR-L88 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrQNpc2UUN3ME21Mlc3QDR4IN88US=> MmLVV2FPT0WU
MDA-MB-134-VI NHz5UpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnflTWM2OD13Lki3OVM3KM7:TR?= NXexcZJsW0GQR1XS
NB5 NFjDOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXY[JNKSzVyPUWuPVI1PCEQvF2= NYTJOFdwW0GQR1XS
GMS-10 NH;Le5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\UdWlEPTB;NT65Olg3OSEQvF2= NHK2NY9USU6JRWK=
CHP-212 NVqzNGhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XuZWlEPTB;Nj60PFI3PyEQvF2= NH;GW5BUSU6JRWK=
TE-11 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLNTWM2OD14LkW1NVgzKM7:TR?= NF;oO2RUSU6JRWK=
SW962 MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;TOmpKSzVyPU[uOlU4PzRizszN MnTBV2FPT0WU
MZ2-MEL M2P3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\6TWM2OD14LkiyNFEyKM7:TR?= NH\NXZNUSU6JRWK=
C-33-A M3z5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\MXpdKSzVyPU[uPVE3QDhizszN MYDTRW5ITVJ?
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T84 NUnad|VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\WdGlEPTB;MkGuPVgyQSEQvF2= NYX0VoVXW0GQR1XS
NCI-H630 NUCwN4FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ{LkWzOlMh|ryP NEX3OY1USU6JRWK=
LU-165 M3nwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjSTHJKSzVyPUKyMlU2PCEQvF2= MU\TRW5ITVJ?
COLO-792 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XlWWlEPTB;MkKuO|EyOSEQvF2= M2L6XnNCVkeHUh?=
CAL-62 NVL3d|YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPnTWM2OD1{Mj63OVE4KM7:TR?= NEn6UoJUSU6JRWK=
HCE-T MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fhc2lEPTB;MkKuPFYxPiEQvF2= NVXsVoZxW0GQR1XS
BB65-RCC MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TaWGlEPTB;MkOuNFM1PCEQvF2= M170R3NCVkeHUh?=
SiHa NHfNdXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPmXm15UUN3ME2yN{4{QTZ6IN88US=> MnHLV2FPT0WU
NCI-H2081 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;LXmlEPTB;MkSuNFY1OSEQvF2= MWrTRW5ITVJ?
U251 NIq1NHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LofWlEPTB;MkSuNFY3QCEQvF2= M12x[HNCVkeHUh?=
LoVo M3HTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;LTWM2OD1{ND65NlgzKM7:TR?= NWfPcZB1W0GQR1XS
GCIY MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHOWIpKSzVyPUK1MlI5PzdizszN M{\tfHNCVkeHUh?=
NUGC-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHyU3VKSzVyPUK1MlM{OTZizszN NYTHdIZRW0GQR1XS
LNCaP-Clone-FGC M2POVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fKZ2lEPTB;MkWuN|Q6QCEQvF2= MlnuV2FPT0WU
PA-1 M3zEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJ3Lk[4N|Mh|ryP Ml7hV2FPT0WU
OE33 NGG4doVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHHWHd[UUN3ME2yOU43QDV|IN88US=> NGLTTGNUSU6JRWK=
HT-29 NWXNVYFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe2elBxUUN3ME2yOU44QDd7IN88US=> MYDTRW5ITVJ?
RCM-1 M3rTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;EUGlEPTB;MkWuPVY2PiEQvF2= MXvTRW5ITVJ?
NCI-H1522 NGHFOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q1fWlEPTB;MkWuPVkyOSEQvF2= NGTnfVZUSU6JRWK=
LB373-MEL-D MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ4LkG3NFgh|ryP NYXHdVlSW0GQR1XS
NCI-H1436 NIHOeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3naZ2lEPTB;Mk[uNlc{QCEQvF2= NInZU|lUSU6JRWK=
COLO-824 NUTScmFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT6do9sUUN3ME2yOk41ODB{IN88US=> NF3EWJVUSU6JRWK=
CP50-MEL-B NVO0cVFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnZUWtiUUN3ME2yOk42Pjd3IN88US=> NYS1e|dWW0GQR1XS
EGI-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvNZYtHUUN3ME2yO{4zPjl6IN88US=> NVTENolKW0GQR1XS
LAN-6 MmfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ5LkO1PVgh|ryP MVHTRW5ITVJ?
GAK NVP6TVZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fQS2lEPTB;MkeuOFIzPSEQvF2= NV72V3pSW0GQR1XS
MDA-MB-175-VII MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfpSYhrUUN3ME2yO{42ODV|IN88US=> NIPrOWhUSU6JRWK=
JVM-2 NWi0T|dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfwcGJCUUN3ME2yO{43PjJ{IN88US=> NUjESlA1W0GQR1XS
UACC-257 NUfDPXU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTNTWM2OD1{Nz62PFc5KM7:TR?= NHrlRZlUSU6JRWK=
SW1783 NGnkRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDaVFlKSzVyPUK3Mlc4QDNizszN NYP4[oRpW0GQR1XS
HT-3 M{Pnfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\oTWM2OD1{OD6yNVY3KM7:TR?= MkTlV2FPT0WU
RL M1TOR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\sTWM2OD1{OD61PVEyKM7:TR?= NXfvPYV4W0GQR1XS
TK10 NF7XT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXJOnpKSzVyPUK4MlY2OzVizszN M{j3eHNCVkeHUh?=
HT55 MoDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDxfYJJUUN3ME2yPU4xPTZ3IN88US=> M1rkb3NCVkeHUh?=
BT-20 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJ7LkC1PFYh|ryP MWDTRW5ITVJ?
TGBC24TKB NE\0fYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jXS2lEPTB;MkmuNVg{OSEQvF2= MWnTRW5ITVJ?
HSC-2 M{nDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XrfGlEPTB;MkmuN|AxOSEQvF2= NYf6UVlyW0GQR1XS
COLO-205 M2rJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvQNZRKSzVyPUK5MlM6PDRizszN M1HyVnNCVkeHUh?=
GT3TKB NYf1c29JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HRfWlEPTB;MkmuOlg4PyEQvF2= MUXTRW5ITVJ?
T47D NITlWnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fT[GlEPTB;MkmuPFU5OiEQvF2= NXnQN5ZpW0GQR1XS
OMC-1 MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\MTWM2OD1|MD6xPVE6KM7:TR?= Ml[zV2FPT0WU
PFSK-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlKzTWM2OD1|MT6yOlU6KM7:TR?= NILQeZVUSU6JRWK=
JEG-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLiTWM2OD1|MT6zOVYyKM7:TR?= MkLwV2FPT0WU
RD NYm0OYExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNzLkWxNVUh|ryP NIPjVnFUSU6JRWK=
NCI-H64 NGXnbXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPFTWM2OD1|Mj60NVc6KM7:TR?= NX3KNpN1W0GQR1XS
DMS-114 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLoTWM2OD1|Mj60NVgzKM7:TR?= NHXHR2NUSU6JRWK=
NCI-H661 NF;lNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32zW2lEPTB;M{KuOlUxOSEQvF2= MoC3V2FPT0WU
CAL-148 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjxbpRKSzVyPUOyMlY3PjVizszN NULaRVJ6W0GQR1XS
HuP-T3 MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnJXVNKSzVyPUOyMlk{OzhizszN M{f3e3NCVkeHUh?=
ES4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTN|LkG3NFUh|ryP M2rsbXNCVkeHUh?=
Ca9-22 NGS3Nm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPRTWM2OD1|Mz60OlAyKM7:TR?= NIS5S2tUSU6JRWK=
LP-1 NUS0e|U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHsSWZKSzVyPUO0MlA6KM7:TR?= M{T2enNCVkeHUh?=
AU565 NF76SWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXu3UnBrUUN3ME2zOE42ODZ7IN88US=> MmHBV2FPT0WU
MDA-MB-453 Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTN3LkG0NlYh|ryP MW\TRW5ITVJ?
SNU-C1 NVG5dmhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfXWnVIUUN3ME2zOU4yPzFizszN NUKycIJ4W0GQR1XS
SW13 NYiweopvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzzTWM2OD1|NT60NFc3KM7:TR?= NU\2NWFVW0GQR1XS
NCI-H2122 MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXDSVhKSzVyPUO1MlU2QThizszN NFj3dndUSU6JRWK=
NCI-H1395 NVPnc3Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN3Lk[2PVEh|ryP NUjqN21oW0GQR1XS
J-RT3-T3-5 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSxR483UUN3ME2zOk4xOjl2IN88US=> M1v6Z3NCVkeHUh?=
COR-L279 NXywPHZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDNTWM2OD1|Nj6xPVgyKM7:TR?= MVPTRW5ITVJ?
ATN-1 NWLy[m8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\CRoNIUUN3ME2zOk45PTF4IN88US=> NGTVN4tUSU6JRWK=
HCC2998 NFfmVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTCTWM2OD1|Nj64OVcyKM7:TR?= M1TIZXNCVkeHUh?=
UM-UC-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\FTWM2OD1|Nj64Olc2KM7:TR?= MoPBV2FPT0WU
DV-90 MkPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN4LkmwOlch|ryP NXnQ[o5TW0GQR1XS
ES8 NY\mUY9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C2cGlEPTB;M{[uPVMyQCEQvF2= MmfyV2FPT0WU
YAPC NYrSUJVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvabpJKSzVyPUO2Mlk3PTRizszN NY\MZY01W0GQR1XS
HCC1599 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTGfplzUUN3ME2zO{4yPjF6IN88US=> NX\BcIk2W0GQR1XS
UMC-11 NFvPZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPPTWM2OD1|Nz6yOVA{KM7:TR?= NWXIUIp4W0GQR1XS
THP-1 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni5TWM2OD1|Nz6yPFY5KM7:TR?= MnzqV2FPT0WU
OCUB-M M1LUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN5LkK4PVEh|ryP MoLzV2FPT0WU
NCI-H1693 NWTYUJRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zaZmlEPTB;M{euN|I{OyEQvF2= NVS3OVhEW0GQR1XS
NCI-H345 MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN5LkO2NlQh|ryP NUnoN4dxW0GQR1XS
COLO-800 MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[3OGlEPTB;M{euOVY4KM7:TR?= NVTq[|lZW0GQR1XS
COLO-320-HSR NYrjSo1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDwWJdWUUN3ME2zPE4{PDl{IN88US=> NUfNTZhGW0GQR1XS
NCI-H596 NVvVNWxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PVS2lEPTB;M{iuOFQ5QSEQvF2= NHzoWpRUSU6JRWK=
NCI-H187 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3mx[GlEPTB;M{iuO|M1PCEQvF2= MWrTRW5ITVJ?
ECC4 NEHEbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrOTWM2OD1|OT6wPFE1KM7:TR?= MVHTRW5ITVJ?
KP-4 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfwTWM2OD1|OT6xNlM2KM7:TR?= MVLTRW5ITVJ?
NCI-H2227 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN7LkO5OFkh|ryP NFTP[5lUSU6JRWK=
22RV1 M{fMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN7LkizPVgh|ryP NITFOoNUSU6JRWK=
SAS NXG4O41UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTRyLkC5OkDPxE1? NUDlc3V3W0GQR1XS
PANC-10-05 NXPUfokxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPBTWM2OD12MD6xPFI5KM7:TR?= NGrBZ5FUSU6JRWK=
MDA-MB-468 NXjCWHl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[2dnhQUUN3ME20NE42OzR4IN88US=> NUPIXnE6W0GQR1XS
RPMI-7951 NW\5bGlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLmXGhZUUN3ME20NU4zODd3IN88US=> M1TWeHNCVkeHUh?=
BB49-HNC NY\zVpl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTRzLkKxO|kh|ryP MX3TRW5ITVJ?
23132-87 NVuyc4dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PYO2lEPTB;NEGuNlc{OiEQvF2= Mn3jV2FPT0WU
HCC1569 NXq1TFU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvSemdxUUN3ME20NU4zQDh3IN88US=> NXL6Z45LW0GQR1XS
CP66-MEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLSTWM2OD12Mj6xPFg3KM7:TR?= NYG3d4N6W0GQR1XS
K-562 M{DV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjiZmlJUUN3ME20Nk4zQDV2IN88US=> NEOy[2xUSU6JRWK=
OCI-AML2 NXrvemJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTR{Lki5O|Qh|ryP M3jnW3NCVkeHUh?=
SW756 M1\4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXHTWM2OD12Mz6wN|g5KM7:TR?= M3XadnNCVkeHUh?=
M14 NV2ybXNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzubHpVUUN3ME20N{4{OTh7IN88US=> NU\Y[nZZW0GQR1XS
NCI-H1623 M4S3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTR|LkS2OEDPxE1? MVPTRW5ITVJ?
KNS-81-FD Mo\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTR|Lke2NkDPxE1? NIW4[IlUSU6JRWK=
TGBC1TKB NGLGOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXu[mczUUN3ME20N{46ODl7IN88US=> M2HafHNCVkeHUh?=
RERF-LC-MS M1O0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\qUYJKSzVyPUSzMlkzQDFizszN NHm3PHJUSU6JRWK=
PC-3 NEix[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3LfFJKSzVyPUS0MlQ{PDdizszN M1jTenNCVkeHUh?=
HuP-T4 M2HKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LReGlEPTB;NESuOFQ4PCEQvF2= M4TuNHNCVkeHUh?=
NCI-H510A NUDZO5NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\Hd2lEPTB;NESuO|A5KM7:TR?= NX3rfpg4W0GQR1XS
LB2518-MEL NXm3UGpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nFXWlEPTB;NESuO|k{PyEQvF2= NX7OZolrW0GQR1XS
TE-5 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorRTWM2OD12NT65OVgyKM7:TR?= MnvKV2FPT0WU
EW-24 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR4LkG3NlMh|ryP MYTTRW5ITVJ?
LB647-SCLC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTR4LkKxOVUh|ryP MX3TRW5ITVJ?
NCI-H524 M1PxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHXdXlKSzVyPUS2MlcyQDVizszN MlzYV2FPT0WU
EW-11 NG\FV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfOTWM2OD12Nj65N|c{KM7:TR?= NUHTOmEyW0GQR1XS
KALS-1 NGPsTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTR5LkKwOlYh|ryP NYXoU3gyW0GQR1XS
BT-474 M1rONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXrTWM2OD12Nz60NlE3KM7:TR?= MX3TRW5ITVJ?
SK-N-AS NFzSZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rvXmlEPTB;NEeuPFg5KM7:TR?= MVfTRW5ITVJ?
HCC2157 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHNRY97UUN3ME20PE4xPzZizszN M4nHenNCVkeHUh?=
HCC1954 M2TIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR6LkG3NFQh|ryP MYrTRW5ITVJ?
FADU MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH75T5JKSzVyPUS4MlMxOzFizszN MlnjV2FPT0WU
S-117 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR6LkO4NVUh|ryP M3fw[nNCVkeHUh?=
LS-1034 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR6LkewOlch|ryP NGXZZXZUSU6JRWK=
CAMA-1 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTXTWM2OD12OT61OVQ{KM7:TR?= M1rrfXNCVkeHUh?=
LU-134-A MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7iOmRKSzVyPUS5MlgxQDVizszN M3W3dXNCVkeHUh?=
NCI-H1838 NH7BT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoGwTWM2OD12OT64NFg4KM7:TR?= MXXTRW5ITVJ?

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体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

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キナーゼ試験:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
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  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
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  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709017 Recruiting Chronic Myeloid Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Korea Otsuka Pharmaceutical Co. Ltd. October 2018 --
NCT03690115 Not yet recruiting Leukemia Myeloid Acute Versailles Hospital October 2018 Phase 2
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03589326 Recruiting Lymphoblastic Leukemia Acute Adult|Acute Lymphoid Leukemia|Leukemia Acute Lymphoblastic|Leukemia Lymphoblastic|Ph1 Chromosome|Leukemia Lymphoblastic Acute Philadelphia-Positive Millennium Pharmaceuticals Inc.|Takeda August 10 2018 Phase 3
NCT03576547 Recruiting Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|t(9;22) M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 26 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID