Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell M4XOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK2TWM2OD1yLkCwNFAxODB|NUmg{txO NVzMXZQyW0GQR1XS
MV-4-11 MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPzenc1UUN3ME2wMlAxODB7NU[g{txO M3rRW3NCVkeHUh?=
MEG-01 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu4OZRKSzVyPUCuNFAxOTJ6IN88US=> NIn3e3FUSU6JRWK=
LAMA-84 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMECwNVY2KM7:TR?= MofpV2FPT0WU
CGTH-W-1 NWDwUWFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LKXmlEPTB;MD6wNFE3QSEQvF2= NH\oRXNUSU6JRWK=
KASUMI-1 NWPHfGt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMECyNVch|ryP M4C1UHNCVkeHUh?=
BE-13 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMECyOVkh|ryP NHH2d5RUSU6JRWK=
CTV-1 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\uTWM2OD1yLkCwOVIyKM7:TR?= NVzkNFF7W0GQR1XS
NKM-1 M3npfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rxSGlEPTB;MD6wNFY2PSEQvF2= NW\ke4R7W0GQR1XS
MONO-MAC-6 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEC4N|ch|ryP M4HBZXNCVkeHUh?=
A204 NHjm[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrVfldKSzVyPUCuNFEzOThizszN MVnTRW5ITVJ?
GDM-1 NEfje3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEG4N|Mh|ryP NXzXO2JbW0GQR1XS
AN3-CA NIPF[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHTdItWUUN3ME2wMlAyQDd|IN88US=> NGDPZWZUSU6JRWK=
BL-70 M3SxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vwNWlEPTB;MD6wNlE6QSEQvF2= Mmr0V2FPT0WU
Daudi MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\JZWlEPTB;MD6wNlU{PyEQvF2= M1TrSnNCVkeHUh?=
KU812 NYPRepF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7WTWM2OD1yLkCyPFQ5KM7:TR?= Mm\pV2FPT0WU
KG-1 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPmd2p5UUN3ME2wMlA{Ojl2IN88US=> MV3TRW5ITVJ?
DOHH-2 M1PXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTWTWM2OD1yLkC0PFA{KM7:TR?= NYD2V|lNW0GQR1XS
HuO9 MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfEcXp1UUN3ME2wMlA2PDR6IN88US=> NGezWmhUSU6JRWK=
EB2 M3fRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPTTWM2OD1yLkC1OVc3KM7:TR?= MW\TRW5ITVJ?
G-402 NXXzO|hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2iycGlEPTB;MD6wOlM1OSEQvF2= M4\hc3NCVkeHUh?=
SU-DHL-1 NVuxVmZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7LTXhKSzVyPUCuNFY{PzlizszN MlXsV2FPT0WU
NCI-H719 M3\0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEe4PFgh|ryP MYfTRW5ITVJ?
MLMA M1PtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OzfWlEPTB;MD6wPVA3KM7:TR?= M3HHUXNCVkeHUh?=
KM12 NFjVS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;ONGlEPTB;MD6wPVc{PyEQvF2= NIDnfG1USU6JRWK=
SUP-T1 MmTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETrZoVKSzVyPUCuNFk6QDJizszN MmjDV2FPT0WU
MZ1-PC MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\vR5R2UUN3ME2wMlEyOzN4IN88US=> MoX3V2FPT0WU
MFE-296 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTRRnZKSzVyPUCuNVE5OzlizszN NWDa[491W0GQR1XS
ALL-PO NX3F[WtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLaTWM2OD1yLkGyOFQ{KM7:TR?= MkSxV2FPT0WU
GB-1 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLOTWM2OD1yLkGyOVEzKM7:TR?= MlLUV2FPT0WU
SIG-M5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjZbYM3UUN3ME2wMlE{OzdizszN MUPTRW5ITVJ?
P30-OHK M1LadGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfsdHVKSzVyPUCuNVU3PzJizszN MlzVV2FPT0WU
NCI-H716 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMU[yOlYh|ryP MV7TRW5ITVJ?
MPP-89 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHId4N7UUN3ME2wMlE3QTN|IN88US=> M1LPe3NCVkeHUh?=
SF126 NVj1SpZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL6XI5bUUN3ME2wMlE4ODZ|IN88US=> MoLTV2FPT0WU
CTB-1 MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\2TWM2OD1yLkG3N|E3KM7:TR?= NF;ZfI5USU6JRWK=
CA46 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf0TWM2OD1yLkG3OFg6KM7:TR?= MXPTRW5ITVJ?
NCI-H520 NYfXcItVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj0W4JKSzVyPUCuNVc4OzJizszN MnrtV2FPT0WU
CAL-85-1 MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPSTWM2OD1yLkG3PVI4KM7:TR?= MkD0V2FPT0WU
NCI-H2342 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj6XYNZUUN3ME2wMlE5PTd5IN88US=> NUPMXo0yW0GQR1XS
697 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqxS5piUUN3ME2wMlE5QDdzIN88US=> Mmr6V2FPT0WU
NY Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rjTmlEPTB;MD6xPVI5PyEQvF2= NHryco1USU6JRWK=
T98G MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq1S|NOUUN3ME2wMlE6OzF6IN88US=> NHvvZWlUSU6JRWK=
NCI-H1703 Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFThUWxKSzVyPUCuNVk3OTVizszN MkPsV2FPT0WU
NCI-H2087 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO3UFN6UUN3ME2wMlIxPDN7IN88US=> NV:3N2llW0GQR1XS
PF-382 M3LSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn2[HBKSzVyPUCuNlA5PzNizszN Ml7YV2FPT0WU
HCT-116 NXK2cpY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vHUWlEPTB;MD6yNVA3QSEQvF2= NEnPcFhUSU6JRWK=
CAKI-1 M1HtTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMkG2OlYh|ryP NWTEe|BJW0GQR1XS
CCF-STTG1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;vbGlEPTB;MD6yNlQ4PSEQvF2= M176UnNCVkeHUh?=
D-392MG NF;yNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17RfmlEPTB;MD6yN|E4PyEQvF2= M2Do[HNCVkeHUh?=
RT-112 NW[4Sm5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG0XHNlUUN3ME2wMlI{Pzl3IN88US=> M2jTS3NCVkeHUh?=
MES-SA MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLuTWM2OD1yLkK0NVg4KM7:TR?= NX3nUIFlW0GQR1XS
LC-2-ad NUHLNWVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMkSyOlUh|ryP M3nJWXNCVkeHUh?=
NOS-1 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjTOVc2UUN3ME2wMlI1OzZ5IN88US=> NHzlOXFUSU6JRWK=
NALM-6 M{jxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrvTXJ[UUN3ME2wMlI2PTR|IN88US=> NIfsVFBUSU6JRWK=
TE-15 M4P1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMk[wPVEh|ryP MmqyV2FPT0WU
786-0 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXJ[|Z6UUN3ME2wMlI3OjJ6IN88US=> MYTTRW5ITVJ?
IST-MES1 M1rLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT1em83UUN3ME2wMlI3QDJ7IN88US=> NYrvdI45W0GQR1XS
KYSE-180 NXXD[pNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMk[4PVEh|ryP NVfnNpRSW0GQR1XS
YT NEnQSWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPTTWM2OD1yLkK2PVc1KM7:TR?= MlezV2FPT0WU
A427 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTiTWM2OD1yLkK3NlY1KM7:TR?= M2L0cHNCVkeHUh?=
KYSE-450 NUPpRY85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TkTGlEPTB;MD6yO|MzQSEQvF2= MVLTRW5ITVJ?
HuH-7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jwUWlEPTB;MD6yO|c3OyEQvF2= NF3GWVhUSU6JRWK=
CAS-1 NEniXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TYWGlEPTB;MD6yPFMxOyEQvF2= NFPKNWhUSU6JRWK=
KURAMOCHI NFHGS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjWS5FKSzVyPUCuNlg1OTlizszN MoLCV2FPT0WU
ACHN MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnW[Yp4UUN3ME2wMlI6OzJ|IN88US=> NXnvOJlpW0GQR1XS
HGC-27 NWfSemFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMkmzOVMh|ryP MoTEV2FPT0WU
A172 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7DTWM2OD1yLkK5OVc4KM7:TR?= MorTV2FPT0WU
SNU-449 M4HBcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMkm5OlQh|ryP NUXle3dlW0GQR1XS
SW982 NGm0[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrFSI1MUUN3ME2wMlI6QTd6IN88US=> MXnTRW5ITVJ?
EFO-21 NXv3NFNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\6TWM2OD1yLkOwOFEyKM7:TR?= NFiyUmdUSU6JRWK=
NCI-H2030 NFXWdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3oNWtKSzVyPUCuN|EyPjRizszN NXTPclJ1W0GQR1XS
HT-144 Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vPTWlEPTB;MD6zNVI5KM7:TR?= NXLpflU5W0GQR1XS
MFE-280 NWDheVRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXQN5VrUUN3ME2wMlMyPDV|IN88US=> M2PYcnNCVkeHUh?=
SK-LU-1 M1j3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwM{G0OlYh|ryP M{\Z[3NCVkeHUh?=
NCI-H2052 NUP4cHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT2W5BKSzVyPUCuN|E1QDRizszN M{GxVHNCVkeHUh?=
SK-HEP-1 NHXkOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfnTWM2OD1yLkOzN|Y5KM7:TR?= MoHIV2FPT0WU
QIMR-WIL MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwM{O0NlQh|ryP NETrNJZUSU6JRWK=
A2780 M2\aWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD1NWQyUUN3ME2wMlM1OzB2IN88US=> NXv5T3ByW0GQR1XS
ACN M1LiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwM{S4O|Mh|ryP M4LI[XNCVkeHUh?=
BxPC-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwM{S5PFkh|ryP MUfTRW5ITVJ?
BCPAP M{TxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfmTWM2OD1yLkO2NFAyKM7:TR?= NYHVeW4zW0GQR1XS
HOP-62 MkTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj0RXRKSzVyPUCuN|YyODZizszN M1Tac3NCVkeHUh?=
SW1710 NVe0cZA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvqTWM2OD1yLkO2OFU2KM7:TR?= NVPVOJJ2W0GQR1XS
OPM-2 NGHHNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{[0O|Mh|ryP M1OwRnNCVkeHUh?=
DBTRG-05MG NFr4[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jPZ2lEPTB;MD6zPFA2PCEQvF2= MVrTRW5ITVJ?
SK-MEL-24 NELpWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG2OYpKUUN3ME2wMlM6PzlzIN88US=> MnuyV2FPT0WU
8305C MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwM{m3PVMh|ryP MXTTRW5ITVJ?
OVCAR-4 M{Lpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz3blQ2UUN3ME2wMlQyPTh4IN88US=> MWPTRW5ITVJ?
HLE NWO1NoE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fW[WlEPTB;MD60NVg3KM7:TR?= NGTtRWVUSU6JRWK=
NCI-H747 NV3BNJNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vMfmlEPTB;MD60NlE{PyEQvF2= NUC2dlYzW0GQR1XS
SW780 NWDWWWZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPPXVdKSzVyPUCuOFI{PDZizszN MlXUV2FPT0WU
KYSE-150 M{T0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwNEK0NVUh|ryP MlzWV2FPT0WU
H4 M3vCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfhTWM2OD1yLkSyOFUyKM7:TR?= NXTzOXpGW0GQR1XS
SW1088 NI\OOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqzTWM2OD1yLkS0N|kh|ryP M3PJNnNCVkeHUh?=
SF268 NUXWSWJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDoTWM2OD1yLkS0PFYh|ryP NUH6XFNHW0GQR1XS
RT4 NH\ZV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIntfGNKSzVyPUCuOFUyOTFizszN M4fpXnNCVkeHUh?=
NCI-H522 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX4TWM2OD1yLkS1Nlch|ryP NH3F[pNUSU6JRWK=
LCLC-97TM1 M{fXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P6ZWlEPTB;MD60OlE6PSEQvF2= MXrTRW5ITVJ?
CAL-39 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH0OG0yUUN3ME2wMlQ3PTF7IN88US=> NXXIUGlOW0GQR1XS
CAL-120 NF3HNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe2TWM2OD1yLkS3OlQ{KM7:TR?= M1GwWnNCVkeHUh?=
ESS-1 NGfsOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzRdWxKSzVyPUCuOFc5OjFizszN NYfuRoJyW0GQR1XS
KARPAS-45 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvt[4lKSzVyPUCuOFg6OzNizszN MVTTRW5ITVJ?
DU-4475 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzTWM2OD1yLkS5OVEyKM7:TR?= M2XGWnNCVkeHUh?=
VMRC-RCZ MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLSclNKSzVyPUCuOFk6ODRizszN NX;ORmlyW0GQR1XS
HOS M3HRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr4[2dKSzVyPUCuOVA{PjVizszN MVjTRW5ITVJ?
MOLT-16 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\EdZFvUUN3ME2wMlUyQDB6IN88US=> MlH2V2FPT0WU
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KNS-42 NXS5RYRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT3TWM2OD1zLki2NlY3KM7:TR?= MojzV2FPT0WU
NCI-H2452 NH2wUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjtV2tKSzVyPUGuPFkxPzRizszN MmfVV2FPT0WU
SK-MEL-2 NF3oTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO3TWM2OD1zLkmwNlcyKM7:TR?= NU\XeJM5W0GQR1XS
OVCAR-5 NX3aXHZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHpTWM2OD1zLkmwOlc2KM7:TR?= NHjxTIpUSU6JRWK=
SNG-M MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[0WGlEPTB;MT65OVg2QCEQvF2= M1XJZnNCVkeHUh?=
A673 M2fBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PL[WlEPTB;MT65O|UyPiEQvF2= NXXLT|VUW0GQR1XS
L-428 NWr4NHVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HNSGlEPTB;MT65PVE4QSEQvF2= NFnodIRUSU6JRWK=
KM-H2 M4DY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPGV2NXUUN3ME2yMlAyODlizszN NWizdGhEW0GQR1XS
MC-IXC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j5SGlEPTB;Mj6wNlI4OyEQvF2= MlOyV2FPT0WU
COLO-678 NEDZXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCxb45DUUN3ME2yMlA1OjB5IN88US=> NYXSZllGW0GQR1XS
MEL-JUSO M2q1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrMTWM2OD1{LkC3PFUyKM7:TR?= NGXs[ZhUSU6JRWK=
HCC38 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwMEi0N|Mh|ryP MkHIV2FPT0WU
UACC-62 M1SyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJwMEi4OVUh|ryP NETrR|BUSU6JRWK=
OAW-42 NFfxWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJwMEm3NVEh|ryP Ml;GV2FPT0WU
LB996-RCC MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPYTWM2OD1{LkGzPFE4KM7:TR?= M4TsSXNCVkeHUh?=
COR-L105 NX\UfWtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJwMU[zO|Mh|ryP NYD3OWdwW0GQR1XS
RCC10RGB MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTUcI1KSzVyPUKuNVg2PzZizszN M4PUWnNCVkeHUh?=
A431 NIPTd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInRUXVKSzVyPUKuNVkxOTlizszN MUfTRW5ITVJ?
NCI-H292 NGD3U25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X3bGlEPTB;Mj6yN|k2OSEQvF2= MkTGV2FPT0WU
SK-UT-1 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fPdWlEPTB;Mj6zN|E5PCEQvF2= NV6xXWZmW0GQR1XS
PANC-08-13 M1XtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuzVHI3UUN3ME2yMlM{OjN3IN88US=> MoP1V2FPT0WU
ST486 NFTS[HVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwNEGwOFgh|ryP MnTEV2FPT0WU
SJSA-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHLTWM2OD1{LkSxNlcyKM7:TR?= MUPTRW5ITVJ?
RKO M4n6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPBTWM2OD1{LkSyNFI6KM7:TR?= MYXTRW5ITVJ?
NCI-H1793 NVL0Zm1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfYfWZSUUN3ME2yMlQ1ODJ7IN88US=> M2\yOHNCVkeHUh?=
639-V NFfHNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwNEWzPFIh|ryP NYPFVJNvW0GQR1XS
ES3 M1Wzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P5O2lEPTB;Mj60PVc{PyEQvF2= NW\vcFVSW0GQR1XS
NCI-H1792 NUX6O3hET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S5ZmlEPTB;Mj61OlgzPiEQvF2= MV\TRW5ITVJ?
NCI-H1651 M4n4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fKcmlEPTB;Mj61PFIyKM7:TR?= MnLqV2FPT0WU
SN12C NEPodIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJwNUi0PFch|ryP M{f5cnNCVkeHUh?=
COLO-679 NYD6fmdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XTTmlEPTB;Mj61PFYxPSEQvF2= MkX6V2FPT0WU
U-118-MG MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwNUi4O|Ih|ryP NV\ESXo1W0GQR1XS
Ramos-2G6-4C10 NXiwW4ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;OZ2lEPTB;Mj62OFgxPyEQvF2= MU\TRW5ITVJ?
HCT-15 M4KyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXRXoFKSzVyPUKuOlg4QTJizszN NHjQZotUSU6JRWK=
MDA-MB-157 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi0TGVRUUN3ME2yMlcxPzR5IN88US=> M{XNVnNCVkeHUh?=
K5 M2LLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XCRmlEPTB;Mj63NVg1PSEQvF2= M{PyZnNCVkeHUh?=
MKN45 NGTBd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwN{OzOlYh|ryP NHq4VJFUSU6JRWK=
DMS-273 NID3fHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnpW|R4UUN3ME2yMlc2PjN{IN88US=> M{n0[HNCVkeHUh?=
C8166 NF;CZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPzTWM2OD1{Lke4OVE{KM7:TR?= MV;TRW5ITVJ?
Calu-3 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwN{i5Olkh|ryP Mk\HV2FPT0WU
SNB75 NGfDTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfETWM2OD1{Lki4OVM2KM7:TR?= MofuV2FPT0WU
BFTC-905 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi4SWl4UUN3ME2yMlkxOTlzIN88US=> MWTTRW5ITVJ?
C-4-II NEmxNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrlTWM2OD1{LkmxN|U{KM7:TR?= MVTTRW5ITVJ?
MS-1 NETtW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qzN2lEPTB;Mj65Olc3QSEQvF2= NVW2VYhNW0GQR1XS
A375 M4fEbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\tXGlsUUN3ME2zMlA5OTh2IN88US=> NUS1SWdDW0GQR1XS
KYSE-70 M3fsfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\mWpRvUUN3ME2zMlA5QDh{IN88US=> MV3TRW5ITVJ?
KYSE-510 NWDzbVBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNwMUC5PVUh|ryP NVL6XXJSW0GQR1XS
LN-405 M{Lhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTNwMUO1NVgh|ryP M2LFNnNCVkeHUh?=
BOKU MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr5cIhKSzVyPUOuNVQzPTZizszN MnH1V2FPT0WU
TE-10 M3rweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\XRWlEPTB;Mz6xO|M3OiEQvF2= NW\OV4E1W0GQR1XS
MKN1 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrTTHU3UUN3ME2zMlE5PDh|IN88US=> MYnTRW5ITVJ?
M059J MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXROGxKSzVyPUOuNlAyPzNizszN MUfTRW5ITVJ?
GOTO NXL3ZWNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LjdGlEPTB;Mz6yNlA{QSEQvF2= MnfyV2FPT0WU
DK-MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTNwMkW5O|Yh|ryP Mn7WV2FPT0WU
NCI-H727 NXzIcY45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr4TWM2OD1|LkK2OVgh|ryP NVzWWodbW0GQR1XS
NB12 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXraVYEzUUN3ME2zMlM{OjJ2IN88US=> NX6yfYNnW0GQR1XS
DOK NV\rT5N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPIUIZ2UUN3ME2zMlM3OTh4IN88US=> NXjRN2wzW0GQR1XS
KYSE-410 M4j0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DxV2lEPTB;Mz6zOlI5PyEQvF2= NF\1VlZUSU6JRWK=
AM-38 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH31SZVKSzVyPUOuN|gxPTFizszN MmrtV2FPT0WU
GR-ST M3zCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH2XoVKSzVyPUOuOFU4OzJizszN NIPwWJFUSU6JRWK=
D-247MG M2C1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjofJFVUUN3ME2zMlQ5OjZ|IN88US=> MVzTRW5ITVJ?
TE-8 NW\NZ4RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Ln[2lEPTB;Mz60PVM{OyEQvF2= M4TWWnNCVkeHUh?=
LS-411N NXmyVGZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[xS2lEPTB;Mz60PVY6OiEQvF2= M3HidXNCVkeHUh?=
SK-MES-1 NHz5clRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Hoe2lEPTB;Mz61OlQ{OyEQvF2= MV;TRW5ITVJ?
SF295 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNwNkG1OVIh|ryP MV3TRW5ITVJ?
SK-MEL-30 NUHLZpBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTNwNkW5NlEh|ryP NYPBS5d{W0GQR1XS
LB2241-RCC Mm\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLmTWM2OD1|Lk[2NlYh|ryP NEnjc4tUSU6JRWK=
PC-14 M3TueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfTTWM2OD1|Lk[2OFM4KM7:TR?= NXzEbVlFW0GQR1XS
EW-7 M13QbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfGc25KSzVyPUOuOlc3QTNizszN MkPRV2FPT0WU
NMC-G1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP5TWM2OD1|LkexPFM4KM7:TR?= M3;XNXNCVkeHUh?=
TE-441-T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;jZ5V{UUN3ME2zMlc{ODJ6IN88US=> M1nPSXNCVkeHUh?=
NCI-H1618 NHPMOpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwOEG4O|Uh|ryP MWjTRW5ITVJ?
PANC-03-27 NGf2cXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTNwOEG5NVYh|ryP M{\3bHNCVkeHUh?=
NCI-H2228 NYLzeIl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzYcHdKSzVyPUOuPFMyOjZizszN NHHwWnhUSU6JRWK=
CAPAN-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTNwOEewNFkh|ryP MVjTRW5ITVJ?
KLE NUPJWWxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNwOUC2O{DPxE1? NXnzW2VPW0GQR1XS
Becker NH[0eoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUeyXXh2UUN3ME2zMlkzQDR7IN88US=> MorwV2FPT0WU
SK-PN-DW MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X6eWlEPTB;ND6wO|k4PCEQvF2= M3vPcXNCVkeHUh?=
Hs-578-T NFLQ[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDRVZpZUUN3ME20MlA5OzB4IN88US=> M3fKbHNCVkeHUh?=
RS4-11 MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRwMUGyOVUh|ryP MkjtV2FPT0WU
D-502MG NFTWXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorCTWM2OD12LkG2PVk4KM7:TR?= M2i4cXNCVkeHUh?=
GI-1 NIT4bHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;jTWM2OD12LkK4Nlk6KM7:TR?= MmXHV2FPT0WU
NCI-H209 NI\EcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzOfpNKSzVyPUSuN|M4QCEQvF2= NYXkRnFUW0GQR1XS
SK-OV-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS0fpNKSzVyPUSuOFgyPDlizszN MVXTRW5ITVJ?
LOUCY MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRwNEi0N|Ih|ryP M2XwZ3NCVkeHUh?=
NCI-H69 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\RUZdCUUN3ME20MlUyPzl|IN88US=> M1jBPXNCVkeHUh?=
SCC-9 M2XRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRwNUOxO|Ih|ryP NFfIemVUSU6JRWK=
NCI-H526 NUjZT2NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRwNUmyPVMh|ryP NILLR3BUSU6JRWK=
NCI-H2170 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q0emlEPTB;ND62Olc4OSEQvF2= M1jiW3NCVkeHUh?=
SR NXq1b5RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLHUlJrUUN3ME20MlcxODR6IN88US=> MXLTRW5ITVJ?
CMK M1\3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HWZ2lEPTB;ND63NlExOSEQvF2= MX\TRW5ITVJ?
COLO-829 NUXSbmZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ZR2lEPTB;ND63O|A1OyEQvF2= NFG5boZUSU6JRWK=
HuO-3N1 M2iyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrSd3FKSzVyPUSuPFMzQDFizszN NEXpOIxUSU6JRWK=
5637 M{mzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37JcGlEPTB;ND65NFQ5PyEQvF2= NVLITHgxW0GQR1XS
A253 M3W0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fQ[GlEPTB;ND65O|cxQCEQvF2= M3\hd3NCVkeHUh?=
NB10 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTVwMEe0PVch|ryP NXLkSWZ{W0GQR1XS
SF539 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVwMEm5OVkh|ryP NES1WIlUSU6JRWK=
HAL-01 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHFZWJKSzVyPUWuNVQ3PDVizszN NHz3Ro1USU6JRWK=
MHH-ES-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLE[2pKSzVyPUWuNVY6OjVizszN MkT3V2FPT0WU
DEL Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVwMke1PFIh|ryP MnryV2FPT0WU
NCI-H1299 MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX0TWM2OD13LkO1NFA4KM7:TR?= M4DFbnNCVkeHUh?=
ChaGo-K-1 M{TLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXkc5lKSzVyPUWuN|UyODdizszN M3PHbnNCVkeHUh?=
HMV-II NX3ofWhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrlWW1bUUN3ME21MlM6PDNizszN MV3TRW5ITVJ?
NB69 NYS4cnpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLENFJKSzVyPUWuN|k3OzFizszN NIrveHJUSU6JRWK=
NCI-H1882 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL1TWM2OD13LkSzN|Y1KM7:TR?= NYjGPFFjW0GQR1XS
SNU-475 M{DxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm5e4hVUUN3ME21MlQ4OTdzIN88US=> MYLTRW5ITVJ?
RXF393 MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3j[4dKSzVyPUWuOFg1QTRizszN MorFV2FPT0WU
CAL-51 M3vpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf2bmlKSzVyPUWuOlI5PTNizszN NHmzfYJUSU6JRWK=
SW1573 NXHy[VduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIniemxKSzVyPUWuOlM2OzRizszN MYHTRW5ITVJ?
GCT MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrye|VKSzVyPUWuO|U6OjlizszN MmriV2FPT0WU
COR-L88 Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfJTWM2OD13Lke2PFQ3KM7:TR?= NGXybphUSU6JRWK=
MDA-MB-134-VI Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTVwOEe1N|Yh|ryP M2\6S3NCVkeHUh?=
NB5 M{HIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTVwOUK0OEDPxE1? M3TZd3NCVkeHUh?=
GMS-10 NFXPUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ThU2lEPTB;NT65Olg3OSEQvF2= NHPvfJdUSU6JRWK=
CHP-212 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfUfodSUUN3ME22MlQ5OjZ5IN88US=> MUfTRW5ITVJ?
TE-11 NFzXbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTZwNUWxPFIh|ryP NHrFS2VUSU6JRWK=
SW962 NWrjNYJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTZwNkW3O|Qh|ryP NWXIXlN4W0GQR1XS
MZ2-MEL NY\OeI1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTZwOEKwNVEh|ryP MmfkV2FPT0WU
C-33-A MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrSTWM2OD14LkmxOlg5KM7:TR?= MVnTRW5ITVJ?
IGR-1 MmnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrFTWM2OD14Lkm3PFI3KM7:TR?= MmjNV2FPT0WU
MOLT-4 NXzxSpJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LTdGlEPTB;Nz6xOVQxPiEQvF2= M{PDfnNCVkeHUh?=
NCI-H1650 NEX2fYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwMkewOFYh|ryP NX7MeZlJW0GQR1XS
AsPC-1 NVTwbmppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;YOGlEPTB;Nz6yPFYxPSEQvF2= MoLjV2FPT0WU
SNU-C2B MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPTSlZ[UUN3ME23MlI6PTdzIN88US=> MXHTRW5ITVJ?
MKN7 NVnFRng{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkSxTWM2OD15LkO3NlM2KM7:TR?= M370T3NCVkeHUh?=
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NCI-H630 M3XrVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfRZYxKSzVyPUKyMlU{PjNizszN NYriNZJqW0GQR1XS
LU-165 M3zoeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzENIxKSzVyPUKyMlU2PCEQvF2= M4LsR3NCVkeHUh?=
COLO-792 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjhdXhKSzVyPUKyMlcyOTFizszN M3vwV3NCVkeHUh?=
CAL-62 M4PpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2wfnNKSzVyPUKyMlc2OTdizszN MXrTRW5ITVJ?
HCE-T Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvkTWM2OD1{Mj64OlA3KM7:TR?= Mnu4V2FPT0WU
BB65-RCC NF70b2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmzNopKSzVyPUKzMlA{PDRizszN MUXTRW5ITVJ?
SiHa MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ|LkO5Olgh|ryP NUTxO4V5W0GQR1XS
NCI-H2081 NY[4cm1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XWfmlEPTB;MkSuNFY1OSEQvF2= Ml;LV2FPT0WU
U251 M{Hlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH3TWM2OD1{ND6wOlY5KM7:TR?= NIK4ZWFUSU6JRWK=
LoVo NX\5NJhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETlboNKSzVyPUK0MlkzQDJizszN MUfTRW5ITVJ?
GCIY NHf4NpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LYeGlEPTB;MkWuNlg4PyEQvF2= NFHncGhUSU6JRWK=
NUGC-3 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHl[HJKSzVyPUK1MlM{OTZizszN NHvYV4RUSU6JRWK=
LNCaP-Clone-FGC MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn2SGRKSzVyPUK1MlM1QThizszN MX\TRW5ITVJ?
PA-1 NX;aNGM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLKO2k2UUN3ME2yOU43QDN|IN88US=> MnHPV2FPT0WU
OE33 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJ3Lk[4OVMh|ryP MXzTRW5ITVJ?
HT-29 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVz2WXJUUUN3ME2yOU44QDd7IN88US=> NGS0cGFUSU6JRWK=
RCM-1 NV\Le3ptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M325ZmlEPTB;MkWuPVY2PiEQvF2= NEHjdYlUSU6JRWK=
NCI-H1522 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;4WWlEPTB;MkWuPVkyOSEQvF2= MmriV2FPT0WU
LB373-MEL-D MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrkUnNKSzVyPUK2MlE4ODhizszN Ml7vV2FPT0WU
NCI-H1436 NUDrVWJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ4LkK3N|gh|ryP Mn3oV2FPT0WU
COLO-824 NW\jNlJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPKTWM2OD1{Nj60NFAzKM7:TR?= Ml\NV2FPT0WU
CP50-MEL-B NI\yfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTpSINKSzVyPUK2MlU3PzVizszN NIfZOnBUSU6JRWK=
EGI-1 M1fxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi5TWM2OD1{Nz6yOlk5KM7:TR?= M2OwPXNCVkeHUh?=
LAN-6 NUXD[2c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K4dWlEPTB;MkeuN|U6QCEQvF2= MkHvV2FPT0WU
GAK NYXWeW57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJ5LkSyNlUh|ryP MXrTRW5ITVJ?
MDA-MB-175-VII MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fHU2lEPTB;MkeuOVA2OyEQvF2= M3jWWHNCVkeHUh?=
JVM-2 NYrSV|NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7aeGV7UUN3ME2yO{43PjJ{IN88US=> MWTTRW5ITVJ?
UACC-257 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;3UXBZUUN3ME2yO{43QDd6IN88US=> NUjpeZFOW0GQR1XS
SW1783 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTOTWM2OD1{Nz63O|g{KM7:TR?= MUTTRW5ITVJ?
HT-3 M2XSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PUV2lEPTB;MkiuNlE3PiEQvF2= MnTuV2FPT0WU
RL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe2TWM2OD1{OD61PVEyKM7:TR?= MoTZV2FPT0WU
TK10 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPDXHVKSzVyPUK4MlY2OzVizszN M2LSfnNCVkeHUh?=
HT55 NV7JTnlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLJTWM2OD1{OT6wOVY2KM7:TR?= MYnTRW5ITVJ?
BT-20 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ7LkC1PFYh|ryP NHjVd4NUSU6JRWK=
TGBC24TKB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS0TWM2OD1{OT6xPFMyKM7:TR?= MonYV2FPT0WU
HSC-2 M3HVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HzUmlEPTB;MkmuN|AxOSEQvF2= Mm\BV2FPT0WU
COLO-205 NG\EVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPjTWM2OD1{OT6zPVQ1KM7:TR?= Mnr5V2FPT0WU
GT3TKB MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HBZ2lEPTB;MkmuOlg4PyEQvF2= NHz5d21USU6JRWK=
T47D Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJ7Lki1PFIh|ryP Ml31V2FPT0WU
OMC-1 NIKyPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTYPGVKSzVyPUOwMlE6OTlizszN NIDRPIZUSU6JRWK=
PFSK-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTNzLkK2OVkh|ryP NWLuenJxW0GQR1XS
JEG-3 M4O4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTNzLkO1OlEh|ryP MnnzV2FPT0WU
RD NH7ac|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHOUIQ4UUN3ME2zNU42OTF3IN88US=> M2fQN3NCVkeHUh?=
NCI-H64 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN{LkSxO|kh|ryP NF3iO3lUSU6JRWK=
DMS-114 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXqW2o1UUN3ME2zNk41OTh{IN88US=> NUi2[lFmW0GQR1XS
NCI-H661 NXX1RpptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTN{Lk[1NFEh|ryP M{HqSXNCVkeHUh?=
CAL-148 NF73OFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN{Lk[2OlUh|ryP NYeyO|NtW0GQR1XS
HuP-T3 NF;JXnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TweGlEPTB;M{KuPVM{QCEQvF2= NI\IclJUSU6JRWK=
ES4 NV\QeXJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELBOXZKSzVyPUOzMlE4ODVizszN M4OwXHNCVkeHUh?=
Ca9-22 NXnCV4xTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN|LkS2NFEh|ryP MYjTRW5ITVJ?
LP-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTN2LkC5JO69VQ>? NHPIWW1USU6JRWK=
AU565 NUjjSIhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;JeI06UUN3ME2zOE42ODZ7IN88US=> M{HzbnNCVkeHUh?=
MDA-MB-453 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN3LkG0NlYh|ryP NWrsVoVlW0GQR1XS
SNU-C1 NITuVFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjWTWM2OD1|NT6xO|Eh|ryP NHXGcJVUSU6JRWK=
SW13 NVm4NYpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G2fGlEPTB;M{WuOFA4PiEQvF2= M1y4V3NCVkeHUh?=
NCI-H2122 M2Pmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPwTHlmUUN3ME2zOU42PTl6IN88US=> MYnTRW5ITVJ?
NCI-H1395 Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjt[HlQUUN3ME2zOU43PjlzIN88US=> NUjVdpJuW0GQR1XS
J-RT3-T3-5 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13tdmlEPTB;M{[uNFI6PCEQvF2= NETvdWlUSU6JRWK=
COR-L279 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33CU2lEPTB;M{[uNVk5OSEQvF2= NHryWFlUSU6JRWK=
ATN-1 NITWRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLXTWM2OD1|Nj64OVE3KM7:TR?= NV\YN|liW0GQR1XS
HCC2998 NF3vTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu2TWM2OD1|Nj64OVcyKM7:TR?= MkPVV2FPT0WU
UM-UC-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H3SWlEPTB;M{[uPFY4PSEQvF2= NIjDcHRUSU6JRWK=
DV-90 NXu1dGprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW2PHZKSzVyPUO2MlkxPjdizszN Ml3yV2FPT0WU
ES8 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrLVnBKSzVyPUO2Mlk{OThizszN NWCxT5hqW0GQR1XS
YAPC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nZd2lEPTB;M{[uPVY2PCEQvF2= MYjTRW5ITVJ?
HCC1599 NUfRfFJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLNeIZ6UUN3ME2zO{4yPjF6IN88US=> NVfMXJdkW0GQR1XS
UMC-11 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjDVWZKSzVyPUO3MlI2ODNizszN M{jDNHNCVkeHUh?=
THP-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfIZ4hVUUN3ME2zO{4zQDZ6IN88US=> Mlj3V2FPT0WU
OCUB-M NFnjbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTN5LkK4PVEh|ryP MkXOV2FPT0WU
NCI-H1693 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN5LkOyN|Mh|ryP NGPtRYlUSU6JRWK=
NCI-H345 NF\RRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN5LkO2NlQh|ryP MkHnV2FPT0WU
COLO-800 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6zdXd5UUN3ME2zO{42PjdizszN NUfHb5dqW0GQR1XS
COLO-320-HSR NG\0WGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrWTWM2OD1|OD6zOFkzKM7:TR?= MoHOV2FPT0WU
NCI-H596 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTN6LkS0PFkh|ryP NVWwUZR4W0GQR1XS
NCI-H187 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\XN5l7UUN3ME2zPE44OzR2IN88US=> NYnlZpQzW0GQR1XS
ECC4 M1;Cemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfZPYpKSzVyPUO5MlA5OTRizszN MUfTRW5ITVJ?
KP-4 NHqxZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKyTWM2OD1|OT6xNlM2KM7:TR?= NFPNT3lUSU6JRWK=
NCI-H2227 NYm0V2Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHFT44zUUN3ME2zPU4{QTR7IN88US=> NX6yWIw{W0GQR1XS
22RV1 M2PZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\KTWM2OD1|OT64N|k5KM7:TR?= MXXTRW5ITVJ?
SAS NWnr[otMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvZRZp7UUN3ME20NE4xQTZizszN NWHMZlF{W0GQR1XS
PANC-10-05 NYW2bmpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPTTWM2OD12MD6xPFI5KM7:TR?= MU\TRW5ITVJ?
MDA-MB-468 M2\VZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD6e2FPUUN3ME20NE42OzR4IN88US=> NWnlVXJjW0GQR1XS
RPMI-7951 NGLKW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTRzLkKwO|Uh|ryP MnjZV2FPT0WU
BB49-HNC NIGwfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n6dGlEPTB;NEGuNlE4QSEQvF2= NFfwbppUSU6JRWK=
23132-87 NXrqWVZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3STWM2OD12MT6yO|MzKM7:TR?= M{T4cHNCVkeHUh?=
HCC1569 NIHLVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;ybZFKSzVyPUSxMlI5QDVizszN MnnUV2FPT0WU
CP66-MEL NVL0dZRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTR{LkG4PFYh|ryP MVPTRW5ITVJ?
K-562 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXmTWM2OD12Mj6yPFU1KM7:TR?= NUHUfnBYW0GQR1XS
OCI-AML2 NFTDWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO2TWM2OD12Mj64PVc1KM7:TR?= NVXvc3BUW0GQR1XS
SW756 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTHOFJrUUN3ME20N{4xOzh6IN88US=> M4fpTXNCVkeHUh?=
M14 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDNTWM2OD12Mz6zNVg6KM7:TR?= MXfTRW5ITVJ?
NCI-H1623 M1\LXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\tZ5IyUUN3ME20N{41PjRizszN MmW4V2FPT0WU
KNS-81-FD NEXtWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTR|Lke2NkDPxE1? M1y2O3NCVkeHUh?=
TGBC1TKB NUm5SXR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFSydHFKSzVyPUSzMlkxQTlizszN NYTYdVFQW0GQR1XS
RERF-LC-MS NXfhSWYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjiRoNnUUN3ME20N{46OjhzIN88US=> MkC5V2FPT0WU
PC-3 NHSxPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHpWWx{UUN3ME20OE41OzR5IN88US=> NFnxbYlUSU6JRWK=
HuP-T4 MkHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITHe|dKSzVyPUS0MlQ1PzRizszN NWHQXWp1W0GQR1XS
NCI-H510A MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnTRWpMUUN3ME20OE44ODhizszN NUizVVV1W0GQR1XS
LB2518-MEL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\rRmlEPTB;NESuO|k{PyEQvF2= NFjXRotUSU6JRWK=
TE-5 NYCzRnZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjuXolKSzVyPUS1Mlk2QDFizszN NWnxU4prW0GQR1XS
EW-24 NUX0eXk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTR4LkG3NlMh|ryP NYqxemZkW0GQR1XS
LB647-SCLC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDrR|BKSzVyPUS2MlIyPTVizszN NUi5fGc1W0GQR1XS
NCI-H524 NXnQc2hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rkR2lEPTB;NE[uO|E5PSEQvF2= NW[0e|RGW0GQR1XS
EW-11 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLaTWM2OD12Nj65N|c{KM7:TR?= MlTxV2FPT0WU
KALS-1 NHLBdmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfsN41KSzVyPUS3MlIxPjZizszN NFLUUplUSU6JRWK=
BT-474 NVnTVG51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\YZmlEPTB;NEeuOFIyPiEQvF2= M4nLdnNCVkeHUh?=
SK-N-AS M1P1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfkWphYUUN3ME20O{45QDhizszN MnvDV2FPT0WU
HCC2157 M3PPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS3TWM2OD12OD6wO|Yh|ryP Mm\QV2FPT0WU
HCC1954 NUDuenZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zRUmlEPTB;NEiuNVcxPCEQvF2= NVuzO5Q4W0GQR1XS
FADU M33hS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTR6LkOwN|Eh|ryP NETOW3VUSU6JRWK=
S-117 NHvjRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTR6LkO4NVUh|ryP MmroV2FPT0WU
LS-1034 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TIcWlEPTB;NEiuO|A3PyEQvF2= NGLKW3pUSU6JRWK=
CAMA-1 M{XpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnKRZhKSzVyPUS5MlU2PDNizszN Mlr3V2FPT0WU
LU-134-A NH3qeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXIS4p2UUN3ME20PU45ODh3IN88US=> MYnTRW5ITVJ?
NCI-H1838 Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;DfZVoUUN3ME20PU45ODh5IN88US=> NFHBbmZUSU6JRWK=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709017 Recruiting Chronic Myeloid Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Korea Otsuka Pharmaceutical Co. Ltd. October 2018 --
NCT03690115 Not yet recruiting Leukemia Myeloid Acute Versailles Hospital October 2018 Phase 2
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03589326 Recruiting Lymphoblastic Leukemia Acute Adult|Acute Lymphoid Leukemia|Leukemia Acute Lymphoblastic|Leukemia Lymphoblastic|Ph1 Chromosome|Leukemia Lymphoblastic Acute Philadelphia-Positive Millennium Pharmaceuticals Inc.|Takeda August 10 2018 Phase 3
NCT03576547 Recruiting Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|t(9;22) M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 26 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Ablシグナル伝達経路

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Tags: Ponatinib (AP24534)を買う | Ponatinib (AP24534) ic50 | Ponatinib (AP24534)供給者 | Ponatinib (AP24534)を購入する | Ponatinib (AP24534)費用 | Ponatinib (AP24534)生産者 | オーダーPonatinib (AP24534) | Ponatinib (AP24534)化学構造 | Ponatinib (AP24534)分子量 | Ponatinib (AP24534)代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID