Bortezomib (PS-341)

For research use only. Not for use in humans.

製品コードS1013 別名：LDP-341, MLM341

Bortezomib (PS-341)化学構造

CAS No. 179324-69-7

Bortezomib (PS-341, LDP-341, MLM341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

サイズ 価格(税別) 在庫  
10mM (1mL in DMSO) JPY 17100 あり
JPY 13600 あり
JPY 46800 あり
JPY 113200 あり
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文献中Selleckの製品使用例(651)

製品安全説明書

Proteasome阻害剤の選択性比較

生物活性

製品説明 Bortezomib (PS-341, LDP-341, MLM341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
ターゲット
NF-κB [6]
()		 20S proteasome [1]
(Cell-free assay)
0.6 nM(Ki)
体外試験

Bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26S proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to Bortezomib has been shown to stabilize p21, p27, and p53, as well as the proapoptotic Bid and Bax proteins, caveolin-1, and inhibitor κB-α, which prevents activation of nuclear factor κB-induced cell survival pathways. Bortezomib also promotes the activation of the proapoptotic c-Jun-NH2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells. [2] Bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of ∼0.1 μM. The average growth inhibition of 50% value for Bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the US National Cancer Institute (NCI) is 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 h results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1. Bortezomib kills PC-3 cells at 24 and 48 hr with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr. [1]
細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1838 NX3kW4NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTRzOE[uN|Ih|ryP MmflQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|I2ODRzLze+V2FPT0WUPD;hQi=>
IMR-5 M4Xibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XTSmlEPTB;M{SwPU43OiEQvF2= MnrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|I2ODRzLze+V2FPT0WUPD;hQi=>
TE-441-T NIHqU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\QcWlEPTB;MkWyNU44KM7:TR?= NFzt[2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
U-698-M NFXuTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ{NkKuNVUh|ryP M{D2b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMzPTB2MT:nQnNCVkeHUkyvZV4>
COLO-824 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7OTWM2OD1zMk[xMlc5KM7:TR?= NU\4TIoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
P31-FUJ M2Tqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP1S3h5UUN3ME2xNVEzNjd3IN88US=> M4jIZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMzPTB2MT:nQnNCVkeHUkyvZV4>
KY821 NWC3enZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFyM{[uNFQh|ryP NX2zdo1sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
RPMI-8866 NYjv[m57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm3TWM2OD1zMEC2MlI5KM7:TR?= NVXldIR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
TC-YIK NXryUI5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jF[2lEPTB;N{ixMlAyKG6P MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
MS-1 MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\XcmlEPTB;N{W5MlQzKG6P NYf1XVVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
DMS-153 NEDncWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH2cIJKSzVyPUe0Ok45OyCwTR?= NX;GWXVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
SUP-T1 M{jSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTZ6Nj6wOEBvVQ>? NFXjSYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
SCC-15 NIfCOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTZ4Nz60O{BvVQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
MSTO-211H M2XUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zGR2lEPTB;NUe0MlI3KG6P NH7MVlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
J-RT3-T3-5 NFfEeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqxTWFKSzVyPUWzNk42PyCwTR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
NCI-H889 NXLWUY5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfJ[G1nUUN3ME20OlEvQTJibl2= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
CPC-N NEH2OnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:0OGdpUUN3ME20NFMvPzdibl2= NUPmPWF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
COLO-668 NF3zXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTRyMz61O{BvVQ>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
NCI-H226 NVjlS3RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vQdWlEPTB;NECzMlI{KG6P NX3pbmZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
TUR MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDlWXVKSzVyPUO5Ok43OSCwTR?= NVTHUIZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
DEL NXXIOlZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;2VGFKSzVyPUO5NU4zPyCwTR?= NVTafo9CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
NCI-H1963 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\FfHVKSzVyPUO4Ok4yQSCwTR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
CA46 M4nxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTN5Mz62N{BvVQ>? NH;4d4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
SNU-C1 Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTN4Mj6wPUBvVQ>? NF\kc2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
THP-1 Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTN{Mj62JI5O MoHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|I2ODRzLze+V2FPT0WUPD;hQi=>
SCH M3KwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XhRmlEPTB;M{KyMlIzKG6P NGraNoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
NCI-H1522 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG4VZV1UUN3ME2zNFcvODVibl2= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
LNCaP-Clone-FGC M{\LOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PsXWlEPTB;Mkm1MlI3KG6P M1qwTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMzPTB2MT:nQnNCVkeHUkyvZV4>
NCI-H2171 M17QPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXjTWM2OD1{OEiuPVIhdk1? NYO4d5MzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
NCI-H187 NEC5SGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPVTWM2OD1{OEeuNFghdk1? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
KASUMI-1 M1\vZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJ6Mz6wOUBvVQ>? NVHLSpR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
SK-MEL-2 M3jLZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJ6MT65JI5O MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
EW-22 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv0TWM2OD1{NkOuO|Uhdk1? NGrFVVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
NCI-H1299 Mor2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TKdGlEPTB;Mk[xMlcyKG6P NE\6Wm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
COR-L279 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm0NXFKSzVyPUK1Nk4yPyCwTR?= M{m2R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMzPTB2MT:nQnNCVkeHUkyvZV4>
NCI-H1155 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HKSGlEPTB;MkOwMlMzKG6P NYruO|BxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
NCI-H1395 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vsT2lEPTB;MkGwMlE{KG6P MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
KM-H2 M{XwTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qybmlEPTB;MUm3MlA2KG6P MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
NCI-H209 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\GTWM2OD1zOU[uOVIhdk1? NFnQWnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
NCI-H510A NI\0NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnNbIJKSzVyPUG4OU4{PyCwTR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
NCI-H1304 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITDfHpKSzVyPUG2PU4zOSCwTR?= MlTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|I2ODRzLze+V2FPT0WUPD;hQi=>
SCLC-21H MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrwdZBKSzVyPUG1PU41OSCwTR?= NYna[IM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
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WSU-NHL NGTQTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K2T2lEPTB;MkiuN|khdk1? NV:4bZB6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
NH-12 M3;ncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJ5Lk[3JI5O NYnF[Y1[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
LU-165 NGLOXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlznTWM2OD1{Nj63NkBvVQ>? NGfDdWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
REH M1zT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fGO2lEPTB;Mk[uOFEhdk1? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
LS-1034 NHXTPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjkfo9KSzVyPUK1Mlc2KG6P M4C2R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMzPTB2MT:nQnNCVkeHUkyvZV4>
HDLM-2 NGnQbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvHTWM2OD1{ND61OEBvVQ>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyzNlUxPDFxJ{7TRW5ITVJ:L3G+
EC-GI-10 NVfWZ3B1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi5TWM2OD1{ND6yN{BvVQ>? MoDQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|I2ODRzLze+V2FPT0WUPD;hQi=>
IM-9 Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnXN4hKSzVyPUKzMlU1KG6P M3njPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFMzPTB2MT:nQnNCVkeHUkyvZV4>
DOHH-2 M{nm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHwR2E2UUN3ME2yN{41PSCwTR?= NVzlfllJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzJ3MESxM{c,W0GQR1XSQE9iRg>?
SIMA NFLYem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELIZWNKSzVyPUKzMlM5KG6P NHjrTIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{OjVyNEGvK|5USU6JRWK8M4E,
EW-12 NGrvSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=