システインプロテアーゼ
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S7379 | E-64 | 11 mg/mL | 71 mg/mL | <1 mg/mL |
| S3025 | PMSF | <1 mg/mL | 35 mg/mL | 15 mg/mL |
| S7393 | E-64d (Aloxistatin, Loxistatin) | <1 mg/mL | 68 mg/mL | 68 mg/mL |
| S7420 | CA-074 methyl ester (CA-074 Me) | 0 mg/mL | 79 mg/mL | 79 mg/mL |
| S7396 | Calpeptin | <1 mg/mL | 72 mg/mL | 72 mg/mL |
| S7386 | MG-101 (ALLN) | <1 mg/mL | 76 mg/mL | 76 mg/mL |
| S7391 | Z-FA-FMK | <1 mg/mL | 77 mg/mL | 34 mg/mL |
| S7380 | Leupeptin Hemisulfate | 95 mg/mL | 95 mg/mL | 95 mg/mL |
| S7392 | Loxistatin Acid (E-64C) | 2 mg/mL | 62 mg/mL | 62 mg/mL |
| S3692 | N-Ethylmaleimide (NEM) | 25 mg/mL | 25 mg/mL | 25 mg/mL |
| S7424 | PD 151746 | <1 mg/mL | 47 mg/mL | 47 mg/mL |
- Cysteine Protease阻害剤(11)
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7379 |
E-64E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. |
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| S3025 |
PMSFPMSF is an irreversible serine/cysteine protease inhibitor. |
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| S7393 |
E-64d (Aloxistatin, Loxistatin)Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. |
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| S7420 |
CA-074 methyl ester (CA-074 Me)CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. |
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| S7396 |
CalpeptinCalpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. |
Western blotting detection of focal adhesion kinase (FAK) expression and its cleaved fragments with different treatments. DTX represents docetaxel, CPP represents calpeptin (a calpain inhibitor). The experiments were carried out 3 times, obtaining essentially similar results.
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| S7386 |
MG-101 (ALLN)MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. |
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| S7391 |
Z-FA-FMKZ-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases. |
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| S7380 |
Leupeptin HemisulfateLeupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin. |
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| S7392 |
Loxistatin Acid (E-64C)Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
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| S3692 |
N-Ethylmaleimide (NEM)N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. |
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| S7424 |
PD 151746PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. |
(A) Quantification of mS100a7a15 mRNA expression of skin from normal and imiquimod-induced psoriatic mouse backs at 5 days. (B) Immunoblot of mS100a7a15, IL-1α and calpain-1 in skin extracts from normal and imiquimod-induced psoriatic mouse backs. (C) HE staining and immunohistochemical analysis of mS100a7a15, calpain-1 in skin tissues as described in fig 4A. The scale bars represent 100 μm. All data are representative of three independent experiments with n = 6 and are means ± SEM. P values were determined by two-tailed t test. *** P<0.001.
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