システインプロテアーゼ

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
水 DMSO アルコール
S7379 E-64 11 mg/mL 71 mg/mL <1 mg/mL
S3025 PMSF <1 mg/mL 35 mg/mL 15 mg/mL
S7393 E-64d (Aloxistatin, Loxistatin) <1 mg/mL 68 mg/mL 68 mg/mL
S7420 CA-074 methyl ester (CA-074 Me) 0 mg/mL 79 mg/mL 79 mg/mL
S7396 Calpeptin <1 mg/mL 72 mg/mL 72 mg/mL
S7386 MG-101 (ALLN) <1 mg/mL 76 mg/mL 76 mg/mL
S7391 Z-FA-FMK <1 mg/mL 77 mg/mL 34 mg/mL
S7380 Leupeptin Hemisulfate 95 mg/mL 95 mg/mL 95 mg/mL
S7392 Loxistatin Acid (E-64C) 2 mg/mL 62 mg/mL 62 mg/mL
S3692 N-Ethylmaleimide (NEM) 25 mg/mL 25 mg/mL 25 mg/mL
S7424 PD 151746 <1 mg/mL 47 mg/mL 47 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7379

E-64

E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM.
Cell, 2018, 175(5):1336-1351
S3025

PMSF

PMSF is an irreversible serine/cysteine protease inhibitor.
S7393

E-64d (Aloxistatin, Loxistatin)

Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.
S7420

CA-074 methyl ester (CA-074 Me)

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
S7396

Calpeptin

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.

Oncol Rep, 2017, 37(6):3651-3659
S7386

MG-101 (ALLN)

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

Graefes Arch Clin Exp Ophthalmol, 2018, 10.1007/s00417-018-4166-7
S7391

Z-FA-FMK

Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.
S7380

Leupeptin Hemisulfate

Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
J Biol Chem, 2017, 292(15):6225-6239
S7392

Loxistatin Acid (E-64C)

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
S3692

N-Ethylmaleimide (NEM)

N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group.

S7424

PD 151746

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.