• 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S4902 QNZ (EVP4593) <1 mg/mL 5 mg/mL <1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S4073 Sodium 4-Aminosalicylate 42 mg/mL 42 mg/mL <1 mg/mL
S7351 JSH-23 <1 mg/mL 48 mg/mL 20 mg/mL
S7414 Caffeic Acid Phenethyl Ester <1 mg/mL 57 mg/mL 57 mg/mL
S9106 Eleutheroside E -1 mg/mL 100 mg/mL -1 mg/mL
S8642 GSK'963 <1 mg/mL 46 mg/mL 46 mg/mL
S3137 Sodium salicylate 32 mg/mL 32 mg/mL <1 mg/mL
S7672 Omaveloxolone (RTA-408) <1 mg/mL 100 mg/mL 20 mg/mL
S3633 Pyrrolidinedithiocarbamate ammonium 32 mg/mL 32 mg/mL 32 mg/mL
S8484 GSK2982772 <1 mg/mL 75 mg/mL 30 mg/mL
S8261 GSK583 <1 mg/mL 79 mg/mL 28 mg/mL
S2261 Andrographolide <1 mg/mL 70 mg/mL <1 mg/mL
S2382 Evodiamine <1 mg/mL <1 mg/mL <1 mg/mL
S2313 Indole-3-carbinol 7 mg/mL 29 mg/mL 29 mg/mL
S7273 SC75741 <1 mg/mL 35 mg/mL <1 mg/mL
S8483 CBL0137 (CBL-0137) 24 mg/mL 38 mg/mL <1 mg/mL
S2321 Magnolol <1 mg/mL 53 mg/mL 53 mg/mL
S3874 Curcumenol -1 mg/mL 46 mg/mL -1 mg/mL
S2341 (-)-Parthenolide <1 mg/mL 49 mg/mL 49 mg/mL
S3604 Triptolide (PG490) <1 mg/mL 72 mg/mL <1 mg/mL
S3867 Cardamonin -1 mg/mL 54 mg/mL -1 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック

QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.



Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.


Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.



JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.


Caffeic Acid Phenethyl Ester

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.


Eleutheroside E

Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.



GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.


Sodium salicylate

Sodium salicylate is used in medicine as an analgesic and antipyretic.


Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.


Pyrrolidinedithiocarbamate ammonium

Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.



GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase inhibitor with the IC50 value of 1 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.



GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.



Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.



Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.



Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.



SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.


CBL0137 (CBL-0137)

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).



Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.



Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.



(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.


Triptolide (PG490)

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein.



Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.



Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.