Acetylcysteine (N-acetylcysteine)

製品コード:S1623 別名:NAC

For research use only.

Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.

Acetylcysteine (N-acetylcysteine)化学構造

CAS No. 616-91-1

サイズ 価格(税別)
JPY 12000
JPY 17600

代表番号: 03-5615-9297|電子メール:[email protected]
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生物活性

製品説明 Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.
ターゲット
NF-κB [8] Ferroptosis [9] ROS [6] TNF-α [7]
体外試験

N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. [1] N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. [2] N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. [3] N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HUVEC cells NVjn[3RMTnWwY4Tpc44h[XO|YYm= M{HoOFEx|ryP M1n0SVJp NFWwbm1JXV[HQ4Oge4Vz\SCycnX0doVifGWmIIfpeIghOTBizszNJG5CSyCob4KgNkBpd3W{czygZY5lKHSqZX6geJJm[XSnZDD3bZRpKDBwNTFOwG0hWEOEIEGxPE4LeHKnc3XueINmKG:oIF7BR{Bnd3JiNEigbI92enNw MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV7MkG5OEc,Ojh3OUKxPVQ9N2F-
HUVEC cells MVzGeY5kfGmxbjDhd5NigQ>? MYKy{txONDUQvF2sPO69VQ>? MXK5NI1qdg>? NF7GbXdJXV[HQ4OgeIhifCC5ZYLlJIV5eG:|ZXSge4l1cCC|ZYL1cUBw\iBiUD6g[oFt[2myYYL1cUBidmRidILlZZRm\CC5aYToJG5CSyB{INM1Ug+9lDRiwsXN89yNQCEEtV2uJHN2eGW{bnH0ZY51KG[{b32gZ5VtfHW{ZTDhcoQhdHm|ZXSgZ4VtdHNMY4XseJVz\SC5ZYLlJI1m[XO3cnXkJIZweiCKMl:yMEBIW0hiYX7kJG1FSSCuZY\lcJMv NWrIUGx2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NFI4PjNpPkKxOlAzPzZ|PD;hQi=>
BL21 (DE3) M4LDe2Z2dmO2aX;uJIF{e2G7 NHS3VlA{OCCvaX7z M2HCUmlvcGmkaYTpc44hd2ZiaHX4ZYhqe3SrZHnu[U11[WepZXSgTW1RNTdiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gSZNkcGW{aXPobYEh[2:uaTDCUFIyKCiGRUOpJINmdGy|IIXzbY5oKG[udX;yc4NqdGyrbjDhd{B{fWK|dILheIUhcW6ldXLheIVlKG[xcjCzNEBucW6|IHL5JHRGS0GQIH\seY9z\XOlZX70JJBt[XSnIILlZYRmeiCjbnHsfZNqeyxiSVO1NEA:KDJyLkeg{txONg>? NHywZoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixOVU{OCd-MkW4NVU2OzB:L3G+
PC12 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MnvzNlQhcHK| MnjVTY5pcWKrdHnvckBw\iB4LXj5[JJwgHmmb4DhcYlv\SCrbnT1Z4VlKGO7dH;0c5hq[2m2eTDpckBz[XRiUFOxNkBk\WyuczDwdoV1emWjdHXkJIZweiB{NDDodpMh[XO|ZYPz[YQh[XNiZXzleoF1cW:wIH;mJIlvfHKjY3XscJVt[XJiZ3z1eIF1cGmxbnWgcIV3\Wx? M4\OVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW4OFU1Lz5zN{G1PFQ2PDxxYU6=
PC12 NEfvT45EgXSxdH;4bYNqfHliYYPzZZk> NFuyPIozPCCqcoO= M1jMOGlvcGmkaYTpc44hd2ZiaInkdo9o\W5icHXyc5hq\GViaX7keYNm\CCleYTveI95cWOrdImgbY4hemG2IGDDNVIh[2WubIOgdJJmfHKnYYTl[EBnd3JiMkSgbJJ{KGG|c3Xzd4VlKGG|IHXs[ZZifGmxbjDv[kBqdnS{YXPlcIx2dGG{IHfseZRifGirb37lJIxmfmWu MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3OES1OEc,OTdzNUi0OVQ9N2F-
NHBE Mn2zR5l1d3SxeHnjbZR6KGG|c3H5 NYCwN2tFOSCvTR?= MWqxPEBpenN? NUO2SXNsS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hVkiERTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHSESGCtbY5lfWOnZDDHV2gh\GWybHX0bY9vKGG2IEGgcW0heHKnaX7jeYJifGWmIH\vdkAyQCCqcoOg[o9tdG:5ZXSgZpkhfEKKUDDh[IRqfGmxbjDmc5IhPCCqcoOgZpkhfGirb4P0ZZIh\HmnIHLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigQ>? NEjaR|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CzNVY4OCd-MkewN|E3PzB:L3G+
HUVEC M1W3d2FvfGmxeHnkZY51KGG|c3H5 MmPpOUBudW:uL1y= M{T2ZVQhcHK| MkfKRY51cW:6aXThcpQh[WO2aY\peJkh[WejaX7zeEBJOk9{LXnu[JVk\WRibHnwbYQh[WOldX31cIF1cW:wIHnuJGhWXkWFIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBOTEFibHX2[Ywh[XRiNTDtcY9tN0xiaX7jeYJifGWmIESgbJJ{KHC{aX;yJJRwKEh{T{KgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEGyJIhzew>? NXjFNJN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFEzQDBpPkKyPFQyOjhyPD;hQi=>
HUVEC MVzBcpRqd3irZHHueEBie3OjeR?= NV\yUFQ6PSCvbX;sM2w> NGTFVFk1KGi{cx?= NWjpcFNESW62aX;4bYRidnRiYXP0bZZqfHliaX6gTHVXTUNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGgzVzJvaX7keYNm\CCJU1igZYN1cX[rdImgZZQhPSCvbX;sM2whcW6ldXLheIVlKDRiaILzJJBzcW:{IITvJGgzVzJiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDF{IHjydy=> NY\odoRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFEzQDBpPkKyPFQyOjhyPD;hQi=>
HUVEC M1KxcWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1jHOlUhdW2xbD;M MVi0JIhzew>? NHTzSpBKdmirYnn0bY9vKG:oIFiyU|IucW6mdXPl[EBkgXSxdH;4bYNqfHliaX6gTHVXTUNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[XRiNTDtcY9tN0xiaX7jeYJifGWmIESgbJJ{KHC{aX;yJJRwKEh{T{KgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEGyJIhzeyCkeTDNWHQh[XO|YYm= NYnhXZJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFEzQDBpPkKyPFQyOjhyPD;hQi=>
HUVEC NV3Fc2NWS3m2b4TvfIlkcXS7IHHzd4F6 MWC1JI1ud2xxTB?= M{DDOVQhcHK| NICzUnVKdmirYnn0bY9vKG:oIFiyU|IucW6mdXPl[EBkgXSxdH;4bYNqfHliaX6gTHVXTUNiY3XscJMh[XO|ZYPz[YQh[XNiTFTIJJJmdGWjc3WgZZQhPSCvbX;sM2whcW6ldXLheIVlKDRiaILzJJBzcW:{IITvJGgzVzJiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDF{IHjyd{BjgSCORFigZZN{[Xl? NWHCOWsxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4OFEzQDBpPkKyPFQyOjhyPD;hQi=>
SH-SY5Y Mn;MUoV2em:ycn;0[YN1cX[nIHHzd4F6 NEf0cmU2KG2P M3;VWVQhcHK| MnrZUoV2em:ycn;0[YN1cX[nIHHjeIl3cXS7IHnuJGgzVzJvc4TpcZVt[XSnZDDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBD[XhiZYjwdoV{e2mxbjDheEA2KG2PIHnuZ5Vj[XSnZDDmc5IhPCCqcoOgdJJqd3JidH:gTFJQOiClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOTJiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM> M3e0UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NECzNFg2Lz5{M{SwN|A5PTxxYU6=
SH-SY5Y NGXSOGdP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? NVH3N4lXPSCvTR?= M3\LeFQhcHK| M4DOdm5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBJOk9{LYP0bY12dGG2ZXSgbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCmb4fudoVofWyjdHnvckBw\iCEY3yyJIV5eHKnc4Ppc44h[XRiNTDtUUBqdmO3YnH0[YQh\m:{IESgbJJ{KHC{aX;yJJRwKEh{T{KgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEGyJIhzeyCkeTDX[ZN1\XKwIHLsc5R1cW6pIHHuZYx6e2m| NIXseJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SwN|A5PSd-MkO0NFMxQDV:L3G+
HT22 NETWcJJP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? M3vaW|UhdU1? MlPSNlQhcHK| NEPqWmNP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDncJV1[W2jdHWtbY5lfWOnZDDj[YxtKGSnYYToJIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYYSgOUBuVSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6 Mk\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMkK0PFEoRjJ7MUKyOFgyRC:jPh?=
HT22 MYDO[ZVzd3C{b4TlZ5RqfmViYYPzZZk> M{jl[lUxKHWP MnLxNVAhfG9iMUKgbJJ{ MkL2UoV2em:ycn;0[YN1cX[nIHHjeIl3cXS7IHHnZYlve3RiZ3z1eIFu[XSnLXnu[JVk\WRiY3XscEBl\WG2aDDpckBud3W|ZTDIWFIzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDhdI9xfG:2aXOgZ4VtdHNiYYSgOVAhfU1iYX\0[ZIhOTBidH:gNVIhcHK|IHL5JGFvdmW6aX6gWk1idGW6YTC0PFgweHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgQ>? Mnj0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMkK0PFEoRjJ7MUKyOFgyRC:jPh?=
HL-7702 M1fVcGhmeGG2b4Dyc5Rm[3SrdnWgZZN{[Xl? M{TCcFExKHWP MUWyOEBpenN? MmHqTIVx[XSxcILveIVkfGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFHQRXAucW6mdXPl[EBk\WyuIHnubpVzgSCrbjDoeY1idiCKTD23O|AzKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIP1dpZqfmGuIILheIUh[XRiMUCgeW0heHKnLXnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJm\m:{ZTDBVGFRKGGmZHn0bY9vKGGwZDDt[YF{fXKnZDC2JIhzeyCyb4P0JGFRSVBiY3jhcIxmdmenIHL5JG1VXCCjc4PhfS=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd{OUC1Okc,Ojh5MkmwOVY9N2F-
体内試験

N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. [5]

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外

化学情報

分子量 163.19
化学式

C5H9NO3S

CAS No. 616-91-1
保管 3 years -20°C powder
Smiles CC(=O)NC(CS)C(=O)O

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05287724 Recruiting Drug: N-acetyl cysteine|Drug: Placebo Pruritus|Skin Disorder Wright State University August 1 2022 Early Phase 1
NCT05241262 Recruiting Drug: N-Acetylcysteine Mitochondrial Disease Darryl C. De Vivo MD|United States Department of Defense|Columbia University June 2022 Phase 1
NCT05348993 Not yet recruiting Drug: G03-52-01|Drug: Placebo Healthy|Botulinum Toxin Ology Bioservices|United States Department of Defense June 15 2022 Phase 2
NCT05273619 Recruiting Drug: XC8 film-coated tablets 10 mg|Drug: Placebo Common Cold|Acute Respiratory Infection|Influenza Human Valenta Pharm JSC April 5 2022 Phase 3
NCT05122559 Recruiting Drug: N-acetyl cysteine|Drug: Placebo Multiple Sclerosis|Multiple Sclerosis Primary Progressive|Multiple Sclerosis Secondary Progressive Emmanuelle Waubant MD PhD|United States Department of Defense|University of California San Francisco February 16 2022 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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