ROS

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1547 Febuxostat <1 mg/mL 63 mg/mL <1 mg/mL
S1623 Acetylcysteine 33 mg/mL 33 mg/mL '''33 mg/mL
S1630 Allopurinol 4 mg/mL 27 mg/mL 3 mg/mL
S6871 Sodium oxamate 22 mg/mL <1 mg/mL '<1 mg/mL
S3616 Asiaticoside <1 mg/mL 100 mg/mL <1 mg/mL
S3631 (S)-Methylisothiourea sulfate 27 mg/mL <1 mg/mL <1 mg/mL
S4017 Allylthiourea <1 mg/mL 23 mg/mL 23 mg/mL
S4853 Ecabet sodium 16 mg/mL 80 mg/mL 3 mg/mL
S8639 Diphenyleneiodonium chloride (DPI) <1 mg/mL 13 mg/mL '<1 mg/mL
S3973 L-SelenoMethionine 39 mg/mL <1 mg/mL -1 mg/mL
S4603 Gallic acid 7 mg/mL 34 mg/mL 34 mg/mL
S1631 Allopurinol Sodium 32 mg/mL 32 mg/mL 2 mg/mL
S9107 Glycitein -1 mg/mL 56 mg/mL -1 mg/mL
S2369 Troxerutin 100 mg/mL 100 mg/mL <1 mg/mL
S7873 Disodium (R)-2-Hydroxyglutarate 38 mg/mL <1 mg/mL <1 mg/mL
S1046 Vandetanib (ZD6474) <1 mg/mL 4 mg/mL ''''<1 mg/mL
S2843 BI-D1870 <1 mg/mL 78 mg/mL ''<1 mg/mL
S5452 Sanguinarine chloride <1 mg/mL 5 mg/mL <1 mg/mL
S7309 BAY 87-2243 <1 mg/mL 33 mg/mL '8 mg/mL
S5263 Pyrroloquinoline Quinone Disodium Salt -1 mg/mL 74 mg/mL -1 mg/mL
S8615 Sodium dichloroacetate (DCA) 30 mg/mL 30 mg/mL '30 mg/mL
S3607 Sarsasapogenin <1 mg/mL <1 mg/mL 5 mg/mL
S2348 Rotenone (Barbasco) <1 mg/mL 55 mg/mL 2 mg/mL
S8661 CA3(CIL56) <1 mg/mL 97 mg/mL ''<1 mg/mL
S5804 N-Acetylcysteine amide 32 mg/mL 32 mg/mL ''13 mg/mL
S2399 Dihydromyricetin <1 mg/mL 64 mg/mL 64 mg/mL
S4263 Efaproxiral Sodium 73 mg/mL 73 mg/mL 73 mg/mL
S2605 Idebenone <1 mg/mL 68 mg/mL 68 mg/mL
S2062 Tiopronin 32 mg/mL 32 mg/mL 32 mg/mL
S4580 Hydroquinone 22 mg/mL 22 mg/mL 22 mg/mL
S5314 HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) -1 mg/mL 47 mg/mL -1 mg/mL
S3838 Carnosic acid -1 mg/mL 66 mg/mL -1 mg/mL
S3840 Baohuoside I -1 mg/mL 100 mg/mL -1 mg/mL
S9021 (20R)Ginsenoside Rg3 -1 mg/mL 60.78 mg/mL -1 mg/mL
S9034 Isochlorogenic acid C -1 mg/mL 100 mg/mL -1 mg/mL
S2332 Neohesperidin <1 mg/mL 122 mg/mL <1 mg/mL
S3885 Pyrogallol -1 mg/mL 25 mg/mL -1 mg/mL
S4511 6-Benzylaminopurine <1 mg/mL 45 mg/mL <1 mg/mL
S7551 Piperlongumine <1 mg/mL 16 mg/mL 6 mg/mL
S7867 Oleuropein 100 mg/mL 100 mg/mL 100 mg/mL
S2363 Tangeretin <1 mg/mL 8 mg/mL <1 mg/mL
S4722 (+)-Catechin 58 mg/mL 58 mg/mL 58 mg/mL
S4723 (-)Epicatechin <1 mg/mL 58 mg/mL <1 mg/mL

ROS製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1547

Febuxostat

Febuxostat is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.

S1623

Acetylcysteine

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.

S1630

Allopurinol

Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.

S6871

Sodium oxamate

Sodium oxamate (SO) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.

S3616

Asiaticoside

Asiaticoside, the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.

S3631

(S)-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).

S4017

Allylthiourea

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

S4853

Ecabet sodium

Ecabet sodium is a widely employed mucoprotective agent for the treatment of gastric ulcers.

S8639

Diphenyleneiodonium chloride (DPI)

Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).

S3816

Dehydroevodiamine

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

S3973

L-SelenoMethionine

L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.

S4603

Gallic acid

Gallic acid, known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.

S1631

Allopurinol Sodium

Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.

S9107

Glycitein

Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.

S2369

Troxerutin

Troxerutin, a natural bioflavonoid isolated from Sophora japonica., has been reported to have many benefits and medicinal properties.

S7873

Disodium (R)-2-Hydroxyglutarate

Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.

S1046

Vandetanib (ZD6474)

Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).

S2843

BI-D1870

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S7309

BAY 87-2243

BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.

S5263

Pyrroloquinoline Quinone Disodium Salt

Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.

S8615

Sodium dichloroacetate (DCA)

Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.

S3607

Sarsasapogenin

Sarsasapogenin (SAR) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages.

S2348

Rotenone (Barbasco)

Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

S8661

CA3(CIL56)

CA3(CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).

S5804

N-Acetylcysteine amide

N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.

S2399

Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

S4263

Efaproxiral Sodium

Efaproxiral Sodium is a synthetic allosteric modifier of hemoglobin, used for brain metastases originating from breast cancer.

S2605

Idebenone

Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

S2062

Tiopronin

Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.

S4580

Hydroquinone

Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.

S4970

Cis-Geraniol|Neryl alcohol

Nerol is a monoterpene found in many essential oils such as lemongrass and hops.

S5314

HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)

HTHQ, which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.

S3838

Carnosic acid

Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.

S3840

Baohuoside I

Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.

S9021

(20R)Ginsenoside Rg3

(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.

S9034

Isochlorogenic acid C

Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.

S2332

Neohesperidin

Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.

S3885

Pyrogallol

Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.

S4511

6-Benzylaminopurine

6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.

S7551

Piperlongumine

Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.

S7867

Oleuropein

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.

S2363

Tangeretin

Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

S4722

(+)-Catechin

Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

S4723

(-)Epicatechin

(−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1547

Febuxostat

Febuxostat is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.

S1623

Acetylcysteine

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.

S1630

Allopurinol

Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.

S6871

Sodium oxamate

Sodium oxamate (SO) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.

S3616

Asiaticoside

Asiaticoside, the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.

S3631

(S)-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).

S4017

Allylthiourea

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

S4853

Ecabet sodium

Ecabet sodium is a widely employed mucoprotective agent for the treatment of gastric ulcers.

S8639

Diphenyleneiodonium chloride (DPI)

Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).

S3816

Dehydroevodiamine

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

S3973

L-SelenoMethionine

L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.

S4603

Gallic acid

Gallic acid, known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.

S1631

Allopurinol Sodium

Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.

S9107

Glycitein

Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.

S2369

Troxerutin

Troxerutin, a natural bioflavonoid isolated from Sophora japonica., has been reported to have many benefits and medicinal properties.

S7873

Disodium (R)-2-Hydroxyglutarate

Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1046

Vandetanib (ZD6474)

Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).

2020, 18;12(1):17

2020, 23;39(1):53

2020, 27;molcanres.1245.2019

S2843

BI-D1870

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

2020, 12(4):e11177

2020, 10.1242/jcs.238295

2020, 521(2):492-498

S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S7309

BAY 87-2243

BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.

2020, 39(1):24

2020, 10;2020:2016809

2019, 10.1016/j.molcel.2019.10.023

S5263

Pyrroloquinoline Quinone Disodium Salt

Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.

S8615

Sodium dichloroacetate (DCA)

Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.

S3607

Sarsasapogenin

Sarsasapogenin (SAR) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages.

S2348

Rotenone (Barbasco)

Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

2020, 4;10(5):1585-1597

2019, 10(1):3856

2018, 55(5):4078-4089

S8661

CA3(CIL56)

CA3(CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).

2020, 13;40(20):3915-3932

2020, 48(1):920-932

2019, 17(10):2029-2041

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S5804

N-Acetylcysteine amide

N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.

2020, 121:105703

2019, 19(2):258-265

2019, 508(4):1271-1278

S2399

Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

2020, 65:109431

2016, 30(6):596-606

2016, 10.18632/oncotarget.10836

S4263

Efaproxiral Sodium

Efaproxiral Sodium is a synthetic allosteric modifier of hemoglobin, used for brain metastases originating from breast cancer.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2605

Idebenone

Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

S2062

Tiopronin

Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.

S4580

Hydroquinone

Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.

2020, 2

S4970

Cis-Geraniol|Neryl alcohol

Nerol is a monoterpene found in many essential oils such as lemongrass and hops.

S5314

HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)

HTHQ, which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.

S3838

Carnosic acid

Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.

2020, 1;10(5):1442-1454

S3840

Baohuoside I

Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.

S9021

(20R)Ginsenoside Rg3

(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.

2020, 10.1002/tox.22899

S9034

Isochlorogenic acid C

Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.

S2332

Neohesperidin

Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.

2019, 864:172712

2017, 7(1):9873

S3885

Pyrogallol

Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.

S4511

6-Benzylaminopurine

6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.

S7551

Piperlongumine

Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.

2020, 65:104775

2020, 13:5591-5603

2020, 29(6):1366-1372

S7867

Oleuropein

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.

S2363

Tangeretin

Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

2019, 11:5231-5242

2018, 10.1002/jcp.27651

S4722

(+)-Catechin

Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

S4723

(-)Epicatechin

(−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.

2020, 4;10(5):1585-1597