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ROS
ROS製品
- All (71)
- ROS阻害剤 (26)
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- 新製品
| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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| S1623 | N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) | Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine)は、プロテアソーム阻害剤の活性を阻害するROS（活性酸素種）阻害剤です。また、腫瘍壊死因子産生阻害剤でもあります。Acetylcysteine(N-acetyl-l-cysteine)は、IκBキナーゼの阻害を介してTNF誘導性のNF-κB活性化を抑制します。Acetylcysteine(N-acetyl-l-cysteine)は、ミトコンドリア依存性経路を介してapoptosisを誘導します。Acetylcysteine(N-acetyl-l-cysteine)は、ferroptosisとvirus replicationを阻害します。溶液は不安定なので、新鮮に調製する必要があります。 |
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| S1046 | Vandetanib | バンデタニブは、細胞フリーアッセイにおいてIC50が40 nMの強力なVEGFR2阻害剤です。また、VEGFR3とEGFRもそれぞれIC50が110 nMおよび500 nMで阻害します。PDGFRβ、Flt1、Tie-2、FGFR1には感受性がなく、IC50は1.1-3.6 μMです。MEK、CDK2、c-Kit、erbB2、FAK、PDK1、Akt、IGF-1Rに対しては10 μMを超えるIC50で活性がありません。バンデタニブ（ZD6474）は、reactive oxygen species (ROS)のレベルを上昇させることにより、apoptosisを増加させ、autophagyを誘導します。 |
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| S7171 | Setanaxib (GKT137831) | Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis. |
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| S2843 | BI-D1870 | BI-D1870は、無細胞アッセイにおいて、S6 ribosome for RSK1/2/3/4に対するATP競合的阻害剤であり、IC50はそれぞれ31 nM/24 nM/18 nM/15 nMです。MST2、GSK-3β、MARK3、CK1、Aurora BよりもRSKに対して10〜100倍の選択性を示します。BI-D1870は、活性酸素種（ROS）の産生、小胞体（ER）ストレスの増加、オートファジーの増加など、抗がん特性を示します。 |
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| S7309 | BAY 87-2243 | BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1. |
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| S8639 | DPI (Diphenyleneiodonium chloride) | DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). | ||
| S8661 | CA3 (CIL56) | CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). | ||
| S7551 | Piperlongumine | Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
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| S2348 | Rotenone | ロテノンは、ミトコンドリア電子伝達の阻害剤である植物性殺虫剤です。ロテノンは、IC50がそれぞれ28.8 nMおよび5.1 nMで、NADH/DB酸化還元酵素およびNADH酸化酵素を阻害します。ロテノンは、ミトコンドリア活性酸素種の産生を促進することにより、アポトーシスを誘発します。ロテノンはパーキンソン病の動物モデルを誘発するために使用できます。 | ||
| S8978 | MitoQ (Mitoquinone) Mesylate | MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid. | ||
| S6871 | Sodium oxamate | Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation. | ||
| S8615 | Sodium Dichloroacetate (DCA) | DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth. | ||
| S5771 | Sulforaphane | Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis. | ||
| S1630 | Allopurinol | Allopurinolは、痛風や腎臓結石の治療、尿酸値の低下に使用される、酵素キサンチンオキシダーゼのプリン類似体阻害剤です。 | ||
| S5804 | N-Acetylcysteine amide (NACA) | N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. | ||
| S2271 | Berberine chloride | Berberine chlorideは、イソキノリンアルカロイド群の第四級アンモニウム塩です。Berberine chlorideは、caspase 3とcaspase 8を活性化し、poly ADP-ribose polymerase (PARP)の切断とcytochrome cの放出を促進します。Berberine chlorideは、c-IAP1、Bcl-2、およびBcl-XLの発現を減少させます。Berberine chlorideは、JNKとp38 MAPKの持続的なリン酸化およびROSの生成を伴うapoptosisを誘導します。Berberine chlorideは、デュアルtopoisomerase IおよびII阻害剤です。Berberine chlorideは、潜在的なautophagyモジュレーターでもあります。 | ||
| S8674 | GO-203 TFA | GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function. | ||
| S9687 | H2DCFDA (DCFH-DA) | H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production. It is de-esterified intracellularly and turns to highly fluorescent 2′,7′-dichlorofluorescein upon oxidation. It is used in sensitive and rapid quantitation of oxygen-reactive species in response to oxidative metabolism; microplate assay for detecting oxidative products in phagocytic cells, and quantitative multiwell myeloid differentiation assay.(Ex/Em=488/525 nm) | ||
| S7873 | Disodium (R)-2-Hydroxyglutarate | Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. | ||
| S1547 | Febuxostat | Febuxostat (TMX 67, TEI-6720)は、キサンチンオキシダーゼを選択的に阻害する化合物であり、Ki値は0.6 nMです。 |
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| S2399 | Dihydromyricetin | Dihydromyricetin（アンペロプシン、アンペロプチン）は、Ampelopsis grossedentata由来の天然の抗酸化フラボノイドです。 |
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| S4603 | Gallic acid | Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs. | ||
| S1631 | Allopurinol Sodium | Allopurinol Sodium は、IC50が7.82±0.12 μMのキサンチンオキシダーゼ阻害剤です。 | ||
| S2332 | Neohesperidin | 柑橘類に含まれるフラバノングリコシドであるNeohesperidin（NSC 31048）は、抗酸化剤です。 | ||
| S8974 | GSK2795039 | GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis. | ||
| S3631 | (S)-Methylisothiourea sulfate | (S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS). | ||
| S2605 | Idebenone | Idebenone (CV-2619) は、コエンザイムQ10 (CoQ10) の合成アナログであり、脳刺激剤です。 | ||
| S3238 | Resibufogenin | Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression. | ||
| S3838 | Carnosic acid | Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. | ||
| S9021 | (20R)Ginsenoside Rg3 | (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite. | ||
| S3885 | Pyrogallol | Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. | ||
| S2062 | Tiopronin | Tioproninは、シスチン沈殿と排泄の速度を制御することにより、シスチン尿症の治療に使用される抗酸化剤です。 | ||
| S5452 | Sanguinarine chloride | Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. | ||
| S4580 | Hydroquinone | Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ) is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. | ||
| S2369 | Troxerutin | ソフォラジャポニカから単離された天然のバイオフラボノイドであるTroxerutinは、多くの利点と薬効があることが報告されています。 | ||
| S3616 | Asiaticoside | Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF. | ||
| S6281 | Sodium Thiocyanate | Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS. | ||
| S3301 | Cynarin | Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization. | ||
| S5709 | Norgestrel | Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity. | ||
| E1961 | NVL-655 (Neladalkib) | NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively. | ||
| S3607 | Sarsasapogenin | Sarsasapogenin (SAR, Parigenin) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages. | ||
| S3578 | Pyrroloquinoline quinone | Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis.Pyrroloquinoline quinone can alleviate allergic airway inflammation in mice by improving the immune microenvironment and regulating the JAK-STAT signaling pathway. This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | ||
| S3205 | Perillaldehyde | Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. | ||
| S3222 | Raspberry ketone glucoside | Raspberry ketone glucoside (RKG), a natural product in raspberry fruit, is an antioxidant that has the inhibitory effect on the melanin synthesis. | ||
| E0224 | Chicoric acid | Chicoric acid is an orally active dicaffeoyltartaric acid with antioxidant, anti-inflammatory, and antidiabetic properties. It induces ROS generation and triggers mitochondria-dependent apoptosis in 3T3-L1 preadipocytes via PI3K/Akt and MAPK pathways. It also enhances glucose uptake and improves insulin resistance. | ||
| E8271New | Sanguinarine citrate | Sanguinarine (gluconate) is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. It activates reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB (NF-κB) signaling pathways to induce apoptosis in head and neck tumor cells and animal models. It also exhibits potent anti-bacterial and anti-inflammatory activities. | ||
| S7913 | MCB-613 | MCB-613 is a potent steroid receptor coactivator (SRC) stimulator. | ||
| S4017 | Allylthiourea | Allylthiourea は、アンモニア酸化を選択的に阻害する代謝阻害剤です。 | ||
| S3590 | Triolein | Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes. | ||
| S4853 | Ecabet sodium | Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. | ||
| S0947 | Cafestol | Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60. | ||
| S3816 | Dehydroevodiamine | Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. | ||
| S4970 | Nerol | Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. | ||
| E1508 | APG-2449 | APG-2449 is an orally active inhibitor of ALK/ROS1/FAK. APG-2449 exerts potent and durable antitumor activity in human non-small-cell lung cancer (NSCLC) and ovarian tumor models. | ||
| S5314 | HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone) | HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. | ||
| S0056 | (E/Z)-BCI | (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | ||
| S0770 | Camalexin | Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities. | ||
| S5263 | Pyrroloquinoline Quinone Disodium Salt | Pyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions. | ||
| S3840 | Baohuoside I | Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. | ||
| S3973 | L-SelenoMethionine | L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. | ||
| S6920 | SEA0400 | SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. | ||
| S9034 | Isochlorogenic acid C | Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71. | ||
| S4263 | Efaproxiral Sodium | Efaproxiral Sodium(RSR13 Sodium)は、乳がん由来の脳転移に用いられる、ヘモグロビンの合成アロステリック修飾因子です。 | ||
| S3357 | Elaidic acid | Elaidic acid is a major trans fatty acid that inhibits cell viability, elevates cell apoptosis by enhancing oxidative stress. Elaidic acid can be used as a pharmaceutical solvent. |
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| S9107 | Glycitein | Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. | ||
| S9611 | ABTL-0812 | ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation. | ||
| S4511 | 6-Benzylaminopurine | 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development. | ||
| S5584 | Citronellol | Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells. | ||
| E7174 | D-α-Tocopherol Succinate | D-α-tocopherol succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E that significantly reduces the cisplatin-induced increase of ROS and decreases cellular necrosis and late apoptosis, thereby inhibiting cisplatin-induced cytotoxicity in HEIOC1 cells. It also exhibits an anti-apoptotic effect. | ||
| S4419 | Ensulizole | Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation. | ||
| S4425 | Rifamycin S | Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. | ||
| S1623 | N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) | Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine)は、プロテアソーム阻害剤の活性を阻害するROS（活性酸素種）阻害剤です。また、腫瘍壊死因子産生阻害剤でもあります。Acetylcysteine(N-acetyl-l-cysteine)は、IκBキナーゼの阻害を介してTNF誘導性のNF-κB活性化を抑制します。Acetylcysteine(N-acetyl-l-cysteine)は、ミトコンドリア依存性経路を介してapoptosisを誘導します。Acetylcysteine(N-acetyl-l-cysteine)は、ferroptosisとvirus replicationを阻害します。溶液は不安定なので、新鮮に調製する必要があります。 |
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| S7171 | Setanaxib (GKT137831) | Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis. |
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| S8639 | DPI (Diphenyleneiodonium chloride) | DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS). | ||
| S8978 | MitoQ (Mitoquinone) Mesylate | MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid. | ||
| S5771 | Sulforaphane | Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis. | ||
| S1630 | Allopurinol | Allopurinolは、痛風や腎臓結石の治療、尿酸値の低下に使用される、酵素キサンチンオキシダーゼのプリン類似体阻害剤です。 | ||
| S1547 | Febuxostat | Febuxostat (TMX 67, TEI-6720)は、キサンチンオキシダーゼを選択的に阻害する化合物であり、Ki値は0.6 nMです。 |
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| S4603 | Gallic acid | Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs. | ||
| S1631 | Allopurinol Sodium | Allopurinol Sodium は、IC50が7.82±0.12 μMのキサンチンオキシダーゼ阻害剤です。 | ||
| S8974 | GSK2795039 | GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis. | ||
| S3631 | (S)-Methylisothiourea sulfate | (S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS). | ||
| S2369 | Troxerutin | ソフォラジャポニカから単離された天然のバイオフラボノイドであるTroxerutinは、多くの利点と薬効があることが報告されています。 | ||
| S3616 | Asiaticoside | Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF. | ||
| S6281 | Sodium Thiocyanate | Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS. | ||
| E1961 | NVL-655 (Neladalkib) | NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively. | ||
| S3578 | Pyrroloquinoline quinone | Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis.Pyrroloquinoline quinone can alleviate allergic airway inflammation in mice by improving the immune microenvironment and regulating the JAK-STAT signaling pathway. This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | ||
| S3205 | Perillaldehyde | Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. | ||
| S4017 | Allylthiourea | Allylthiourea は、アンモニア酸化を選択的に阻害する代謝阻害剤です。 | ||
| S3590 | Triolein | Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes. | ||
| S4853 | Ecabet sodium | Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. | ||
| S0947 | Cafestol | Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60. | ||
| S3816 | Dehydroevodiamine | Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. | ||
| E1508 | APG-2449 | APG-2449 is an orally active inhibitor of ALK/ROS1/FAK. APG-2449 exerts potent and durable antitumor activity in human non-small-cell lung cancer (NSCLC) and ovarian tumor models. | ||
| S3973 | L-SelenoMethionine | L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. | ||
| S6920 | SEA0400 | SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. | ||
| S9107 | Glycitein | Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. | ||
| S1046 | Vandetanib | バンデタニブは、細胞フリーアッセイにおいてIC50が40 nMの強力なVEGFR2阻害剤です。また、VEGFR3とEGFRもそれぞれIC50が110 nMおよび500 nMで阻害します。PDGFRβ、Flt1、Tie-2、FGFR1には感受性がなく、IC50は1.1-3.6 μMです。MEK、CDK2、c-Kit、erbB2、FAK、PDK1、Akt、IGF-1Rに対しては10 μMを超えるIC50で活性がありません。バンデタニブ（ZD6474）は、reactive oxygen species (ROS)のレベルを上昇させることにより、apoptosisを増加させ、autophagyを誘導します。 |
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| S2843 | BI-D1870 | BI-D1870は、無細胞アッセイにおいて、S6 ribosome for RSK1/2/3/4に対するATP競合的阻害剤であり、IC50はそれぞれ31 nM/24 nM/18 nM/15 nMです。MST2、GSK-3β、MARK3、CK1、Aurora BよりもRSKに対して10〜100倍の選択性を示します。BI-D1870は、活性酸素種（ROS）の産生、小胞体（ER）ストレスの増加、オートファジーの増加など、抗がん特性を示します。 |
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| S7309 | BAY 87-2243 | BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1. |
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| S8661 | CA3 (CIL56) | CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS). | ||
| S2348 | Rotenone | ロテノンは、ミトコンドリア電子伝達の阻害剤である植物性殺虫剤です。ロテノンは、IC50がそれぞれ28.8 nMおよび5.1 nMで、NADH/DB酸化還元酵素およびNADH酸化酵素を阻害します。ロテノンは、ミトコンドリア活性酸素種の産生を促進することにより、アポトーシスを誘発します。ロテノンはパーキンソン病の動物モデルを誘発するために使用できます。 | ||
| S6871 | Sodium oxamate | Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation. | ||
| S8615 | Sodium Dichloroacetate (DCA) | DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth. | ||
| S2271 | Berberine chloride | Berberine chlorideは、イソキノリンアルカロイド群の第四級アンモニウム塩です。Berberine chlorideは、caspase 3とcaspase 8を活性化し、poly ADP-ribose polymerase (PARP)の切断とcytochrome cの放出を促進します。Berberine chlorideは、c-IAP1、Bcl-2、およびBcl-XLの発現を減少させます。Berberine chlorideは、JNKとp38 MAPKの持続的なリン酸化およびROSの生成を伴うapoptosisを誘導します。Berberine chlorideは、デュアルtopoisomerase IおよびII阻害剤です。Berberine chlorideは、潜在的なautophagyモジュレーターでもあります。 | ||
| S7873 | Disodium (R)-2-Hydroxyglutarate | Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. | ||
| S3238 | Resibufogenin | Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression. | ||
| S5452 | Sanguinarine chloride | Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. | ||
| S3607 | Sarsasapogenin | Sarsasapogenin (SAR, Parigenin) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages. | ||
| E8271New | Sanguinarine citrate | Sanguinarine (gluconate) is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. It activates reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB (NF-κB) signaling pathways to induce apoptosis in head and neck tumor cells and animal models. It also exhibits potent anti-bacterial and anti-inflammatory activities. | ||
| S7913 | MCB-613 | MCB-613 is a potent steroid receptor coactivator (SRC) stimulator. | ||
| S0056 | (E/Z)-BCI | (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | ||
| S0770 | Camalexin | Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities. | ||
| S5263 | Pyrroloquinoline Quinone Disodium Salt | Pyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions. | ||
| S3357 | Elaidic acid | Elaidic acid is a major trans fatty acid that inhibits cell viability, elevates cell apoptosis by enhancing oxidative stress. Elaidic acid can be used as a pharmaceutical solvent. |
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| S9611 | ABTL-0812 | ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation. | ||
| S5584 | Citronellol | Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells. | ||
| S4425 | Rifamycin S | Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. | ||
| S5804 | N-Acetylcysteine amide (NACA) | N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. | ||
| S2399 | Dihydromyricetin | Dihydromyricetin（アンペロプシン、アンペロプチン）は、Ampelopsis grossedentata由来の天然の抗酸化フラボノイドです。 |
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| S3301 | Cynarin | Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization. | ||
| S4263 | Efaproxiral Sodium | Efaproxiral Sodium(RSR13 Sodium)は、乳がん由来の脳転移に用いられる、ヘモグロビンの合成アロステリック修飾因子です。 | ||
| E7174 | D-α-Tocopherol Succinate | D-α-tocopherol succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E that significantly reduces the cisplatin-induced increase of ROS and decreases cellular necrosis and late apoptosis, thereby inhibiting cisplatin-induced cytotoxicity in HEIOC1 cells. It also exhibits an anti-apoptotic effect. | ||
| S4419 | Ensulizole | Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation. | ||
| E8271New | Sanguinarine citrate | Sanguinarine (gluconate) is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. It activates reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB (NF-κB) signaling pathways to induce apoptosis in head and neck tumor cells and animal models. It also exhibits potent anti-bacterial and anti-inflammatory activities. |
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