Antiviral

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1102	U0126-EtOH	<1 mg/mL	85 mg/mL	<1 mg/mL
S1537	Vadimezan (ASA404)	<1 mg/mL	7 mg/mL	''''<1 mg/mL
S2713	Geldanamycin (NSC 122750)	<1 mg/mL	36 mg/mL	'<1 mg/mL
S1401	Tenofovir	2 mg/mL	4 mg/mL	<1 mg/mL
S4879	Tenofovir hydrate	10 mg/mL	<1 mg/mL	''<1 mg/mL
S3356	Phosphonoacetic acid	28 mg/mL	28 mg/mL	'''28 mg/mL
S3380	Tecovirimat	<1 mg/mL	75 mg/mL	''''''75 mg/mL
S9669	U18666A	40 mg/mL	30 mg/mL	'''''85 mg/mL
S2764	DTNB	<1 mg/mL	79 mg/mL	'79 mg/mL
S6867	Glyceryl monocaprate (Monocaprin)	<1 mg/mL	49 mg/mL	''49 mg/mL
S6801	AKOS B018304	<1 mg/mL	53 mg/mL	'2 mg/mL
S1623	Acetylcysteine (N-acetylcysteine)	33 mg/mL	33 mg/mL	'33 mg/mL
S2239	Tubacin	<1 mg/mL	100 mg/mL	<1 mg/mL
S8750	NGI-1 (ML414)	<1 mg/mL	79 mg/mL	'<1 mg/mL
S9303	Saikosaponin B2	-1 mg/mL	100 mg/mL	-1 mg/mL
S7775	Emricasan (IDN-6556)	<1 mg/mL	100 mg/mL	'''100 mg/mL
S9063	Harringtonine	-1 mg/mL	100 mg/mL	-1 mg/mL
S8932	Remdesivir (GS-5734)	<1 mg/mL	100 mg/mL	''''16 mg/mL
S6814	GS-441524	<1 mg/mL	58 mg/mL	'<1 mg/mL
S3251	Goitrin	-1 mg/mL	100 mg/mL	-1 mg/mL
S2504	Ribavirin (ICN-1229)	49 mg/mL	49 mg/mL	''<1 mg/mL
S1807	Aciclovir (BW 248U)	<1 mg/mL	45 mg/mL	''<1 mg/mL
S1637	Docosanol	<1 mg/mL	<1 mg/mL	'4 mg/mL
S2420	Aloperine	12 mg/mL	2 mg/mL	'46 mg/mL
S2486	Moroxydine HCl	42 mg/mL	42 mg/mL	'<1 mg/mL
S2467	Famciclovir	64 mg/mL	64 mg/mL	'48 mg/mL
S1883	Idoxuridine	<1 mg/mL	35 mg/mL	'<1 mg/mL
S4184	Penciclovir	1 mg/mL	34 mg/mL	''<1 mg/mL
S8071	UNC0638	6 mg/mL	100 mg/mL	100 mg/mL
S9224	Dehydroandrographolide Succinate	-1 mg/mL	100 mg/mL	-1 mg/mL
S5684	Lapachol	-1 mg/mL	48 mg/mL	-1 mg/mL
S9278	Saikosaponin C	-1 mg/mL	100 mg/mL	-1 mg/mL
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol	-1 mg/mL	36 mg/mL	''-1 mg/mL
S5020	Tilorone dihydrochloride	96 mg/mL	43 mg/mL	'96 mg/mL
S5016	Isoprinosine	100 mg/mL	100 mg/mL	'2 mg/mL
S9078	Epigoitrin	-1 mg/mL	4.89 mg/mL	-1 mg/mL
S6067	2,4-dichlorobenzyl alcohol	-1 mg/mL	35 mg/mL	'-1 mg/mL
S2334	Oleanolic Acid	<1 mg/mL	21 mg/mL	7 mg/mL
S9099	Orientin	-1 mg/mL	89 mg/mL	-1 mg/mL
S9328	5,6,7-Trimethoxyflavone	-1 mg/mL	10 mg/mL	'-1 mg/mL
S9120	Scutellarein	-1 mg/mL	57 mg/mL	-1 mg/mL
S4518	Chloroxylenol	<1 mg/mL	31 mg/mL	'31 mg/mL
S9136	Neochlorogenic acid	-1 mg/mL	70 mg/mL	-1 mg/mL
S4408	Procodazole	<1 mg/mL	38 mg/mL	'''<1 mg/mL

Antiviral製品

All (45) Antiviral阻害剤(20) Antiviralモジュレータ(1)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1102	U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.	Theranostics, 2021, 11(3):996-1015 ACS Appl Mater Interfaces, 2021, 13(1):97-111 Cell Rep, 2021, 35(5):109069	Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK.
S1537	Vadimezan (ASA404) Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.	J Immunol, 2021, 206(9):2061-2074 Immunity, 2020, 7 pii: S1074-7613(20)30129-1 Sci Rep, 2020, 10(1):21360	(B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
S2713	Geldanamycin (NSC 122750) Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.	J Virol, 2021, JVI0059421 Anal Chem, 2020, 92(1):1363-1371 Anal Chem, 2020, 10.1021/acs.analchem.0c02756	Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
S1401	Tenofovir Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.	Antiviral Res, 2021, S0166-3542(21)00068-1 PLoS Pathog, 2020, 16(12):e1009024 Cells, 2020, 17;9(4) pii: E1003	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S4879^新	Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
S3356^新	Phosphonoacetic acid Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S3380^新	Tecovirimat Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.
S9669^新	U18666A U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.
S2764^新	DTNB DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.
S6867^新	Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S6801^新	AKOS B018304 AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.
S1623	Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.	Redox Biol, 2021, S2213-2317(21)00076-8 Br J Pharmacol, 2021, 178(5):1182-1199 J Exp Clin Cancer Res, 2021, 40(1):121	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S2239	Tubacin Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Cancers (Basel), 2020, 12(11)E3172 FASEB J, 2020, 10.1096/fj.202001508R Int J Mol Sci, 2020, 22(1)E142	Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
S8750	NGI-1 (ML414) NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.
S5554	Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S9303	Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S7775	Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.	Cell Death Differ, 2021, 10.1038/s41418-020-00685-9 Cell Death Dis, 2021, 12(2):140 Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(5):158902
S9063	Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.
S8932	Remdesivir (GS-5734) Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Nat Commun, 2021, 12(1):668 Cell Rep, 2021, 35(1):108940 mBio, 2021, 12(1)e02754-20
S6814	GS-441524 GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.	Front Pharmacol, 2020, 11:606097
S3251^新	Goitrin Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.
S2504	Ribavirin (ICN-1229) Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.	Antiviral Res, 2021, S0166-3542(21)00068-1 Int J Mol Sci, 2021, 22(9)4559 ACS Infect Dis, 2020, acsinfecdis.0c00486	(E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.
S1807	Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.	Sci Adv, 2020, 6(49)eabd9443 ACS Infect Dis, 2020, 6(11):2926-2937 Antimicrob Agents Chemother, 2020, AAC.00245-20	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
S1637	Docosanol Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production)
S2420	Aloperine Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.	J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2 Int J Mol Sci, 2019, 20(21)E5315 PeerJ, 2019, 7:e7652
S2486	Moroxydine HCl Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S2467	Famciclovir Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.	Sci Adv, 2020, 6(49)eabd9443 Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8
S1883	Idoxuridine Idoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.
S4184	Penciclovir Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.	ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083 Antiviral Res, 2021, S0166-3542(21)00068-1 Sci Adv, 2020, 6(49)eabd9443
S8071	UNC0638 UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.	Sci Adv, 2021, 7(3)eaba8053 Nat Commun, 2020, 11(1):604 Cell Rep, 2020, 33(4):108315
S9224	Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S5684	Lapachol Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S9278	Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol 4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties.
S5020	Tilorone dihydrochloride Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.
S5016	Isoprinosine Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.
S9078	Epigoitrin Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
S6067	2,4-dichlorobenzyl alcohol 2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.
S2334	Oleanolic Acid Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.	J Cell Sci, 2021, 134(8)jcs255273 J Asian Nat Prod Res, 2019, 21(6):522-527 J Asian Nat Prod Res, 2018, 10.1080/10286020.2018.1461087
S9099	Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9328	5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
S9120	Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
S4518	Chloroxylenol Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.
S9136	Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S4408	Procodazole Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1102	U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.	Theranostics, 2021, 11(3):996-1015 ACS Appl Mater Interfaces, 2021, 13(1):97-111 Cell Rep, 2021, 35(5):109069	Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK.
S1537	Vadimezan (ASA404) Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.	J Immunol, 2021, 206(9):2061-2074 Immunity, 2020, 7 pii: S1074-7613(20)30129-1 Sci Rep, 2020, 10(1):21360	(B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
S2713	Geldanamycin (NSC 122750) Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.	J Virol, 2021, JVI0059421 Anal Chem, 2020, 92(1):1363-1371 Anal Chem, 2020, 10.1021/acs.analchem.0c02756	Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
S1401	Tenofovir Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.	Antiviral Res, 2021, S0166-3542(21)00068-1 PLoS Pathog, 2020, 16(12):e1009024 Cells, 2020, 17;9(4) pii: E1003	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S4879^新	Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
S3356^新	Phosphonoacetic acid Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S3380^新	Tecovirimat Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.
S9669^新	U18666A U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication.
S2764^新	DTNB DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases.
S6867^新	Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S6801^新	AKOS B018304 AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.
S1623	Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.	Redox Biol, 2021, S2213-2317(21)00076-8 Br J Pharmacol, 2021, 178(5):1182-1199 J Exp Clin Cancer Res, 2021, 40(1):121	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S2239	Tubacin Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Cancers (Basel), 2020, 12(11)E3172 FASEB J, 2020, 10.1096/fj.202001508R Int J Mol Sci, 2020, 22(1)E142	Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
S8750	NGI-1 (ML414) NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.
S5554	Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S9303	Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S7775	Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.	Cell Death Differ, 2021, 10.1038/s41418-020-00685-9 Cell Death Dis, 2021, 12(2):140 Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(5):158902
S9063	Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.
S8932	Remdesivir (GS-5734) Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Nat Commun, 2021, 12(1):668 Cell Rep, 2021, 35(1):108940 mBio, 2021, 12(1)e02754-20
S6814	GS-441524 GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.	Front Pharmacol, 2020, 11:606097

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S3251^新	Goitrin Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.

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S3251^新

Goitrin

Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2504	Ribavirin (ICN-1229) Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.	Antiviral Res, 2021, S0166-3542(21)00068-1 Int J Mol Sci, 2021, 22(9)4559 ACS Infect Dis, 2020, acsinfecdis.0c00486	(E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.
S1807	Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.	Sci Adv, 2020, 6(49)eabd9443 ACS Infect Dis, 2020, 6(11):2926-2937 Antimicrob Agents Chemother, 2020, AAC.00245-20	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
S1637	Docosanol Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production)
S2420	Aloperine Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.	J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2 Int J Mol Sci, 2019, 20(21)E5315 PeerJ, 2019, 7:e7652
S2486	Moroxydine HCl Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S2467	Famciclovir Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.	Sci Adv, 2020, 6(49)eabd9443 Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8
S1883	Idoxuridine Idoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.
S4184	Penciclovir Penciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity.	ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083 Antiviral Res, 2021, S0166-3542(21)00068-1 Sci Adv, 2020, 6(49)eabd9443
S8071	UNC0638 UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.	Sci Adv, 2021, 7(3)eaba8053 Nat Commun, 2020, 11(1):604 Cell Rep, 2020, 33(4):108315
S9224	Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S5684	Lapachol Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S9278	Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol 4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties.
S5020	Tilorone dihydrochloride Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.
S5016	Isoprinosine Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.
S9078	Epigoitrin Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
S6067	2,4-dichlorobenzyl alcohol 2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.
S2334	Oleanolic Acid Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.	J Cell Sci, 2021, 134(8)jcs255273 J Asian Nat Prod Res, 2019, 21(6):522-527 J Asian Nat Prod Res, 2018, 10.1080/10286020.2018.1461087
S9099	Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9328	5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
S9120	Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
S4518	Chloroxylenol Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.
S9136	Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S4408	Procodazole Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.

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Antiviral

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Antiviral製品