Antiviral
阻害剤の選択性比較
カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
---|---|---|---|---|
水 | DMSO | アルコール | ||
S1102 | U0126-EtOH | <1 mg/mL | 85 mg/mL | '<1 mg/mL |
S1537 | Vadimezan (ASA404) | <1 mg/mL | 7 mg/mL | ''''<1 mg/mL |
S2713 | Geldanamycin (NSC 122750) | <1 mg/mL | 36 mg/mL | '<1 mg/mL |
S1401 | Tenofovir | 2 mg/mL | 4 mg/mL | <1 mg/mL |
S6865 | Alisporivir | -1 mg/mL | 100 mg/mL | -1 mg/mL |
E0365 | Fucoidan | 48 mg/mL | <1 mg/mL | <1 mg/mL |
E0153 | Lithium Chloride | 8 mg/mL | 8 mg/mL | 8 mg/mL |
E0150 | Carrageenan | 50 mg/mL | 50 mg/mL | <1 mg/mL |
E0010 | Hypocrellin A | <1 mg/mL | 25 mg/mL | ''<1 mg/mL |
S1623 | Acetylcysteine (N-acetylcysteine) | 33 mg/mL | 33 mg/mL | '33 mg/mL |
S2239 | Tubacin | <1 mg/mL | 100 mg/mL | <1 mg/mL |
S4879 | Tenofovir hydrate | 10 mg/mL | <1 mg/mL | ''<1 mg/mL |
S8750 | NGI-1 (ML414) | <1 mg/mL | 79 mg/mL | '<1 mg/mL |
S3380 | Tecovirimat | <1 mg/mL | 75 mg/mL | ''''''75 mg/mL |
S6867 | Glyceryl monocaprate (Monocaprin) | <1 mg/mL | 49 mg/mL | ''49 mg/mL |
S9303 | Saikosaponin B2 | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S2764 | DTNB | <1 mg/mL | 79 mg/mL | '79 mg/mL |
S7775 | Emricasan (IDN-6556) | <1 mg/mL | 100 mg/mL | '''100 mg/mL |
S9063 | Harringtonine | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S3356 | Phosphonoacetic acid | 28 mg/mL | 28 mg/mL | '''28 mg/mL |
S8932 | Remdesivir (GS-5734) | <1 mg/mL | 100 mg/mL | ''''16 mg/mL |
S9669 | U18666A | 40 mg/mL | 30 mg/mL | '''''85 mg/mL |
S6801 | AKOS B018304 | <1 mg/mL | 53 mg/mL | '2 mg/mL |
S6814 | GS-441524 | <1 mg/mL | 58 mg/mL | '<1 mg/mL |
S9926 | ML-SA1 | <1 mg/mL | 18 mg/mL | '2 mg/mL |
S3251 | Goitrin | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S2504 | Ribavirin (ICN-1229) | 49 mg/mL | 49 mg/mL | ''<1 mg/mL |
S1807 | Aciclovir (BW 248U) | <1 mg/mL | 45 mg/mL | ''<1 mg/mL |
S1637 | Docosanol | <1 mg/mL | <1 mg/mL | '4 mg/mL |
S2420 | Aloperine | 12 mg/mL | 2 mg/mL | '46 mg/mL |
S2486 | Moroxydine HCl | 42 mg/mL | 42 mg/mL | '<1 mg/mL |
S2467 | Famciclovir | 64 mg/mL | 64 mg/mL | '48 mg/mL |
S1883 | Idoxuridine | <1 mg/mL | 35 mg/mL | '<1 mg/mL |
S4184 | Penciclovir | 1 mg/mL | 34 mg/mL | ''<1 mg/mL |
S8071 | UNC0638 | 6 mg/mL | 100 mg/mL | 100 mg/mL |
S9224 | Dehydroandrographolide Succinate | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S5684 | Lapachol | -1 mg/mL | 48 mg/mL | -1 mg/mL |
S9278 | Saikosaponin C | -1 mg/mL | 100 mg/mL | -1 mg/mL |
S4942 | 4-Hydroxy-3,5-dimethoxybenzyl alcohol | -1 mg/mL | 36 mg/mL | ''-1 mg/mL |
S5020 | Tilorone dihydrochloride | 96 mg/mL | 43 mg/mL | '96 mg/mL |
S5016 | Isoprinosine | 100 mg/mL | 100 mg/mL | '2 mg/mL |
S9078 | Epigoitrin | -1 mg/mL | 4.89 mg/mL | -1 mg/mL |
S6067 | 2,4-dichlorobenzyl alcohol | -1 mg/mL | 35 mg/mL | '-1 mg/mL |
S2334 | Oleanolic Acid | <1 mg/mL | 21 mg/mL | 7 mg/mL |
S9099 | Orientin | -1 mg/mL | 89 mg/mL | -1 mg/mL |
S9328 | 5,6,7-Trimethoxyflavone | -1 mg/mL | 10 mg/mL | '-1 mg/mL |
S9120 | Scutellarein | -1 mg/mL | 57 mg/mL | -1 mg/mL |
S4518 | Chloroxylenol | <1 mg/mL | 31 mg/mL | '31 mg/mL |
S9136 | Neochlorogenic acid | -1 mg/mL | 70 mg/mL | -1 mg/mL |
S4408 | Procodazole | <1 mg/mL | 38 mg/mL | '''<1 mg/mL |
Antiviral製品
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
---|---|---|---|
S1102 |
U0126-EtOHU0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
![]() ![]() Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK. |
|
S1537 |
Vadimezan (ASA404)Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. |
![]() ![]() (B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
|
|
S2713 |
Geldanamycin (NSC 122750)Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. |
![]() ![]() Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
|
|
S1401 |
TenofovirTenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
![]() ![]() The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; **** p<0.0001; *** p<0.001 (unpaired t-test). |
|
S6865新 |
AlisporivirAlisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. |
||
E0365新 |
FucoidanFucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc. |
||
E0153新 |
Lithium ChlorideLithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats. |
||
E0150新 |
CarrageenanCarrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity. |
||
E0010新 |
Hypocrellin AHypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC. |
||
S1623 |
Acetylcysteine (N-acetylcysteine)Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared. |
![]() ![]() (C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
|
|
S2239 |
TubacinTubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
![]() ![]() Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
|
|
S4879 |
Tenofovir hydrateTenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
||
S8750 |
NGI-1 (ML414)NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses. |
||
S5554 |
Lanatoside CLanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways. |
||
S3380 |
TecovirimatTecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection. |
||
S6867 |
Glyceryl monocaprate (Monocaprin)Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. |
||
S9303 |
Saikosaponin B2Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
||
S2764 |
DTNBDTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
||
S7775 |
Emricasan (IDN-6556)Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
||
S9063 |
HarringtonineHarringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
||
S3356 |
Phosphonoacetic acidPhosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
||
S8932 |
Remdesivir (GS-5734)Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
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S9669 |
U18666AU18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication. |
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S6801 |
AKOS B018304AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity. |
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S6814 |
GS-441524GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM. |
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S9926新 |
ML-SA1ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral. |
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S3251 |
GoitrinGoitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity. |
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S2504 |
Ribavirin (ICN-1229)Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. |
![]() ![]() (E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells. |
|
S1807 |
Aciclovir (BW 248U)Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
![]() ![]() (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
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S1637 |
DocosanolDocosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production) |
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S2420 |
AloperineAloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. |
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S2486 |
Moroxydine HClMoroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines. |
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S2467 |
FamciclovirFamciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. |
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S1883 |
IdoxuridineIdoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM. |
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S4184 |
PenciclovirPenciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity. |
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S8071 |
UNC0638UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. |
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S9224 |
Dehydroandrographolide SuccinateDehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects. |
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S5684 |
LapacholLapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity. |
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S9278 |
Saikosaponin CSaikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities. |
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S4942 |
4-Hydroxy-3,5-dimethoxybenzyl alcohol4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties. |
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S5020 |
Tilorone dihydrochlorideTilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties. |
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S5016 |
IsoprinosineIsoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities. |
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S9078 |
EpigoitrinEpigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities. |
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S6067 |
2,4-dichlorobenzyl alcohol2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. |
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S2334 |
Oleanolic AcidOleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties. |
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S9099 |
OrientinOrientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects. |
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S9328 |
5,6,7-Trimethoxyflavone5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial. |
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S9120 |
ScutellareinScutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities |
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S4518 |
ChloroxylenolChloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus. |
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S9136 |
Neochlorogenic acidNeochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. |
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S4408 |
ProcodazoleProcodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
---|---|---|---|
S1102 |
U0126-EtOHU0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
![]() ![]() Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK. |
|
S1537 |
Vadimezan (ASA404)Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. |
![]() ![]() (B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
|
|
S2713 |
Geldanamycin (NSC 122750)Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. |
![]() ![]() Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
|
|
S1401 |
TenofovirTenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
![]() ![]() The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; **** p<0.0001; *** p<0.001 (unpaired t-test). |
|
S6865新 |
AlisporivirAlisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. |
||
E0365新 |
FucoidanFucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc. |
||
E0153新 |
Lithium ChlorideLithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats. |
||
E0150新 |
CarrageenanCarrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity. |
||
E0010新 |
Hypocrellin AHypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC. |
||
S1623 |
Acetylcysteine (N-acetylcysteine)Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared. |
![]() ![]() (C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
|
|
S2239 |
TubacinTubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
![]() ![]() Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
|
|
S4879 |
Tenofovir hydrateTenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
||
S8750 |
NGI-1 (ML414)NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses. |
||
S5554 |
Lanatoside CLanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways. |
||
S3380 |
TecovirimatTecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection. |
||
S6867 |
Glyceryl monocaprate (Monocaprin)Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. |
||
S9303 |
Saikosaponin B2Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
||
S2764 |
DTNBDTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
||
S7775 |
Emricasan (IDN-6556)Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
||
S9063 |
HarringtonineHarringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
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S3356 |
Phosphonoacetic acidPhosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities. |
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S8932 |
Remdesivir (GS-5734)Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. |
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S9669 |
U18666AU18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication. |
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S6801 |
AKOS B018304AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity. |
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S6814 |
GS-441524GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S9926新 |
ML-SA1ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S3251 |
GoitrinGoitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S2504 |
Ribavirin (ICN-1229)Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. |
2022, 13(1):2079 2022, e0219321 2021, 196:105209 |
![]() ![]() (E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells. |
S1807 |
Aciclovir (BW 248U)Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
2022, S0939-6411(22)00047-9 2021, 9(3):e0064621 2021, 12:722748 |
![]() ![]() (A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
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S1637 |
DocosanolDocosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement. (ED50=2.5 mg/mL for plaque inhibition, and ED50=1.7 mg/mL for inhibition of virus production) |
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S2420 |
AloperineAloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. |
2021, 21(1):662 2021, 74:101706 2020, 10.1007/s00432-020-03157-2 |
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S2486 |
Moroxydine HClMoroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines. |
2022, 10.1007/s13577-022-00671-y 2021, 10.1007/s13577-021-00639-4 2021, 34(6):1911-1918 |
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S2467 |
FamciclovirFamciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. |
2022, S0939-6411(22)00047-9 2022, 10.1007/s13577-022-00671-y 2021, 10.1007/s13577-021-00639-4 |
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S1883 |
IdoxuridineIdoxuridine (NSC 39661, SKF 14287) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM. |
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S4184 |
PenciclovirPenciclovir (BRL-39123, VSA 671) is a purine acyclic nucleoside analogue with potent antiviral activity. |
2022, S0939-6411(22)00047-9 2021, 10.1021/acsinfecdis.1c00083 2021, S0166-3542(21)00068-1 |
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S8071 |
UNC0638UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. |
2022, 18(5):e1010505 2021, e2100779 2021, 7(3)eaba8053 |
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S9224 |
Dehydroandrographolide SuccinateDehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects. |
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S5684 |
LapacholLapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity. |
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S9278 |
Saikosaponin CSaikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities. |
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S4942 |
4-Hydroxy-3,5-dimethoxybenzyl alcohol4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol) is a kind of phenol with antiviral properties. |
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S5020 |
Tilorone dihydrochlorideTilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties. |
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S5016 |
IsoprinosineIsoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities. |
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S9078 |
EpigoitrinEpigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities. |
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S6067 |
2,4-dichlorobenzyl alcohol2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. |
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S2334 |
Oleanolic AcidOleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties. |
2021, 134(8)jcs255273 2021, 12:697483 2019, 21(6):522-527 |
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S9099 |
OrientinOrientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects. |
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S9328 |
5,6,7-Trimethoxyflavone5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial. |
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S9120 |
ScutellareinScutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities |
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S4518 |
ChloroxylenolChloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus. |
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S9136 |
Neochlorogenic acidNeochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. |
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S4408 |
ProcodazoleProcodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections. |