Mangiferin

別名:Alpizarin, Chinomin, Hedysarid

Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.

Mangiferin化学構造

CAS No. 4773-96-0

サイズ 価格(税別) 在庫状況
JPY 17400 国内在庫あり
JPY 37500 国内在庫あり

代表番号: 045-509-1970|電子メール:[email protected]
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文献中Selleckの製品使用例(1)

製品安全説明書

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Mangiferin関連製品

Nrf2阻害剤の選択性比較

生物活性

製品説明 Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.
Targets
Nrf2 [3] NF-κB [4]
In Vitro
In vitro

Mangiferin possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory effects. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, providing a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. Mangiferin exerts a pro-hypoglycemic role by modulating glucose metabolism, ameliorating insulin resistance, lowering cholesterol synthesis, and inhibiting the expression of the tumor necrosis factor α and inducible nitric oxide synthase. It also induces apoptosis and inhibits the progression and promotion of cell proliferation by interfering with cell cycle regulation, the signaling of several cancer transduction pathways in tumor cells[1].

細胞実験 細胞株 RAW 264.7 cells
濃度 10, 20 and 40 μM
反応時間 16 h
実験の流れ

RAW 264.7 cells are seeded in 6 well plates at a density of 2 × 105 cells/well and then pre-incubated with different concentrations of PT-Mangiferin (10, 20 and 40 μM). The cells are stimulated with LPS (1 μg/ml) for 16 h and then treated with 10 μM DCFH-DA (2',7'-dichlorodihydrofluorescein diacetate) and further incubated for 15 min at 37 °C. The cells are collected, washed with PBS and total of 10000 events are analyzed in FL1 channel by Flow cytometry.

In Vivo
In Vivo

Mangiferin can pass through the blood-ocular barrier and has been shown to be effective in curtailing various eye diseases. Administration of mangiferin (100 mg/kg BW) dissolved in corn oil in healthy male Swiss albino mice lowers the activity of lysosomal enzymes such as β-glucuronidase, acidphosphatase, β-galactosidase and N-acetyl glucosaminidase. Oral administration of mangiferin (100 miligram/kilogram BW) through the diet for 18 weeks significantly ameliorates the elevated levels of glycoprotein components, membrane lipid peroxidation, and ATPases in lung carcinoma-induced animals. Mangiferin also ameliorates intestinal inflammation and impairs the gastrointestinal transit postoperative ileus (POI) of rats. It recovers delayed intestinal transit induced by intestinal manipulation. In mice, Mangiferin shows a gastroprotective effect. Administration of mangiferin (3, 10 and 30 mg/kg) decreases ethanol-induced gastric damage by 30, 35 and 63% respectively, and reduced indomethacin-induced gastric damage by 22, 23, and 57% respectively. In pylorus-ligated rats, gastric secretion and total acidity significantly decrease by mangiferin, and it effectively prevents the depletion of the ethanol-related protein from the gastric mucosa of the non-protein sulfhydryl content. Mangiferin exhibits an antidiabetic role in adult C57BL/6 J mice. It has a significant role in the reduction of cholesterol, triglycerides, and free fatty acid (FFA) levels in both serum and heart, and can also enhance heart tissue phospholipid levels in isoproterenol-induced cardiotoxic rats. Mangiferin has a cytotoprotective role against the neurotoxicity and cognitive impairment induced by aluminium chloride in male Swiss albino mice[1].

化学情報

分子量 422.34 化学式

C19H18O11

CAS No. 4773-96-0 SDF Download Mangiferin SDFをダウンロードする
Smiles C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O
保管

In vitro
Batch:

DMSO : 89 mg/mL ( (210.73 mM); 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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