Nrf2

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S8790 ML385 <1 mg/mL 74 mg/mL <1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S7864 Oltipraz <1 mg/mL 39 mg/mL <1 mg/mL
S3784 Obacunone -1 mg/mL 90 mg/mL -1 mg/mL
S5929 4-Octyl Itaconate <1 mg/mL 48 mg/mL 48 mg/mL
S4990 TBHQ -1 mg/mL 33 mg/mL -1 mg/mL

Nrf2製品

新Nrf2製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8790

ML385

ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2.

S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

S7864

Oltipraz

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

S5771

sulforaphane

Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2.

S3784

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

S5929

4-Octyl Itaconate

4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.

S4990

TBHQ

Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.

S4712

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8790

ML385

ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

2013, 10.3109/14756366.2013.837901

2016, 27(35):355101

2017, 803:167-173

S7864

Oltipraz

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

2017, 10.1007/s00204-017-2070-2

2018, 41(3):948-958

S5771

sulforaphane

Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2.

S3784

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

S5929

4-Octyl Itaconate

4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.

S4990

TBHQ

Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.

2019, 10.1016/j.bbadis.2018.12.007

2017, 2017:3754942

S4712

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.

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