Nrf2

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7956 Brustaol <1 mg/mL 100 mg/mL <1 mg/mL
S8790 ML385 <1 mg/mL 74 mg/mL '<1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S2586 Dimethyl Fumarate <1 mg/mL 29 mg/mL 10 mg/mL
S7864 Oltipraz <1 mg/mL 39 mg/mL <1 mg/mL
S4863 4-Hydroxyphenylacetic acid -1 mg/mL 30 mg/mL -1 mg/mL
S6647 Bardoxolone <1 mg/mL 6 mg/mL <1 mg/mL
S3784 Obacunone -1 mg/mL 90 mg/mL -1 mg/mL
S3808 Mangiferin -1 mg/mL 84 mg/mL -1 mg/mL
S4990 TBHQ -1 mg/mL 33 mg/mL -1 mg/mL
S5929 4-Octyl Itaconate <1 mg/mL 48 mg/mL 48 mg/mL

Nrf2製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7956

Brustaol

Brustaol, isolated from the fruit of B. javanica, is a NRF2 inhibitor.

S8790

ML385

ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.

S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

S2586

Dimethyl Fumarate

Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.

S7864

Oltipraz

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

S4863

4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid, a chemical compound found in olive oil and beer, is an intermediate used to synthesize atenolol and 3,4-dihydroxyphenylacetic acid.

S6647

Bardoxolone

Bardoxolone,acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.

S5771

sulforaphane

Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2.

S3784

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

S3808

Mangiferin

Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements.

S4990

TBHQ

Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.

S5929

4-Octyl Itaconate

4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.

S4712

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7956

Brustaol

Brustaol, isolated from the fruit of B. javanica, is a NRF2 inhibitor.

S8790

ML385

ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

2020, 15;10:3016

2020, 29(6):1366-1372

2020, 58(1):25-34

S2586

Dimethyl Fumarate

Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.

2020, 16;16(3):e1008341

2020, 1;10(5):1442-1454

2014, 15(12):1646-57

S7864

Oltipraz

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

2019, 219:119368

2019, 137:1-12

2018, 41(3):948-958

S4863

4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid, a chemical compound found in olive oil and beer, is an intermediate used to synthesize atenolol and 3,4-dihydroxyphenylacetic acid.

S6647

Bardoxolone

Bardoxolone,acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells.

S5771

sulforaphane

Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2.

2019, 74:105646

S3784

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

S3808

Mangiferin

Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements.

S4990

TBHQ

Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.

2020, 12;2020:1898213

2019, 10.1016/j.bbadis.2018.12.007

2019, 39(10):1394-1404

S5929

4-Octyl Itaconate

4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.

S4712

Diethylmaleate

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.