微小管関連
シグナル伝達経路
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1150 | Paclitaxel | <1 mg/mL | 171 mg/mL | 18 mg/mL |
| S1148 | Docetaxel | <1 mg/mL | 100 mg/mL | 53 mg/mL |
| S1241 | Vincristine sulfate | 60 mg/mL | 100 mg/mL | <1 mg/mL |
| S1364 | Patupilone (EPO906, Epothilone B) | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| S1165 | ABT-751 (E7010) | <1 mg/mL | 74 mg/mL | 12 mg/mL |
| S5919 | KHS101 hydrochloride | 3 mg/mL | 75 mg/mL | 57 mg/mL |
| S8789 | SSE15206 | <1 mg/mL | 74 mg/mL | <1 mg/mL |
| S3970 | Vindoline | -1 mg/mL | 91 mg/mL | -1 mg/mL |
| S2775 | Nocodazole | <1 mg/mL | 7 mg/mL | <1 mg/mL |
| S3022 | Cabazitaxel | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S2195 | Lexibulin (CYT997) | <1 mg/mL | 86 mg/mL | 20 mg/mL |
| S1297 | Epothilone A | <1 mg/mL | 99 mg/mL | 99 mg/mL |
| S7204 | Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium | 28 mg/mL | <1 mg/mL | <1 mg/mL |
| S1640 | Albendazole | <1 mg/mL | 17 mg/mL | <1 mg/mL |
| S7336 | CW069 | <1 mg/mL | 100 mg/mL | 4 mg/mL |
| S1836 | Albendazole Oxide | <1 mg/mL | 11 mg/mL | <1 mg/mL |
| S7721 | Monomethyl auristatin E (MMAE) | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S4114 | Triclabendazole | <1 mg/mL | 72 mg/mL | <1 mg/mL |
| S7787 | Docetaxel Trihydrate | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S7783 | Combretastatin A4 | <1 mg/mL | 63 mg/mL | 34 mg/mL |
| S2284 | Colchicine | 80 mg/mL | 80 mg/mL | 80 mg/mL |
| S4071 | Griseofulvin | <1 mg/mL | 50 mg/mL | <1 mg/mL |
| S7762 | TRx0237 (LMTX) mesylate | 95 mg/mL | 95 mg/mL | <1 mg/mL |
| S7497 | CK-636 | <1 mg/mL | 57 mg/mL | 50 mg/mL |
| S3725 | ELR-510444 | <1 mg/mL | 73 mg/mL | 24 mg/mL |
| S4269 | Vinorelbine Tartrate | 100 mg/mL | 100 mg/mL | 100 mg/mL |
| S7495 | TAI-1 | <1 mg/mL | 86 mg/mL | <1 mg/mL |
| S7930 | Ixabepilone (BMS-247550) | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S4505 | Vinblastine sulfate | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S7493 | INH1 | <1 mg/mL | 61 mg/mL | 61 mg/mL |
| S7494 | INH6 | <1 mg/mL | 64 mg/mL | 11 mg/mL |
- Microtubule Associated阻害剤(32)
- 新Microtubule Associated製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1150 |
PaclitaxelPaclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. |
(F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.
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| S1148 |
DocetaxelDocetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts from (D). Scale bar, 100 mm. Data represent the mean ± SD. *p < 0.05.
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| S1241 |
Vincristine sulfateVincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. |
Plk inhibitor cooperates with chemotherapeutic agents. Conditional patched mutant tumor cells were treated with increasing concentrations of the chemotherapeutic agents vincristine alone or in combination with 10 nMol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours.
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| S1364 |
Patupilone (EPO906, Epothilone B)Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2. |
Matrigel invasion assay of H1299 cells treated with SDF-1α or SDF-1α plus Epothilone B prior to 0 or 2 Gy irradiation. After the treatment for 12 h, the H1299 cells that migrated to the bottom surface of the membrane were stained with Giemsa, and the number of migrated cells was calculated manually. |
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| S1165 |
ABT-751 (E7010)ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. |
Cell viability in H292 monolayer cells after 3-day treatment and spheroid volume in H292 3D culture
after 7-day treatment with ABT751. Data points are means ?SD for three individual experiments. IC50 values were calculated to emphasize the differences in drug potency in 2D verses 3D cultures. ABT751, IC50 of 177.2 ?17.3 nM for 2D and 670.2 ?257.6 nM for 3D.
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| S5919新 |
KHS101 hydrochloride |
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| S8789新 |
SSE15206SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. |
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| S3970新 |
VindolineVindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly. |
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| S2775 |
NocodazoleNocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. |
A, HeLa cells were treated with DMSO, Taxol (100 nM for 16 h), or Nocodazole (Noco, 100 ng/ml for 16 h). Total cell lysates were probed with the indicated antibodies against Hippo components on Phos-tag SDS-polyacrylamide gels. O and * mark the non-phosphorylated and phosphorylated proteins, respectively. |
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| S3022 |
CabazitaxelCabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. |
Quantification of colony formation assays of aggressive PC cells (DU145-DR and 22Rv1-DR) transfected with control siRNA or two siRNAs targeting each specific nucleoporin following 72 hour treatment with cabazitaxel (25 nM) and single dose radiation (5 Gys).
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| S2195 |
Lexibulin (CYT997)Lexibulin (CYT997) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2. |
CYT997 inhibits cellular proliferation in acute myeloid leukemia (AML) cell lines. Cell viability was measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in 96-well plates in the presence of increasing concentrations of CYT997 for 24 h.The results represent the mean ?SD of four replicates. |
|
| S1297 |
Epothilone AEpothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM. |
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| S7204 |
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) DisodiumFosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Phase 3. |
Real-time hemodynamic changes in the tumor upon administration of CA4P. Panel A shows the MRI anatomical reference of the tumor, followed by sO2 maps of a slice of brain showing the largest cross section of the tumor at time points 0, 1, 4 and 6 h. post CA4P administration. Panel B shows the real-time sO2 changes in the tumor and contralateral brain occurring immediately post CA4P administration over 1 hour in a representative animal. SD is represented by lighter shades on the graph. Panel C shows the real-time sO2 changes in the tumor and contralateral brain occurring immediately post CA4P administration (n = 4). Panel D shows the quantification of hypoxia in tumors using CAIX as a marker at times 0 (n = 3), 1 (n = 4) and 6 h. (n = 3) post CA4P administration. Unpaired t-test showed statistically significant difference in CAIX staining at 1 hour post CA4P administration compared to 0 and 6 hours. ** ‐ P > 0.01. Black dotted circle and Red full circle denote the ROIs drawn at the tumor and contralateral brain respectively to compute the sO2.
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| S1640 |
AlbendazoleAlbendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. |
Dose-dependent disruption in the distribution of α-tubulin following exposure to albendazole. Experimental treatments included vehicle (DMSO), 0.1 μM, 0.5 μM and 1 μM albendazole for 24 hours. α-tubulin was visualized using immunofluorescence (green) and nuclei were stained with DAPI (blue). 40x fluorescence microscopy was used to assess changes in cellular morphology and tubulin distribution.
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| S7336 |
CW069CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP. |
Spindle morphology before and after addition of the HSET inhibitor (CW069, 200 μM). MTs were visualized by SiR-tubulin staining. Arrowheads indicate split poles. Images were acquired with 5 z-sections (separated by 3 μm) and displayed after maxium projection. Two independent KO lines were analysed (clones #4 and #23). Bar, 5 μm.
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| S1836 |
Albendazole OxideAlbendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. |
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| S7721 |
Monomethyl auristatin E (MMAE)Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent . |
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| S4114 |
TriclabendazoleTriclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. |
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| S7787 |
Docetaxel TrihydrateDocetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts. Scale bar, 100 μm. Data represent the mean ± SD. *p < 0.05.
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| S2254 |
4-Demethylepipodophyllotoxin(NSC-122819,VM-26)4'-Demethylepipodophyllotoxin is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. |
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| S7783 |
Combretastatin A4Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3. |
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| S2284 |
ColchicineColchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. |
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| S4071 |
GriseofulvinGriseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function. |
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| S7762 |
TRx0237 (LMTX) mesylateTRx 0237 (LMTX™) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
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| S7497 |
CK-636CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
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| S3725 |
ELR-510444ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. |
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| S4269 |
Vinorelbine TartrateVinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. |
JQ1 and chemotherapeutics (vinorelbine, docetaxel, cisplatin and carboplatin) cooperate to induce apoptosis. MDA-MB-231 and HS578T were exposed to drugs alone and in combination with JQ1, at the indicated doses. Apoptosis was examined after 72 hours of treatment by flow cytometry using Annexin V/ PI staining as previously described.
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| S7495 |
TAI-1TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
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| S7930 |
Ixabepilone (BMS-247550)Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. |
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| S4505 |
Vinblastine sulfateVinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. |
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| S7493 |
INH1INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. |
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| S7494 |
INH6INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
