Docetaxel

製品コードS1148 別名：RP56976, NSC 628503

Docetaxel化学構造

分子量(MW)：807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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文献中Selleckの製品使用例(11)

カスタマーフィードバック(6)

  • Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

  • Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

    Biomed Pharmacother, 2018, 99:445-450. Docetaxel purchased from Selleck.

製品安全説明書

Microtubule Associated阻害剤の選択性比較

生物活性

製品説明 Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
ターゲット
Microtubules [1]
(Cell-free assay)
体外試験

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]
細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjxTWM2OD1yLkCwNFE{OiEQvF2= MoHyV2FPT0WU
5637 NWXHV5IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET6dVZKSzVyPUCuNFAxOTR|IN88US=> NXPDVGRTW0GQR1XS
HT-144 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXPZnRyUUN3ME2wMlAxODF3NzFOwG0> Mn33V2FPT0WU
NCI-H292 M{PVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XRRWlEPTB;MD6wNFAyPTlizszN MmX4V2FPT0WU
HCE-T M{Pkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\sTppKSzVyPUCuNFAxOTZ{IN88US=> MnLCV2FPT0WU
ESS-1 NUnC[oQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrxVXNKSzVyPUCuNFAxOTd7IN88US=> M1vZcXNCVkeHUh?=
D-566MG MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCyTnNKSzVyPUCuNFAxOTh{IN88US=> NUPOcHcxW0GQR1XS
CAL-62 NV\n[YhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfjbYdwUUN3ME2wMlAxODF6NTFOwG0> MX7TRW5ITVJ?
GT3TKB NWrTWXExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vJPWlEPTB;MD6wNFAzOzJizszN MnrqV2FPT0WU
HSC-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X1dGlEPTB;MD6wNFAzOzlizszN M4S3UnNCVkeHUh?=
KOSC-2 NVS0XmZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\MT2lEPTB;MD6wNFAzPTVizszN NWf3U5BnW0GQR1XS
NB14 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fOTWlEPTB;MD6wNFAzPiEQvF2= M4\5U3NCVkeHUh?=
ES8 NH;ITIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\3WXNKSzVyPUCuNFAxOjZizszN MUjTRW5ITVJ?
BFTC-905 NFjKUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXaTWM2OD1yLkCwNFI3QCEQvF2= MmTzV2FPT0WU
A498 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\aTWM2OD1yLkCwNFI4QCEQvF2= MmixV2FPT0WU
HO-1-N-1 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjLfFdMUUN3ME2wMlAxODJ6MTFOwG0> NES5T5ZUSU6JRWK=
SF539 NUDuT494T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PEOWlEPTB;MD6wNFA{ODJizszN M2DoNXNCVkeHUh?=
HuO-3N1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrD[lFCUUN3ME2wMlAxODNyMjFOwG0> MVTTRW5ITVJ?
NCI-H510A MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPwPJhbUUN3ME2wMlAxODN|NjFOwG0> MonuV2FPT0WU
CAL-27 NGWwZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDLemVYUUN3ME2wMlAxODN|OTFOwG0> MVPTRW5ITVJ?
TE-8 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMECwN|Y3KM7:TR?= MkDKV2FPT0WU
VA-ES-BJ M2qy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LJXGlEPTB;MD6wNFA{PzVizszN MVzTRW5ITVJ?
RH-1 NHjwWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkixTWM2OD1yLkCwNFM5PiEQvF2= M12we3NCVkeHUh?=
COLO-800 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMECwN|g5KM7:TR?= MWrTRW5ITVJ?
ES7 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL3TWM2OD1yLkCwNFM5QSEQvF2= M1LvVnNCVkeHUh?=
GAMG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP5c2FKSzVyPUCuNFAxPDF4IN88US=> Mlv4V2FPT0WU
Ca9-22 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXNTWM2OD1yLkCwNFQzOyEQvF2= M4K4dXNCVkeHUh?=
SBC-1 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO0TWM2OD1yLkCwNFQ{KM7:TR?= NXTa[JNUW0GQR1XS
RPMI-7951 M{j3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTPOYhzUUN3ME2wMlAxODR2ODFOwG0> NHf2fnJUSU6JRWK=
SW1710 M{TzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D3d2lEPTB;MD6wNFA1PjZizszN M4Tt[HNCVkeHUh?=
HGC-27 NVvoWoF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X1[2lEPTB;MD6wNFA1PzFizszN Mn\WV2FPT0WU
MC-IXC NIrlTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jSU2lEPTB;MD6wNFA1PzlizszN NXjHOolMW0GQR1XS
FTC-133 NHi5d29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPITWM2OD1yLkCwNFQ5QSEQvF2= NGjiZplUSU6JRWK=
HT-1080 M3zXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\FUJN6UUN3ME2wMlAxODVyMTFOwG0> M2[0VHNCVkeHUh?=
NMC-G1 M1rjWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDne|Y2UUN3ME2wMlAxODVzNzFOwG0> MVzTRW5ITVJ?
GI-1 M1exeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP0TWM2OD1yLkCwNFUzQCEQvF2= NV6wfYpVW0GQR1XS
CGTH-W-1 NF3ITGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTFVXBUUUN3ME2wMlAxODV2MjFOwG0> M4TZOnNCVkeHUh?=
A2058 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37lbWlEPTB;MD6wNFA2PDRizszN NEXIPWpUSU6JRWK=
ETK-1 M3TVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX22UYNFUUN3ME2wMlAxODV3ODFOwG0> MoToV2FPT0WU
NEC8 NGTidJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\PWWZKSzVyPUCuNFAxPTZzIN88US=> NID0doFUSU6JRWK=
TE-11 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPmdGNpUUN3ME2wMlAxODV4OTFOwG0> NWjvRmdDW0GQR1XS
NCI-H720 NH:y[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxVnlKSzVyPUCuNFAxPThizszN Mm\yV2FPT0WU
PSN1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHoTWM2OD1yLkCwNFU5OSEQvF2= NHTuW|NUSU6JRWK=
SW780 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7lc4xKSzVyPUCuNFAxPTh5IN88US=> M3HJUHNCVkeHUh?=
8-MG-BA NF;hfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\wfW5KSzVyPUCuNFAxPTh7IN88US=> NHfiZ2FUSU6JRWK=
EC-GI-10 MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrTToEzUUN3ME2wMlAxODV7MjFOwG0> M3jlZXNCVkeHUh?=
SJSA-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jicGlEPTB;MD6wNFA3OTVizszN Mor1V2FPT0WU
639-V NIH1b|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW2fHpKSzVyPUCuNFAxPjR5IN88US=> NH;vdFBUSU6JRWK=
PFSK-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\kTWM2OD1yLkCwNFY2PyEQvF2= NH3oeWpUSU6JRWK=
DMS-273 NGjoS|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjtTWM2OD1yLkCwNFY4PCEQvF2= M1vWRXNCVkeHUh?=
TE-9 M1yxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrSTWM2OD1yLkCwNFY4PiEQvF2= Mk[zV2FPT0WU
SCC-25 M1HXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GxVmlEPTB;MD6wNFA3QCEQvF2= M{fDV3NCVkeHUh?=
PA-1 NELsbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\OTWM2OD1yLkCwNFY5PyEQvF2= MYTTRW5ITVJ?
MHH-ES-1 MkHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXv[oZKSzVyPUCuNFAxPyEQvF2= MlvMV2FPT0WU
Daoy Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm1TWM2OD1yLkCwNFch|ryP NVTrc|ZOW0GQR1XS
G-402 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXGfJZKSzVyPUCuNFAxPzB4IN88US=> NFnKR3RUSU6JRWK=
YKG-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK5eZdKSzVyPUCuNFAxPzB5IN88US=> M{XPeXNCVkeHUh?=
Ca-Ski MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknGTWM2OD1yLkCwNFczQCEQvF2= NGfmbo1USU6JRWK=
CHP-212 NX21PGFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jDS2lEPTB;MD6wNFA4OyEQvF2= MVHTRW5ITVJ?
SCC-4 NH\QOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7X[Hc{UUN3ME2wMlAxODd|OTFOwG0> NX3nelJ7W0GQR1XS
EW-3 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHnb2RPUUN3ME2wMlAxODd2NTFOwG0> NYPC[VlDW0GQR1XS
P12-ICHIKAWA NVzBNlZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMECwO|Q2KM7:TR?= MUHTRW5ITVJ?
HSC-2 M4q0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\wTWM2OD1yLkCwNFc2PSEQvF2= NYjFc293W0GQR1XS
HN M4GxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMECwO|U5KM7:TR?= NV\3OmNDW0GQR1XS
LXF-289 NIn3Z5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILqXI5KSzVyPUCuNFAxPzV6IN88US=> Mo\CV2FPT0WU
ES1 MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMECwO|ch|ryP MXPTRW5ITVJ?
NTERA-S-cl-D1 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzmb5hKSzVyPUCuNFAxPzd|IN88US=> MoLZV2FPT0WU
K5 NXzDb49CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Tpc2lEPTB;MD6wNFA4PzhizszN NVv3TGxYW0GQR1XS
HOS MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnUTWM2OD1yLkCwNFc5OiEQvF2= M3jocXNCVkeHUh?=
YH-13 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\WbmlEPTB;MD6wNFA4QTFizszN MVrTRW5ITVJ?
SW954 NWrFb214T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfE[49KSzVyPUCuNFAxQDJ|IN88US=> MoSyV2FPT0WU
KYSE-510 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfRTWM2OD1yLkCwNFg1KM7:TR?= NWf4d4xFW0GQR1XS
8505C NVLOdmg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e3fGlEPTB;MD6wNFA5PTRizszN MkXkV2FPT0WU
A549 NGHzT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPzOnVRUUN3ME2wMlAxODh6MjFOwG0> NYHEPVRwW0GQR1XS
Detroit562 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHBXnVKSzVyPUCuNFAxQTB{IN88US=> NFnadZNUSU6JRWK=
ES5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfuNGZKSzVyPUCuNFAxQTFizszN MlTFV2FPT0WU
KYSE-140 M3TVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMECwPVM{KM7:TR?= MXXTRW5ITVJ?
GMS-10 NHLOWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XCTGlEPTB;MD6wNFA6PDFizszN NETwTpdUSU6JRWK=
D-263MG NG\MfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMECwPVQ4KM7:TR?= NXe1TWZUW0GQR1XS
BCPAP NF:0NpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\WTWM2OD1yLkCwNFk1PyEQvF2= M4TmWXNCVkeHUh?=
CHL-1 NUHjcmxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PYXmlEPTB;MD6wNFA6PThizszN NXzpXJdvW0GQR1XS
RKO NGXZNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXuTWM2OD1yLkCwNFk5QSEQvF2= NWnwR2NVW0GQR1XS
SW48 NWfpeIJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;ITWM2OD1yLkCwNVAyKM7:TR?= M323THNCVkeHUh?=
BPH-1 NF7EOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCxTWM2OD1yLkCwNVAzKM7:TR?= M{DjZ3NCVkeHUh?=
EFO-27 NVvPbpRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;sNWlEPTB;MD6wNFExOiEQvF2= NEnWUo1USU6JRWK=
CAL-33 M33VbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfnTWM2OD1yLkCwNVA1KM7:TR?= NWLId5h{W0GQR1XS
NCI-H1792 M3HZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMECxNFQh|ryP MUPTRW5ITVJ?
BB30-HNC M2C1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMECxNFUh|ryP M1LTbnNCVkeHUh?=
VM-CUB-1 NV7tcVllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMECxNFUh|ryP M4ruWnNCVkeHUh?=
TE-5 NGDm[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;HTpRKSzVyPUCuNFAyODZizszN NFjvSVRUSU6JRWK=
NB13 NXvEdHhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jC[GlEPTB;MD6wNFExPyEQvF2= MYLTRW5ITVJ?
NBsusSR NGDuVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e4U2lEPTB;MD6wNFEyKM7:TR?= MlzhV2FPT0WU
LNCaP-Clone-FGC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFq4e21KSzVyPUCuNFAyOSEQvF2= M{PKdXNCVkeHUh?=
EPLC-272H MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTsXI1KSzVyPUCuNFAyOTFizszN NEnBeXBUSU6JRWK=
KNS-62 NUnwcW1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECxNVIh|ryP M3ntV3NCVkeHUh?=
RERF-LC-MS NF7kNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjLXFdsUUN3ME2wMlAxOTF|IN88US=> NGn4WJlUSU6JRWK=
LOXIMVI MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTDTWM2OD1yLkCwNVE3KM7:TR?= M{DWTHNCVkeHUh?=
KINGS-1 NYDCdlJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn6TWM2OD1yLkCwNVE4KM7:TR?= MmH3V2FPT0WU
T98G M1joW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMECxNVch|ryP MVjTRW5ITVJ?
HCC1806 NGD1XnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HIUGlEPTB;MD6wNFEyQCEQvF2= M3nHd3NCVkeHUh?=
MZ1-PC NGn2cnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HwZWlEPTB;MD6wNFEyQCEQvF2= NUW5UZdOW0GQR1XS
RT-112 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjCcGc4UUN3ME2wMlAxOTF7IN88US=> MX\TRW5ITVJ?
LK-2 MlHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMECxNlEh|ryP NVrhNGd4W0GQR1XS
A375 NFzPXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMECxNlEh|ryP NFPhc2RUSU6JRWK=
SF268 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMECxNlEh|ryP NX7zc45jW0GQR1XS
H9 NX:3ZndGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMECxNlQh|ryP NEexXnRUSU6JRWK=
KYSE-410 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMECxNlQh|ryP NYfpVJF2W0GQR1XS
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SW982 NV;lZVhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfab|JKSzVyPUCuNFAyOjdizszN MWnTRW5ITVJ?
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LCLC-103H NULB[G9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXrXmw4UUN3ME2wMlAxOjl|IN88US=> Mm\jV2FPT0WU
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NUGC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXMUFdxUUN3ME2wMlAxOzB6IN88US=> M2HZbHNCVkeHUh?=
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22RV1 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:yb2FSUUN3ME2wMlAxOzF3IN88US=> NXPpcIRKW0GQR1XS
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ONS-76 M3rX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHPR2p{UUN3ME2wMlAxOzJ{IN88US=> Mn\6V2FPT0WU
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AGS NG\hW5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W3SGlEPTB;MD6wNFMzQCEQvF2= MVjTRW5ITVJ?
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLQZWxWUUN3ME2wMlAxOzJ7IN88US=> MoHhV2FPT0WU
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CTV-1 NF3hSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDiOXpKSzVyPUCuNFA{OzdizszN MVrTRW5ITVJ?
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U-266 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\qOnl5UUN3ME2wMlAxOzR6IN88US=> Mm\MV2FPT0WU
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GI-ME-N NYq1eFJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXBdGpGUUN3ME2wMlAxOzV6IN88US=> Mny4V2FPT0WU
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NCI-H520 MlfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfyeIN3UUN3ME2wMlAxOzd{IN88US=> MYPTRW5ITVJ?
L-363 M{[0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHsTWM2OD1yLkCwN|c3KM7:TR?= MnTjV2FPT0WU
CAL-12T M13peGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMECzO|Yh|ryP NIXvdINUSU6JRWK=
BT-20 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPTTIRWUUN3ME2wMlAxOzd4IN88US=> NFf0fnVUSU6JRWK=
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NCI-H1395 NXrONnYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzpWlZMUUN3ME2wMlAxOzl4IN88US=> NI\5c2JUSU6JRWK=
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OVCAR-3 NX[4PVhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoCzTWM2OD1yLkCwOFA4KM7:TR?= MnXEV2FPT0WU
KM12 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTvSoF[UUN3ME2wMlAxPDB6IN88US=> MXLTRW5ITVJ?
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OCUB-M MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv6ZXg{UUN3ME2wMlAxPDN6IN88US=> NFrJV2xUSU6JRWK=
Calu-6 M3TleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEC0OFch|ryP NVGzUFU{W0GQR1XS
MDA-MB-453 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLhfWRoUUN3ME2wMlAxPDVzIN88US=> NV;6WnN6W0GQR1XS
MKN45 NU\uPWU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnXTWM2OD1yLkCwOFU{KM7:TR?= MWTTRW5ITVJ?
ECC10 M3\TTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEC0OkDPxE1? MkLPV2FPT0WU
RVH-421 M2DLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vEZmlEPTB;MD6wNFQ3OSEQvF2= NX2zZoxxW0GQR1XS
TGBC11TKB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPmSINQUUN3ME2wMlAxPDZ7IN88US=> MljJV2FPT0WU
MOLT-4 NGi2bXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUmyd2hiUUN3ME2wMlAxPDdzIN88US=> M4DxUXNCVkeHUh?=
LN-405 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHvTWM2OD1yLkCwOFgzKM7:TR?= M2rKVHNCVkeHUh?=
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RPMI-8226 M134T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q4cWlEPTB;MD6wNFQ6PyEQvF2= NYXpeIZuW0GQR1XS
KYSE-150 NHTQSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXobVVKSzVyPUCuNFA1QTlizszN NGjPOFJUSU6JRWK=
NCI-H1666 NE\PWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEC1NFUh|ryP M{C4cnNCVkeHUh?=
Mewo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEC1NFUh|ryP MknDV2FPT0WU
AN3-CA MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\BTWM2OD1yLkCwOVA4KM7:TR?= NVGxdoRHW0GQR1XS
COLO-680N M1HMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEC1NFgh|ryP NI\ST2JUSU6JRWK=
FADU MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe1TnBKSzVyPUCuNFA2OSEQvF2= NVqybHRyW0GQR1XS
GB-1 NVfXN21zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXNWYVuUUN3ME2wMlAxPTFzIN88US=> NXvJcWJJW0GQR1XS
KASUMI-1 M4HHSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPITWM2OD1yLkCwOVEyKM7:TR?= MWTTRW5ITVJ?
NOMO-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKySplHUUN3ME2wMlAxPTF|IN88US=> NVfyNI43W0GQR1XS
BV-173 Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEC1N{DPxE1? MlfuV2FPT0WU
RO82-W-1 NVfHR3g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXtTWM2OD1yLkCwOVMyKM7:TR?= Mli5V2FPT0WU
LB2241-RCC NGTQSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfpV4FKSzVyPUCuNFA2OzFizszN M37TUXNCVkeHUh?=
NCI-H2170 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXuTWM2OD1yLkCwOVM2KM7:TR?= NHfsUopUSU6JRWK=
SK-N-AS NFvpdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3izOmlEPTB;MD6wNFU{PSEQvF2= NWnZPXBUW0GQR1XS
NCI-H1651 NIrCe5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLzPYJoUUN3ME2wMlAxPTRizszN M3\2SXNCVkeHUh?=
NCI-SNU-5 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;zWWlEPTB;MD6wNFU1PSEQvF2= NIDqPWZUSU6JRWK=
SN12C NEfXZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXRfHNKSzVyPUCuNFA2PSEQvF2= Mo\UV2FPT0WU
KY821 NVHMcZBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEC1OVEh|ryP MXLTRW5ITVJ?
SW1573 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvsR5NCUUN3ME2wMlAxPTV2IN88US=> MkTUV2FPT0WU
OE19 M3rl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DnfGlEPTB;MD6wNFU2QSEQvF2= NWTLfGpiW0GQR1XS
MPP-89 M{XuNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTURVFoUUN3ME2wMlAxPTZ5IN88US=> M2TXNHNCVkeHUh?=
HuCCT1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDtU2VZUUN3ME2wMlAxPTZ6IN88US=> NGm1NplUSU6JRWK=
SW1783 NV3tWGhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\kTWM2OD1yLkCwOVch|ryP MWfTRW5ITVJ?
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OVCAR-4 M13yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXpTWM2OD1yLkCwOVg3KM7:TR?= NGr5bGVUSU6JRWK=
MMAC-SF MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi4TWhiUUN3ME2wMlAxPTh4IN88US=> NYjzTHptW0GQR1XS
COLO-824 NF\M[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHuTWM2OD1yLkCwOVkh|ryP NEfsWnhUSU6JRWK=
HCC38 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\pVWlEPTB;MD6wNFYh|ryP MlizV2FPT0WU
NCI-H1648 NV;G[otNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEC2NFEh|ryP Mn3LV2FPT0WU
NCI-H1573 NGnQWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny0TWM2OD1yLkCwOlA4KM7:TR?= M4jk[HNCVkeHUh?=
MFM-223 M1P4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ez[2lEPTB;MD6wNFYyPiEQvF2= MUjTRW5ITVJ?
NCI-H810 NI\6cnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEC2NlIh|ryP MmS2V2FPT0WU
EM-2 NYi4OWM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLoTWM2OD1yLkCwOlI{KM7:TR?= NH\5flFUSU6JRWK=
D-283MED NX75cph5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEC2NlQh|ryP MVnTRW5ITVJ?
NCI-H1755 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEC2NlQh|ryP NUXTeGNDW0GQR1XS
KYSE-70 NGrGRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEC2NlQh|ryP NIDVR|hUSU6JRWK=
SW626 NHLOeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1KwOmlEPTB;MD6wNFYzPCEQvF2= MWnTRW5ITVJ?
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DOHH-2 NHHRS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\PdYpKSzVyPUCuNFA3OyEQvF2= M4rNcHNCVkeHUh?=
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IGR-1 M4HQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXidpQxUUN3ME2wMlAxPjRzIN88US=> MXjTRW5ITVJ?
ACN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i5Z2lEPTB;MD6wNFY1PCEQvF2= NHr5THVUSU6JRWK=
KARPAS-45 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e5[WlEPTB;MD6wNFY2OiEQvF2= NHT2bplUSU6JRWK=
HC-1 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\NbJFKSzVyPUCuNFA3PTZizszN MnLSV2FPT0WU
MZ2-MEL NWfRb|YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LpcmlEPTB;MD6wNFY2QCEQvF2= NWPj[oE2W0GQR1XS
NCI-H1355 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXBd4ZKSzVyPUCuNFA3PzlizszN M{G0WnNCVkeHUh?=
HuP-T4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3pTWM2OD1yLkCwOlc6KM7:TR?= MnLqV2FPT0WU
AsPC-1 NGDZfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzKbmU3UUN3ME2wMlAxPjh|IN88US=> M{HOR3NCVkeHUh?=
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CP50-MEL-B NIf6[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3uZZFwUUN3ME2wMlAxPjl|IN88US=> M174PHNCVkeHUh?=
DMS-114 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGeyTJVKSzVyPUCuNFA3QTZizszN NHT1dmVUSU6JRWK=
KYSE-520 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TKNGlEPTB;MD6wNFch|ryP MXfTRW5ITVJ?
NCI-H2228 M3L5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrQNnNKSzVyPUCuNFA4OjVizszN NILKZ4VUSU6JRWK=
COLO-829 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrrPFhKSzVyPUCuNFA4OjVizszN MXXTRW5ITVJ?
NCI-H2052 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvHbW9FUUN3ME2wMlAxPzJ5IN88US=> NYX1WFlWW0GQR1XS
HOP-92 NH;UNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEC3N{DPxE1? NXHBb2FrW0GQR1XS
MDA-MB-231 M{TBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vPcWlEPTB;MD6wNFc{KM7:TR?= M3u3dHNCVkeHUh?=
SK-MEL-30 NF\jTHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXmTWM2OD1yLkCwO|MzKM7:TR?= M1LNfXNCVkeHUh?=
NCI-H2087 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEC3OFgh|ryP M1;sV3NCVkeHUh?=
SW900 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjSVVk3UUN3ME2wMlAxPzV3IN88US=> NGm3SVdUSU6JRWK=
NCI-H358 NF7oTI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTZTWM2OD1yLkCwO|U5KM7:TR?= MnrUV2FPT0WU
NCI-H2126 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L4XGlEPTB;MD6wNFc4OyEQvF2= NG[2eFJUSU6JRWK=
TGBC24TKB NXLyTm9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\5OJpTUUN3ME2wMlAxPzhzIN88US=> NHnFfoJUSU6JRWK=
786-0 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX4OJNKSzVyPUCuNFA4QDZizszN NVnOWYlbW0GQR1XS
no-10 NFG1SXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDYNnpKUUN3ME2wMlAxPzh6IN88US=> NIjWbnFUSU6JRWK=
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LU-65 NYjpSZVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DVOGlEPTB;MD6wN|kxPCEQvF2= MmrNV2FPT0WU
NB6 M4\vWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDFVpZKSzVyPUCuNFM6PTJizszN NV7mT5RUW0GQR1XS
HT NFLmTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xz[WlEPTB;MD6wOFAxPyEQvF2= MWPTRW5ITVJ?
COLO-684 M3vFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXtTWM2OD1yLkC0NFk2KM7:TR?= NFrPeItUSU6JRWK=
NCI-H1693 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMESzNFUh|ryP M{PWN3NCVkeHUh?=
LAN-6 NXnIZ45tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjOWnlHUUN3ME2wMlA1OzN3IN88US=> MlTkV2FPT0WU
MDA-MB-175-VII MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjYTWM2OD1yLkC0OFE4KM7:TR?= M3zYOnNCVkeHUh?=
KMOE-2 NV7mO|hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W0ZmlEPTB;MD6wOFQ3QSEQvF2= MUTTRW5ITVJ?
DMS-79 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDmPG1PUUN3ME2wMlA1PTd7IN88US=> NHfaNGRUSU6JRWK=
MHH-NB-11 M3TBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn5WXFCUUN3ME2wMlA1PjF2IN88US=> MYHTRW5ITVJ?
NCI-H69 M4rxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\SSYx5UUN3ME2wMlA1QDR7IN88US=> NXLzWow6W0GQR1XS
KE-37 NVTXW2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3YR2psUUN3ME2wMlA2ODFizszN MkPRV2FPT0WU
Ramos-2G6-4C10 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG3SlJKSzVyPUCuNFUxPjdizszN MkW0V2FPT0WU
NCI-H1793 NIrM[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX4enlDUUN3ME2wMlA2ODl|IN88US=> MVrTRW5ITVJ?
HT-1376 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;nRVFqUUN3ME2wMlA2OTh4IN88US=> MlvRV2FPT0WU
EKVX MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnOWmlKSzVyPUCuNFU{QDRizszN M4\nW3NCVkeHUh?=
Capan-2 NIT0U2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi3SIpKSzVyPUCuNFU{QTZizszN MXXTRW5ITVJ?
DoTc2-4510 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T4PWlEPTB;MD6wOVQ1PiEQvF2= MkHSV2FPT0WU
UACC-893 M4j1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofDTWM2OD1yLkC1OFYzKM7:TR?= M4TzNHNCVkeHUh?=
SK-MEL-3 M2P3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHJTXFKSzVyPUCuNFU4QDhizszN NHHkW5RUSU6JRWK=
SK-MEL-1 NEHjc3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn1TJNKSzVyPUCuNFU5KM7:TR?= MlLQV2FPT0WU
SW948 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEW5PVYh|ryP MkDOV2FPT0WU
P30-OHK MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLGUYVSUUN3ME2wMlA3OTZ5IN88US=> MXzTRW5ITVJ?
NH-12 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwME[yOFQh|ryP NGezS|dUSU6JRWK=
KU-19-19 NH\tOoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XWN2lEPTB;MD6wOlM3OSEQvF2= MljEV2FPT0WU
A431 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vpd2lEPTB;MD6wOlM4PCEQvF2= MlzRV2FPT0WU
NCI-H2405 NVfQUINmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnjWFBXUUN3ME2wMlA3Ozh|IN88US=> NYTldmVKW0GQR1XS
KARPAS-299 NInhRlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17B[2lEPTB;MD6wOlU5OiEQvF2= M3jJO3NCVkeHUh?=
BALL-1 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDCTWM2OD1yLkC2Olc1KM7:TR?= NELIfYNUSU6JRWK=
KURAMOCHI M4LLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;TTWM2OD1yLkC3NFc{KM7:TR?= M2\pW3NCVkeHUh?=
LS-1034 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHlS2lKSzVyPUCuNFc{PjlizszN M2LvRnNCVkeHUh?=
MFE-280 NEG0NmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEe1N|Yh|ryP MWXTRW5ITVJ?
HOP-62 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr1fY4xUUN3ME2wMlA4Pjd4IN88US=> NXGySXp2W0GQR1XS
KG-1 M3LuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjTbpRQUUN3ME2wMlA4Pzh5IN88US=> M1qybHNCVkeHUh?=
CW-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjQTWM2OD1yLkC3PFMzKM7:TR?= M2ezU3NCVkeHUh?=
SW837 NXWwXnJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrB[W1DUUN3ME2wMlA5OzR{IN88US=> MoTwV2FPT0WU
MFH-ino NGrmNolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m1VGlEPTB;MD6wPFUxOSEQvF2= MYPTRW5ITVJ?
HCC1419 NXi2[49sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHJTm5lUUN3ME2wMlA5QTh5IN88US=> MWrTRW5ITVJ?
HMV-II M{fERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\oenZWUUN3ME2wMlA6ODFizszN M1L0V3NCVkeHUh?=
BEN NH;VfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3LdHB{UUN3ME2wMlA6Ozh3IN88US=> M{[xZXNCVkeHUh?=
SK-N-FI MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpfYxiUUN3ME2wMlA6PTV4IN88US=> M{jqUXNCVkeHUh?=
JVM-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\BbolKSzVyPUCuNFk4OTZizszN NYrUdXNKW0GQR1XS
CAL-54 NILw[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUCwOEDPxE1? NVrJeXBJW0GQR1XS
T84 NWfKXG4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r3TGlEPTB;MD6xNFk2OiEQvF2= MlTLV2FPT0WU
SHP-77 M3PRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjJeJlVUUN3ME2wMlEyPjRzIN88US=> MX3TRW5ITVJ?
G-361 M4DBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTZWoNKSzVyPUCuNVI{OjRizszN MknPV2FPT0WU
Calu-3 Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DIeGlEPTB;MD6xN|gyPiEQvF2= MUPTRW5ITVJ?
HCC1937 NF;WWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2izPGlEPTB;MD6xOFk{PyEQvF2= NWflWXc6W0GQR1XS
KM-H2 MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXjTWM2OD1yLkG1NFEh|ryP NXPWXIZzW0GQR1XS
769-P MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPqdWZSUUN3ME2wMlE2QDR|IN88US=> MYXTRW5ITVJ?
NCI-H1304 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPQPVdKSzVyPUCuNVYxPjFizszN NFzze4xUSU6JRWK=
D-542MG MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMU[yO|gh|ryP NYnKRYhVW0GQR1XS
ATN-1 M2jsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS4TWM2OD1yLkG3OFQyKM7:TR?= MWXTRW5ITVJ?
NCI-H2029 NXrXRoZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMkCyOFMh|ryP MVnTRW5ITVJ?
ZR-75-30 NWfFdXBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDtSWdKSzVyPUCuNlA3PDNizszN MkO4V2FPT0WU
SW1116 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj3fIFlUUN3ME2wMlIyOTF5IN88US=> M1vRd3NCVkeHUh?=
CCRF-CEM MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[yTWM2OD1yLkK3OlE1KM7:TR?= MUfTRW5ITVJ?
LU-135 MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G4RWlEPTB;MD6yO|c{QSEQvF2= NUS1c4d{W0GQR1XS
MC116 NHnTbYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH72W4FKSzVyPUCuNlg{ODlizszN MmjPV2FPT0WU
LS-513 Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf6ZXREUUN3ME2wMlI5Pzd|IN88US=> MWrTRW5ITVJ?
NCI-H630 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELGcnNKSzVyPUCuNlk{PzZizszN NUXvXmN5W0GQR1XS
L-428 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3uTnlKSzVyPUCuNlk5QDNizszN NEjPN|JUSU6JRWK=
UM-UC-3 M4jhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\CTWM2OD1yLkOxNlkyKM7:TR?= MoG0V2FPT0WU
NCI-H1838 NU\ZXG5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;ROGxwUUN3ME2wMlMyPzh2IN88US=> MXjTRW5ITVJ?
HEL NFjmS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwM{KyOEDPxE1? NUnBdnVZW0GQR1XS
OCI-AML2 MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm1TVZKSzVyPUCuN|IzQThizszN NEfBc2hUSU6JRWK=
A3-KAW NWnacHdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonUTWM2OD1yLkOzOFc4KM7:TR?= NEXJblhUSU6JRWK=
IGROV-1 NVr1SYw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwM{O3OVUh|ryP M{PWbXNCVkeHUh?=
Mo-T NHq3PG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{O4OVMh|ryP M4\MV3NCVkeHUh?=
HDLM-2 NUDaVWJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXBTWM2OD1yLkOzPUDPxE1? MUnTRW5ITVJ?
HCC1569 NV7xRmFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwM{SzNFkh|ryP NGrqd4dUSU6JRWK=
COLO-678 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG0T4VKSzVyPUCuN|cxODJizszN M3jXOXNCVkeHUh?=
COR-L105 NUSxW3p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPtc4VnUUN3ME2wMlM4QTNizszN MWrTRW5ITVJ?
SK-MEL-24 M2DmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfMR25QUUN3ME2wMlM5Ozh{IN88US=> NIn1UpJUSU6JRWK=
COLO-320-HSR NWDrUnQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG3TWM2OD1yLkSzPVc3KM7:TR?= MU\TRW5ITVJ?
C8166 MorPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq0PI1iUUN3ME2wMlQ6ODJ|IN88US=> M4TGNnNCVkeHUh?=
COLO-679 NGrLellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OyW2lEPTB;MD62NlE4OiEQvF2= NWTpVWxLW0GQR1XS
TE-12 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLZTWM2OD1yLk[1N|k1KM7:TR?= NYDkSY8zW0GQR1XS
HAL-01 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlyxTWM2OD1yLk[2NlIh|ryP NFzrdVlUSU6JRWK=
H-EMC-SS NWfnUZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPFUmZlUUN3ME2wMlcxPTR4IN88US=> NXm3OZN[W0GQR1XS
SNU-449 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwN{K3OFgh|ryP NF23N4VUSU6JRWK=
C32 M2nIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwN{SxNVIh|ryP NVPVNIM1W0GQR1XS
K-562 NXXhRXBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK4NI1kUUN3ME2wMlc4ODJ2IN88US=> NHLUXXlUSU6JRWK=
DJM-1 NVzKVWM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyyTWM2OD1yLke4O|gyKM7:TR?= NWfkN4NnW0GQR1XS
RCC10RGB NGPWVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPa[lFVUUN3ME2wMlc6OTh|IN88US=> M4G0[nNCVkeHUh?=
CAL-85-1 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\aRmlEPTB;MD65NFch|ryP MlPwV2FPT0WU
NY M1zhZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7Bb2VpUUN3ME2wMlk{OzV{IN88US=> NH3YVXlUSU6JRWK=
NCI-H1993 NGL6WXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjrdHBXUUN3ME2xMlE6Ojh7IN88US=> NWL6NoFMW0GQR1XS
SK-OV-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELuO5ZKSzVyPUGuNlIxQDlizszN M1LXcnNCVkeHUh?=

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい
体内試験 Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

お薦めの試験操作（参考用のみ）

細胞試験： [5]
+ 展開
  • 細胞株： Human gastric cancer cell lines MKN-28
  • 濃度： 6 nM
  • 反応時間： 3 days
  • 実験の流れ： 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (参考用のみ)
動物試験：[6]
+ 展開
  • 動物モデル： Human colon carcinomas xenografts CX-1
  • 製剤： 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • 投薬量： 33 mg/kg
  • 投与方法： i.v. every 4 days for 3 injections
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。 		2mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 807.88
化学式

C43H53NO14
CAS No. 114977-28-5
保管 粉
in solvent
別名 RP56976, NSC 628503

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

総分子量：g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03742986 Not yet recruiting Breast Cancer New York University School of Medicine April 2019 Phase 2
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer January 7 2019 Phase 2
NCT03329378 Not yet recruiting Locally Advanced Breast Cancer Icahn School of Medicine at Mount Sinai December 2018 Phase 2
NCT03693612 Not yet recruiting Neoplasms GlaxoSmithKline|MedImmune LLC December 3 2018 Phase 2
NCT03739710 Not yet recruiting Neoplasms GlaxoSmithKline December 7 2018 Phase 2
NCT03700099 Not yet recruiting Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc December 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須
selleck catalog

Microtubule Associatedシグナル伝達経路

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    Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

  • Combretastatin A4

    Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.

  • Paclitaxel

    Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

  • Vincristine sulfate

    Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

  • Nocodazole

    Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.

  • Vinorelbine Tartrate

    Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

Tags: Docetaxelを買う | Docetaxel ic50 | Docetaxel供給者 | Docetaxelを購入する | Docetaxel費用 | Docetaxel生産者 | オーダーDocetaxel | Docetaxel化学構造 | Docetaxel分子量 | Docetaxel代理店
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