Docetaxel

製品コードS1148 別名：RP56976, NSC 628503

Docetaxel化学構造

分子量(MW)：807.88

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

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文献中Selleckの製品使用例(12)

カスタマーフィードバック(7)

  • Immunohistochemistry and quantification of cleaved caspase 3 expression in DU145-DR tumor xenografts from (D). Scale bar, 100 mm. Data represent the mean ± SD. *p < 0.05.

    Cell, 2018, 174(5):1200-1215. Docetaxel purchased from Selleck.

    Viability of cells after exposure to 0, 10, or 10,000 nM docetaxel, assessed by calcein-AM staining (green, left panels) and ethidium homodimer-1 (red, middle panels).

    Mol Pharmaceutics, 2014, 11: 2040−50. Docetaxel purchased from Selleck.

  • J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

    J Transl Med 2013 0.6. Docetaxel purchased from Selleck.

  • TNBC and non-TNBC cells were treated for 6 d with the specified concentrations of docetaxel (doc) alone, TTK inhibitor (TTKi) alone or the combinations. The survival of cells was measured using the MTS/MTA assay. ***P<0.001 comparing the combination with single agents and with non-TNBC cell lines.

    Oncogenesis, 2014, 3: e100 . Docetaxel purchased from Selleck.

    Cell cycle study of percent cell populations in various phases after treatment with vehicle, HCI-2509 in increasing concentrations and docetaxel alone and in combination with HCI-2509 using (a) PC3 cells. Student's unpaired t-tests, using GraphPad Prism software, were used to calculate two-tailed P-values for each experiment to determine statistical significance between untreated and treated samples. The statistically significant P-values are labeled in each figure with an asterisk. (Replicated two more times, representative graph shown).

    Prostate Cancer Prostatic Dis, 2016, 19(4):349-357. Docetaxel purchased from Selleck.

  • Biomed Pharmacother, 2018, 99:445-450. Docetaxel purchased from Selleck.

製品安全説明書

Microtubule Associated阻害剤の選択性比較

生物活性

製品説明 Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
ターゲット
Microtubules [1]
(Cell-free assay)
体外試験

Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle. [2] Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively. [4] Docetaxel inhibits endothelial cell migration that does not affects microtubule gross morphology or inhibit cell proliferation, although they does produce more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. HUVEC chemotaxis stimulated by either of two angiogenic factors, thymidine phosphorylase or VEGF, is inhibited by Docetaxel with IC 50 of 10 pM and is ablated at 1 nM. [7] Docetaxel induces human monocytes, but not RAW 264.7 murine macrophages, Prostaglandin H Synthase-2m (PGHS-2) expression. [8]
細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HSC-3 NGDz[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HZU2lEPTB;MD6wNFAyOzJizszN NHnZ[lFUSU6JRWK=
5637 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLUR4pKUUN3ME2wMlAxODF2MzFOwG0> NF3ZOmNUSU6JRWK=
HT-144 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vHTmlEPTB;MD6wNFAyPTdizszN M2\qe3NCVkeHUh?=
NCI-H292 NXjvO5pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[0[2lEPTB;MD6wNFAyPTlizszN MVvTRW5ITVJ?
HCE-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\MV2NKSzVyPUCuNFAxOTZ{IN88US=> M{jaXHNCVkeHUh?=
ESS-1 NV\UUlFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;mfHNKSzVyPUCuNFAxOTd7IN88US=> M1zWfHNCVkeHUh?=
D-566MG NHrtb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMECwNVgzKM7:TR?= MWHTRW5ITVJ?
CAL-62 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnRWGlKSzVyPUCuNFAxOTh3IN88US=> M1jrXHNCVkeHUh?=
GT3TKB NEjHbGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXJTWM2OD1yLkCwNFI{OiEQvF2= NGW1SpFUSU6JRWK=
HSC-4 M3T3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXtVHdTUUN3ME2wMlAxODJ|OTFOwG0> NX3DdVhCW0GQR1XS
KOSC-2 M2CzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGru[2pKSzVyPUCuNFAxOjV3IN88US=> NIfDNGZUSU6JRWK=
NB14 NIDxW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMECwNlYh|ryP MXPTRW5ITVJ?
ES8 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPQSGRwUUN3ME2wMlAxODJ4IN88US=> NIDNeldUSU6JRWK=
BFTC-905 NUjJXo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjYTWM2OD1yLkCwNFI3QCEQvF2= M1vtd3NCVkeHUh?=
A498 MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\aSpRKSzVyPUCuNFAxOjd6IN88US=> MkLtV2FPT0WU
HO-1-N-1 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFewWY1KSzVyPUCuNFAxOjhzIN88US=> MV3TRW5ITVJ?
SF539 M4HyeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3hTWM2OD1yLkCwNFMxOiEQvF2= MmnsV2FPT0WU
HuO-3N1 M2\4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXFTWM2OD1yLkCwNFMxOiEQvF2= MWLTRW5ITVJ?
NCI-H510A MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrvTWM2OD1yLkCwNFM{PiEQvF2= Mn;lV2FPT0WU
CAL-27 NI\PdVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK3TWM2OD1yLkCwNFM{QSEQvF2= NEexNINUSU6JRWK=
TE-8 M{Gy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMECwN|Y3KM7:TR?= M{HGXXNCVkeHUh?=
VA-ES-BJ NIj0RWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH5cZRbUUN3ME2wMlAxODN5NTFOwG0> NVizO5RVW0GQR1XS
RH-1 NGrURldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Oz[WlEPTB;MD6wNFA{QDZizszN M4nXSHNCVkeHUh?=
COLO-800 NYn0V3piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMECwN|g5KM7:TR?= NHvLeItUSU6JRWK=
ES7 M4XoVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMECwN|g6KM7:TR?= M3jWV3NCVkeHUh?=
GAMG M2LpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMECwOFE3KM7:TR?= M4fleXNCVkeHUh?=
Ca9-22 NG[1epdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS0NXBKSzVyPUCuNFAxPDJ|IN88US=> M4LFb3NCVkeHUh?=
SBC-1 M{LneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HsbmlEPTB;MD6wNFA1OyEQvF2= MXzTRW5ITVJ?
RPMI-7951 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT4TWM2OD1yLkCwNFQ1QCEQvF2= MV7TRW5ITVJ?
SW1710 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMECwOFY3KM7:TR?= NYXwSmRkW0GQR1XS
HGC-27 M2nDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMECwOFcyKM7:TR?= NYX1TlRIW0GQR1XS
MC-IXC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmzboVtUUN3ME2wMlAxODR5OTFOwG0> MoPEV2FPT0WU
FTC-133 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTielFJUUN3ME2wMlAxODR6OTFOwG0> MnfVV2FPT0WU
HT-1080 NULmSHYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jUPWlEPTB;MD6wNFA2ODFizszN MVTTRW5ITVJ?
NMC-G1 MnHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKwTWM2OD1yLkCwNFUyPyEQvF2= MVTTRW5ITVJ?
GI-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzDbmNQUUN3ME2wMlAxODV{ODFOwG0> M2rTSXNCVkeHUh?=
CGTH-W-1 M4r5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjFXWVKSzVyPUCuNFAxPTR{IN88US=> MnTSV2FPT0WU
A2058 NEW5XHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMECwOVQ1KM7:TR?= NHfrZVlUSU6JRWK=
ETK-1 NXzQZ|hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;0TWM2OD1yLkCwNFU2QCEQvF2= NVKwRZZlW0GQR1XS
NEC8 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMECwOVYyKM7:TR?= NVr3XJJmW0GQR1XS
TE-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmqzTWM2OD1yLkCwNFU3QSEQvF2= NF3Kb2dUSU6JRWK=
NCI-H720 NInVU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\DTWM2OD1yLkCwNFU5KM7:TR?= NH3nSYdUSU6JRWK=
PSN1 M1\YUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILzU4xKSzVyPUCuNFAxPThzIN88US=> MYnTRW5ITVJ?
SW780 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW5TWM2OD1yLkCwNFU5PyEQvF2= MV3TRW5ITVJ?
8-MG-BA MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMECwOVg6KM7:TR?= MmX3V2FPT0WU
EC-GI-10 M3O4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMECwOVkzKM7:TR?= MY\TRW5ITVJ?
SJSA-1 NX;hV45ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknpTWM2OD1yLkCwNFYyPSEQvF2= NVX4OGVVW0GQR1XS
639-V NHOxW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMECwOlQ4KM7:TR?= MlfSV2FPT0WU
PFSK-1 M2K4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMECwOlU4KM7:TR?= MmX2V2FPT0WU
DMS-273 NX\Fe|FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX1N|dKSzVyPUCuNFAxPjd2IN88US=> M3;SSnNCVkeHUh?=
TE-9 NFrrbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jV[mlEPTB;MD6wNFA3PzZizszN MYPTRW5ITVJ?
SCC-25 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMECwOlgh|ryP NVPx[Gt4W0GQR1XS
PA-1 MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMECwOlg4KM7:TR?= M4HLc3NCVkeHUh?=
MHH-ES-1 M13tcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\1dVN4UUN3ME2wMlAxODdizszN NEP2NJFUSU6JRWK=
Daoy NFTqeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF71ZnNKSzVyPUCuNFAxPyEQvF2= MnXuV2FPT0WU
G-402 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXHTWM2OD1yLkCwNFcxPiEQvF2= MmjIV2FPT0WU
YKG-1 Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrqRWNKSzVyPUCuNFAxPzB5IN88US=> NX\DVGJLW0GQR1XS
Ca-Ski Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXG3dYpUUUN3ME2wMlAxODd{ODFOwG0> NWH0eZFCW0GQR1XS
CHP-212 M13HTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnwenZrUUN3ME2wMlAxODd|IN88US=> MYjTRW5ITVJ?
SCC-4 NHL2[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL4TWM2OD1yLkCwNFc{QSEQvF2= M3XmV3NCVkeHUh?=
EW-3 M{XudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXlPHRKSzVyPUCuNFAxPzR3IN88US=> NXLycoVxW0GQR1XS
P12-ICHIKAWA MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fjZmlEPTB;MD6wNFA4PDVizszN NF\KO5pUSU6JRWK=
HSC-2 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH3TWM2OD1yLkCwNFc2PSEQvF2= MofNV2FPT0WU
HN MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPRWIdpUUN3ME2wMlAxODd3ODFOwG0> M4TESHNCVkeHUh?=
LXF-289 NIfsWWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnYZVFKSzVyPUCuNFAxPzV6IN88US=> M2XrWXNCVkeHUh?=
ES1 M{LaN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDld3JJUUN3ME2wMlAxODd5IN88US=> MYDTRW5ITVJ?
NTERA-S-cl-D1 NV7YbIo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL0Z|RbUUN3ME2wMlAxODd5MzFOwG0> NGnyOlNUSU6JRWK=
K5 M{P2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXSTWM2OD1yLkCwNFc4QCEQvF2= MVTTRW5ITVJ?
HOS MoWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMECwO|gzKM7:TR?= MULTRW5ITVJ?
YH-13 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm4d4tKSzVyPUCuNFAxPzlzIN88US=> NF3aZpFUSU6JRWK=
SW954 NFu2eHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HqO2lEPTB;MD6wNFA5OjNizszN NHnjO|VUSU6JRWK=
KYSE-510 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\BTWM2OD1yLkCwNFg1KM7:TR?= NXrIV3FxW0GQR1XS
8505C M1q4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXTcGJ2UUN3ME2wMlAxODh3NDFOwG0> NXjz[41iW0GQR1XS
A549 NX:ydYpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nFcWlEPTB;MD6wNFA5QDJizszN Mli1V2FPT0WU
Detroit562 MkTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G3WWlEPTB;MD6wNFA6ODJizszN NVrWbo1YW0GQR1XS
ES5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLxTWM2OD1yLkCwNFkyKM7:TR?= MYfTRW5ITVJ?
KYSE-140 Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMECwPVM{KM7:TR?= MXrTRW5ITVJ?
GMS-10 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMECwPVQyKM7:TR?= M17qUnNCVkeHUh?=
D-263MG M2jLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KzZ2lEPTB;MD6wNFA6PDdizszN NWXWRoNyW0GQR1XS
BCPAP M4XGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPuPFlKSzVyPUCuNFAxQTR5IN88US=> NHPB[GtUSU6JRWK=
CHL-1 NHrXRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLzWZJKSzVyPUCuNFAxQTV6IN88US=> NVHPO3k6W0GQR1XS
RKO NEK4V|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ztPGlEPTB;MD6wNFA6QDlizszN MVnTRW5ITVJ?
SW48 NH65OXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHFVIRGUUN3ME2wMlAxOTBzIN88US=> NV;kO4kzW0GQR1XS
BPH-1 NX;LOVNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjzVJRbUUN3ME2wMlAxOTB{IN88US=> NXruRlA2W0GQR1XS
EFO-27 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMECxNFIh|ryP NUDz[Yk3W0GQR1XS
CAL-33 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOyd2FKSzVyPUCuNFAyODRizszN M3vGNnNCVkeHUh?=
NCI-H1792 MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkSwTWM2OD1yLkCwNVA1KM7:TR?= NIO0bZZUSU6JRWK=
BB30-HNC MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7tTWM2OD1yLkCwNVA2KM7:TR?= MU\TRW5ITVJ?
VM-CUB-1 M3LmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LlcWlEPTB;MD6wNFExPSEQvF2= MX7TRW5ITVJ?
TE-5 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnvVHlzUUN3ME2wMlAxOTB4IN88US=> M36wZnNCVkeHUh?=
NB13 NWHkVGxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMECxNFch|ryP M1PZWXNCVkeHUh?=
NBsusSR NYO4[ZR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzlTWM2OD1yLkCwNVEh|ryP NFH3S|dUSU6JRWK=
LNCaP-Clone-FGC M3jZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMECxNUDPxE1? NYGxSpExW0GQR1XS
EPLC-272H NFXCTIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS0TWM2OD1yLkCwNVEyKM7:TR?= NVLXNlZCW0GQR1XS
KNS-62 NYPmUWtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv1VZhRUUN3ME2wMlAxOTF{IN88US=> M1XleXNCVkeHUh?=
RERF-LC-MS MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMECxNVMh|ryP MkfiV2FPT0WU
LOXIMVI NITrXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TjR2lEPTB;MD6wNFEyPiEQvF2= NUDSN4VQW0GQR1XS
KINGS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3FTWM2OD1yLkCwNVE4KM7:TR?= NFjrbmhUSU6JRWK=
T98G MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILnV4tKSzVyPUCuNFAyOTdizszN M4\tOHNCVkeHUh?=
HCC1806 M162fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HOTWlEPTB;MD6wNFEyQCEQvF2= MX;TRW5ITVJ?
MZ1-PC NIjwNlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TheWlEPTB;MD6wNFEyQCEQvF2= M3rw[XNCVkeHUh?=
RT-112 NFHzd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fafGlEPTB;MD6wNFEyQSEQvF2= MVrTRW5ITVJ?
LK-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrVenJTUUN3ME2wMlAxOTJzIN88US=> NIGwW|NUSU6JRWK=
A375 NIPIV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz6dZppUUN3ME2wMlAxOTJzIN88US=> M4\vT3NCVkeHUh?=
SF268 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMECxNlEh|ryP M1TtTHNCVkeHUh?=
H9 NVH5cFVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LS[mlEPTB;MD6wNFEzPCEQvF2= NFW0dYlUSU6JRWK=
KYSE-410 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K3UWlEPTB;MD6wNFEzPCEQvF2= MlrhV2FPT0WU
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22RV1 MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KxOGlEPTB;MD6wNFMyPSEQvF2= NFnJ[XNUSU6JRWK=
MKN28 NHXIW2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\TfIlQUUN3ME2wMlAxOzF5IN88US=> NVzKcYFNW0GQR1XS
ONS-76 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHm[|RiUUN3ME2wMlAxOzJ{IN88US=> MmfJV2FPT0WU
SH-4 MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrZb|BKSzVyPUCuNFA{OjJizszN Mo\kV2FPT0WU
MIA-PaCa-2 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HjN2lEPTB;MD6wNFMzPCEQvF2= NXXnUJVrW0GQR1XS
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NCI-H520 NFOzRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMECzO|Ih|ryP MlzXV2FPT0WU
L-363 NF\x[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMECzO|Yh|ryP NEe3[VRUSU6JRWK=
CAL-12T NUnyS4pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r0fmlEPTB;MD6wNFM4PiEQvF2= NVn4cnA3W0GQR1XS
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NCI-H1395 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjwTWM2OD1yLkCwN|k3KM7:TR?= M4fneHNCVkeHUh?=
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OVCAR-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DuPGlEPTB;MD6wNFQxPyEQvF2= MX3TRW5ITVJ?
KM12 NWDicG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\DWpllUUN3ME2wMlAxPDB6IN88US=> MmXLV2FPT0WU
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EW-24 NVfMR3BoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEC0N|Mh|ryP MYnTRW5ITVJ?
CAL-120 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnXOGlKSzVyPUCuNFA1OzVizszN MnryV2FPT0WU
JAR MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33EVWlEPTB;MD6wNFQ{PyEQvF2= NEfGbIpUSU6JRWK=
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OCUB-M MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEC0N|gh|ryP NH;lZ|NUSU6JRWK=
Calu-6 MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7OfoZnUUN3ME2wMlAxPDR5IN88US=> MmL0V2FPT0WU
MDA-MB-453 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zHcGlEPTB;MD6wNFQ2OSEQvF2= NV7SOI1OW0GQR1XS
MKN45 M3\ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPuN4tKSzVyPUCuNFA1PTNizszN MWPTRW5ITVJ?
ECC10 NY\CXW1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DPc2lEPTB;MD6wNFQ3KM7:TR?= M2XVenNCVkeHUh?=
RVH-421 NIDLZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;1ZWVvUUN3ME2wMlAxPDZzIN88US=> NVXBVpZ6W0GQR1XS
TGBC11TKB NXTqR3JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEC0Olkh|ryP NFrz[WZUSU6JRWK=
MOLT-4 MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFztXIZKSzVyPUCuNFA1PzFizszN NVnsXFBqW0GQR1XS
LN-405 MkPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrpcZhVUUN3ME2wMlAxPDh{IN88US=> MofXV2FPT0WU
S-117 M2P1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEC0PFYh|ryP NIewelhUSU6JRWK=
RPMI-8226 NGC0d5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7zTWM2OD1yLkCwOFk4KM7:TR?= MX7TRW5ITVJ?
KYSE-150 NETkNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;TTGlEPTB;MD6wNFQ6QSEQvF2= MkPtV2FPT0WU
NCI-H1666 NV7TcnpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\mcVlpUUN3ME2wMlAxPTB3IN88US=> NVL5WoJOW0GQR1XS
Mewo M3H5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjKdopKSzVyPUCuNFA2ODVizszN NEPhWYhUSU6JRWK=
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COLO-680N MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jGXGlEPTB;MD6wNFUxQCEQvF2= MYHTRW5ITVJ?
FADU Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:3co5KSzVyPUCuNFA2OSEQvF2= NXHld2xpW0GQR1XS
GB-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLsUpVKSzVyPUCuNFA2OTFizszN NHrPN5dUSU6JRWK=
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NOMO-1 M{fENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEC1NVMh|ryP MlnCV2FPT0WU
BV-173 NGLDZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEC1N{DPxE1? Moj5V2FPT0WU
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LB2241-RCC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlqxTWM2OD1yLkCwOVMyKM7:TR?= M3;ISHNCVkeHUh?=
NCI-H2170 NFzTcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvSfItKSzVyPUCuNFA2OzVizszN M3rURnNCVkeHUh?=
SK-N-AS NHPm[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\BNWlEPTB;MD6wNFU{PSEQvF2= MU\TRW5ITVJ?
NCI-H1651 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXrbpZWUUN3ME2wMlAxPTRizszN NFK0WGhUSU6JRWK=
NCI-SNU-5 NFu1WGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TE[mlEPTB;MD6wNFU1PSEQvF2= MVXTRW5ITVJ?
SN12C M4fkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEC1OUDPxE1? NELIeGhUSU6JRWK=
KY821 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHLWJNKSzVyPUCuNFA2PTFizszN M1LYS3NCVkeHUh?=
SW1573 NU\Nb2djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrZTWM2OD1yLkCwOVU1KM7:TR?= M2e5OHNCVkeHUh?=
OE19 NXXTNmVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXJS4VzUUN3ME2wMlAxPTV7IN88US=> MWTTRW5ITVJ?
MPP-89 M3qwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvVTWM2OD1yLkCwOVY4KM7:TR?= NGjFflhUSU6JRWK=
HuCCT1 NHm5eZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPiTWM2OD1yLkCwOVY5KM7:TR?= NYnYb3h3W0GQR1XS
SW1783 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\MepNSUUN3ME2wMlAxPTdizszN M2r6PXNCVkeHUh?=
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OVCAR-4 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y0ZmlEPTB;MD6wNFU5PiEQvF2= NYmxU|BlW0GQR1XS
MMAC-SF Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEC1PFYh|ryP MXHTRW5ITVJ?
COLO-824 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7mTWM2OD1yLkCwOVkh|ryP NUW3c452W0GQR1XS
HCC38 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjNV5NkUUN3ME2wMlAxPiEQvF2= M{Xld3NCVkeHUh?=
NCI-H1648 M2\TUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TwOGlEPTB;MD6wNFYxOSEQvF2= NIHKcoFUSU6JRWK=
NCI-H1573 MoP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknaTWM2OD1yLkCwOlA4KM7:TR?= M2XzW3NCVkeHUh?=
MFM-223 M1PjRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHN[JhKSzVyPUCuNFA3OTZizszN NFr4T4ZUSU6JRWK=
NCI-H810 NHG2UotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X1XmlEPTB;MD6wNFYzOiEQvF2= Mmi2V2FPT0WU
EM-2 NFTGO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHmRo1yUUN3ME2wMlAxPjJ|IN88US=> MmLaV2FPT0WU
D-283MED MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnaTWM2OD1yLkCwOlI1KM7:TR?= NFftWoFUSU6JRWK=
NCI-H1755 NEWyTm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEC2NlQh|ryP NHK2XXFUSU6JRWK=
KYSE-70 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEC2NlQh|ryP MWfTRW5ITVJ?
SW626 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEC2NlQh|ryP MUXTRW5ITVJ?
WM-115 Ml3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPQVZMxUUN3ME2wMlAxPjJ5IN88US=> MX7TRW5ITVJ?
NB69 NHvE[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;YenlJUUN3ME2wMlAxPjJ7IN88US=> NHfmWHVUSU6JRWK=
DOHH-2 NI\tPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrDbppKSzVyPUCuNFA3OyEQvF2= MWHTRW5ITVJ?
MEL-JUSO NHnufFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG2cYY1UUN3ME2wMlAxPjN7IN88US=> M3;2V3NCVkeHUh?=
IGR-1 M2DYXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\FXmlEPTB;MD6wNFY1OSEQvF2= NVPIWoplW0GQR1XS
ACN M2iyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DMOGlEPTB;MD6wNFY1PCEQvF2= M{fOfnNCVkeHUh?=
KARPAS-45 NVLLXoMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEC2OVIh|ryP M2e5[3NCVkeHUh?=
HC-1 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzPTWM2OD1yLkCwOlU3KM7:TR?= NFXsb3lUSU6JRWK=
MZ2-MEL NUX6fnJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvHTWM2OD1yLkCwOlU5KM7:TR?= NWDsZ2JQW0GQR1XS
NCI-H1355 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPHVI5KSzVyPUCuNFA3PzlizszN MU\TRW5ITVJ?
HuP-T4 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXkOoVmUUN3ME2wMlAxPjd7IN88US=> MoG5V2FPT0WU
AsPC-1 NIDDb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPWc3dKUUN3ME2wMlAxPjh|IN88US=> NF72bGJUSU6JRWK=
SCC-15 NEH0bWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEC2PFkh|ryP Mk\YV2FPT0WU
CP50-MEL-B NUPOO4hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoizTWM2OD1yLkCwOlk{KM7:TR?= MlG1V2FPT0WU
DMS-114 NVrNVG4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLwWFZtUUN3ME2wMlAxPjl4IN88US=> M3i1fHNCVkeHUh?=
KYSE-520 MkS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEC3JO69VQ>? NUXYd|MyW0GQR1XS
NCI-H2228 NWT6OFNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnzTWM2OD1yLkCwO|I2KM7:TR?= NH;QfZdUSU6JRWK=
COLO-829 MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr3TWM2OD1yLkCwO|I2KM7:TR?= NXe5[Jc1W0GQR1XS
NCI-H2052 NHPyTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV2zb|hFUUN3ME2wMlAxPzJ5IN88US=> MljvV2FPT0WU
HOP-92 NFXsZ|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnhTWM2OD1yLkCwO|Mh|ryP MmrKV2FPT0WU
MDA-MB-231 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DwOWlEPTB;MD6wNFc{KM7:TR?= MkWwV2FPT0WU
SK-MEL-30 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDSfWVmUUN3ME2wMlAxPzN{IN88US=> M3S5fnNCVkeHUh?=
NCI-H2087 NWPIbVlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTV2lEPTB;MD6wNFc1QCEQvF2= MoXIV2FPT0WU
SW900 NHPXUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLUdJNKSzVyPUCuNFA4PTVizszN MUHTRW5ITVJ?
NCI-H358 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW5co5KSzVyPUCuNFA4PThizszN MlL1V2FPT0WU
NCI-H2126 Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSyZmRIUUN3ME2wMlAxPzd|IN88US=> MVrTRW5ITVJ?
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SK-OV-3 M4HBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFwMkKwPFkh|ryP MYHTRW5ITVJ?

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい
体内試験 Docetaxel (33 mg/kg/dose, given i.v. every 4 days for 3 injections) results in a tumor growth delay of 19.3 days in M2OL2 colon xenografts. Docetaxel also shows great antitumor activities in MX-1, SK-MEL-2, LX-1 and OVCAR-3 xenografts. Docetaxel inhibits the angiogenic response to fibroblast growth factor 2 with IC 50 of 5.4 mg/kg when injected twice weekly over a 14-day period, and angiogenesis is completely blocked in mice that receives 10 mg/kg Docetaxel. Docetaxel has selectivity for endothelial cell migration and/or microvessel formation because infiltration of inflammatory cells into the Matrigel plug is much less sensitive to inhibition by Docetaxel. [7]

お薦めの試験操作（参考用のみ）

細胞試験： [5]
+ 展開
  • 細胞株： Human gastric cancer cell lines MKN-28
  • 濃度： 6 nM
  • 反応時間： 3 days
  • 実験の流れ： 2000 cells in 180 μL of medium are seeded in a 96-well plate, and 20 μL of drug solution is simultaneously added in triplicate to each well. The plate is incubated for 3 days at 37°C in a humidified atmosphere of 5% CO2. On day 3, 25 μL of MTT reagent is added to each well. After 4 h of incubation, the medium is removed by aspiration. 0.2 mL of dimethylsulphoxide (DMSO) is added to each well and thoroughly mixed by using a mechanical plate mixer to dissolve the resulting MTT-formazan crystals. Absorbance at 540 nm (OD) is measured by a reader.
    (参考用のみ)
動物試験：[6]
+ 展開
  • 動物モデル： Human colon carcinomas xenografts CX-1
  • 製剤： 50 mg/mL stock solution in ethanol by adding an equal volume of polysorbate 80 and diluting with 5% dextrose in water to the final volume
  • 投薬量： 33 mg/kg
  • 投与方法： i.v. every 4 days for 3 injections
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (123.78 mM)
Ethanol 53 mg/mL warmed (65.6 mM)
Water Insoluble
体内 左から（NMPから）右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。 		2mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 807.88
化学式

C43H53NO14
CAS No. 114977-28-5
保管 粉
in solvent
別名 RP56976, NSC 628503

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA（製品ページで利用可能な）。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます：

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます：C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA（オンラインで利用できる）で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください：

総分子量：g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03742986 Not yet recruiting Breast Cancer New York University School of Medicine April 2019 Phase 2
NCT03609047 Not yet recruiting Breast Cancer Stage II|Breast Cancer Stage III European Organisation for Research and Treatment of Cancer - EORTC|Pfizer January 7 2019 Phase 2
NCT03329378 Not yet recruiting Locally Advanced Breast Cancer Icahn School of Medicine at Mount Sinai December 2018 Phase 2
NCT03693612 Not yet recruiting Neoplasms GlaxoSmithKline|MedImmune LLC December 3 2018 Phase 2
NCT03739710 Not yet recruiting Neoplasms GlaxoSmithKline December 7 2018 Phase 2
NCT03700099 Not yet recruiting Prostate Cancer|Castration-resistant Prostate Cancer Instituto do Cancer do Estado de São Paulo|Astellas Pharma Inc December 2018 Phase 2

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

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Microtubule Associatedシグナル伝達経路

相関Microtubule Associated製品

  • TAI-1

    TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.

  • Docetaxel Trihydrate

    Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

  • Combretastatin A4

    Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.

  • Paclitaxel

    Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

  • Vincristine sulfate

    Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

  • Nocodazole

    Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.

  • Vinorelbine Tartrate

    Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

Tags: Docetaxelを買う | Docetaxel ic50 | Docetaxel供給者 | Docetaxelを購入する | Docetaxel費用 | Docetaxel生産者 | オーダーDocetaxel | Docetaxel化学構造 | Docetaxel分子量 | Docetaxel代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID