3,4',5-Trimethoxy-trans-stilbene

製品コードS3888 バッチS388801

化学情報

	Synonyms	MR-3	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₇H₁₈O₃
	分子量	270.32	CAS No.	22255-22-7
Solubility (25°C)*	体外	DMSO	54 mg/mL (199.76 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	3,4',5-Trimethoxy-trans-stilbene is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.
in vitro	Treatment with MR-3 at different concentrations ranging from 0 to 10 μM exhibits no cytotoxic effects on the A549 cells. MR-3 inhibits adhesion, migration, and invasion of A549 cells. The anti-invasive effects of MR-3 on A549 cells are likely mediated through the inhibition of phosphorylation of JNK and p38, as well as a reduction in the protein levels of nuclear factorkappa B (NF-kB) and activator protein-1 (AP-1) in the nucleus, ultimately leading to downregulation of MMP-2 expression^[1].

製品説明

3,4',5-Trimethoxy-trans-stilbene is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.

in vitro

Treatment with MR-3 at different concentrations ranging from 0 to 10 μM exhibits no cytotoxic effects on the A549 cells. MR-3 inhibits adhesion, migration, and invasion of A549 cells. The anti-invasive effects of MR-3 on A549 cells are likely mediated through the inhibition of phosphorylation of JNK and p38, as well as a reduction in the protein levels of nuclear factorkappa B (NF-kB) and activator protein-1 (AP-1) in the nucleus, ultimately leading to downregulation of MMP-2 expression^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	A549 cells
	濃度	1, 5, 10, 25, 50, or 100 μM
	反応時間	24 h
	実験の流れ	The A549 cells are treated with MR-3 at various concentrations (1, 5, 10, 25, 50, or 100 μM) for 24 h. Cell viability is assassed by MTT assay.

参考

[1] Yang YT, et al. Mol Nutr Food Res. 2009, 53(3):407-16.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。