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Synonyms | 3-(1H-1,2,3-triazol-4-yl) pyridine | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C7H6N4 |
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分子量 | 146.15 | CAS No. | 120241-79-4 | ||||
Solubility (25°C)* | 体外 | DMSO | 29 mg/mL (198.42 mM) | ||||
Ethanol | 29 mg/mL (198.42 mM) | ||||||
Water (warmed with 50ºC water bath) | 1.25 mg/mL (8.55 mM) | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively. |
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in vitro | Melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium)[2]. |
細胞アッセイ | 細胞株 | HepG2 cells |
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濃度 | 50 μM | |
反応時間 | 12 h | |
実験の流れ | Cells are randomly divided into the following treatment groups: 10 μM Cd; melatonin (1 μM)+10 μM Cd; 3-TYP (50 μM)+10 μM Cd; and 3-TYP (50 μM)+melatonin (1 μM)+10 μM Cd. cells are treated for 12 h. The role of the SIRT3-SOD2 pathway in hepatic cell protection after melatonin pretreatment is investigated. |
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動物実験 | 動物モデル | Sprague-Dawley rats |
投薬量 | 5 mg/kg | |
投与方法 | i.v. |
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Data from [Data independently produced by , , CNS Neurosci Ther, 2018, doi:10.1111/cns.13053]
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation [ PLoS Pathog, 2024, 20(3):e1012082] | PubMed: 38470932 |
Gravitational and mechanical forces drive mitochondrial translation [ bioRxiv, 2024, 10.1101/2023.01.18.524628] | PubMed: none |
Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes [ Preprint, 2024 , 2024011891] | PubMed: none |
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation [ Autophagy, 2023, 1-15.] | PubMed: 37651673 |
Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure [ EBioMedicine, 2023, 10.1016/j.ebiom.2023.104863] | PubMed: 37950995 |
PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation [ Cell Death Dis, 2023, 14(7):457] | PubMed: 37479690 |
Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis [ Free Radic Biol Med, 2023, 202:62-75] | PubMed: 36997099 |
Honokiol attenuates mitochondrial fission and cell apoptosis by activating Sirt3 in intracerebral hemorrhage [ Chin Med J (Engl), 2023, 136(6):719-731] | PubMed: 36805606 |
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3 [ Exp Mol Med, 2022, 10.1038/s12276-022-00745-9] | PubMed: 35338257 |
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells [ Dev Cell, 2022, 57(2):260-276.e9] | PubMed: 35077680 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。