3-TYP

製品コードS8628 バッチS862802

印刷

化学情報

Synonyms

3-(1H-1,2,3-triazol-4-yl) pyridine

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₇H₆N₄

分子量

146.15

CAS No.

120241-79-4

Solubility (25°C)*

体外

DMSO

125 mg/mL (855.28 mM)

Ethanol

20 mg/mL (136.84 mM)

Water (warmed with 50ºC water bath)

2 mg/mL (13.68 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	6.250mg/ml (42.76mM)	Taking the 1 mL working solution as an example, add 50 μL of 125 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	12.500mg/ml (85.53mM)	Taking the 1 mL working solution as an example, add 50 μL of 250 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
in vitro	Melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium)^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	50 μM
	反応時間	12 h
	実験の流れ	Cells are randomly divided into the following treatment groups: 10 μM Cd; melatonin (1 μM)+10 μM Cd; 3-TYP (50 μM)+10 μM Cd; and this compound+melatonin (1 μM)+10 μM Cd. cells are treated for 12 h. The role of the SIRT3-SOD2 pathway in hepatic cell protection after melatonin pretreatment is investigated.
動物実験	動物モデル	Sprague-Dawley rats
	投薬量	5 mg/kg
	投与方法	i.v.

参考

https://pubmed.ncbi.nlm.nih.gov/22835719/
https://pubmed.ncbi.nlm.nih.gov/26120888/
https://pubmed.ncbi.nlm.nih.gov/27067422/

カスタマーフィードバック

: Data from [Data independently produced by , , CNS Neurosci Ther, 2018, doi:10.1111/cns.13053]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma [ Cell Death Dis, 2025, 16(1):160]	PubMed: 40050614
Apelin/APJ alleviates diabetic nephropathy by improving glomerular endothelial cells dysfunction via SIRT3‑KLF15 [ Mol Med Rep, 2025, 31(5)122]	PubMed: 40052569
Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis [ Cell Rep, 2024, 43(9):114728]	PubMed: 39264808
Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis [ Elife, 2024, 13RP93125]	PubMed: 39693143
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation [ PLoS Pathog, 2024, 20(3):e1012082]	PubMed: 38470932
Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes [ Int J Mol Sci, 2024, 25(6)3450]	PubMed: 38542426
Decrotonylation of cGAS K254 prompts homologous recombination repair by blocking its DNA binding and releasing PARP1 [ J Biol Chem, 2024, 300(8):107554]	PubMed: 39002667
Gravitational and mechanical forces drive mitochondrial translation [ bioRxiv, 2024, 10.1101/2023.01.18.524628]	PubMed: none
Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes [ Preprint, 2024 , 2024011891]	PubMed: none
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation [ Autophagy, 2023, 1-15.]	PubMed: 37651673

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。