3-TYP

製品コードS8628 バッチS862802

印刷

化学情報

Synonyms

3-(1H-1,2,3-triazol-4-yl) pyridine

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₇H₆N₄

分子量

146.15

CAS No.

120241-79-4

Solubility (25°C)*

体外

DMSO

125 mg/mL (855.28 mM)

Ethanol

20 mg/mL (136.84 mM)

Water (warmed with 50ºC water bath)

2 mg/mL (13.68 mM)

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 Corn oil

6.25mg/ml

Taking the 1 mL working solution as an example, add 50 μL of 125 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
in vitro	Melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium)^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HepG2 cells
	濃度	50 μM
	反応時間	12 h
	実験の流れ	Cells are randomly divided into the following treatment groups: 10 μM Cd; melatonin (1 μM)+10 μM Cd; 3-TYP (50 μM)+10 μM Cd; and 3-TYP (50 μM)+melatonin (1 μM)+10 μM Cd. cells are treated for 12 h. The role of the SIRT3-SOD2 pathway in hepatic cell protection after melatonin pretreatment is investigated.
動物実験	動物モデル	Sprague-Dawley rats
	投薬量	5 mg/kg
	投与方法	i.v.

参考

カスタマーフィードバック

: Data from [Data independently produced by , , CNS Neurosci Ther, 2018, doi:10.1111/cns.13053]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation [ PLoS Pathog, 2024, 20(3):e1012082]	PubMed: 38470932
Gravitational and mechanical forces drive mitochondrial translation [ bioRxiv, 2024, 10.1101/2023.01.18.524628]	PubMed: none
Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes [ Preprint, 2024 , 2024011891]	PubMed: none
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation [ Autophagy, 2023, 1-15.]	PubMed: 37651673
Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure [ EBioMedicine, 2023, 10.1016/j.ebiom.2023.104863]	PubMed: 37950995
PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation [ Cell Death Dis, 2023, 14(7):457]	PubMed: 37479690
Honokiol prevents chronic cerebral hypoperfusion induced astrocyte A1 polarization to alleviate neurotoxicity by targeting SIRT3-STAT3 axis [ Free Radic Biol Med, 2023, 202:62-75]	PubMed: 36997099
Honokiol attenuates mitochondrial fission and cell apoptosis by activating Sirt3 in intracerebral hemorrhage [ Chin Med J (Engl), 2023, 136(6):719-731]	PubMed: 36805606
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3 [ Exp Mol Med, 2022, 10.1038/s12276-022-00745-9]	PubMed: 35338257
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells [ Dev Cell, 2022, 57(2):260-276.e9]	PubMed: 35077680

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。