4-Hydroxybenzyl alcohol

製品コードS3857 バッチS385701

印刷

化学情報

Chemical Structure Synonyms P-Methylolphenol, 4-Methylolphenol Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C7H8O2
分子量 124.14 CAS No. 623-05-2
Solubility (25°C)* 体外 DMSO 24 mg/mL (193.33 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.
in vitro 4-hydroxybenzyl alcohol has been shown to suppress inflammation, which is most probably due to its capability of reducing cyclooxygenase activity. HBA acts as a typical pleiotropic agent, which targets multiple mechanisms of angiogenesis, including production of angiogenic growth factors and MMPs, endothelial cell proliferation and migration as well as vascular sprouting and network formation[1].
in vivo 4-hydroxybenzyl alcohol inhibits the vascularization of newly developing tumors and that this is associated with a reduced growth rate of the malignant tissue. It ameliorates cerebral ischaemic injury due to the inhibition of apoptotic pathways and the up-regulation of protein disulphide isomerase without inducing any toxic effects at doses up to 200 mg/kg. It exerts an anxiolytic-like action via the activation of the 5-hydroxytryptaminergic nervous system[1].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 CT26.WT cell line
濃度 1-100 mM
反応時間 24 h
実験の流れ Cells are cultured in presence of 1-100 mM HBA. Cells exposed to vehicle (DMSO) serve as control. After 24h, 10μL of WST-1 reagent per 100μL medium are added into each well. After 30min at 37°C, absorption is measured at 450 nm with 620 nm as reference using a microplate reader and corrected to blank values (wells without cells).
動物実験 動物モデル BALB/c mice
投薬量 200 mg/kg
投与方法 i.p.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。