EIPA (L593754)

製品コードS9849 バッチS984901

化学情報

	Synonyms	L593754; MH 12-43	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₁H₁₈ClN₇O
	分子量	299.76	CAS No.	1154-25-2
Solubility (25°C)*	体外	DMSO	60 mg/mL (200.16 mM)
		Ethanol	30 mg/mL (100.08 mM)
		Water	2 mg/mL (6.67 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	EIPA (L593754; MH 12-43) acts as an inhibitor of macropinocytosis and sodium-hydrogen exchangers(NHE) (IC50=0.033μg/mL). EIPA blocks the activity of Na(+)/H(+) exchanger, which are plasma membrane proteins implicated in all forms of macropinocytosis.
in vitro	This compound rapidly and reversibly block Ca²⁺-activated TRPP3 channel activation, with IC₅₀s of 10.5 μM.
in vivo	EIPA downregulates endothelial cell activation of NF-kappaB and VCAM-1 expression and attenuates the early inflammatory stages of atherogenesis and stent intimal formation.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Xenopus laevis oocyte
	濃度	100 μM
	反応時間	30 min
	実験の流れ	The uptake of radioactive ₄₅Ca₂₊ mediated by TRPP3 channel is tested using the standard NaCl-containing solution, plus 1 mM nonradiolabeled CaCl2 and radiolabeled ₄₅Ca₂₊ in the presence and absence of 100 μM EIPA. Control uptake level is obtained using H2O-injected oocytes.
動物実験	動物モデル	Murine Model of Atherogenesis (apoE-/- mice)
	投薬量	3 mg/kg
	投与方法	s.c.

参考

https://pubmed.ncbi.nlm.nih.gov/24184990/
https://pubmed.ncbi.nlm.nih.gov/17804601/
https://pubmed.ncbi.nlm.nih.gov/15505102/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip [ J Adv Res, 2025, S2090-1232(25)00267-X]	PubMed: 40262719
An anti-CD19-exosome delivery system navigates the blood-brain barrier for targeting of central nervous system lymphoma [ J Nanobiotechnology, 2025, 23(1):173]	PubMed: 40045315
Amniotic epithelial Cell microvesicles uptake inhibits PBMCs and Jurkat cells activation by inducing mitochondria-dependent apoptosis [ iScience, 2025, 28(2):111830]	PubMed: 39967871
Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A [ Sci Rep, 2025, 15(1):2585]	PubMed: 39833342
WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors [ Gastroenterology, 2024, S0016-5085(24)05182-5]	PubMed: 38971196
Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11 [ Microbiol Spectr, 2023, 10.1128/spectrum.02553-23]	PubMed: 37962380
In Vivo Functional Assay in Fish Gills: Exploring Branchial Acid-Excreting Mechanisms in Zebrafish [ Int J Mol Sci, 2022, 23(8)4419]	PubMed: 35457237
Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis [ Viruses, 2022, 14(3)496]	PubMed: 35336903

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。