8-Bromo-cAMP Sodium Salt

製品コードS7857 バッチS785707

印刷

化学情報

Synonyms

8-Br-Camp sodium salt

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₀H₁₀BrN₅NaO₆P

分子量

430.08

CAS No.

76939-46-3

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

125 mg/mL (290.64 mM)

Water (warmed with 50ºC water bath)

100 mg/mL (232.51 mM)

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	4.300mg/ml (10.00mM)	Taking the 1 mL working solution as an example, add 50 μL 86 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	8-Bromo-cAMP sodium salt is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.
in vitro	8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. ^[1] In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. ^[2]

製品説明

8-Bromo-cAMP sodium salt is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.

in vitro

8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. ^[1]

In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. ^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BEAS-2B cells
	濃度	100 μM
	反応時間	1 h
	実験の流れ	Cells were treated with various concentrations of 8-Br-cAMP.
動物実験	動物モデル	Sprague-Dawley rats
	投薬量	5 mg/kg
	投与方法	i.c.v.

参考

https://pubmed.ncbi.nlm.nih.gov/21120637/
https://pubmed.ncbi.nlm.nih.gov/25150062/
https://pubmed.ncbi.nlm.nih.gov/35463083/

カスタマーフィードバック

: , , Development, 2016, 143(12):2103-10.

: Data from [Data independently produced by , , J Cell Mol Med, 2018, 22(11):5518-5532]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation [ Nat Cell Biol, 2025, NONE]	PubMed: 41094030
VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway [ Stem Cell Res Ther, 2025, 16(1):336]	PubMed: 40597262
Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs [ Elife, 2024, 13RP97507]	PubMed: 39642055
MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury [ Stem Cell Res Ther, 2024, 15(1):438]	PubMed: 39563422
AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission [ Biomed Pharmacother, 2024, 176:116858]	PubMed: 38850669
Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage [ J Transl Med, 2024, 22(1):478]	PubMed: 38769534
β3-Adrenoceptor as a new player in the sympathetic regulation of the renal acid-base homeostasis [ Front Physiol, 2024, 15:1304375]	PubMed: 38455846
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm [ Protein Cell, 2023, 14(4):262-278]	PubMed: 37084236
METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility [ Reprod Biol Endocrinol, 2023, 21(1):99]	PubMed: 37891533
METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility [ Reprod Biol Endocrinol, 2023, 21(1):99]	PubMed: 37891533

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。