8-Bromo-cAMP

製品コードS7857 バッチS785703

印刷

化学情報

Chemical Structure Synonyms 8-Br-Camp,8-Bromo-cAMP Sodium Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C10H10BrN5NaO6P
分子量 430.08 CAS No. 76939-46-3
Solubility (25°C)* 体外 Water 86 mg/mL warmed with 50ºC water bath (199.96 mM)
DMSO 5 mg/mL warmed with 50ºC water bath (11.62 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.
in vitro

8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. [1]

In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. [2]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 BEAS-2B cells
濃度 100 μM
反応時間 1 h
実験の流れ

Cells were treated with various concentrations of 8-Br-cAMP.
動物実験 動物モデル Sprague-Dawley rats
投薬量 5 mg/kg
投与方法 i.c.v.

カスタマーフィードバック

, , Development, 2016, 143(12):2103-10.

Data from [Data independently produced by , , J Cell Mol Med, 2018, 22(11):5518-5532]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

β3-Adrenoceptor as a new player in the sympathetic regulation of the renal acid-base homeostasis [ Front Physiol, 2024, 15:1304375] PubMed: 38455846
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm [ Protein Cell, 2023, 14(4):262-278] PubMed: 37084236
METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility [ Reprod Biol Endocrinol, 2023, 21(1):99] PubMed: 37891533
METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility [ Reprod Biol Endocrinol, 2023, 21(1):99] PubMed: 37891533
High extracellular glucose promotes cell motility by modulating cell deformability and contractility via the cAMP-RhoA-ROCK axis in human breast cancer cells [ Mol Biol Cell, 2023, 34(8):ar79] PubMed: 37195739
Derivation of totipotent-like stem cells with blastocyst-like structure forming potential [ Cell Res, 2022, 10.1038/s41422-022-00668-0] PubMed: 35508506
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma [ Signal Transduct Target Ther, 2022, 7(1):46] PubMed: 35169126
Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids [ Biology (Basel), 2022, 11(4)493] PubMed: 35453693
Inhibition of PDE10A-Rescued TBI-Induced Neuroinflammation and Apoptosis through the cAMP/PKA/NLRP3 Pathway [ Evid Based Complement Alternat Med, 2022, 2022:3311250] PubMed: 35463083
Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis [ Cell Rep, 2021, 37(12):110137] PubMed: 34936872

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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