Barasertib (AZD1152-HQPA)

製品コードS1147 バッチS114707

化学情報

	Synonyms	AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₆H₃₀FN₇O₃
	分子量	507.56	CAS No.	722544-51-6
Solubility (25°C)*	体外	DMSO	100 mg/mL (197.02 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.
in vitro	Barasertib (AZD1152-HQPA), a highly selective Aurora B inhibitor, causes polyploidy and apoptosis in many cancer cell lines.^[1]
in vivo	Barasertib (AZD1152-HQPA) is an aurora B kinase inhibitor, and has efficacy against RB1 / SCLC cell line xenografts, RB1 / SCLC PDXs, and autochthonous Rb1 / neuroendocrine tumors.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	NCI-H82 cells, SCLC and NSCLC cell lines
	濃度	--
	反応時間	--
	実験の流れ	--
動物実験	動物モデル	mouse models of RB1−/− neuroendocrine cancers
	投薬量	i.v.
	投与方法

参考

カスタマーフィードバック

: Data from [Data independently produced by Nature, 2014, 508(7494), 118-22]

: Data from [Data independently produced by J Exp Med, 2014, 10.1084/jem.20141123]

: Data from [Oncogene, 2014, 33, 3550-60]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3]	PubMed: 38262581
Detection of senescence using machine learning algorithms based on nuclear features [ Nat Commun, 2024, 15(1):1041]	PubMed: 38310113
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells [ Br J Cancer, 2024, 10.1038/s41416-024-02584-z]	PubMed: 38287178
Chromosomal passenger complex condensates generate parallel microtubule bundles in vitro [ J Biol Chem, 2024, S0021-9258(24)00045-0]	PubMed: 38272221
Inhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions [ Sci Rep, 2024, 14(1):4303]	PubMed: 38383756
Molecular landscape and functional characterization of centrosome amplification in ovarian cancer [ Nat Commun, 2023, 14(1):6505]	PubMed: 37845213
Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis [ Nat Commun, 2023, 14(1):1680]	PubMed: 36973261
Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation [ Haematologica, 2023, 108(9):2487-2502]	PubMed: 37021526
Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation [ Haematologica, 2023, 108(9):2487-2502]	PubMed: 37021526
Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment [ Cell Rep, 2023, 42(9):113098]	PubMed: 37714156

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。