Acyclovir (Aciclovir)

製品コードS1807 バッチS180702

印刷

化学情報

Chemical Structure Synonyms Acycloguanosine, ACV, NSC 645011,BW 248U Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C8H11N5O3
分子量 225.2 CAS No. 59277-89-3
Solubility (25°C)* 体外 DMSO 45 mg/mL (199.82 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
in vitro

Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].
in vivo

low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , Oncol Rep, 2017, 37(4):2109-2120]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Topical phenylbutyrate antagonizes NF-κB signaling and resolves corneal inflammation [ iScience, 2022, 25(12):105682] PubMed: 36536680
Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers [ Pharmaceutics, 2022, 14(3)536] PubMed: 35335912
Safety, efficacy and delivery of multiple nucleoside analogs via drug encapsulated carbon (DECON) based sustained drug release platform [ Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9] PubMed: 35314347
Harringtonine Inhibits Herpes Simplex Virus Type 1 Infection by Reducing Herpes Virus Entry Mediator Expression [ Front Microbiol, 2021, 12:722748] PubMed: 34531841
6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes [ Microbiol Spectr, 2021, 9(3):e0064621] PubMed: 34730435
A natural product, (S)-10-Hydroxycamptothecin inhibits pseudorabies virus proliferation through DNA damage dependent antiviral innate immunity [ Vet Microbiol, 2021, 265:109313] PubMed: 34968801
Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs [ ACS Infect Dis, 2020, 6(11):2926-2937] PubMed: 33078609
In Vitro and In Vivo Activity, Tolerability and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus-2 Genital Infection [ Antimicrob Agents Chemother, 2020, AAC.00245-20] PubMed: 32601167
Anti-HSV-1 effect of dihydromyricetin from Ampelopsis grossedentata via the TLR9-dependent anti-inflammatory pathway [ J Glob Antimicrob Resist, 2020, S2213-7165(20)30264-2] PubMed: 33161114
Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing [ Sci Adv, 2020, 6(49)eabd9443] PubMed: 33277262

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。