Alendronate sodium trihydrate

製品コードS1624 バッチS162402

化学情報

	Synonyms	G-704650, MK-217	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄H₁₃NO₇P₂.3H₂O.Na
	分子量	326.13	CAS No.	121268-17-5
Solubility (25°C)*	体外	Water	20 mg/mL warmed with 50ºC water bath (61.32 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	窒素含有ビスフォスフォネートであるAlendronate sodium trihydrate（G-704650、MK-217）は、骨粗しょう症の治療と予防に使用される強力な骨吸収抑制剤です。
in vitro	Alendronate, acting directly on osteoclasts, inhibits a rate-limiting step in the cholesterol biosynthesis pathway, essential for osteoclast function. Alendronate inhibits the isoprenoid biosynthesis pathway and interferes with protein prenylation, as a result of reduced geranylgeranyl diphosphate levels. Alendronate inhibits the incorporation of [(3)H]mevalonolactone into proteins of 18-25 kDa and into nonsaponifiable lipids, including sterols in osteoclasts. Alendronate causes a dose-dependent inhibition of [(3)H]MVA incorporation into sterols and a concomitant increase in incorporation of radiolabel into IPP and DMAPP.
in vivo	Alendronate causes erosions in the rabbit stomach, but not antral ulceration in rats. Alendronate increases the incidence and size of indomethacin-induced antral ulcers. Alendronate also enhances indomethacin-induced gastricdamage in the rat, and delayed gastric ulcer healing. Alendronate (0.04-0.1 mg/kg twice weekly or 0.1 mg/kg weekly) partially blocks the establishment of bone metastases by human PC-3 ML cells and results in tumor formation in the peritoneum and other soft tissues. Alendronate pretreatment of mice (0.1 mg/kg twice weekly or weekly) and dosing along with taxol (10-50 mg/kg/day, twice weekly, or weekly) blocks the growth of PC-3 ML tumors in the bone marrow and soft tissues in a statistically significant manner and improves survival rates significantly by 4-5 weeks.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/9874784/
https://pubmed.ncbi.nlm.nih.gov/10620343/
https://pubmed.ncbi.nlm.nih.gov/10600541/

https://pubmed.ncbi.nlm.nih.gov/9444970/
https://pubmed.ncbi.nlm.nih.gov/9186547/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information. [ Nat Commun, 2017, 8(1):573]	PubMed: 28924171

A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information. [ Nat Commun, 2017, 8(1):573]

PubMed: 28924171

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。