Amphotericin B

製品コードS1636 バッチS163605

化学情報

	Synonyms	NSC 527017	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄₇H₇₃NO₁₇
	分子量	924.08	CAS No.	1397-89-3
Solubility (25°C)*	体外	DMSO	4.5 mg/mL (4.86 mM)
		Water	4.5 mg/mL (4.86 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
in vitro	Amphotericin B administration is limited by infusion-related toxicity, including fever and chills, an effect postulated to result from proinflammatory cytokine production by innate immune cells. Amphotericin B induces signal transduction and inflammatory cytokine release from cells expressing TLR2 and CD14. ^[1] Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. ^[2] Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K+ leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na+ entry into the cells. ^[3]
in vivo	Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE). ^[4] Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice. ^[5]

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参考

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Interactions between antifungals and everolimus against Cryptococcus neoformans [ Front Cell Infect Microbiol, 2023, 13:1131641]	PubMed: 37026056
Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo [ Front Cell Infect Microbiol, 2022, 12:1074903]	PubMed: 36569209
Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs [ Biomed Chromatogr, 2022, e5519.]	PubMed: 36208186
Targeted gene correction and functional recovery in achondroplasia patient-derived iPSCs [ Stem Cell Res Ther, 2021, 12(1):485]	PubMed: 34454631
Synthetic Derivatives of Ciclopirox are Effective Inhibitors of Cryptococcus neoformans [ ACS Omega, 2021, 6(12):8477-8487]	PubMed: 33817509
Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi [ Nat Microbiol, 2020, 10.1038/s41564-020-00790-y]	PubMed: 32958858
Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus. [ J Antimicrob Chemother, 2019, 74(10):2950-2958]	PubMed: 31361006
In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris. [ J Antimicrob Chemother, 2019, 74(10):2943-2949]	PubMed: 31325309
Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection. [ Sci Rep, 2019, 9(1):9482]	PubMed: 31263150
In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection. [ Antimicrob Agents Chemother, 2018, 62(5)]	PubMed: 29439966

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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