受注:045-509-1970 |
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Synonyms | ZD-1033 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C17H19N5 |
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分子量 | 293.37 | CAS No. | 120511-73-1 | |
Solubility (25°C)* | 体外 | DMSO | 59 mg/mL (201.11 mM) | |
Ethanol | 59 mg/mL (201.11 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids. |
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in vitro | Anastrozole has high intrinsic potency in vitro and inhibits human placental aromatase with an IC50 of 15 nM. Anastrozole it is 200 times as potent as AG, twice as potent as 4-OHA and one third as potent as fadrozole. [1]. Anastrozole inhibits aromatase by binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid hormones. [2] |
in vivo | Anastrozole (0.1 mg/kg) given orally to mature rats on Day 2 or 3 of the estrous cycle, blocked ovulation in mature females; in pubertal rats, the same dose given for 3 days completely blocks androstenedione-stimulated uterine development. These effects may be attributes to inhibition of the normal preovulatory rise in ovarian follicular estrogen synthesis in mature females and to inhibition of metabolism of the exogenous androstenedione by the immature ovary in prepubertal females. Twice-daily administration of >9.1 mg/kg of Anastrozole given orally to male pigtailed monkeys inhibits peripheral aromatase, thereby reducing circulating estradiol concentrations by 50% to 60%. [2] |
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Data from [Data independently produced by , , Oncotarget, 2016, 7(34):54157-54173]
Data from [Data independently produced by , , Int J Oncol, 2015, 46(4):1481-90. ]
CDK4/6 inhibitors induce breast cancer senescence with enhanced anti-tumor immunogenic properties compared with DNA-damaging agents [ Mol Oncol, 2023, 10.1002/1878-0261.13541] | PubMed: 37854019 |
SERPINA3-ANKRD11-HDAC3 pathway induced aromatase inhibitor resistance in breast cancer can be reversed by HDAC3 inhibition [ Commun Biol, 2023, 6(1):695] | PubMed: 37414914 |
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis [ Cell Discov, 2022, 8(1):40] | PubMed: 35504898 |
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis [ Nat Commun, 2022, 13(1):4995] | PubMed: 36008411 |
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SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy [ J Med Virol, 2022, 94(11):5174-5188] | PubMed: 35765167 |
Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling [ Int J Biol Sci, 2022, 18(4):1539-1554] | PubMed: 35280671 |
STING controls energy stress-induced autophagy and energy metabolism via STX17 [ J Cell Biol, 2022, 221(7)e202202060] | PubMed: 35510944 |
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation [ iScience, 2022, 25(7):104544] | PubMed: 35747386 |
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] | PubMed: 35207746 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。