Artemisinin

製品コードS1282 バッチS128201

化学情報

	Synonyms	Qinghaosu, NSC 369397	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₅H₂₂O₅
	分子量	282.33	CAS No.	63968-64-9
Solubility (25°C)*	体外	DMSO	57 mg/mL (201.89 mM)
		Ethanol	24 mg/mL (85.0 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.
in vitro	Artemisinin's antimalarial activity has been shown to be mediated by activated oxygen (i.e., superoxide, hydrogen peroxide, and/or hydroxyl radicals). Artemisinin and heroin appear to be forming an adduct whose behavior resembles the behavior of the parasite Artemisinin product. ^[1] Artemisinin activity can be potentiated by oxygen and oxidizing agents and attenuated by reducing agents. Artemisinin susceptibility can be influenced by genetic changes in the loci encoding P. falciparum multidrug resistance protein 1 (PfMDR1) and P. falciparum chloroquine resistance transporter (PfCRT). ^[2] Artemisinins are effective not only against multi-resistant strains of P. falciparum, but have broad stage specificity against the Plasmodium life cycle including activity throughout the asexual blood stages and also the sexual gametocyte stages which may reduce the spread of the disease in areas of low transmission. Artemisinins have also been investigated for their antiproliferative effects against a wide range of cancer cell lines. Artemisinin is active against other parasite species such as Toxoplasma and Babesia that do not contain hematin. Artemisinin results in decreased proliferation, increased levels of oxidative stress, induction of apoptosis and inhibition of angiogenesis in cancer cells. Artemisinins have also been shown to inhibit the falcipains, a papain family cysteine protease that aid hemoglobin degradation. ^[3]

製品説明

Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.

in vitro

Artemisinin's antimalarial activity has been shown to be mediated by activated oxygen (i.e., superoxide, hydrogen peroxide, and/or hydroxyl radicals). Artemisinin and heroin appear to be forming an adduct whose behavior resembles the behavior of the parasite Artemisinin product. ^[1] Artemisinin activity can be potentiated by oxygen and oxidizing agents and attenuated by reducing agents. Artemisinin susceptibility can be influenced by genetic changes in the loci encoding P. falciparum multidrug resistance protein 1 (PfMDR1) and P. falciparum chloroquine resistance transporter (PfCRT). ^[2] Artemisinins are effective not only against multi-resistant strains of P. falciparum, but have broad stage specificity against the Plasmodium life cycle including activity throughout the asexual blood stages and also the sexual gametocyte stages which may reduce the spread of the disease in areas of low transmission. Artemisinins have also been investigated for their antiproliferative effects against a wide range of cancer cell lines. Artemisinin is active against other parasite species such as Toxoplasma and Babesia that do not contain hematin. Artemisinin results in decreased proliferation, increased levels of oxidative stress, induction of apoptosis and inhibition of angiogenesis in cancer cells. Artemisinins have also been shown to inhibit the falcipains, a papain family cysteine protease that aid hemoglobin degradation. ^[3]

プロトコル(参考用のみ)

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation [ Drug Des Devel Ther, 2023, 17:1679-1697]	PubMed: 37309415
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9]	PubMed: 35868306
Artemisinin Attenuates Transplant Rejection by Inhibiting Multiple Lymphocytes and Prolongs Cardiac Allograft Survival [ Front Immunol, 2021, 12:634368]	PubMed: 33717174
Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells [ Int Immunopharmacol, 2021, 95:107541]	PubMed: 33756232
Artemisinin inhibits the replication of flaviviruses by promoting the type I interferon production. [ Antiviral Res, 2020, 29:104810]	PubMed: 32360948
Anti-SARS-CoV-2 Potential of Artemisinins In Vitro [ ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522]	PubMed: 32786284
Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea. [ Biomed Pharmacother, 2019, 117:109181]	PubMed: 31387196

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。