Baicalein

製品コードS2268 バッチS226802

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₀O₅

分子量

270.24

CAS No.

491-67-8

Solubility (25°C)*

体外

DMSO

54 mg/mL (199.82 mM)

Ethanol

5 mg/mL (18.5 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
in vitro	Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).^[2]
in vivo	Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.^[3]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Neonatal rat ventricular myocytes (NRVMs)
	濃度	10 μM
	反応時間	48 h
	実験の流れ	Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6).
動物実験	動物モデル	Nlrp3^-/- (021302) mice, Gsdmd^-/- (032410) mice, C57BL/6J WT mice
	投薬量	30 mg/kg
	投与方法	--

参考

https://pubmed.ncbi.nlm.nih.gov/19074529/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956446/
https://pubmed.ncbi.nlm.nih.gov/33272570/

カスタマーフィードバック

: , , Mol Cell Biochem, 2015, 406:111–119.

: , , Biochem Biophys Res Commun, 2016, 473(4):775-80.

: Data from [Data independently produced by , , Chem Biol Interact, 2018, 285:48-58]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays [ SLAS Discov, 2024, S2472-5552(24)00007-8]	PubMed: 38301954
Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis [ Redox Rep, 2023, 28(1):2152607]	PubMed: 36692085
Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline [ Microbiol Spectr, 2023, 11(3):e0470222]	PubMed: 37070985
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke [ J Transl Int Med, 2023, 11(2):178-188]	PubMed: 37408574
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9]	PubMed: 35868306
Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation [ Pharmacol Res, 2022, 185:106489]	PubMed: 36228869
Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies [ Int J Biol Macromol, 2022, S0141-8130(22)02224-3]	PubMed: 36252624
奥曲肽联合黄芩素抑制胰腺神经内分泌肿瘤细胞增殖和迁移. [ Progress in Modern Biomedicine, 2022, Vol.22]	PubMed: none
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360]	PubMed: 34918496
pH-dependent rearrangement determines the iron-activation and antitumor activity of artemisinins [ Free Radic Biol Med, 2021, 163:234-242]	PubMed: 33359684

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。