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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C15H10O5 |
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分子量 | 270.24 | CAS No. | 491-67-8 | |
Solubility (25°C)* | 体外 | DMSO | 54 mg/mL (199.82 mM) | |
Ethanol | 1 mg/mL (3.7 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. |
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in vitro | Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).[2] |
in vivo | Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.[3] |
細胞アッセイ | 細胞株 | Neonatal rat ventricular myocytes (NRVMs) |
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濃度 | 10 μM | |
反応時間 | 48 h | |
実験の流れ | Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6). |
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動物実験 | 動物モデル | Nlrp3-/- (021302) mice, Gsdmd-/- (032410) mice, C57BL/6J WT mice |
投薬量 | 30 mg/kg | |
投与方法 | -- |
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, , Mol Cell Biochem, 2015, 406:111–119.
, , Biochem Biophys Res Commun, 2016, 473(4):775-80.
Data from [Data independently produced by , , Chem Biol Interact, 2018, 285:48-58]
Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays [ SLAS Discov, 2024, S2472-5552(24)00007-8] | PubMed: 38301954 |
Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis [ Redox Rep, 2023, 28(1):2152607] | PubMed: 36692085 |
Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline [ Microbiol Spectr, 2023, 11(3):e0470222] | PubMed: 37070985 |
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke [ J Transl Int Med, 2023, 11(2):178-188] | PubMed: 37408574 |
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9] | PubMed: 35868306 |
Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation [ Pharmacol Res, 2022, 185:106489] | PubMed: 36228869 |
Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies [ Int J Biol Macromol, 2022, S0141-8130(22)02224-3] | PubMed: 36252624 |
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360] | PubMed: 34918496 |
pH-dependent rearrangement determines the iron-activation and antitumor activity of artemisinins [ Free Radic Biol Med, 2021, 163:234-242] | PubMed: 33359684 |
Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy [ Molecules, 2021, 26(5)1210] | PubMed: 33668293 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。