Budesonide

製品コードS1286 バッチS128602

印刷

化学情報

Chemical Structure Synonyms Labazenit Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C25H34O6
分子量 430.53 CAS No. 51333-22-3
Solubility (25°C)* 体外 DMSO 86 mg/mL (199.75 mM)
Ethanol 45 mg/mL (104.52 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
in vitro

Budesonide effectively inhibits production of eotaxin and RANTES protein although this compound inhibits the expression of chemokine mRNA to a variable extent in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. It inhibits both RANTES- and eotaxin promoter-driven reporter gene activity in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. This chemical also selectively accelerates the decay of eotaxin and MCP-4 mRNA in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. [1] It time- and protein synthesis-dependently reduces VEGF secretion and VEGF mRNA expression in both cell types and these effects are inhibited by mifepristone (RU 486), a glucocorticoid receptor antagonist, suggesting that this compound reduces VEGF secretion and expression through its glucocorticoid receptor-mediated action. [2] It causes a dose-dependent, almost total, inhibition of swine dust-induced IL-6 and IL-8 release from epithelial cells and LPS-induced IL-6 and TNF-alpha from alveolar macrophages. [3]
in vivo

Budesonide totally prevents the increased production of TNF-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemoattractive protein (MCP)-1 after LPS challenge at both low (2.5 mg/mL/kg) and high (50 mg/mL/kg) concentrations in rats. [4] This compound exerts its effects of chemoprevention through growth arrest via Mad2/3 and through apoptosis via Bim/Blk and, by inference, caspase-8/9 in A/J mice. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10553092/
  • https://pubmed.ncbi.nlm.nih.gov/11502275/
  • https://pubmed.ncbi.nlm.nih.gov/10442524/
  • https://pubmed.ncbi.nlm.nih.gov/15967733/
  • https://pubmed.ncbi.nlm.nih.gov/15361829/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism [ Arch Toxicol, 2025, 99(3):1105-1116] PubMed: 39714734
Identification and Validation of Small Molecules with Mucin-Selective Regiospecific Binding in the Gastrointestinal Tract [ bioRxiv, 2025, 2025.03.31.646052] PubMed: 40235971
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination [ Front Mol Neurosci, 2024, 17:1473960] PubMed: 39473481
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids [ Front Immunol, 2023, 14:1097383] PubMed: 36911731
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids [ Front Immunol, 2023, 14:1097383] PubMed: 36911731
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium [ Front Immunol, 2022, 13:882277] PubMed: 35655783
Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo [ Int J Mol Sci, 2021, 22(14)7540] PubMed: 34299155
Antiviral Effect of Budesonide against SARS-CoV-2 [ Viruses, 2021, 13(7)1411] PubMed: 34372616
Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors. [ Sci Rep, 2020, 24;10(1):5363] PubMed: 32210313
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction [ Drug Test Anal, 2020, 10.1002/dta.2917] PubMed: 32852861

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。