Ciclopirox

製品コードS2528 バッチS252801

印刷

化学情報

Synonyms

HOE 296b, Penlac

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₂H₁₇NO₂

分子量

207.27

CAS No.

29342-05-0

Solubility (25°C)*

体外

DMSO

41 mg/mL (197.8 mM)

Ethanol

41 mg/mL (197.8 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	3.000mg/ml (14.47mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ciclopirox（HOE 296b、Penlac）は、鉄キレーターとして機能する広範囲なFungal剤です。
in vitro	Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. This compound-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF). It inhibits growth of C. albicans yeast and hyphal cells in a dose-dependent manner. This chemical blocks H2O2-induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Deltapsim). It completely blocks H2O2-stimulated release of lactate dehydrogenase (a marker of cell death) and decreases in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK-HEP-1 cells. This compound effectively inhibits H2O2-induced mitochondrial permeability transition pore (MPTP) opening. It increases the MTP, maintained it high, and blocks the ATP depletion in glucose-deprived SIN-1-treated astrocytes. This chemical protects astrocytes from peroxynitritecytotoxicity by attenuating peroxynitrite-induced mitochondrial dysfunction. It is a substituted pyridone antimycotic drug, unrelated to the imidazole derivatives and its topical application ensures maximum local bioavailability. This compound acts on fungi by inhibiting the intracellular uptake of essential substrates and ions and this probably acts on the Candida ability to express its adherence mechanisms.

製品説明

Ciclopirox（HOE 296b、Penlac）は、鉄キレーターとして機能する広範囲なFungal剤です。

in vitro

Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. This compound-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF). It inhibits growth of C. albicans yeast and hyphal cells in a dose-dependent manner. This chemical blocks H2O2-induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Deltapsim). It completely blocks H2O2-stimulated release of lactate dehydrogenase (a marker of cell death) and decreases in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK-HEP-1 cells. This compound effectively inhibits H2O2-induced mitochondrial permeability transition pore (MPTP) opening. It increases the MTP, maintained it high, and blocks the ATP depletion in glucose-deprived SIN-1-treated astrocytes. This chemical protects astrocytes from peroxynitritecytotoxicity by attenuating peroxynitrite-induced mitochondrial dysfunction. It is a substituted pyridone antimycotic drug, unrelated to the imidazole derivatives and its topical application ensures maximum local bioavailability. This compound acts on fungi by inhibiting the intracellular uptake of essential substrates and ions and this probably acts on the Candida ability to express its adherence mechanisms.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/12594177/
https://pubmed.ncbi.nlm.nih.gov/15790671/
https://pubmed.ncbi.nlm.nih.gov/15806112/

https://pubmed.ncbi.nlm.nih.gov/12243770/
https://pubmed.ncbi.nlm.nih.gov/1492854/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy [ Cell Death Dis, 2021, 12(12):1141]	PubMed: 34887387
Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages [ J Transl Med, 2021, 19(1):347]	PubMed: 34389031
Protective Effect of Ciclopirox against Ovariectomy-Induced Bone Loss in Mice by Suppressing Osteoclast Formation and Function [ Int J Mol Sci, 2021, 22(15)8299]	PubMed: 34361069
MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin [ Free Radic Res, 2021, 1-18]	PubMed: 34181495
High-throughput functional annotation of natural products by integrated activity profiling [ bioRxiv, 2019, 10.1101/748129]	PubMed: N/A

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。