Clindamycin HCl

製品コードS2457 バッチS245701

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₈H₃₃ClN₂O₅S.HCl
	分子量	461.44	CAS No.	21462-39-5
Solubility (25°C)*	体外	DMSO	92 mg/mL (199.37 mM)
		Water	92 mg/mL (199.37 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
in vitro	Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. ^[1]
in vivo	Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. ^[1] Clindamycin hydrochloride significantly reduces oral malodor from the dogs' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. ^[2] Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. ^[3] Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days. ^[4]

プロトコル(参考用のみ)

参考

[4] Bloom PB, et al. J Am Anim Hosp Assoc,?001, 37(6), 537-542.

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Zika virus cell tropism in the developing human brain and inhibition by azithromycin. [ Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413]	PubMed: 27911847

Zika virus cell tropism in the developing human brain and inhibition by azithromycin. [ Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413]

PubMed: 27911847

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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