Clopidogrel (SR-25990C) Bisulfate

製品コードS1415 バッチS141503

印刷

化学情報

Chemical Structure Synonyms Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H16ClNO2S.H2SO4
分子量 419.9 CAS No. 120202-66-6
Solubility (25°C)* 体外 DMSO 83 mg/mL (197.66 mM)
Ethanol 46 mg/mL (109.54 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent.
in vitro Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]
in vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]

プロトコル(参考用のみ)

カスタマーフィードバック

, , Cell, 2018, 172(3):564-577.e13

Data from [Data independently produced by , , Mol Carcinog, 2018, 57(12):1690-1697]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Clopidogrel Administration Impairs Post-Stroke Learning and Memory Recovery in Mice [ Int J Mol Sci, 2023, 24(14)11706] PubMed: 37511466
P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition [ Mol Ther, 2022, S1525-0016(22)00420-8] PubMed: 35791881
XJ-8, a natural compound isolated from Sanguis draxonis, inhibits platelet function and thrombosis by targeting MAP3K3 [ J Thromb Haemost, 2021, 10.1111/jth.15593] PubMed: 34780114
Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures [ Cell Rep, 2020, 33(5):108346] PubMed: 33147450
Towards the Therapeutic Use of TSP-1 (Thrombospondin-1)/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent [ Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120314571] PubMed: 33232198
P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine. [ J Neuroinflammation, 2019, 16(1):217] PubMed: 31722730
FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway [Toeda Y Mol Carcinog, 2018, 57(12):1690-1697] PubMed: 30129678
Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease. [Pagan JD, et al. Cell, 2017, S0092-8674(17)31431-9] PubMed: 29275858

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。