Curcumin

製品コードS1848 バッチS184805

化学情報

	Synonyms	Diferuloylmethane, Natural Yellow 3, Turmeric yellow	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₂₀O₆
	分子量	368.38	CAS No.	458-37-7
Solubility (25°C)*	体外	DMSO	73 mg/mL (198.16 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
in vitro	Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1^[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells^[3].
in vivo	Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB^[4].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	murine melanoma cell subline(B16-R)
	濃度	0-100 μM
	反応時間	24-48 h
	実験の流れ	1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay.
動物実験	動物モデル	Female B6D2F1 mice (6-8 weeks old)
	投薬量	25 mg/kg
	投与方法	i.p.

参考

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カスタマーフィードバック

: Data from [Oncol Res, 2014, 21(3), 137-44]

: Data from [Oncol Res, 2014, 21(3), 137-44]

: Data from [Data independently produced by , , J Exp Clin Cancer Res, 2018, 37(1):303]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The Cytotoxic Effect of Curcumin in Rhabdomyosarcoma Is Associated with the Modulation of AMPK, AKT/mTOR, STAT, and p53 Signaling [ Nutrients, 2023, 15(3)740]	PubMed: 36771452
Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway [ Phytother Res, 2022, 36(3):1326-1337]	PubMed: 35080289
MicroRNA profiling of paediatric AML with FLT-ITD or MLL-rearrangements: Expression signatures and in vitro modulation of miR-221-3p and miR-222-3p with BRD4/HATs inhibitors [ Oncol Rep, 2022, 48(6)221]	PubMed: 36321792
Curcumin assists anti-EV71 activity of IFN-α by inhibiting IFNAR1 reduction in SH-SY5Y cells [ Gut Pathog, 2022, 14(1):8]	PubMed: 35151347
Curcumin Inhibits the Growth and Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis [ Dis Markers, 2022, 2022:3129781]	PubMed: 35585935
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication [ Nat Metab, 2021, 10.1038/s42255-021-00479-4]	PubMed: 34580494
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360]	PubMed: 34918496
Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer [ Phytomedicine, 2021, 85:153547]	PubMed: 33812170
Curcumin Blunts IL-6 Dependent Endothelial-to-Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation [ Front Immunol, 2021, 12:656242]	PubMed: 34122411
Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway [ Int J Mol Sci, 2021, 22(12)6570]	PubMed: 34207376

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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