Cyclosporine

製品コードS1514 バッチS151402

印刷

化学情報

Chemical Structure Synonyms Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C62H111N11O12
分子量 1202.61 CAS No. 79217-60-0
Solubility (25°C)* 体外 DMSO 100 mg/mL warmed with 50ºC water bath (83.15 mM)
Ethanol 100 mg/mL (83.15 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
in vitro Cyclosporine induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. [1] Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. Cyclosporine through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. Cyclosporine also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. [2] Cyclosporine-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism responsible for the interaction between Cyclosporine and mycophenolate mofetil (MMF). [3] Cyclosporine inhibits biochemical and morphological differentiation of skeletal muscle cells while having a minimal effect on proliferation. [4]
in vivo Cyclosporine enhances tumour growth in immunodeficient SCID-beige mice. [1] Cyclosporine inhibits muscle regeneration after induced trauma in mice. [4] Cyclosporine peaks at 1 hour in blood, spleen, and kidney, with higher concentrations in spleen and kidney than in blood. [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

ATP/IL-33-Co-Sensing by Mast Cells (MCs) Requires Activated c-Kit to Ensure Effective Cytokine Responses [ Cells, 2023, 12(23)2696] PubMed: 38067124
Masitinib Inhibits Hepatitis A Virus Replication [ Int J Mol Sci, 2023, 24(11)9708] PubMed: 37298659
Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion [ Cell Rep, 2021, 34(10):108832] PubMed: 33691113
Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis [ Eur J Pharmacol, 2021, 898:173999] PubMed: 33675785
Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. [ Nat Microbiol, 2019, 4(11):1840-1850] PubMed: 31611641
Inhibition of MDR1 overcomes resistance to brentuximab vedotin in Hodgkin lymphoma. [ Clin Cancer Res, 2019, clincanres.1768.2019] PubMed: 31811017
A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors [ Oncotarget, 2019, 10(18):1669-1687] PubMed: 30899440
Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo. [ Arch Oral Biol, 2019, 97:42-51] PubMed: 30342306
[ Theranostics, 2018, ] PubMed: 30083255
Polydopamine-coated Au-Ag nanoparticle-guided photothermal colorectal cancer therapy through multiple cell death pathways [Hao M Acta Biomater, 2018, 83:414-424] PubMed: 30366131

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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