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Synonyms | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C62H111N11O12 |
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分子量 | 1202.61 | CAS No. | 79217-60-0 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL warmed with 50ºC water bath (83.15 mM) | |
Ethanol | 100 mg/mL (83.15 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
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in vitro | Cyclosporine induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. [1] Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. Cyclosporine through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. Cyclosporine also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. [2] Cyclosporine-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism responsible for the interaction between Cyclosporine and mycophenolate mofetil (MMF). [3] Cyclosporine inhibits biochemical and morphological differentiation of skeletal muscle cells while having a minimal effect on proliferation. [4] |
in vivo | Cyclosporine enhances tumour growth in immunodeficient SCID-beige mice. [1] Cyclosporine inhibits muscle regeneration after induced trauma in mice. [4] Cyclosporine peaks at 1 hour in blood, spleen, and kidney, with higher concentrations in spleen and kidney than in blood. [5] |
ATP/IL-33-Co-Sensing by Mast Cells (MCs) Requires Activated c-Kit to Ensure Effective Cytokine Responses [ Cells, 2023, 12(23)2696] | PubMed: 38067124 |
Masitinib Inhibits Hepatitis A Virus Replication [ Int J Mol Sci, 2023, 24(11)9708] | PubMed: 37298659 |
Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion [ Cell Rep, 2021, 34(10):108832] | PubMed: 33691113 |
Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis [ Eur J Pharmacol, 2021, 898:173999] | PubMed: 33675785 |
Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. [ Nat Microbiol, 2019, 4(11):1840-1850] | PubMed: 31611641 |
Inhibition of MDR1 overcomes resistance to brentuximab vedotin in Hodgkin lymphoma. [ Clin Cancer Res, 2019, clincanres.1768.2019] | PubMed: 31811017 |
A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors [ Oncotarget, 2019, 10(18):1669-1687] | PubMed: 30899440 |
Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo. [ Arch Oral Biol, 2019, 97:42-51] | PubMed: 30342306 |
[ Theranostics, 2018, ] | PubMed: 30083255 |
Polydopamine-coated Au-Ag nanoparticle-guided photothermal colorectal cancer therapy through multiple cell death pathways [Hao M Acta Biomater, 2018, 83:414-424] | PubMed: 30366131 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。