Daidzein

製品コードS1849 バッチS184901

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₅H₁₀O₄

分子量

254.24

CAS No.

486-66-8

Solubility (25°C)*

体外

DMSO

51 mg/mL (200.59 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.55mg/ml (10.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 51 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.36mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 7.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Daidzeinは、マメ科植物に含まれる天然のイソフラボン phytoestrogen であり、食品や栄養補助食品の成分として使用されています。
in vitro	Daidzein inhibits iNOS protein and mRNA expression and also NO production in a dose-dependent manner. This compound also inhibits the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS. This chemical (1 μM and 10 μM) causes a significant elevation of protein content, alkaline phosphatase activity, and DNA content in cells; those increases are about 1.4-, 1.5-, and 2.0-fold, respectively. It (2-50 mM) increases the viability of osteoblasts by about 1.4-fold. This compound (2-100 mM) increases the alkaline phosphatase activity and osteocalcin synthesis of osteoblasts by about 1.4- and 2.0-fold, respectively. It stimulates osteoblast differentiation at various stages (from osteoprogenitors to terminally differentiated osteoblasts). This chemical (1 μM and 10 μM) causes a significant increase of alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in bone tissues. The compound-induced increase of calcium content and alkaline phosphatase activity in bone tissues is completely prevented by cycloheximide (1 μM).
in vivo	Daidzein results in reduced body weight, a fact that may be explained by reduced feed consumption in female rats. This compound results in slight, but not significant, decreases in ovarian and uterine weights, and mammary gland size in female rats.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/18274639/
https://pubmed.ncbi.nlm.nih.gov/10660113/
https://pubmed.ncbi.nlm.nih.gov/12628484/

https://pubmed.ncbi.nlm.nih.gov/10391128/
https://pubmed.ncbi.nlm.nih.gov/11812927/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

In Silico and In Vitro multiple analysis approach for screening naturally derived ligands for red seabream aryl hydrocarbon receptor [ Ecotoxicol Environ Saf, 2024, 275:116262]	PubMed: 38569320
Basic Fibroblast Growth Factor Protects Astrocytes Against Ischemia/Reperfusion Injury by Upregulating the Caveolin-1/VEGF Signaling Pathway [Liu M J Mol Neurosci, 2018, 64(2):211-223]	PubMed: 29299743

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。