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Synonyms | Collettiside III, Saponin | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C45H72O16 |
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分子量 | 869.04 | CAS No. | 19057-60-4 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (115.06 mM) | |
Ethanol | 25 mg/mL (28.76 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities. |
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in vitro | Dioscin is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. [1] Dioscin induces apotosis in Hela cells by down regulating caspase-8 activity and up regulating caspase-9 activity. [2] |
in vivo | LD50: Mice >300mg/kg [3] |
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Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin [ J Cancer, 2024, 15(5):1366-1377] | PubMed: 38356707 |
Cannabidiol Does Not Impact Acute Anabolic or Inflammatory Signaling in Skeletal Muscle In Vitro [ Cannabis Cannabinoid Res, 2021, 10.1089/can.2021.0132] | PubMed: 34762497 |
Dioscin induces ferroptosis and synergistic cytotoxicity with chemotherapeutics in melanoma cells [ Biochem Biophys Res Commun, 2021, 557:213-220] | PubMed: 33878610 |
Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. [ Mol Med Rep, 2020, 21(1):304-310] | PubMed: 31746382 |
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression [Wang YC Int J Biol Sci, 2018, 14(1):47-56] | PubMed: 29483824 |
Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mTOR pathways [Chen L Life Sci, 2018, 209:420-429] | PubMed: 30125581 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。