Econazole nitrate

製品コードS2535 バッチS253502

印刷

化学情報

Synonyms

NSC 243115,Spectazole

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₈H₁₅Cl₃N₂O.HNO₃

分子量

444.7

CAS No.

24169-02-6

Solubility (25°C)*

体外

DMSO

89 mg/mL (200.13 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.
in vitro	Econazole nitrate is an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). ^[1] This compound inhibits the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method and colony forming assay. This compound results in typical characteristics of apoptosis including the morphological changes and DNA fragmentation in MCF-7 cells. This compound results in the decrease expression of procaspase-3, procaspase-9 and bcl-2. ^[2] This compound inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). This compound produces an essentially complete inhibition of the TRPM2-mediated current. ^[3] This compound (25-50 mM) partially inhibits capacitative Ca2+ entry induced by cyclopiazonic acid, another endoplasmic reticulum Ca2+ pump inhibitor. This compound induces Ca2+ influx via two separate pathways: one is sensitive to La3+, the other is not. ^[4] This compound reversibly inhibits (Bu)(2)cAMP-stimulated progesterone production in a dose- and time-dependent manner in MA-10 cells without affecting total protein synthesis or P450(scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme expression or activity. ^[5] This compound is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. This compound (5-20 mM) arrests human colon cancer cells at the G0/G1 phase of the cell cycle. This compound induces COLO 205 cells apoptosis evidenced by ladder formation in DNA fragmentation assay and sub-G1 peak. ^[6]

製品説明

Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.

in vitro

Econazole nitrate is an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). ^[1] This compound inhibits the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method and colony forming assay. This compound results in typical characteristics of apoptosis including the morphological changes and DNA fragmentation in MCF-7 cells. This compound results in the decrease expression of procaspase-3, procaspase-9 and bcl-2. ^[2] This compound inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). This compound produces an essentially complete inhibition of the TRPM2-mediated current. ^[3] This compound (25-50 mM) partially inhibits capacitative Ca2+ entry induced by cyclopiazonic acid, another endoplasmic reticulum Ca2+ pump inhibitor. This compound induces Ca2+ influx via two separate pathways: one is sensitive to La3+, the other is not. ^[4] This compound reversibly inhibits (Bu)(2)cAMP-stimulated progesterone production in a dose- and time-dependent manner in MA-10 cells without affecting total protein synthesis or P450(scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme expression or activity. ^[5] This compound is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. This compound (5-20 mM) arrests human colon cancer cells at the G0/G1 phase of the cell cycle. This compound induces COLO 205 cells apoptosis evidenced by ladder formation in DNA fragmentation assay and sub-G1 peak. ^[6]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/16423345/
https://pubmed.ncbi.nlm.nih.gov/25587322/
https://pubmed.ncbi.nlm.nih.gov/15549272/

https://pubmed.ncbi.nlm.nih.gov/9990306/
https://pubmed.ncbi.nlm.nih.gov/11282276/
https://pubmed.ncbi.nlm.nih.gov/15919146/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors [ Nat Commun, 2024, 15(1):8708]	PubMed: 39379362
Econazole selectively induces cell death in NF1-homozygous mutant tumor cells [ Cell Rep Med, 2023, 4(12):101309]	PubMed: 38086379
Terconazole, an Azole Antifungal Drug, Increases Cytotoxicity in Antimitotic Drug-Treated Resistant Cancer Cells with Substrate-Specific P-gp Inhibitory Activity [ Int J Mol Sci, 2022, 23(22)13809]	PubMed: 36430288
Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells [ Biomol Ther (Seoul), 2020, 25]	PubMed: 32209732

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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