17β-Estradiol

製品コードS1709 バッチS170903

化学情報

	Synonyms	17β-estradiol, β-Estradiol, E2, 17β-Oestradiol	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₈H₂₄O₂
	分子量	272.38	CAS No.	50-28-2
Solubility (25°C)*	体外	DMSO	54 mg/mL (198.25 mM)
		Ethanol	8 mg/mL (29.37 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Estradiol（17β-エストラジオール、β-エストラジオール、E2、17β-Oestradiol）は、ヒトの性ホルモンでありステロイドであり、主要な女性ホルモンです。Estradiolは、estrogen receptor β (ERβ)経路を介してIL-6の発現をアップレギュレートします。
in vitro	Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. This compound treatment resulted in a 46% increase in NMDA receptor binding. It increases NMDA receptor binding in parallel with dendritic spine and synapse density. This chemical treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. This compound is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons. It exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. This chemical inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.
in vivo	Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. This compound alone can reverse the ovariectomy-induced decrease in spine density. It combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following this chemical alone.

製品説明

Estradiol（17β-エストラジオール、β-エストラジオール、E2、17β-Oestradiol）は、ヒトの性ホルモンでありステロイドであり、主要な女性ホルモンです。Estradiolは、estrogen receptor β (ERβ)経路を介してIL-6の発現をアップレギュレートします。

in vitro

Estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. This compound treatment resulted in a 46% increase in NMDA receptor binding. It increases NMDA receptor binding in parallel with dendritic spine and synapse density. This chemical treatment results in increased sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and that this increase is well correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells.

This compound is found to reduce Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. 17 alpha-Estradiol also reduces Ba2+ currents but is significantly less effective than 17 beta-estradiol in rat neostriatal neurons.

It exerts a dose-dependent inhibition of IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. This chemical inhibits both TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.

in vivo

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

This compound alone can reverse the ovariectomy-induced decrease in spine density. It combined with Progesterone initially increases spine density for a period of 2 to 6 hours but then results in a much sharper decrease than is observed following this chemical alone.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HCC1806 cells
	濃度	10 nM
	反応時間	24 h
	実験の流れ	Cells were treated with vehicle or 10 nM E2 for 24 hours.
動物実験	動物モデル	Female Sprague-Dawley rats
	投薬量	10 µg
	投与方法	s.c.

参考

https://pubmed.ncbi.nlm.nih.gov/9030643/
https://pubmed.ncbi.nlm.nih.gov/8551343/
https://pubmed.ncbi.nlm.nih.gov/1541679/

https://pubmed.ncbi.nlm.nih.gov/1613547/
https://pubmed.ncbi.nlm.nih.gov/8245220/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation [ Cancer Cell, 2025, 43(5):891-904.e10]	PubMed: 40250444
Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis [ Nat Commun, 2025, 16(1):758]	PubMed: 39824794
Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer [ Cell Rep Med, 2025, 6(7):102192]	PubMed: 40516531
17β-Estradiol Promotes Tumorigenicity Through an Autocrine AREG/EGFR Loop in ER-α-Positive Breast Cancer Cells [ Cells, 2025, 14(10)703]	PubMed: 40422206
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia [ iScience, 2024, 27(3):109125]	PubMed: 38420594
Testosterone and estradiol reduce inflammation of human macrophages induced by anti-SARS-CoV-2 IgG [ Eur J Immunol, 2024, e2451226.]	PubMed: 39246165
Synthesis of a [18F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module: In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging [ Pharmaceuticals (Basel), 2024, 17(3)388]	PubMed: 38543174
Injectable Biomimetic Hydrogel Constructs for Cell-Based Menopausal Hormone Therapy with Reduced Breast Cancer Potential [ Biomater Res, 2024, 28:0054]	PubMed: 39135549
Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals [ Biomater Res, 2024, 28:0010]	PubMed: 38464469
Drug-drug interaction potentials of tucatinib inhibition of human UDP-glucuronosyltransferases [ Chem Biol Interact, 2023, 381:110574]	PubMed: 37263554

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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