Ethinyl Estradiol

製品コードS1625 バッチS162503

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C20H24O2
分子量 296.4 CAS No. 57-63-6
Solubility (25°C)* 体外 DMSO 59 mg/mL (199.05 mM)
Ethanol 59 mg/mL (199.05 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Ethinyl Estradiolは、ほとんどすべての現代の経口避妊薬配合で使用されている、経口生物活性型エストロゲンです。
in vitro Ethinyl Estradiol increases respiratory chain activity in both cultured rat hepatocytesand HepG2 cells. This compound is a strong promoter of hepatocarcinogenesis. It enhances the transcript levels of nuclear genome- and mitochondrial genome-encoded genes and respiratory chain activity in female rat liver, and also inhibits transforming growth factor beta (TGFbeta)-induced apoptosis in cultured liver slices and hepatocytes from female rats. This chemical increases the transcript levels of the mitochondrial genome-encoded genes cytochrome oxidase subunits I, II, and III in cultured female rathepatocytes. It significantly increases both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form is not affected.
in vivo Ethinyl Estradiol (50 mg/kg/day) increases anogenital distance and reduces pup body weight at postnatal day 2, accelerates the age at vaginal opening, reduces F1 fertility and F2 litter sizes, and induces malformations of the external genitalia (5 mg/kg) in the female Long-Evans rat. This compound increases the number of low density lipoprotein (LDL) receptors in livers of rats, thereby producing a profound fall in plasma cholesterol levels. It exerts the same effect in livers of male and female rabbits and that the increase in receptor number is correlated with a 6- to 8-fold increase in the levels of receptor mRNA.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10543024/
  • https://pubmed.ncbi.nlm.nih.gov/12857939/
  • https://pubmed.ncbi.nlm.nih.gov/19864446/
  • https://pubmed.ncbi.nlm.nih.gov/2418443/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations [ Hum Mol Genet, 2020, ddaa244] PubMed: 33231680
Evaluation of dietary dose administration as an alternative to oral gavage in the rodent uterotrophic and Hershberger assays [ Regul Toxicol Pharmacol, 2020, S0273-2300(20)30246-4] PubMed: 33181237

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。