Fluconazole

製品コードS1331 バッチS133150

印刷

化学情報

Chemical Structure Synonyms UK 49858 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C13H12F2N6O
分子量 306.27 CAS No. 86386-73-4
Solubility (25°C)* 体外 DMSO 61 mg/mL (199.17 mM)
Ethanol 61 mg/mL (199.17 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.
in vitro

Fluconazole in combination with amphotericin B (AmB) has a synergistic effect on C. albicans planktonic cells but does not alter AmB activity against biofilms. This compound and caspofungin have an antagonistic effect against biofilms but not with planktonic cells. It-mediated membrane perturbation (due to inhibition of ergosterol biosynthesis) increases calcineurin inhibitor intracellular concentrations. This treatment significantly reduces levels of ergosterol within the cell in C. albicans planktonic cells, leading to cell membrane perturbation. [1] Its activity is less sensitive to acidic medium than is that of ketoconazole. The compound is approximately 16-fold less active than ketoconazole against 35 representative isolates of C. albicans at physiologic pH. [2] Fluvastatin, a cholesterol-lowering drug, exhibits minimal activity (MICs of 64 to >128 mg/mL) against Candida species and Cryptococcus neoformans. This chemical combined with itraconazole exhibits potent activities against C. albicans, C. tropicalis, C. parapsilosis, and C. neoformans, including flucon- azole-resistant strains of C. albicans and C. tropicalis. [3]
in vivo

Fluconazole is very effective in prolonging survival of rats infected with a representative candidal strain. [3] This compound has a dramatic effect on the fungicidal activity of flucytosine in murine cryptococcal meningitis. It combined with flucytosine and amphotericin B have significantly improved activity against cryptococcal meningitis compared with the activity of each drug used alone. [4]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/18180354/
  • https://pubmed.ncbi.nlm.nih.gov/3022641/
  • https://pubmed.ncbi.nlm.nih.gov/9087504/
  • https://pubmed.ncbi.nlm.nih.gov/8878602/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Rad6 and Bre1 ubiquitin ligase negatively regulate biofilm formation and virulence in Candida glabrata [ J Infect, 2025, 91(3):106595] PubMed: 40850399
Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis [ PLoS Pathog, 2025, 21(5):e1013220] PubMed: 40424325
Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species [ Infect Drug Resist, 2025, 18:783-789] PubMed: 39958982
In vitro interactions of proton pump inhibitors and azoles against pathogenic fungi [ Front Cell Infect Microbiol, 2024, 14:1296151] PubMed: 38304196
In vivo RNA sequencing reveals a crucial role of Fus3-Kss1 MAPK pathway in Candida glabrata pathogenicity [ mSphere, 2024, 9(11):e0071524] PubMed: 39475321
Interactions between antifungals and everolimus against Cryptococcus neoformans [ Front Cell Infect Microbiol, 2023, 13:1131641] PubMed: 37026056
BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation [ Nat Commun, 2022, 13(1):1658] PubMed: 35351876
Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo [ Nat Commun, 2022, 13(1):4295] PubMed: 35879318
Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo [ Nat Commun, 2022, 13(1):4295] PubMed: 35879318
Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo [ Front Cell Infect Microbiol, 2022, 12:1074903] PubMed: 36569209

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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