Fudosteine

製品コードS2129 バッチS212902

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₆H₁₃NO₃S
	分子量	179.24	CAS No.	13189-98-5
Solubility (25°C)*	体外	Water	36 mg/mL (200.84 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Fudosteineは、慢性呼吸器疾患の適応を持つ粘液活性剤として使用される、システイン誘導体であり、MUC5AC mucin過剰分泌阻害剤です。
in vitro	Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. This compound (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. It significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. This chemical inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. Its treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. This agent inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of this compound are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. It significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. This substance scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction.
in vivo	Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. This compound increases chloride ion concentration in broncho-alveolar lavage of rats.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/19188555/
https://pubmed.ncbi.nlm.nih.gov/15649854/
https://pubmed.ncbi.nlm.nih.gov/18579549/

https://pubmed.ncbi.nlm.nih.gov/21782562/
https://pubmed.ncbi.nlm.nih.gov/11188505/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway [ Eur J Pharmacol, 2022, 926:175047]	PubMed: 35609679

Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway [ Eur J Pharmacol, 2022, 926:175047]

PubMed: 35609679

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。