Glycyrrhizin (NSC 167409)

製品コードS2302 バッチS230207

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄₂H₆₂O₁₆
	分子量	822.93	CAS No.	1405-86-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (121.51 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
in vitro	Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM^[4].
in vivo	Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice^[3].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Cell-free assays
	濃度	0.16 μM
	反応時間
	実験の流れ
動物実験	動物モデル	Swiss albino mice
	投薬量	1.5, 3.0 and 6.0 mg/kg
	投与方法	i.p.

参考

[4] Hatano T, et al. Chem Pharm Bull (Tokyo). 1991, 39(5):1238-43.

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カスタマーフィードバック

: Data from [Data independently produced by , , DNA Cell Biol, 2017, 36(1):67-76]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis [ Ecotoxicol Environ Saf, 2024, 272:116068]	PubMed: 38330871
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 14:1024706]	PubMed: 36761729
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 10.3389/fimmu.2023.1024706]	PubMed: 36761729
Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome in vitro and in vivo [ J Ethnopharmacol, 2023, 303:115948]	PubMed: 36423713
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712]	PubMed: 37354638
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage [ J Neurochem, 2023, 167(3):410-426]	PubMed: 37753942
Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway [ Oxid Med Cell Longev, 2022, 2022:8438528]	PubMed: 35432719
Inhibition of HMGB1/TLR4 Signaling Pathway by Digitoflavone: A Potential Therapeutic Role in Alcohol-Associated Liver Disease [ J Agric Food Chem, 2022, 70(9):2968-2983]	PubMed: 35212223
Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation [ Int Immunopharmacol, 2022, 108:108730]	PubMed: 35354111
HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury [ J Neuroinflammation, 2021, 18(1):241]	PubMed: 34666797

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。