Guaifenesin

製品コードS1740 バッチS174001

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₀H₁₄O₄

分子量

198.22

CAS No.

93-14-1

Solubility (25°C)*

体外

DMSO

40 mg/mL (201.79 mM)

Ethanol

40 mg/mL (201.79 mM)

Water

25 mg/mL (126.12 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Guaifenesin is an expectorant used to relieve chest congestion.
in vivo	Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. This compound (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. It (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. ^[1] This chemical (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. ^[2] It (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. ^[3] This compound prevents adverse anesthetic induction events caused by Propofol in horse. It (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. ^[4] This chemical (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. It (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. ^[5]

製品説明

Guaifenesin is an expectorant used to relieve chest congestion.

in vivo

Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. This compound (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. It (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. ^[1] This chemical (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. ^[2] It (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. ^[3] This compound prevents adverse anesthetic induction events caused by Propofol in horse. It (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. ^[4] This chemical (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. It (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. ^[5]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/3651894/
https://pubmed.ncbi.nlm.nih.gov/18052732/
https://pubmed.ncbi.nlm.nih.gov/11131605/

https://pubmed.ncbi.nlm.nih.gov/22126682/
https://pubmed.ncbi.nlm.nih.gov/12444496/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Repurposing amiodarone for bladder cancer treatment [ Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433]	PubMed: 40353763

Repurposing amiodarone for bladder cancer treatment [ Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433]

PubMed: 40353763

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。