Hydrocortisone

製品コードS1696 バッチS169602

化学情報

	Synonyms	NSC 10483	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₃₀O₅
	分子量	362.46	CAS No.	50-23-7
Solubility (25°C)*	体外	DMSO	73 mg/mL (201.4 mM)
		Ethanol	23 mg/mL (63.45 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
in vitro	Hydrocortisone prevents endothelial barrier breakdown in response to pro-inflammatory stimuli (TNFalpha administration) in the human brain microvascular endothelial cell line hCMEC/D3, which could be demonstrated to be partly based on maintenance of occludin levels. ^[1] Hydrocortisone-treated dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibits production of IFN-gamma but induces an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces T-cell proliferation in dendritic cells. ^[2] Hydrocortisone prevents TNF-alpha induced severe degradation of the glycocalyx, increased coronary resistance, heightened vascular leak and permeability to hydroxyethyl starch and caused mast-cell degranulation in isolated guinea pig hearts. ^[3] Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation in isolated guinea pig hearts. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as release of histamine from resident mast cells. ^[4] Hydrocortisone increases the levels of IL-4-induced germ line C epsilon transcripts by twofold and delivers the signal required for transcription of mature C epsilon mRNA. Hydrocortisone induces S mu-S epsilon deletional switch recombination in IL-4-treated B cells, and support a model of sequential isotype switching from IgM to IgE via IgG4. ^[5]

製品説明

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.

in vitro

Hydrocortisone prevents endothelial barrier breakdown in response to pro-inflammatory stimuli (TNFalpha administration) in the human brain microvascular endothelial cell line hCMEC/D3, which could be demonstrated to be partly based on maintenance of occludin levels. ^[1]

Hydrocortisone-treated dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibits production of IFN-gamma but induces an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces T-cell proliferation in dendritic cells. ^[2]

Hydrocortisone prevents TNF-alpha induced severe degradation of the glycocalyx, increased coronary resistance, heightened vascular leak and permeability to hydroxyethyl starch and caused mast-cell degranulation in isolated guinea pig hearts. ^[3]

Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation in isolated guinea pig hearts. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as release of histamine from resident mast cells. ^[4]

Hydrocortisone increases the levels of IL-4-induced germ line C epsilon transcripts by twofold and delivers the signal required for transcription of mature C epsilon mRNA. Hydrocortisone induces S mu-S epsilon deletional switch recombination in IL-4-treated B cells, and support a model of sequential isotype switching from IgM to IgE via IgG4. ^[5]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	CD34+ cells
	濃度	1 μM
	反応時間	16 h
	実験の流れ	Cells were treated with indicated concentrations of drug.
動物実験	動物モデル	Male wistar rats
	投薬量	1.5 mg/100 g
	投与方法	i.v.

参考

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling [ Int J Radiat Oncol Biol Phys, 2024, S0360-3016(24)00307-9]	PubMed: 38364946
Glucocorticoids modulate neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system [ Neurobiol Stress, 2024, 28:100593]	PubMed: 38075025
Evolutionary histories of breast cancer and related clones [ Nature, 2023, 620(7974):607-614]	PubMed: 37495687
PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652 [ Cell Rep, 2023, 10.1016/j.celrep.2023.113343]	PubMed: 37906592
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer [ Life Sci Alliance, 2023, 6(10)e202302009]	PubMed: 37536978
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer [ Life Sci Alliance, 2023, 6(10)e202302009]	PubMed: 37536978
Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia [ Research Square, 2023, 10.21203/rs.3.rs-3629594/v1]	PubMed: none
Protocol to develop a microfluidic human corneal barrier-on-a-chip to evaluate the corneal epithelial wound repair process [ STAR Protoc, 2023, 4(1):102122]	PubMed: 36861830
Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells [ Cell Discov, 2022, 8(1):121]	PubMed: 36344493
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice [ Nat Commun, 2022, 13(1):6233]	PubMed: 36280666

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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