Icariin

製品コードS2312 バッチS231205

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C33H40O15
分子量 676.66 CAS No. 489-32-7
Solubility (25°C)* 体外 DMSO 100 mg/mL (147.78 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/12646997/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1 [ Naunyn Schmiedebergs Arch Pharmacol, 2025, none] PubMed: 39812768
Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro [ J Vet Res, 2024, 68(1):35-44] PubMed: 38525227
Icariin regulates acidic microenvironment to alleviate pain caused by postmenopausal osteoporosis in the elderly [ Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468.] PubMed: none
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] PubMed: 37354638
Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1 [ J Orthop Surg Res, 2023, 18(1):500] PubMed: 37454090
Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1 [ J Orthop Surg Res, 2023, 18(1):500] PubMed: 37454090
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study [ Phytomedicine, 2021, 80:153387] PubMed: 33130473
Combined protective effects of icariin and selenomethionine on novel chronic tubulointerstitial nephropathy models in vivo and in vitro [ Br J Nutr, 2021, 1-11] PubMed: 33663624
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Effect of icariin on apoptosis in hippocampal neurons cultured in high glucose [ J Tradit Chin Med, 2018, 38(4):556-561] PubMed: 32186080

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。