Ifosfamide

製品コードS1302 バッチS130202

印刷

化学情報

Chemical Structure Synonyms NSC109724, Isophosphamide Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C7H15Cl2N2O2P
分子量 261.09 CAS No. 3778-73-2
Solubility (25°C)* 体外 DMSO 52 mg/mL (199.16 mM)
Water 52 mg/mL (199.16 mM)
Ethanol 52 mg/mL (199.16 mM)
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
in vitro

Ifosfamide (50 mM) increases CYP3A4, CYP2C8, and CYP2C9 protein levels in hepatocytes, which thereby enhances their own rates of 4-hydroxylation in the cultured hepatocytes. This compound only induces CYP3A4 in one human hepatocyte culture that contained the polymorphically expressed CYP3A5 in addition to the more widely expressed CYP3A4. [1] It is a prodrug metabolised in the liver by cytochrome P450 mixed-function oxidase enzymes to isofosforamide mustard, the active alkylating compound. This drug has produced favourable response rates in small cell lung cancer, paediatric solid tumours, non-Hodgkin's and Hodgkin's lymphoma, and ovarian cancer. [2] It is highly cytotoxic to MCF-7 cells following stable transfection of CYP2B1 but exhibits no toxicity to parental tumor cells or to a beta-galactosidase-expressing MCF-7 transfectant, this cytotoxicity could be appreciably blocked by the CYP2B1 inhibitor metyrapone. [3] When combined with Zoledronic acid, it is more effective than each agent alone in preventing tumor recurrence, improving tissue repair, and increasing bone formation as revealed by the analysis of trabecular architecture. [4]
in vivo

Ifosfamide (100 mg/kg, 200 mg/kg and 400 mg/kg) injected intraperitoneally induces a dose dependent increase in bladder wet weight and Evans blue extravasation in mice. This compound reveals extensive cystitis characterized by acute inflammation with vascular congestion, edema, hemorrhage and fibrin deposition, neutrophil cell infiltration and epithelial denudation in mice. It shows intense reactivity to inducible nitric oxide synthase in the cytoplasm as well as intense and diffuse necrosis on hematoxylin and eosin staining. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/9157990/
  • https://pubmed.ncbi.nlm.nih.gov/1720382/
  • https://pubmed.ncbi.nlm.nih.gov/8640822/
  • https://pubmed.ncbi.nlm.nih.gov/15894525/
  • https://pubmed.ncbi.nlm.nih.gov/11956484/

カスタマーフィードバック

Data from [Data independently produced by , , Tumour Biol, 2016, 37(2):2341-51]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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