Isotretinoin (13-cis retinoic acid)

製品コードS1379 バッチS137901

印刷

化学情報

Chemical Structure Synonyms Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C20H28O2
分子量 300.44 CAS No. 4759-48-2
Solubility (25°C)* 体外 DMSO 60 mg/mL (199.7 mM)
Ethanol 8 mg/mL warmed with 50ºC water bath (26.62 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
in vitro Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2]
in vivo Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System [ Int J Mol Sci, 2022, 23(16)9366] PubMed: 36012634
Neuronal Differentiation-Related Epigenetic Regulator ZRF1 Has Independent Prognostic Value in Neuroblastoma but Is Functionally Dispensable In Vitro [ Cancers -Basel), 2021, 13(19)4845] PubMed: 34638328
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma [ Sci Adv, 2021, 7(43):eabe0834] PubMed: 34669465
The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis [ Cell Death Dis, 2020, 11(9):773] PubMed: 32943619
11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma [ Cell Rep, 2020, 32(12):108171] PubMed: 32966799
MYT1 Attenuates Neuroblastoma Cell Differentiation by Interacting With the LSD1/CoREST Complex [ Oncogene, 2020, 39(21):4212-4226] PubMed: 32251364
Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid [ Sci Rep, 2018, 8(1):12960] PubMed: 30154523
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain [ Elife, 2016, 5e14713] PubMed: 27130733

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。