Leucovorin (Folinic acid) Calcium Pentahydrate

製品コードS1236 バッチS123607

化学情報

	Synonyms	NSC-3590 Calcium Pentahydrate, Calcium Folinatc, Citrovorum Factor	Storage (From the date of receipt)	4°C (in the dark)
	化学式	C₂₀H₃₁CaN₇O₁₂
	分子量	601.58	CAS No.	6035-45-6
Solubility (25°C)*	体外	Water	100 mg/mL warmed with 50ºC water bath (166.22 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared.
in vitro	Leucovorin administration increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase in two murine colon tumors. ^[1] Leucovorin, Gemcitabine, Oxaliplatin, and 5-fluorouracil is a powerful antitumor and immunomodulating regimen that can make the tumor cells a suitable means to induce an Ag-specific CTL response. ^[2] Leucovorin (20 mM) increases the cytotoxicity in all three replicate experiments in 10 of the 11 human colorectal carcinoma cell lines. ^[3] Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells. ^[4] Leucovorin (LV) is a reduced folate cofactor that competes with RTX for transport and polyglutamation in both tumor and normal tissues and thus has potential as a rescue agent. Leucovorin reverses the growth-inhibitory, and potentially cytotoxic, effects of RTX on populations of viable cells. ^[5]
in vivo	Leucovorin (200 mg/kg), which is given after the onset of severe weight loss and diarrhea (twice daily, days 5-7) in mice, prevents further weight loss and induces earlier recovery. Leucovorin (100 or 200 mg/kg; twice daily on days 4-6) reduces the RTX concentration in the liver 2-4-fold on days 7, 9, and 11 compared with controls. ^[5] Leucovorin/5-FU and Gastrimmune (200 mg/mL) combinations (12.5 and 20 mg/kg) increase the therapeutic effects on the in vivo growth of DHDK12 tumors when compared to the agents given singly. ^[6]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/1516048/
https://pubmed.ncbi.nlm.nih.gov/16002679/
https://pubmed.ncbi.nlm.nih.gov/2973527/

https://pubmed.ncbi.nlm.nih.gov/1376779/
https://pubmed.ncbi.nlm.nih.gov/10999757/
https://pubmed.ncbi.nlm.nih.gov/9506532/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma [ J Exp Clin Cancer Res, 2025, 44(1):13]	PubMed: 39810240
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity [ Cell Rep Med, 2023, 4(10):101200]	PubMed: 37734378
Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity [ Cell Rep Med, 2023, S2666-3791(23)00367-1]	PubMed: 37734378
Synergistic Effect of Lenvatinib and Chemotherapy in Hepatocellular Carcinoma Using Preclinical Models [ J Hepatocell Carcinoma, 2023, 10:483-495]	PubMed: 37007211
Synergistic Effect of Lenvatinib and Chemotherapy in Hepatocellular Carcinoma Using Preclinical Models [ J Hepatocell Carcinoma, 2023, 10:483-495]	PubMed: 37007211
3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma [ J Clin Invest, 2022, 132(24)e151604]	PubMed: 36282600
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360]	PubMed: 34918496
Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer [ Cell Prolif, 2021, e13031]	PubMed: 33755268
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models [ Virus Res, 2021, 302:198469]	PubMed: 34090962

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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