Levodopa

製品コードS1726 バッチS172602

印刷

化学情報

Chemical Structure Synonyms L-DOPA Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H11NO4

分子量 197.19 CAS No. 59-92-7
Solubility (25°C)* 体外 5%TFA 3 mg/mL (15.21 mM)
DMSO Insoluble
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Clear solution
5%5%TFA 40%PEG300 5%Tween80 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.15mg/ml (0.76mM) Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified 5%TFA stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution
5% 5%TFA 95% Corn oil

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 0.15mg/ml (0.76mM) Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear 5%TFA stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Levodopa(L-DOPA) is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
in vitro

Levodopa produces at 25-200 μM concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. This compound results in a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network. [1] It induces dyskinesia in the absence of dopamine by excessive inhibition of neurons of the putamen-globus pallidus (GPe) projection and subsequent disinhibition of the globus pallidus (GPe). This chemical results in a decrease in cytochrome oxidase messenger RNA expression in the globus pallidus (GPi). [2]
in vivo

Levodopa elicits the development of a variety of abnormal movements in monkeys with parkinsonism induced by the neurotoxin MPTP. This compound administrations result in an ectopic induction of the dopamine D3receptor expression in the CdPu in 6-OHDA-lesioned rats. [3] This chemical (50 mg/kg) increases anandamide concentrations throughout thebasal ganglia via activation of dopamine D1/D2 receptors in intact rats. It produces increasingly severe oro-lingual involuntary movements which are attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg) in lesioned rats. [4] This compound administration reverses the up-regulation of D2 dopamine receptors seen in severely lesioned rats provided evidence that it reaches a biologically active concentration at the basal ganglia. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/8499605/
  • https://pubmed.ncbi.nlm.nih.gov/15102749/
  • https://pubmed.ncbi.nlm.nih.gov/90966399/
  • https://pubmed.ncbi.nlm.nih.gov/14511339/
  • https://pubmed.ncbi.nlm.nih.gov/9585350/

カスタマーフィードバック

Data from [Data independently produced by , , PLoS ONE, 12(3), e0173240]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Coeloglossum viride Var. Bracteatum Extract Attenuates MPTP-Induced Neurotoxicity in vivo by Restoring BDNF-TrkB and FGF2-Akt Signaling Axis and Inhibiting RIP1-Driven Inflammation [ Front Pharmacol, 2022, 13:903235] PubMed: 35571135
Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells. [Lu J, et al. PLoS One, 2017, 12(3):e0173240] PubMed: 28253352

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。